LOCUS       NM_001007020            1434 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus high mobility group nucleosomal binding domain 3
            (Hmgn3), transcript variant 2, mRNA.
ACCESSION   NM_001007020 XM_217219
VERSION     NM_001007020.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Rochman,M., Taher,L., Kurahashi,T., Cherukuri,S., Uversky,V.N.,
            Landsman,D., Ovcharenko,I. and Bustin,M.
  TITLE     Effects of HMGN variants on the cellular transcription profile
  JOURNAL   Nucleic Acids Res 39 (10), 4076-4087 (2011)
   PUBMED   21278158
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   Kurahashi,T., Furusawa,T., Ueda,T. and Bustin,M.
  TITLE     The nucleosome binding protein HMGN3 is expressed in pancreatic
            alpha-cells and affects plasma glucagon levels in mice
  JOURNAL   J Cell Biochem 109 (1), 49-57 (2010)
   PUBMED   19885867
REFERENCE   3  (bases 1 to 1434)
  AUTHORS   Ueda,T., Furusawa,T., Kurahashi,T., Tessarollo,L. and Bustin,M.
  TITLE     The nucleosome binding protein HMGN3 modulates the transcription
            profile of pancreatic beta cells and affects insulin secretion
  JOURNAL   Mol Cell Biol 29 (19), 5264-5276 (2009)
   PUBMED   19651901
REFERENCE   4  (bases 1 to 1434)
  AUTHORS   West,K.L., Castellini,M.A., Duncan,M.K. and Bustin,M.
  TITLE     Chromosomal proteins HMGN3a and HMGN3b regulate the expression of
            glycine transporter 1
  JOURNAL   Mol Cell Biol 24 (9), 3747-3756 (2004)
   PUBMED   15082770
REFERENCE   5  (bases 1 to 1434)
  AUTHORS   West,K.L., Ito,Y., Birger,Y., Postnikov,Y., Shirakawa,H. and
            Bustin,M.
  TITLE     HMGN3a and HMGN3b, two protein isoforms with a tissue-specific
            expression pattern, expand the cellular repertoire of
            nucleosome-binding proteins
  JOURNAL   J Biol Chem 276 (28), 25959-25969 (2001)
   PUBMED   11356838
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM058030.1 and BC082036.1.
            
            On Jan 15, 2011 this sequence version replaced NM_001007020.1.
            
            Transcript Variant: This variant (2) is not spliced at the 3' end,
            resulting in an upstream stop codon, as compared to variant 1. The
            resulting isoform (2) has a shorter and distinct C-terminus, as
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082036.1, DY309082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                FM058030.1         1-45
            46-1434             BC082036.1         1-1389
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1434
                     /gene="Hmgn3"
                     /note="high mobility group nucleosomal binding domain 3"
                     /db_xref="GeneID:113990"
                     /db_xref="RGD:1359106"
     exon            1..149
                     /gene="Hmgn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..422
                     /gene="Hmgn3"
                     /note="isoform 2 is encoded by transcript variant 2; high
                     mobility group nucleosome-binding domain-containing
                     protein 3; high mobility group nucleosome binding domain
                     3"
                     /codon_start=1
                     /product="high mobility group nucleosome-binding
                     domain-containing protein 3 isoform 2"
                     /protein_id="NP_001007021.1"
                     /db_xref="GeneID:113990"
                     /db_xref="RGD:1359106"
                     /translation="MPKRKSPENAEGKDGAKLTKQEPTRRSARLSAKPVPPKPEPKPR
                     KTSAKKEPGTKINRAAKGKKEEKQEAGKEGTAPSANGDTKAEEVLSTNASH"
     exon            150..200
                     /gene="Hmgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            201..230
                     /gene="Hmgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            231..281
                     /gene="Hmgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            282..1407
                     /gene="Hmgn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggaggtgc aggtcggaga ggccgggcta gccgagccca ttgcaggagt agcagcagcg
       61 gccaggcagc atccaacagc gtgccaggca gcccagcccg ttgctttact ttttgctgta
      121 ccaacgtagt cattatgccg aagagaaagt ctcctgagaa tgccgagggc aaagatggag
      181 ccaagctaac gaagcaggag cccacgagac ggtcggccag attgtcagcg aaacctgttc
      241 caccaaaacc ggagcctaaa ccaagaaaaa catctgctaa gaaagaaccc ggaacaaaga
      301 ttaacagagc tgctaagggg aagaaggaag aaaagcagga agctggaaag gaaggtactg
      361 caccatctgc aaatggtgac actaaagctg aagaggtact ttccacaaac gcctcccact
      421 gaccgaatga gtgtcttaaa cgaaattgct cagtccttca gctctggata gcacgctcat
      481 aacgtctctc tttattgcct gtaatgttac tgcagatcca cgtctctcgt tcaactgtta
      541 atgtctcagc ctgcagaagt cccccaccca gcacactgtc agtaaagggg cagattgaaa
      601 cagtgagagt taagggtaca gtagacattc tgcatgtttg cagtgactag aatgagagag
      661 tagcgtgctg tttcttatca tgcacactgg agcctgcagg taaggcttct gtggttgttt
      721 aaatagcaga aagcaataaa cgctgcaaag tgtcgccata atgcattcct gccttgtctg
      781 tccgcccaga gttgacgtgt gtttccaagt agaccgaagc aaaaacaaga ggccaaacgc
      841 tcaagtgtgt ttcttggtgg gtgaaagtgc ctttgcttat aattgtttta ctggtaacta
      901 gatgtccttt ctttctctct ctaattcaca ggcacagaga actgataacg agggagaatg
      961 aattgtcatg gaaaactagg gtcgatttca cgtacctctg gggacaactt ttaaaagcta
     1021 tttttaccaa gtattttgta aatgctaatt ttttaggact cttactagtc ggcataaaat
     1081 ctatatgaag atggacattt tatcctccta tggtgatgtt ttctggaaac ttccatcatc
     1141 ctcaagtcaa gtaaatacca atttaatatc ggagctgcgt gtaaaatgga ttcagcattc
     1201 catgcccttg ctttaaaaat ttagtcctgt gcataccgtg gtgtttttac tgtgcatatt
     1261 tgactttttc atgcaatttt tctagagcaa taatcagtgg tgcttttgtg cctaggtttt
     1321 atgtgatttt aatgaaatgt ggatagttgt ggccacctgc tgactatttg tggtttaaaa
     1381 taaaaaggtt ttcctgtctg caaaataaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
