LOCUS       NM_022180               4416 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hepatocyte nuclear factor 4, alpha (Hnf4a),
            transcript variant 1, mRNA.
ACCESSION   NM_022180
VERSION     NM_022180.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4416)
  AUTHORS   Melis,M., Marino,R., Tian,J., Johnson,C., Sethi,R., Oertel,M.,
            Fox,I.J. and Locker,J.
  TITLE     Mechanism and Effect of HNF4alpha Decrease in a Rat Model of
            Cirrhosis and Liver Failure
  JOURNAL   Cell Mol Gastroenterol Hepatol 17 (3), 453-479 (2024)
   PUBMED   37993018
  REMARK    GeneRIF: Mechanism and Effect of HNF4alpha Decrease in a Rat Model
            of Cirrhosis and Liver Failure.
REFERENCE   2  (bases 1 to 4416)
  AUTHORS   Zhan,H., Zhang,Q., Zhang,C., Cheng,J., Yang,Y., Liu,C., Li,S.,
            Wang,C., Yang,J., Ge,H., Zhou,D., Li,B., Wei,H. and Hu,C.
  TITLE     Targeted Activation of HNF4alpha by AMPK Inhibits Apoptosis and
            Ameliorates Neurological Injury Caused by Cardiac Arrest in Rats
  JOURNAL   Neurochem Res 48 (10), 3129-3145 (2023)
   PUBMED   37338793
  REMARK    GeneRIF: Targeted Activation of HNF4alpha by AMPK Inhibits
            Apoptosis and Ameliorates Neurological Injury Caused by Cardiac
            Arrest in Rats.
REFERENCE   3  (bases 1 to 4416)
  AUTHORS   Fan,J.Y., Dama,G., Liu,Y.L., Guo,W.Y. and Lin,J.T.
  TITLE     [Combinational Overexpression of Foxa3 and Hnf4alpha Enhance the
            Proliferation and Prolong the Functional Maintenance of Primary
            Hepatocytes]
  JOURNAL   Mol Biol (Mosk) 57 (4), 668-670 (2023)
   PUBMED   37528786
  REMARK    GeneRIF: [Combinational Overexpression of Foxa3 and Hnf4alpha
            Enhance the Proliferation and Prolong the Functional Maintenance of
            Primary Hepatocytes].
REFERENCE   4  (bases 1 to 4416)
  AUTHORS   Hu,C., Jing,R., Wen,C., Qi,T., Bai,X., Wang,Y., Shao,Y. and Pei,C.
  TITLE     HNF4A Negatively Regulated Posterior Capsular Opacification via
            Transcriptional Inhibition of MMP2
  JOURNAL   Curr Eye Res 48 (7), 627-638 (2023)
   PUBMED   36988559
  REMARK    GeneRIF: HNF4A Negatively Regulated Posterior Capsular
            Opacification via Transcriptional Inhibition of MMP2.
REFERENCE   5  (bases 1 to 4416)
  AUTHORS   Zheng,X., Wang,G., Yuan,J., Li,N., Yan,B., Yan,J. and Sheng,Y.
  TITLE     hsa-miR-34a-5p Ameliorates Hepatic Ischemia/Reperfusion Injury Via
            Targeting HNF4alpha
  JOURNAL   Turk J Gastroenterol 33 (7), 596-605 (2022)
   PUBMED   35879917
  REMARK    GeneRIF: hsa-miR-34a-5p Ameliorates Hepatic Ischemia/Reperfusion
            Injury Via Targeting HNF4alpha.
REFERENCE   6  (bases 1 to 4416)
  AUTHORS   Ginsburg,G.S., Ozer,J. and Karathanasis,S.K.
  TITLE     Intestinal apolipoprotein AI gene transcription is regulated by
            multiple distinct DNA elements and is synergistically activated by
            the orphan nuclear receptor, hepatocyte nuclear factor 4
  JOURNAL   J Clin Invest 96 (1), 528-538 (1995)
   PUBMED   7615825
REFERENCE   7  (bases 1 to 4416)
  AUTHORS   Chen,W.S., Manova,K., Weinstein,D.C., Duncan,S.A., Plump,A.S.,
            Prezioso,V.R., Bachvarova,R.F. and Darnell,J.E. Jr.
  TITLE     Disruption of the HNF-4 gene, expressed in visceral endoderm, leads
            to cell death in embryonic ectoderm and impaired gastrulation of
            mouse embryos
  JOURNAL   Genes Dev 8 (20), 2466-2477 (1994)
   PUBMED   7958910
REFERENCE   8  (bases 1 to 4416)
  AUTHORS   Ang,S.L., Wierda,A., Wong,D., Stevens,K.A., Cascio,S., Rossant,J.
            and Zaret,K.S.
  TITLE     The formation and maintenance of the definitive endoderm lineage in
            the mouse: involvement of HNF3/forkhead proteins
  JOURNAL   Development 119 (4), 1301-1315 (1993)
   PUBMED   8306889
REFERENCE   9  (bases 1 to 4416)
  AUTHORS   Hata,S., Tsukamoto,T. and Osumi,T.
  TITLE     A novel isoform of rat hepatocyte nuclear factor 4 (HNF-4)
  JOURNAL   Biochim Biophys Acta 1131 (2), 211-213 (1992)
   PUBMED   1610903
REFERENCE   10 (bases 1 to 4416)
  AUTHORS   Sladek,F.M., Zhong,W.M., Lai,E. and Darnell,J.E. Jr.
  TITLE     Liver-enriched transcription factor HNF-4 is a novel member of the
            steroid hormone receptor superfamily
  JOURNAL   Genes Dev 4 (12B), 2353-2365 (1990)
   PUBMED   2279702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM042560.1, CK483260.1, D10554.1, JAXUCZ010000003.1 and FQ095211.1.
            
            On Aug 10, 2012 this sequence version replaced NM_022180.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.10985.1,
                                           SRR26643288.16657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               FM042560.1         6-176
            172-875             CK483260.1         1-704
            876-1565            D10554.1           752-1441
            1566-4390           JAXUCZ010000003.1  172664928-172667752
            4391-4416           FQ095211.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..4416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..4416
                     /gene="Hnf4a"
                     /gene_synonym="Hnf4; Hnf4alpha"
                     /note="hepatocyte nuclear factor 4, alpha"
                     /db_xref="GeneID:25735"
                     /db_xref="RGD:2810"
     exon            1..255
                     /gene="Hnf4a"
                     /gene_synonym="Hnf4; Hnf4alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1565
                     /gene="Hnf4a"
                     /gene_synonym="Hnf4; Hnf4alpha"
                     /note="isoform 1 is encoded by transcript variant 1; alpha
                     transcription factor 4; HNF-4-alpha; transcription factor
                     14; transcription factor HNF-4; nuclear receptor subfamily
                     2 group A member 1; TCF-14; hepatic nuclear factor 4,
                     alpha"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 4-alpha isoform 1"
                     /protein_id="NP_071516.2"
                     /db_xref="GeneID:25735"
                     /db_xref="RGD:2810"
                     /translation="MRLSKTLADMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSE
                     GANLNSSNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQC
                     VVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEV
                     LSQQITSPISGINGDIRAKRIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVA
                     LLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPF
                     QELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRF
                     GELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAPHAHHPLHPH
                     LMQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAATPETPQPSPPSGSGSESYKLLP
                     GAITTIVKPPSAIPQPTITKQEAI"
     exon            256..430
                     /gene="Hnf4a"
                     /gene_synonym="Hnf4; Hnf4alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            431..525
                     /gene="Hnf4a"
                     /gene_synonym="Hnf4; Hnf4alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            526..632
                     /gene="Hnf4a"
                     /gene_synonym="Hnf4; Hnf4alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            633..788
                     /gene="Hnf4a"
                     /gene_synonym="Hnf4; Hnf4alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            789..876
                     /gene="Hnf4a"
                     /gene_synonym="Hnf4; Hnf4alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1032
                     /gene="Hnf4a"
                     /gene_synonym="Hnf4; Hnf4alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1269
                     /gene="Hnf4a"
                     /gene_synonym="Hnf4; Hnf4alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1422
                     /gene="Hnf4a"
                     /gene_synonym="Hnf4; Hnf4alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..4396
                     /gene="Hnf4a"
                     /gene_synonym="Hnf4; Hnf4alpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgaaacag aggaaggcag agaagggacc tgggaggagg caggaggagg gcggggacgg
       61 aggggctggg gctcagccca ggggcttggg tagcatcctg ggcagggcag gacagggggc
      121 tgaggggtgg gtagaggaga atgcgactct ctaaaaccct cgccgacatg gacatggctg
      181 actacagtgc tgccttggac ccagcctaca ccaccctgga gtttgaaaat gtgcaggtgt
      241 tgaccatggg caatgacaca tccccatctg aaggtgccaa cctcaactca tccaacagcc
      301 tgggtgtcag tgccctgtgt gccatctgtg gcgatcgggc cactggcaaa cactacggag
      361 cctcaagctg tgacggctgc aagggattct tcaggaggag cgtgaggaag aaccacatgt
      421 actcctgcag gtttagcagg cagtgcgtgg tagacaaaga taagaggaac cagtgtcgtt
      481 actgcaggct caagaagtgc ttccgggctg gcatgaagaa agaagccgtc caaaatgagc
      541 gggatcggat cagcacgcgg aggtcaagct acgaggacag cagcctaccc tccattaatg
      601 cgctcctgca ggcagaggtc ctgtctcagc agatcacctc ccccatctct gggatcaatg
      661 gcgacattcg ggccaagagg attgccaaca tcacggatgt gtgtgagtct atgaaggagc
      721 agctgctggt tctggtcgaa tgggccaagt acatcccggc cttctgtgaa cttcttctgg
      781 atgaccaggt ggcgctgctc agagcccacg ctggtgagca cctgctgctt ggagccacca
      841 agaggtccat ggtgttcaag gatgtgctgc tcctaggcaa tgactacatc gtccctcggc
      901 actgtccaga gctagcagag atgagccgtg tgtccattcg catcctcgat gagctggtct
      961 tgcccttcca agagctgcag atcgatgata atgaatacgc ctgcctcaaa gccatcatct
     1021 tctttgaccc agatgccaag gggctgagtg acccaggcaa gatcaagcgg ctgcggtcac
     1081 aggtgcaggt gagcctggag gattacatca acgaccggca gtatgactct cggggtcgtt
     1141 ttggagagct gctgctgctc ctgcccactc tgcagagcat tacctggcag atgatcgagc
     1201 agatccagtt catcaagctc tttggcatgg ccaagattga caacctgctg caggagatgc
     1261 tgcttggagg gtctgccagt gacgcgcccc acgcccacca ccccctgcac cctcacctga
     1321 tgcaagaaca catgggcacc aatgtcatag ttgccaacac gatgccctct cacctcagca
     1381 atggacagat gtgtgagtgg ccccggccca gggggcaggc agccacccct gagactccac
     1441 agccatcacc accaagtggc tctggatctg aatcctacaa gctcctgcca ggagccatca
     1501 ccaccatcgt caagcctccc tctgccatcc cccagccaac gatcaccaag caggaagcca
     1561 tctagcaagc cgccgggggg tgggggtgag gcttctgctg gctcacaccc tcagagagcg
     1621 cctgggtgta acttagtcac ggcaaagagg atgtgacaag agggaccagt cccagagcag
     1681 ccactgaaag ggcttgtagg cccaaaaaca tgcgctgagg atcgcatgca ttgccacccc
     1741 tgaccccaca tccggagggc agggctttgc cttgaggaga ccccggcggg gggatgtctt
     1801 ccgctgcctg gactcttctc aagttgaagc tgccgtcttc atcttcccct catatcttcc
     1861 ctcaacttct tcacccctaa aggacaacca tctgcagatg ttgcaggacc ttgtttaaaa
     1921 acaactccct tctctctcag ctggggcctc ttccttcctg gtgctggtca gggggcctgg
     1981 aaacaaacct tctgaggtca catcagcctg cattgtagta ttcctctctc ctgctgtccc
     2041 aacctcaggt gacctgctac cttcctctat agttaccttc ctctgccatc tgacttctcc
     2101 aaagccatct cactggaggc tgaggaagcc atgacaacca ttttcattct gagaaccttc
     2161 tgtaagcact gacctgggtg aggtagaggg taggagttgc catccctcct ctgcccacat
     2221 cacgacgatt cttgcctcta gcactaggct attaactttg gagtgatagg ccctatggct
     2281 ttctacagca gagaaccacc caagggtggt gattaaacag aatgtggaga gagggtggcc
     2341 gccattggga aagtacctag gaagaggcaa gctttgtgtt tgtcccttga cagggaaggt
     2401 aggcttctgg ctagttttag gggacagcag cctggacaaa ggcctatggg taggcaaaat
     2461 agtataggag ggaggcgatg aagaaattgg ttcccatgga gttgtgatag ggcacacgct
     2521 ggggaccatt gaacgacaaa ctgaggtcag gggtagctgc cgtgcggggc tgtcagaaga
     2581 tgaggacagc atcctgcaga gataggactg ctgagatgga ttgaggaggc catgctagag
     2641 cctacggatg agacaaaggg atggctcaga gttctcccag gacctgtcag tctcttccgt
     2701 acttccagac gacgtcacaa gacgttagac agccatcatt ccatagaacc ttccctgcaa
     2761 cccagacatc attatggaag atataagtag aggatcttaa ctgcctcaca ggaagttctt
     2821 gtctcccctg gtatggaatt cagagagttc ctcgtccttt acccgtgtca aacccagagg
     2881 cttactctct ccagagctgg ccagccagag actgttttaa agtcccctgg aagtcaagaa
     2941 tccagtttac tgataagagt aaagttgatc caggactcct gtcctttttt cccactgatc
     3001 tacccaagta ttggtgagga gcagcaagtc atggatcctg gaggagggac cagtctagtc
     3061 tggcagtcag ggctgaggag tttgggtgag aggcagaaag acaagaaagc ctgggtttca
     3121 ggcttgcttg aggagctaca ttcaaggtac attctggagc tcctcatccc cagcaggcag
     3181 agatccaccc ctggctaact cttgacgact ttgcggagcc cctataaagt gcctctgacc
     3241 aacggacaca agaggaatat cccctggaaa tgaaccaagt ggaaagaatg agctgtgaga
     3301 ctggatagtt atggtgcctc aagctgatcc ttctgagtgg atggggctag caccccagtg
     3361 tccatcaagc gaggtctatc cttctgagtg gcagggctag cactccagtg tccagaaatt
     3421 ccagtcttaa tgataggtcc tctgaaaaag aggtgcagag gagtaatggg gccagctgct
     3481 taaagcaaaa gaatacccac aggccaggac tgtcagaaca ggttgagtca accccttaaa
     3541 gccaagttct aggtctcaag agtggctttt ccatgctcag agccctcaag acttccttgg
     3601 ccactctcac tccagtgccc ccagagaccc cagccagatt gctcagactg ccctgcatga
     3661 aggcaggaca gttgaactcc tctggtcctt atcttctatc cctccatccc cagtgacatc
     3721 atgagaagag taggtgatgt tgggatttgg tggtagcagt cttctggggc gggggtcagt
     3781 cgctgtccca gtcagtcctt tctgaaggag aaatccattc cacattatta acttgattac
     3841 aacgcaggaa gcacgcgata aaggaaagtc tactcttctg attgcaagct gaagacacta
     3901 cgttggagcc tttttcttct gagccttgtt tctagtacat aatacgatgg gactaagtag
     3961 aagctgctgg tgggcaaggg tgggtgccac agtttttccc caagagcagc ctctttactt
     4021 cagggaattc tcggaaactt tcaggattcg gggggcttcc ctgggaggag acgagagagg
     4081 attagaagcg gacatccacg gcttcttgtg atgaccacgc cttttgtctt tgctagaact
     4141 ctctgtgact tcccctggtg aattctaatc acggacttca cgccaagcat ccggaagtac
     4201 gctgagcccc catcagatca atcagcactt tcctgtggtt gtgcaaacat cactgggtcc
     4261 cacactgatc cccaagtccc caccatcact gcccaagggg ttaaaaaaga aaaaaaaccc
     4321 tcaaaaacag ttcttacttc tgtgttttag caaaaattta tcaaacaaaa taaatgatac
     4381 atatgttttc taagtcaaaa aaaaaaaaaa aaaaaa
//
