LOCUS       NM_012580               1600 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus heme oxygenase 1 (Hmox1), mRNA.
ACCESSION   NM_012580
VERSION     NM_012580.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1600)
  AUTHORS   Liu,H.L., Wu,T., Zeng,X., Cao,W.Y. and Wu,S.K.
  TITLE     Acupoint Autohemotherapy Alleviates Airway Inflammation in
            Asthmatic Rats via Upregulating Expression of Hemeoxygenase-1
  JOURNAL   J Acupunct Meridian Stud 17 (5), 149-157 (2024)
   PUBMED   39444099
  REMARK    GeneRIF: Acupoint Autohemotherapy Alleviates Airway Inflammation in
            Asthmatic Rats via Upregulating Expression of Hemeoxygenase-1.
REFERENCE   2  (bases 1 to 1600)
  AUTHORS   Xiao,B., Zhu,Y., Liu,M., Chen,M., Huang,C., Xu,D., Wang,F., Sun,S.,
            Huang,J., Sun,N. and Yang,F.
  TITLE     miR-340-3p-modified bone marrow mesenchymal stem cell-derived
            exosomes inhibit ferroptosis through METTL3-mediated m6A
            modification of HMOX1 to promote recovery of injured rat uterus
  JOURNAL   Stem Cell Res Ther 15 (1), 224 (2024)
   PUBMED   39075530
  REMARK    GeneRIF: miR-340-3p-modified bone marrow mesenchymal stem
            cell-derived exosomes inhibit ferroptosis through METTL3-mediated
            m[6]A modification of HMOX1 to promote recovery of injured rat
            uterus.
            Erratum:[Stem Cell Res Ther. 2024 Oct 10;15(1):357. doi:
            10.1186/s13287-024-03985-w.. PMID: 39390524]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1600)
  AUTHORS   Li,M. and Zheng,N.
  TITLE     The Role of Heme Oxygenase 1 in Rheumatoid Arthritis and IL-1
            Induced Inflammatory Cell Model
  JOURNAL   Ann Clin Lab Sci 54 (4), 446-451 (2024)
   PUBMED   39293832
  REMARK    GeneRIF: The Role of Heme Oxygenase 1 in Rheumatoid Arthritis and
            IL-1 Induced Inflammatory Cell Model.
REFERENCE   4  (bases 1 to 1600)
  AUTHORS   Tao,W., Lu,Y., Xiao,R., Zhang,J., Hu,P., Zhao,N., Peng,W., Qian,K.
            and Liu,F.
  TITLE     LncRNA HMOX1 alleviates renal ischemia-reperfusion-induced
            ferroptotic injury via the miR-3587/HMOX1 axis
  JOURNAL   Cell Signal 119, 111165 (2024)
   PUBMED   38583746
  REMARK    GeneRIF: LncRNA HMOX1 alleviates renal ischemia-reperfusion-induced
            ferroptotic injury via the miR-3587/HMOX1 axis.
REFERENCE   5  (bases 1 to 1600)
  AUTHORS   Wang,Y., Qiu,J., Yan,H., Zhang,N., Gao,S., Xu,N., Wang,C. and
            Lou,H.
  TITLE     The Bach1/HO-1 pathway regulates oxidative stress and contributes
            to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells
            and mice
  JOURNAL   Arch Toxicol 98 (6), 1781-1794 (2024)
   PUBMED   38573338
  REMARK    GeneRIF: The Bach1/HO-1 pathway regulates oxidative stress and
            contributes to ferroptosis in doxorubicin-induced cardiomyopathy in
            H9c2 cells and mice.
REFERENCE   6  (bases 1 to 1600)
  AUTHORS   McCoubrey,W.K. Jr., Ewing,J.F. and Maines,M.D.
  TITLE     Human heme oxygenase-2: characterization and expression of a
            full-length cDNA and evidence suggesting that the two HO-2
            transcripts may differ by choice of polyadenylation signal
  JOURNAL   Arch Biochem Biophys 295 (1), 13-20 (1992)
   PUBMED   1575508
REFERENCE   7  (bases 1 to 1600)
  AUTHORS   Ishikawa,K., Sato,M. and Yoshida,T.
  TITLE     Expression of rat heme oxygenase in Escherichia coli as a
            catalytically active, full-length form that binds to bacterial
            membranes
  JOURNAL   Eur J Biochem 202 (1), 161-165 (1991)
   PUBMED   1935972
REFERENCE   8  (bases 1 to 1600)
  AUTHORS   Yoshida,T. and Sato,M.
  TITLE     Posttranslational and direct integration of heme oxygenase into
            microsomes
  JOURNAL   Biochem Biophys Res Commun 163 (2), 1086-1092 (1989)
   PUBMED   2783112
REFERENCE   9  (bases 1 to 1600)
  AUTHORS   Muller,R.M., Taguchi,H. and Shibahara,S.
  TITLE     Nucleotide sequence and organization of the rat heme oxygenase gene
  JOURNAL   J Biol Chem 262 (14), 6795-6802 (1987)
   PUBMED   3032976
REFERENCE   10 (bases 1 to 1600)
  AUTHORS   Shibahara,S., Muller,R., Taguchi,H. and Yoshida,T.
  TITLE     Cloning and expression of cDNA for rat heme oxygenase
  JOURNAL   Proc Natl Acad Sci U S A 82 (23), 7865-7869 (1985)
   PUBMED   3865203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091164.1.
            
            On Mar 13, 2005 this sequence version replaced NM_012580.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091164.1, EV768426.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1600
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..1600
                     /gene="Hmox1"
                     /gene_synonym="Heox; HEOXG; Hmox; Ho-1; Ho1; hsp32"
                     /note="heme oxygenase 1"
                     /db_xref="GeneID:24451"
                     /db_xref="RGD:2806"
     exon            1..139
                     /gene="Hmox1"
                     /gene_synonym="Heox; HEOXG; Hmox; Ho-1; Ho1; hsp32"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..986
                     /gene="Hmox1"
                     /gene_synonym="Heox; HEOXG; Hmox; Ho-1; Ho1; hsp32"
                     /EC_number="1.14.14.18"
                     /note="heme oxygenase (decyclizing) 1; heme oxygenase
                     (decycling) 1"
                     /codon_start=1
                     /product="heme oxygenase 1"
                     /protein_id="NP_036712.1"
                     /db_xref="GeneID:24451"
                     /db_xref="RGD:2806"
                     /translation="MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSR
                     EGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQ
                     EAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSS
                     GEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQ
                     ALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLS
                     FLLATVAVGIYAM"
     exon            140..260
                     /gene="Hmox1"
                     /gene_synonym="Heox; HEOXG; Hmox; Ho-1; Ho1; hsp32"
                     /inference="alignment:Splign:2.1.0"
     exon            261..752
                     /gene="Hmox1"
                     /gene_synonym="Heox; HEOXG; Hmox; Ho-1; Ho1; hsp32"
                     /inference="alignment:Splign:2.1.0"
     exon            753..852
                     /gene="Hmox1"
                     /gene_synonym="Heox; HEOXG; Hmox; Ho-1; Ho1; hsp32"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1547
                     /gene="Hmox1"
                     /gene_synonym="Heox; HEOXG; Hmox; Ho-1; Ho1; hsp32"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctccaga gtttccgcct ccaaccagcg agtggagcct gccggagcag agccatctcg
       61 agcggagccc ggagcctgaa gcgagcggag ccagcctgaa ctagcccagt cccgcgatgg
      121 agcgcccaca gctcgacagc atgtcccagg atttgtccga ggccttgaag gaggccacca
      181 aggaggtgca catccgtgca gagaattctg agttcatgag gaactttcag aagggtcagg
      241 tgtccaggga aggctttaag ctggtgatgg cctccttgta ccatatctat acggccctgg
      301 aagaggagat agagcgaaac aagcagaacc cagtctatgc cccactctac ttccctgagg
      361 agctgcaccg aagggctgcc ctagagcagg acatggcctt ctggtatggg ccccactggc
      421 aggaggccat cccttacaca ccagccacac agcactacgt aaagcgtctc cacgaggtgg
      481 gaggtactca tcctgagctg ctggtggccc acgcatatac ccgctacctg ggtgacctct
      541 cagggggtca ggtcctgaag aagattgcgc agaaggccat ggccttgcca agctctgggg
      601 aaggcctggc ttttttcacc ttcccgagca tcgacaaccc caccaagttc aaacagctct
      661 atcgtgctcg catgaacact ctggagatga cccccgaggt caagcacagg gtgacagaag
      721 aggctaagac cgccttcctg ctcaacattg agctgtttga ggagctgcag gcactgctga
      781 cagaggaaca caaagaccag agtccctcac agacagagtt tcttcgccag aggcctgcta
      841 gcctggttca agatactacc tctgcagaga cgccccgagg aaaatcccag atcagcacta
      901 gttcatccca gacaccgctc ctgcgatggg tcctcacact cagtttcctg ttggcgaccg
      961 tggcagtggg aatttatgcc atgtaaatgc agtgttggcc cccagaggct gtgaactctg
     1021 tctcatgtag ccttctctct gcaggggaga atcttgcctg gctctctttt cttgggcctc
     1081 taagaaagct tttggggttc ctcgccccct tcctgtgtct tcctttgtct ctctggaatg
     1141 gaaggagatg cctggcacat ttccctcacc aaaagcacag ccaggggcct gaacttggaa
     1201 accagcagcc ccaaatcctg caacagagcc ccagaactgt ggtcggtaga ggcggctgtt
     1261 ctgagcccag tgcccttggt agtcggcgtc catgttgact gaccatgact gctttccccc
     1321 agcgtcatgg ccactttgat atcagtgtgc agagattttc tgtcttgtgt ttctgtcttg
     1381 tttttgttat ttccccagtt ctaccagtgt aatggtattt tttgttgtat cgattgtttt
     1441 tttattctaa ccaagtaggg ctgtcttttg aggggtgggt ggtatttaat aattgtaacc
     1501 ttggtctcta acttctgtgt gaaataataa atggcattat ctaataaaaa aaaaaaaaaa
     1561 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
