LOCUS       NM_012964               2286 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hyaluronan-mediated motility receptor (Hmmr),
            mRNA.
ACCESSION   NM_012964
VERSION     NM_012964.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2286)
  AUTHORS   Bahrami,S.B., Tolg,C., Peart,T., Symonette,C., Veiseh,M.,
            Umoh,J.U., Holdsworth,D.W., McCarthy,J.B., Luyt,L.G., Bissell,M.J.,
            Yazdani,A. and Turley,E.A.
  TITLE     Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel
            target for promoting subcutaneous adipogenesis
  JOURNAL   Integr Biol (Camb) 9 (3), 223-237 (2017)
   PUBMED   28217782
  REMARK    GeneRIF: Blocking RHAMM function by peptide injection or topical
            application is a novel and minimally invasive method for
            potentially promoting subcutaneous adipogenesis in lipodystrophic
            diseases and a complementary tool to subcutaneous fat augmentation
            techniques.
REFERENCE   2  (bases 1 to 2286)
  AUTHORS   Mondalek,F.G., Fung,K.M., Yang,Q., Wu,W., Lu,W., Palmer,B.W.,
            Frimberger,D.C., Greenwood-Van Meerveld,B., Hurst,R.E., Kropp,B.P.
            and Lin,H.K.
  TITLE     Temporal expression of hyaluronic acid and hyaluronic acid
            receptors in a porcine small intestinal submucosa-augmented rat
            bladder regeneration model
  JOURNAL   World J Urol 33 (8), 1119-1128 (2015)
   PUBMED   25253654
  REMARK    GeneRIF: RHAMM mRNA increased over the course of bladder
            regeneration.
REFERENCE   3  (bases 1 to 2286)
  AUTHORS   Ma,X., Pearce,J.D., Wilson,D.B., English,W.P., Edwards,M.S. and
            Geary,R.L.
  TITLE     Loss of the hyaluronan receptor RHAMM prevents constrictive artery
            wall remodeling
  JOURNAL   J Vasc Surg 59 (3), 804-813 (2014)
   PUBMED   23768790
  REMARK    GeneRIF: RHAMM and hyaluronic acid mediate smooth muscle cell
            interactions with collagen and changes in SMC shape, polarity, and
            movement.
REFERENCE   4  (bases 1 to 2286)
  AUTHORS   Silverman-Gavrila,R., Silverman-Gavrila,L., Hou,G., Zhang,M.,
            Charlton,M. and Bendeck,M.P.
  TITLE     Rear polarization of the microtubule-organizing center in
            neointimal smooth muscle cells depends on PKCalpha, ARPC5, and
            RHAMM
  JOURNAL   Am J Pathol 178 (2), 895-910 (2011)
   PUBMED   21281821
  REMARK    GeneRIF: Both ARPC5 and RHAMM, in addition to PKC, were required
            for migration of neointimal smooth muscle cells.
REFERENCE   5  (bases 1 to 2286)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2286)
  AUTHORS   Zaman,A., Cui,Z., Foley,J.P., Zhao,H., Grimm,P.C., Delisser,H.M.
            and Savani,R.C.
  TITLE     Expression and role of the hyaluronan receptor RHAMM in
            inflammation after bleomycin injury
  JOURNAL   Am J Respir Cell Mol Biol 33 (5), 447-454 (2005)
   PUBMED   16037485
  REMARK    GeneRIF: The interaction of RHAMM with hyaluronic acid is a
            critical component of the recruitment of inflammatory cells to the
            lung after injury.
REFERENCE   7  (bases 1 to 2286)
  AUTHORS   Lynn,B.D., Li,X., Cattini,P.A., Turley,E.A. and Nagy,J.I.
  TITLE     Identification of sequence, protein isoforms, and distribution of
            the hyaluronan-binding protein RHAMM in adult and developing rat
            brain
  JOURNAL   J Comp Neurol 439 (3), 315-330 (2001)
   PUBMED   11596057
REFERENCE   8  (bases 1 to 2286)
  AUTHORS   Lynn,B.D., Li,X., Cattini,P.A. and Nagy,J.I.
  TITLE     Sequence, protein expression and extracellular-regulated kinase
            association of the hyaladherin RHAMM (receptor for hyaluronan
            mediated motility) in PC12 cells
  JOURNAL   Neurosci Lett 306 (1-2), 49-52 (2001)
   PUBMED   11403955
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF336825.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_012964.3.
            
            On May 6, 2004 this sequence version replaced NM_012964.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF133037.1, AF336825.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2286
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2286
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /note="hyaluronan-mediated motility receptor"
                     /db_xref="GeneID:25460"
                     /db_xref="RGD:2805"
     exon            1..70
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..2166
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /note="receptor for hyaluronan-mediated motility;
                     intracellular hyaluronic acid-binding protein"
                     /codon_start=1
                     /product="hyaluronan-mediated motility receptor"
                     /protein_id="NP_037096.2"
                     /db_xref="GeneID:25460"
                     /db_xref="RGD:2805"
                     /translation="MSFPKAPLKRFNDPSGCAPSPGAYDVKTSESTKGPVSFQKSQRF
                     KNQRESQQNLNIDKDTTLLASAKKAKTLVSKKESQKNDKDVKRLEKEIHVLLQERGTQ
                     DKRIQDMESELENTEANLNAPVTEKPSLSANNASLEKRLTELTRANELLKSKFSEDAH
                     QKNMRTLSLELMKLRNKRETKMRSMMAKQEGMELKLQATQKDLIESKGKIVQLEGKLV
                     SIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEEDLKEKDREILCLKQSL
                     EEKVSFSKQIEDLTVKCQLLEAERDDLVSKDRERAESLSAEMQVLTEKLLLERQEYEK
                     LQQNELQSQSLLQQEKELSAHLQQQLCSFQEEMTSERNVFKEQLKLALDELDAVQQKK
                     EQSEKLVKQLEEETKSTAEQLRRLDDLLREKEIELEKRTAAHAQATVIAQEKYSDTAQ
                     TLRDVTAQLESYKSSTLKEIEDLKLENLTLQEKVAMAEKRVEDVQQQILTAESTNQEY
                     AKVVQDLQNSSTLKEAEIKEITSSYLEKITDLQNQLRQQNEDFRKQLEEEGAKMTEKE
                     TAVTELTMEINKWRLLYEELFDKTKPFQQQLDAFEAEKQALLNEHGATQEQLSKIRDS
                     YAQLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRSQLAKRKQNELRLQGELDKALGI
                     RHFDPSKAFCHESKENVTLKTPLKEGNPNCC"
     exon            71..169
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            170..249
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            250..297
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            298..486
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            487..573
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            574..674
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            675..749
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            750..925
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1074
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1289
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1406
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1553
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1706
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1806
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1983
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2146
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2286
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgcatctgg acccaggcgc tagaatgtcc ttccctaagg cgcccctgaa aagattcaat
       61 gacccttcgg gttgtgctcc atctccaggt gcttacgatg ttaaaacttc agaatcaact
      121 aaaggaccag tgtcttttca gaaatcacaa agatttaaaa accaaagaga gtctcaacaa
      181 aatcttaaca ttgacaaaga tacgaccttg cttgcttctg ctaaaaaagc aaagacgttg
      241 gtgtcaaaga aggagtctca gaagaatgat aaagatgtga agagattaga aaaagagatt
      301 catgttcttt tgcaagaacg agggactcag gacaaacgga tccaggacat ggagtctgag
      361 ttggagaata cagaagccaa tctaaatgca ccagtcacag agaaaccatc tctgtctgcc
      421 aataatgctt cactggaaaa acggcttact gagctgacca gagccaacga gctcctaaag
      481 tctaagtttt ctgaagatgc tcaccaaaag aatatgagaa ctctaagcct ggaattgatg
      541 aaactgagaa ataagagaga gacaaagatg aggagcatga tggctaaaca ggaaggcatg
      601 gagctgaagc tgcaggccac tcagaaggac ctcattgagt ctaaggggaa aatagtacag
      661 ctggagggaa aacttgtttc aatagagaaa gaaaagatcg atgaaaaatc tgaaacagaa
      721 aaactcttag aatacataga agaaattagc tgtgcatctg atcaagtgga aaaatacaaa
      781 ctagatattg cccagttaga agaagatttg aaagagaagg atcgtgagat tttatgcctt
      841 aagcaatctc ttgaggaaaa ggtttccttt tctaagcaaa tagaagacct gactgttaaa
      901 tgtcagctgc ttgaagcaga aagagatgat ctcgtcagca aggacagaga aagggctgaa
      961 agcctcagtg ctgagatgca ggttctaaca gagaagctgc ttctagaaag gcaagaatat
     1021 gaaaagctgc aacaaaatga attgcaaagc cagtcacttc tgcagcaaga aaaggaactg
     1081 tctgctcatc ttcagcagca gctctgctca tttcaagagg aaatgacctc cgagaggaat
     1141 gtctttaaag aacagttgaa gcttgccctg gatgagctgg atgccgtcca gcagaaaaag
     1201 gagcagagtg aaaagctggt taaacagcta gaagaggaaa cgaagtcaac tgcggaacag
     1261 ctgaggcggc tggatgatct gctgagagag aaagaaattg aactggagaa aagaaccgct
     1321 gcacatgccc aggccactgt gattgcgcaa gagaagtaca gtgacacagc gcagactctg
     1381 agagatgtta ctgctcagtt agaaagctat aagtcatcaa cacttaaaga aatagaagat
     1441 cttaaactgg agaatttgac tctacaagaa aaagtagcca tggctgagaa aagggtagaa
     1501 gatgttcaac aacaaatatt aacagctgag agcacaaatc aggaatatgc aaaggtggtt
     1561 caagatttgc agaacagctc aacattgaaa gaagcagaaa ttaaagaaat cacatcttca
     1621 tatcttgaga aaataactga tttgcaaaat caactccgac aacaaaatga agactttagg
     1681 aagcagctgg aagaggaagg ggcaaaaatg acagagaaag aaactgcagt gacagaatta
     1741 accatggaaa ttaataaatg gcgtctccta tatgaagaac tgtttgacaa aactaaacct
     1801 tttcagcaac aactggatgc cttcgaagca gagaagcagg cactgttgaa tgaacatggt
     1861 gcaactcagg agcagctaag taaaatcaga gactcctacg cacagctgct tggccaccag
     1921 aatctgaagc aaaaaatcaa acatgtcgtg aaattgaaag atgaaaatag ccagctcaaa
     1981 tcggaggtgt caaaactccg atctcagctt gctaaaagga aacaaaatga gctcagactt
     2041 cagggagaat tagataaagc tctgggcatc aggcactttg acccttctaa ggctttttgc
     2101 catgaatcta aggagaatgt gaccctcaag actccattga aagaaggcaa cccgaactgc
     2161 tgctgagtca gactgcaggg accgtggaag tggacgtcca agatacttgc tgaagattgt
     2221 tctcttcatt attcttgata ttatgtttat agtatatatt atataatgta tttaatttct
     2281 actgcc
//
