LOCUS       NM_001025624            1253 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus high mobility group nucleosomal binding domain 2
            (Hmgn2), mRNA.
ACCESSION   NM_001025624 XM_580083
VERSION     NM_001025624.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1253)
  AUTHORS   Li,X., Venugopalan,S.R., Cao,H., Pinho,F.O., Paine,M.L.,
            Snead,M.L., Semina,E.V. and Amendt,B.A.
  TITLE     A model for the molecular underpinnings of tooth defects in
            Axenfeld-Rieger syndrome
  JOURNAL   Hum Mol Genet 23 (1), 194-208 (2014)
   PUBMED   23975681
REFERENCE   2  (bases 1 to 1253)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1253)
  AUTHORS   Rochman,M., Taher,L., Kurahashi,T., Cherukuri,S., Uversky,V.N.,
            Landsman,D., Ovcharenko,I. and Bustin,M.
  TITLE     Effects of HMGN variants on the cellular transcription profile
  JOURNAL   Nucleic Acids Res 39 (10), 4076-4087 (2011)
   PUBMED   21278158
REFERENCE   4  (bases 1 to 1253)
  AUTHORS   Feng,Y., Huang,N., Wu,Q. and Wang,B.
  TITLE     HMGN2: a novel antimicrobial effector molecule of human mononuclear
            leukocytes?
  JOURNAL   J Leukoc Biol 78 (5), 1136-1141 (2005)
   PUBMED   16204630
REFERENCE   5  (bases 1 to 1253)
  AUTHORS   Cattaruzza,M., Schafer,K. and Hecker,M.
  TITLE     Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes
            smooth muscle cell proliferation
  JOURNAL   J Biol Chem 277 (8), 6582-6589 (2002)
   PUBMED   11748220
REFERENCE   6  (bases 1 to 1253)
  AUTHORS   Mohamed,O.A., Bustin,M. and Clarke,H.J.
  TITLE     High-mobility group proteins 14 and 17 maintain the timing of early
            embryonic development in the mouse
  JOURNAL   Dev Biol 229 (1), 237-249 (2001)
   PUBMED   11133167
REFERENCE   7  (bases 1 to 1253)
  AUTHORS   Shakoori,A.R., Owen,T.A., Shalhoub,V., Stein,J.L., Bustin,M.,
            Stein,G.S. and Lian,J.B.
  TITLE     Differential expression of the chromosomal high mobility group
            proteins 14 and 17 during the onset of differentiation in mammalian
            osteoblasts and promyelocytic leukemia cells
  JOURNAL   J Cell Biochem 51 (4), 479-487 (1993)
   PUBMED   8496248
REFERENCE   8  (bases 1 to 1253)
  AUTHORS   Malhotra,V., Tatke,M., Khanna,S.K. and Gondal,R.
  TITLE     Thymic histology in myasthenia gravis
  JOURNAL   Indian J Chest Dis Allied Sci 34 (3), 117-121 (1992)
   PUBMED   1302218
REFERENCE   9  (bases 1 to 1253)
  AUTHORS   Nielsen,E., Welinder,B. and Madsen,O.D.
  TITLE     Protein HMG-17 is hyper-expressed in rat glucagonoma. Single-step
            isolation and sequencing
  JOURNAL   Eur J Biochem 192 (1), 81-86 (1990)
   PUBMED   2169420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB614313.1 and BC099815.1.
            
            On Dec 23, 2009 this sequence version replaced NM_001025624.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220601.1, FQ219745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                CB614313.1         10-34
            26-1253             BC099815.1         1-1228
FEATURES             Location/Qualifiers
     source          1..1253
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1253
                     /gene="Hmgn2"
                     /gene_synonym="Hmg17"
                     /note="high mobility group nucleosomal binding domain 2"
                     /db_xref="GeneID:114637"
                     /db_xref="RGD:620649"
     exon            1..171
                     /gene="Hmgn2"
                     /gene_synonym="Hmg17"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..429
                     /gene="Hmgn2"
                     /gene_synonym="Hmg17"
                     /note="high mobility group nucleosome-binding
                     domain-containing protein 2; high mobility group protein
                     17; high mobility group nucleosome binding domain 2"
                     /codon_start=1
                     /product="non-histone chromosomal protein HMG-17"
                     /protein_id="NP_001020795.1"
                     /db_xref="GeneID:114637"
                     /db_xref="RGD:620649"
                     /translation="MPKRKAEGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPKPKKA
                     PAKKGEKVPKGKKGKADAGKDANNPAENGDAKTDQAQKADGAGDAK"
     exon            172..216
                     /gene="Hmgn2"
                     /gene_synonym="Hmg17"
                     /inference="alignment:Splign:2.1.0"
     exon            217..246
                     /gene="Hmgn2"
                     /gene_synonym="Hmg17"
                     /inference="alignment:Splign:2.1.0"
     exon            247..297
                     /gene="Hmgn2"
                     /gene_synonym="Hmg17"
                     /inference="alignment:Splign:2.1.0"
     exon            298..393
                     /gene="Hmgn2"
                     /gene_synonym="Hmg17"
                     /inference="alignment:Splign:2.1.0"
     exon            394..1228
                     /gene="Hmgn2"
                     /gene_synonym="Hmg17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttctaacc ggtccggggc tcccagcgct ataaaaactt tataaacccc ccggagcccg
       61 agcagtgtga agaagcagcg aggacgaccc ccggacggac caaacccgtg cgccgctgta
      121 aacccgtgct cagcgccgac gtcccctgcc gccgccatgc ccaaaagaaa ggctgaaggg
      181 gatgctaaag gagacaaagc caaggtgaag gacgagccac agagaagatc tgcaaggttg
      241 tctgctaaac ctgctcctcc aaagccagag cccaagccta aaaaggcccc tgcaaagaag
      301 ggagagaagg tacccaaggg gaagaagggg aaagcggatg ctggtaagga tgcgaataat
      361 cctgcagaaa acggagatgc caaaacagac caggcacaga aagcggacgg tgctggagat
      421 gccaagtgac gtgtgtgcgt ttttgataac tgtgtacttc tggtgactgt acagtttgaa
      481 atactatttt ttatcaagtt ttataaaaat gcagaatttt gttttacttt tttttttttt
      541 aaactatatt gttagcacac ggaacacttc attgttgtgg ggggaaggat catgtgtcac
      601 caacaaagta tcacccaagc tgaattgagg acagaaaatc tctttccttg ataatttcaa
      661 aaggttcctc ttggcttcca ggagagacat cctggtcttg cgtaggtggc caccaaggcc
      721 aaaaaaaggc cttgtggtct gaggaaactc taaattcatt tctatatcct gttccctccc
      781 cctgtaccat caacatagac ttaattccct taaaaccaga gacctgttgg gagcctcacc
      841 cccaaaattg gttttctagt ctattgggcg acgtggactt tgcagtgact tcgcgtgttc
      901 tcggaagatc actggttcct tttataaaag attgtggatc ttcagattga ttctgccatg
      961 ttcagttcct gacagtcagg gtcggcttgt ggaaagttgt taaacaactt ccttaatgtg
     1021 aaatgtcaac cctcactcta agctacttcc cctttcaaag cattgaatga agacttcatt
     1081 gggttttata gtggatttct gattttggta gtctatacaa gaagggaatt tgaaagttct
     1141 tgtatattgt tgactgtctg cccatgtcct gcctgaaata ccatgattgt ttatgaaaag
     1201 tatctttaat aaagctggtt acagttaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
