LOCUS       NM_001415032            3833 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus HMG-box containing 4 (Hmgxb4), transcript variant
            4, mRNA.
ACCESSION   NM_001415032 XM_006255143
VERSION     NM_001415032.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3833)
  AUTHORS   Vermeulen,M., Eberl,H.C., Matarese,F., Marks,H., Denissov,S.,
            Butter,F., Lee,K.K., Olsen,J.V., Hyman,A.A., Stunnenberg,H.G. and
            Mann,M.
  TITLE     Quantitative interaction proteomics and genome-wide profiling of
            epigenetic histone marks and their readers
  JOURNAL   Cell 142 (6), 967-980 (2010)
   PUBMED   20850016
REFERENCE   2  (bases 1 to 3833)
  AUTHORS   Zhou,J., Hu,G. and Wang,X.
  TITLE     Repression of smooth muscle differentiation by a novel high
            mobility group box-containing protein, HMG2L1
  JOURNAL   J Biol Chem 285 (30), 23177-23185 (2010)
   PUBMED   20511232
  REMARK    GeneRIF: the first evidence of this novel HMG2L1 molecule playing
            an important role in attenuating smooth muscle differentiation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Dec 20, 2022 this sequence version replaced XM_006255143.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.58560.1,
                                           SRR26643297.50967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000019.1  13370559-13370623
            66-169              JAXUCZ010000019.1  13375120-13375223
            170-318             JAXUCZ010000019.1  13375829-13375977
            319-397             JAXUCZ010000019.1  13376078-13376156
            398-1332            JAXUCZ010000019.1  13376923-13377857
            1333-1414           JAXUCZ010000019.1  13397899-13397980
            1415-1479           JAXUCZ010000019.1  13399850-13399914
            1480-1585           JAXUCZ010000019.1  13401168-13401273
            1586-1755           JAXUCZ010000019.1  13401913-13402082
            1756-1878           JAXUCZ010000019.1  13406814-13406936
            1879-3833           JAXUCZ010000019.1  13407352-13409306
FEATURES             Location/Qualifiers
     source          1..3833
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..3833
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /note="HMG-box containing 4"
                     /db_xref="GeneID:307667"
                     /db_xref="RGD:1305783"
     exon            1..65
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            66..169
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1923
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /note="isoform 2 is encoded by transcript variant 4;
                     high-mobility group protein 2-like 1; HMG box domain
                     containing 4; HMG domain-containing protein 4; high
                     mobility group box 2-like 1"
                     /codon_start=1
                     /product="HMG domain-containing protein 4 isoform 2"
                     /protein_id="NP_001401961.1"
                     /db_xref="GeneID:307667"
                     /db_xref="RGD:1305783"
                     /translation="MAYDDSMKKEDCFDGDHSFEDIGLAAGRSQREKKRSYKDFLREE
                     EEVAAQVRSSSKKKSKDSDLFFLGTDTHKKKRKHSPDDFYYGDISTLESSQKKKKKSS
                     PQSPDTAMDLLKAITSPLAAGAKSSKKAGEKSCSSSSHSESRKEHHKKKGNGSTGEPS
                     LDDSNAHKPKRMKPLYVNTETLTLREPDGLKMRLILSPKEKGSSSVEEEAFQYPAQQA
                     SLKKPSKKLAREEQGALLLGHELQSLLKTARKKHKSSSDSHSSPGPEGCGSDGSQLPE
                     PHSANLDITGLDPILVESESSSAGELEAGELVIDDSYREIKKKKKSKKSKKKKDKDRH
                     KEKRHSRTKRSSTREHGTAREHMLVSSPASSIPTLPLPALHTDGHGEKKKKKEEKDRE
                     RERGEKPKKKNMSAYQVFCKEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKDKLIWK
                     QKAQYLQHKQNKAEATTVKRKASSAEGTMKVRASSVGILSPQKKSPPTTMLLPASPAK
                     APETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSIICALGPLACLT
                     TQLPELNGCPKQVLSNTLDNIAYIMPGL"
     exon            170..318
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..397
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..1332
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1414
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1479
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1585
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1755
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1878
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..3833
                     /gene="Hmgxb4"
                     /gene_synonym="Hmg2l1; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctccttct ccaagatggc ggcggtcggc ggcgctgagg cgggatccga gcgagccgag
       61 tgaagacctg gtcctgtaga cgggaaggag cctggacaca gtgacacagc acattctcaa
      121 aggccctgca ggaccaccat ggcttatgat gactccatga agaaagaaga ttgctttgat
      181 ggtgatcaca gctttgagga cataggactt gcagctggcc gaagccaacg agaaaagaag
      241 cggtcttaca aagatttctt aagggaagag gaggaagttg ctgcgcaggt caggagttct
      301 tccaagaaga agtcaaagga cagtgatctg ttcttcttgg ggacggacac acacaagaag
      361 aagaggaagc actcccccga tgatttctac tatggagaca tttcgacttt ggaatcatca
      421 cagaagaaaa agaagaaatc tagtccacag tctcctgaca cagcaatgga cctgttgaaa
      481 gctatcacct ccccgctggc agcaggggcc aagtcctcta agaaggcagg ggagaaatcc
      541 tgcagttctt caagccattc agagagcaga aaggaacacc acaagaagaa gggcaacggc
      601 agcactggag agccctccct ggatgacagc aatgcccaca aacccaaaag aatgaagcca
      661 ttgtacgtga acacagagac gctgactctc cgagagcctg acggcttaaa gatgagactt
      721 attctctcac caaaggagaa ggggagcagc tcagtggagg aggaggcttt tcagtaccct
      781 gcccaacagg cttctctgaa gaagccctcc aagaaattag ctcgagaaga gcaaggtgct
      841 ttactcctag gacacgagct acagagcctc ctaaaaacgg cccggaagaa gcacaagtca
      901 tcctcggact cgcactcctc tcctggccca gaaggctgtg ggtcggatgg ctcccagctt
      961 ccagaacccc acagtgccaa tctcgacatc acagggcttg acccaatcct agtggagtca
     1021 gagtcgtcct cagctgggga gctggaggcc ggggagctgg tgatagacga ctcctacagg
     1081 gagatcaaga agaagaagaa gtcaaaaaag agcaagaaga agaaggacaa ggacagacac
     1141 aaggagaagc ggcactcccg gaccaagagg agctctacca gagagcatgg cactgcccga
     1201 gagcacatgc tggtatccag ccctgcctcc agtatcccca ccctgccact tcctgctcta
     1261 cacacagacg gacatgggga gaagaagaag aaaaaggaag aaaaggacag agagagagag
     1321 aggggagaaa agccgaaaaa gaagaacatg tctgcctacc aggtattctg taaggaatac
     1381 cgggtaacca ttgtggctga ccatccaggt atagattttg gggaacttag taaaaaattg
     1441 gctgaagtat ggaagcagtt gccagaaaaa gacaaactga tctggaagca aaaggctcag
     1501 tatctgcagc acaaacagaa caaagctgaa gccacaactg tgaaaagaaa agcgtccagt
     1561 gcagaaggca ccatgaaagt cagagcttct tctgtgggaa tactttcacc ccaaaagaag
     1621 tccccaccga ccacaatgct tttgccagcc tcaccagcca aagctcctga aaccgagccc
     1681 attgatgtcg ccgctcatct ccagttgctg ggagagtccc tcagcctcat tggacaccgc
     1741 ctgcaggaga cagagggcat ggtagcagtg tccggaagct tgtcagtgct cctggactcc
     1801 attatctgtg ctcttggccc tttggcatgc ctgaccacac aactacctga actgaatggc
     1861 tgtcctaaac aggtcttgtc aaacacgctg gacaacattg catacatcat gcccggactg
     1921 tgacctccaa gaagcctggg acagaagact gtctacccct tcgtttatgt atatatgact
     1981 gttccagatc ttccactgac ctctgggtgt aggttttaaa tttttatatc tatatataca
     2041 tatataatgt atagtatata cataggatta taactacttt gcttttaata attttatgaa
     2101 atggcaaagg tttagctaaa aggaaacttt ggcatgaatg tgggcttgga attatttttt
     2161 tgtgaaaaaa aatctgcctt aaaaaaatca gtgtaatttg gggactaggg gcttattctg
     2221 ggtgccatat gtatctcctt gtaaaatgct aaaatgtgat tttttttcca agcttgggtt
     2281 tgcctgcaga cccatcgctg accatttgcc ttacctgtct tagaatcaga agtgtagtga
     2341 agatcatggg aggaggccag ctgactacag actttccaac atgggataat ctgggggagg
     2401 tggagcttag gtggactgag taggggactc attcccgttc ctgctaaaga ggtatctgtg
     2461 tctccagttt tattgtaccc acagtaccac agagtcgtgg gcaccatcta tagcctcagt
     2521 gtgtgattct tggccacaga aaaataaata ccttggagaa accaaagctg ttggtgccac
     2581 ctgttgaacc tgcttgtctg gccagcaagg cttggtgtac aaaacacaaa gctgccgtct
     2641 ttcactggcg gcattgggtg cccaccaact cccgagagat tctgcagctt agctgcctgg
     2701 tggctcttgg ttcagctctg gttcccctgg tgggtacttt gtgctctgca ttccacacgg
     2761 agctggacca cagagaagtc cttggttctc agtagggtta tctatatgtg tgtttgagtg
     2821 tatattttaa ttatgtgtat ttaactcttt agaatttctt agattttaat ttatcctgta
     2881 aatttctgta catataattt aaaaacaagc ctccagcagc aggaacatgt ggagcataca
     2941 gatttgtcat ttcttaatgt ctgtctaaaa gcctcaagtc gtccatatgt ttaggtgttg
     3001 tgactcagaa aggaacttca tggccctcaa taatgttagg aaagtgaaat agaaaggaat
     3061 ggcaccattc taactgccct tattcccaaa gaaccaggcc tgcttcccat cagagagaag
     3121 atatctcaac actccagggt tgtttggaaa tgtggtgagt tagccaagct ttcttcctct
     3181 ggcctggaag aacatggcag catcactgta aacctctggg gaccatgtag ccagctggca
     3241 tcctaggtaa caccttccca tagcccgact gctgtcatgg ccgagcttct cacaggagtt
     3301 ctggaggctc tgtccccatc tcagctcaga gcagtgctga gatgtaatct gagaaatgga
     3361 gacaggaaca ggaatatgtg ggaactgaaa tcaagcaaag cagaaattta aatttgagtt
     3421 aacatgtcag aacctccttt gaacctgcag aagtttgctg tgaggaacgg cacccaggag
     3481 aggccaagga aggcatgtat cgtttaggaa gcagccagtc ctccattgcc cttgctacag
     3541 acagttgtga actcctgagg agaacgggct ttttcgtgtt tgttttcctc tgaagcctag
     3601 ccctgttgta tttgtattaa agatttgtac acatttgtat aataatctgt accttgtggt
     3661 atttggtact attagaggaa aaactttgga ttcaggcctt cttgctgttt ttatatcatt
     3721 gttttatttt gttttttaaa taaatcctag tggtttgatc caaatcctat tacagttgta
     3781 taaagaaaca aaattttgta cttatattaa agatctcatt tttaatattt ata
//
