LOCUS       NP_037096                713 aa            linear   ROD 03-APR-2024
DEFINITION  hyaluronan-mediated motility receptor [Rattus norvegicus].
ACCESSION   NP_037096
VERSION     NP_037096.2
DBSOURCE    REFSEQ: accession NM_012964.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 713)
  AUTHORS   Bahrami,S.B., Tolg,C., Peart,T., Symonette,C., Veiseh,M.,
            Umoh,J.U., Holdsworth,D.W., McCarthy,J.B., Luyt,L.G., Bissell,M.J.,
            Yazdani,A. and Turley,E.A.
  TITLE     Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel
            target for promoting subcutaneous adipogenesis
  JOURNAL   Integr Biol (Camb) 9 (3), 223-237 (2017)
   PUBMED   28217782
  REMARK    GeneRIF: Blocking RHAMM function by peptide injection or topical
            application is a novel and minimally invasive method for
            potentially promoting subcutaneous adipogenesis in lipodystrophic
            diseases and a complementary tool to subcutaneous fat augmentation
            techniques.
REFERENCE   2  (residues 1 to 713)
  AUTHORS   Mondalek,F.G., Fung,K.M., Yang,Q., Wu,W., Lu,W., Palmer,B.W.,
            Frimberger,D.C., Greenwood-Van Meerveld,B., Hurst,R.E., Kropp,B.P.
            and Lin,H.K.
  TITLE     Temporal expression of hyaluronic acid and hyaluronic acid
            receptors in a porcine small intestinal submucosa-augmented rat
            bladder regeneration model
  JOURNAL   World J Urol 33 (8), 1119-1128 (2015)
   PUBMED   25253654
  REMARK    GeneRIF: RHAMM mRNA increased over the course of bladder
            regeneration.
REFERENCE   3  (residues 1 to 713)
  AUTHORS   Ma,X., Pearce,J.D., Wilson,D.B., English,W.P., Edwards,M.S. and
            Geary,R.L.
  TITLE     Loss of the hyaluronan receptor RHAMM prevents constrictive artery
            wall remodeling
  JOURNAL   J Vasc Surg 59 (3), 804-813 (2014)
   PUBMED   23768790
  REMARK    GeneRIF: RHAMM and hyaluronic acid mediate smooth muscle cell
            interactions with collagen and changes in SMC shape, polarity, and
            movement.
REFERENCE   4  (residues 1 to 713)
  AUTHORS   Silverman-Gavrila,R., Silverman-Gavrila,L., Hou,G., Zhang,M.,
            Charlton,M. and Bendeck,M.P.
  TITLE     Rear polarization of the microtubule-organizing center in
            neointimal smooth muscle cells depends on PKCalpha, ARPC5, and
            RHAMM
  JOURNAL   Am J Pathol 178 (2), 895-910 (2011)
   PUBMED   21281821
  REMARK    GeneRIF: Both ARPC5 and RHAMM, in addition to PKC, were required
            for migration of neointimal smooth muscle cells.
REFERENCE   5  (residues 1 to 713)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (residues 1 to 713)
  AUTHORS   Zaman,A., Cui,Z., Foley,J.P., Zhao,H., Grimm,P.C., Delisser,H.M.
            and Savani,R.C.
  TITLE     Expression and role of the hyaluronan receptor RHAMM in
            inflammation after bleomycin injury
  JOURNAL   Am J Respir Cell Mol Biol 33 (5), 447-454 (2005)
   PUBMED   16037485
  REMARK    GeneRIF: The interaction of RHAMM with hyaluronic acid is a
            critical component of the recruitment of inflammatory cells to the
            lung after injury.
REFERENCE   7  (residues 1 to 713)
  AUTHORS   Lynn,B.D., Li,X., Cattini,P.A., Turley,E.A. and Nagy,J.I.
  TITLE     Identification of sequence, protein isoforms, and distribution of
            the hyaluronan-binding protein RHAMM in adult and developing rat
            brain
  JOURNAL   J Comp Neurol 439 (3), 315-330 (2001)
   PUBMED   11596057
REFERENCE   8  (residues 1 to 713)
  AUTHORS   Lynn,B.D., Li,X., Cattini,P.A. and Nagy,J.I.
  TITLE     Sequence, protein expression and extracellular-regulated kinase
            association of the hyaladherin RHAMM (receptor for hyaluronan
            mediated motility) in PC12 cells
  JOURNAL   Neurosci Lett 306 (1-2), 49-52 (2001)
   PUBMED   11403955
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF336825.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NP_037096.3.
            
            On May 6, 2004 this sequence version replaced NP_037096.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF133037.1, AF336825.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     Protein         1..713
                     /product="hyaluronan-mediated motility receptor"
                     /note="receptor for hyaluronan-mediated motility;
                     intracellular hyaluronic acid-binding protein"
                     /calculated_mol_wt=82264
     Region          16..337
                     /region_name="HMMR_N"
                     /note="Hyaluronan mediated motility receptor N-terminal;
                     pfam15905"
                     /db_xref="CDD:464932"
     Region          <249..>550
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          552..708
                     /region_name="HMMR_C"
                     /note="Hyaluronan mediated motility receptor C-terminal;
                     pfam15908"
                     /db_xref="CDD:464934"
     CDS             1..713
                     /gene="Hmmr"
                     /gene_synonym="RHAMM"
                     /coded_by="NM_012964.2:25..2166"
                     /db_xref="GeneID:25460"
                     /db_xref="RGD:2805"
ORIGIN      
        1 msfpkaplkr fndpsgcaps pgaydvktse stkgpvsfqk sqrfknqres qqnlnidkdt
       61 tllasakkak tlvskkesqk ndkdvkrlek eihvllqerg tqdkriqdme selenteanl
      121 napvtekpsl sannaslekr lteltranel lkskfsedah qknmrtlsle lmklrnkret
      181 kmrsmmakqe gmelklqatq kdlieskgki vqlegklvsi ekekidekse teklleyiee
      241 iscasdqvek ykldiaqlee dlkekdreil clkqsleekv sfskqiedlt vkcqlleaer
      301 ddlvskdrer aeslsaemqv lteklllerq eyeklqqnel qsqsllqqek elsahlqqql
      361 csfqeemtse rnvfkeqlkl aldeldavqq kkeqseklvk qleeetksta eqlrrlddll
      421 rekeielekr taahaqatvi aqekysdtaq tlrdvtaqle syksstlkei edlklenltl
      481 qekvamaekr vedvqqqilt aestnqeyak vvqdlqnsst lkeaeikeit ssylekitdl
      541 qnqlrqqned frkqleeega kmteketavt eltmeinkwr llyeelfdkt kpfqqqldaf
      601 eaekqallne hgatqeqlsk irdsyaqllg hqnlkqkikh vvklkdensq lksevsklrs
      661 qlakrkqnel rlqgeldkal girhfdpska fcheskenvt lktplkegnp ncc
//
