LOCUS       NM_017268               3270 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus 3-hydroxy-3-methylglutaryl-CoA synthase 1
            (Hmgcs1), mRNA.
ACCESSION   NM_017268 XM_346614
VERSION     NM_017268.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3270)
  AUTHORS   Wang,F., Xiang,H., Fischer,G., Liu,Z., Dupont,M.J., Hogan,Q.H. and
            Yu,H.
  TITLE     HMG-CoA synthase isoenzymes 1 and 2 localize to satellite glial
            cells in dorsal root ganglia and are differentially regulated by
            peripheral nerve injury
  JOURNAL   Brain Res 1652, 62-70 (2016)
   PUBMED   27671501
  REMARK    GeneRIF: Results identify 3-hydroxy-3-methylglutaryl coenzyme A
            synthase isoenzymes 1 and 2 as the alternative markers for
            satellite glial cells (SGCs) in dorsal root ganglia (DRGs).
            Downregulated HMGCS1 expression in DRGs after spinal nerve injury
            may reflect a potential role of abnormal sterol metabolism of SGCs
            in the nerve injured-induced neuropathic pain.
REFERENCE   2  (bases 1 to 3270)
  AUTHORS   Yan,X., Liu,J., Luo,Z., Ding,Q., Mao,X., Yan,M., Yang,S., Hu,X.,
            Huang,J. and Luo,Z.
  TITLE     Proteomic profiling of proteins in rat spinal cord induced by
            contusion injury
  JOURNAL   Neurochem Int 56 (8), 971-983 (2010)
   PUBMED   20399821
REFERENCE   3  (bases 1 to 3270)
  AUTHORS   Shafqat,N., Turnbull,A., Zschocke,J., Oppermann,U. and Yue,W.W.
  TITLE     Crystal structures of human HMG-CoA synthase isoforms provide
            insights into inherited ketogenesis disorders and inhibitor design
  JOURNAL   J Mol Biol 398 (4), 497-506 (2010)
   PUBMED   20346956
REFERENCE   4  (bases 1 to 3270)
  AUTHORS   Einbond,L.S., Soffritti,M., Esposti,D.D., Park,T., Cruz,E., Su,T.,
            Wu,H.A., Wang,X., Zhang,Y.J., Ham,J., Goldberg,I.J., Kronenberg,F.
            and Vladimirova,A.
  TITLE     Actein activates stress- and statin-associated responses and is
            bioavailable in Sprague-Dawley rats
  JOURNAL   Fundam Clin Pharmacol 23 (3), 311-321 (2009)
   PUBMED   19527300
REFERENCE   5  (bases 1 to 3270)
  AUTHORS   Liu,Z., Rudd,M.D., Hernandez-Gonzalez,I., Gonzalez-Robayna,I.,
            Fan,H.Y., Zeleznik,A.J. and Richards,J.S.
  TITLE     FSH and FOXO1 regulate genes in the sterol/steroid and lipid
            biosynthetic pathways in granulosa cells
  JOURNAL   Mol Endocrinol 23 (5), 649-661 (2009)
   PUBMED   19196834
  REMARK    Erratum:[Mol Endocrinol. 2009 Sep;23(9):1522]
REFERENCE   6  (bases 1 to 3270)
  AUTHORS   Royo,T., Ayte,J., Albericio,F., Giralt,E., Haro,D. and Hegardt,F.G.
  TITLE     Diurnal rhythm of rat liver cytosolic
            3-hydroxy-3-methylglutaryl-CoA synthase
  JOURNAL   Biochem J 280 (Pt 1) (Pt 1), 61-64 (1991)
   PUBMED   1683769
REFERENCE   7  (bases 1 to 3270)
  AUTHORS   Tulp,O.L., Abdollahi,A., Stevens,C. and Schnitzer-Polokoff,R.
  TITLE     The effects of the intestinal glucosidase inhibitor acarbose on
            cholesterogenesis in corpulent rats
  JOURNAL   Comp Biochem Physiol A Comp Physiol 100 (3), 763-768 (1991)
   PUBMED   1685984
REFERENCE   8  (bases 1 to 3270)
  AUTHORS   Ayte,J., Gil-Gomez,G. and Hegardt,F.G.
  TITLE     Nucleotide sequence of a rat liver cDNA encoding the cytosolic
            3-hydroxy-3-methylglutaryl coenzyme A synthase
  JOURNAL   Nucleic Acids Res 18 (12), 3642 (1990)
   PUBMED   1972979
REFERENCE   9  (bases 1 to 3270)
  AUTHORS   Auestad,N., Korsak,R.A., Morrow,J.W., West,D.B., Bergstrom,J.D. and
            Edmond,J.
  TITLE     Lipogenic potential in liver of the preweanling rat: influence of
            dietary cholesterol
  JOURNAL   FASEB J 2 (15), 3108-3112 (1988)
   PUBMED   2903839
REFERENCE   10 (bases 1 to 3270)
  AUTHORS   Balasubramaniam,S., Goldstein,J.L. and Brown,M.S.
  TITLE     Regulation of cholesterol synthesis in rat adrenal gland through
            coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A
            synthase and reductase activities
  JOURNAL   Proc Natl Acad Sci U S A 74 (4), 1421-1425 (1977)
   PUBMED   16260
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017268.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X52625.1, AY724522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                JAXUCZ010000002.1  53382304-53382325
            23-81               JAXUCZ010000002.1  53386325-53386383
            82-539              JAXUCZ010000002.1  53391071-53391528
            540-665             JAXUCZ010000002.1  53391915-53392040
            666-830             JAXUCZ010000002.1  53392747-53392911
            831-996             JAXUCZ010000002.1  53394140-53394305
            997-1167            JAXUCZ010000002.1  53395163-53395333
            1168-1274           JAXUCZ010000002.1  53396064-53396170
            1275-1400           JAXUCZ010000002.1  53396730-53396855
            1401-1564           JAXUCZ010000002.1  53397021-53397184
            1565-3270           JAXUCZ010000002.1  53398102-53399807
FEATURES             Location/Qualifiers
     source          1..3270
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q15"
     gene            1..3270
                     /gene="Hmgcs1"
                     /note="3-hydroxy-3-methylglutaryl-CoA synthase 1"
                     /db_xref="GeneID:29637"
                     /db_xref="RGD:70970"
     exon            1..22
                     /gene="Hmgcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            23..81
                     /gene="Hmgcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            82..539
                     /gene="Hmgcs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1654
                     /gene="Hmgcs1"
                     /EC_number="2.3.3.10"
                     /note="HMG-CoA synthase; 3-hydroxy-3-methylglutaryl
                     coenzyme A synthase; hydroxymethylglutaryl-CoA synthase 1;
                     3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble);
                     3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
                     (soluble)"
                     /codon_start=1
                     /product="hydroxymethylglutaryl-CoA synthase, cytoplasmic"
                     /protein_id="NP_058964.1"
                     /db_xref="GeneID:29637"
                     /db_xref="RGD:70970"
                     /translation="MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDA
                     GKYTIGLGQARMGFCTDREDINSLCLTVVQKLMERNSLSYDCIGRLEVGTETIIDKSK
                     SVKSNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDI
                     AIYASGNARPTGGVGAVALLIGPNAPVIFDRGLRGTHMQHAYDFYKPDMLSEYPVVDG
                     KLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLA
                     RMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASAELFNQKTKAS
                     LLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDA
                     TPGSALDKITASLCDLKSRLDSRTCVAPDVFAENMKLREDTHHLANYIPQCSIDSLFE
                     GTWYLVRVDEKHRRTYARRPSTNDHSLDEGVGLVHSNTATEHIPSPAKKVPRLPATSG
                     EPESAVISNGEH"
     exon            540..665
                     /gene="Hmgcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..830
                     /gene="Hmgcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..996
                     /gene="Hmgcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1167
                     /gene="Hmgcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1274
                     /gene="Hmgcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1400
                     /gene="Hmgcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1564
                     /gene="Hmgcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..3270
                     /gene="Hmgcs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagggtcc gatcgcgttt ggtgcctgaa ggaggaaccg gtgacagacc tggagactac
       61 agttctctgt ccttcacaca gctctttcac catgcctggg tcacttcctt tgaatgcaga
      121 ggcttgctgg ccaaaagatg tgggaatcgt tgcccttgaa atctactttc cttctcagta
      181 tgttgatcaa gctgagttgg aaaaatacga tggtgtagat gctggaaagt ataccattgg
      241 cctgggccag gccaggatgg gcttctgcac ggatcgcgaa gacatcaact ctctctgcct
      301 gactgtggtt cagaaactga tggagagaaa tagcctttcc tatgactgca ttgggcggct
      361 ggaagtcggg acagagacaa tcatcgacaa atcaaaatcc gtgaagtcta atttgatgca
      421 gctgtttgag gagtctggga atacagatat agaaggaata gatacaacta atgcatgcta
      481 tgggggcaca gccgcagtct tcaatgctgt gaactggatc gaatccagct cttgggatgg
      541 acgatacgct ttggtagttg caggagacat cgctatatat gcctcaggaa acgccaggcc
      601 tacaggtgga gttggagctg tggctctgct aattgggcca aatgctcctg taatttttga
      661 ccgagggctt cgtgggacac acatgcagca tgcctacgac ttttacaagc ctgacatgct
      721 ctctgaatac cctgtggtag atggaaaact ctccatacag tgctacctca gcgcattgga
      781 ccgctgctat tctgtctacc gcaaaaagat ccgggcccag tggcagaaag agggaaagga
      841 taaagatttt accctgaatg attttggctt catgatcttt cactcgccat actgtaaact
      901 ggtgcagaaa tctctagcta ggatgttcct gaatgacttt cttaacgatc aaaacagaga
      961 caaaaacagt atttacagtg ggctggaagc ctttggggat gtgaaattag aagatactta
     1021 cttcgacaga gatgtggaaa aggcatttat gaaggctagt gctgagctat tcaaccagaa
     1081 aacaaaggca tctttgcttg tatcgaatca aaatggaaac atgtacacat cctctgtata
     1141 cggttccctt gcttctgttc tggcacagta ctcacctcaa cagttggccg ggaagaggat
     1201 tggagtgttc tcttacggtt ctggcttggc tgccacactc tactccctta aagtcacaca
     1261 agatgccaca ccaggatctg ctcttgacaa aataacagca agtttatgtg accttaagtc
     1321 aaggcttgac tcaagaacgt gtgtggcacc agacgtcttt gctgaaaaca tgaagctcag
     1381 agaggacaca catcacttag ccaactatat tccccagtgt tcaatagatt cactcttcga
     1441 aggaacatgg tatctagtca gagtggatga aaagcacaga agaacttacg cccggcgtcc
     1501 ctccacaaat gaccacagtt tggatgaagg agtgggactt gtgcattcaa acacagctac
     1561 agagcatatt ccaagcccgg ctaagaaagt gccaagactt cctgcgacct cgggcgaacc
     1621 tgagtcggct gtcatcagta acggggagca ctgagagccc gtggccttca cagaggctcg
     1681 gggctgggat ggggtatgga aacggttaga ggaatggatg tcttgggaca attttacaga
     1741 ttacgtgttg cttaaaaatg taatgtaact gacacagagc ccagaaaact gttgtgtttt
     1801 tggagaagtc tccgctgagc tcctaacaca cttcctgctg tgggctggcc aatggtgaat
     1861 gtactgcgat ggtgttaagg gctctgcaga acgtcatacc tcgctgcatg tttacacgca
     1921 tgcgggttag gcttcaaact cggtctgaac tgagtgcttc tgactgcaaa ggcagaggta
     1981 ctgctgtcca gtttaaaaaa ttgttttttt tttttttaat gtgtaagaat ttttatactt
     2041 aaataaaaaa aagtacctgt agcttttggg ggaaaaaaaa aacctttttc taggttgggg
     2101 attgtggaat ttaaatgtta cacataaact ctgcttaatg gcaaggcaaa catttatctt
     2161 tttcgaagat ttataaatcc tgaagagaaa aaaagagggt atggttctag gatctggatg
     2221 aaccatcagt gagaaaggtt agtcataatc aagtgagcag aaggatgctg gcgttgagca
     2281 ggcctctgtc acagcaacca gggctctgtg ggcacagctg agggaacttt ctggccaggt
     2341 gcccgtgact gctgctcagc tgcactgaga tgcagtggag ctgctgcacg gaagcttgct
     2401 gtggtgctga gcgccttacc tgcgggataa agtgtaaagt aggagggatg ggcagggcac
     2461 tattaggtta cagtgttaca gacccaggtt atagacttga cagctcaaac tcaccagaca
     2521 cctttttccc tttgtggttt gtgtattttt tgtgttttgt ttgttttttt tatattgttc
     2581 aattaaaaat tagaaaattt aacctacgtt ttcacatagt ctgattagcc aaaaggaatt
     2641 tcacttcaag atctagaaat agaattcata acattttttc ctaaactttg acttttaaaa
     2701 caacgaaaat taccacatga gatgaacaag aaaattcatt agaaagttct ctggatgatt
     2761 tttggtgctg aactgacatg agcctcatag actgtaaaac agaggtagtt gaaactaatg
     2821 tacagaacta cattttttaa ttttatttgc atttaattct gtgaagtttc agttatctaa
     2881 aataaacaca taaacgtgta atgtttcaga ttgcaaggtg agatgtaatg tagcatttgt
     2941 aagatattct tgtcaatatt aactggtagg attttgattt gtacagtttt aattggttaa
     3001 aatgatctca ttttaacatc cactgctata gatgaatgat gtaagctcag atttaatgaa
     3061 tggtggggaa atggtgcatg taattttttc gcaagtatcg agagttctgt atgttttgaa
     3121 aagaataatt taacgtttgg gtgccaggaa gggggctttc ccagagtcca ttgccaggcg
     3181 tgggcaagcc tcgcaatgtt ggcacggagc gttaaccaca ccttactaat agcaagggga
     3241 ataactttga aataaagttt tagacaaata
//
