LOCUS       NM_013134               4319 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr),
            mRNA.
ACCESSION   NM_013134
VERSION     NM_013134.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4319)
  AUTHORS   Liu,Y., Qu,H.Q., Chang,X., Qu,J., Mentch,F.D., Nguyen,K., Tian,L.,
            Glessner,J., Sleiman,P.M.A. and Hakonarson,H.
  TITLE     Mutation burden analysis of six common mental disorders in African
            Americans by whole genome sequencing
  JOURNAL   Hum Mol Genet 31 (22), 3769-3776 (2022)
   PUBMED   35642741
REFERENCE   2  (bases 1 to 4319)
  AUTHORS   Khan,A.A., Sundar,P., Natarajan,B., Gupta,V., Arige,V., Reddy,S.S.,
            Barthwal,M.K. and Mahapatra,N.R.
  TITLE     An evolutionarily-conserved promoter allele governs HMG-CoA
            reductase expression in spontaneously hypertensive rat
  JOURNAL   J Mol Cell Cardiol 158, 140-152 (2021)
   PUBMED   34081950
  REMARK    GeneRIF: An evolutionarily-conserved promoter allele governs
            HMG-CoA reductase expression in spontaneously hypertensive rat.
REFERENCE   3  (bases 1 to 4319)
  AUTHORS   Gutierrez,L.L.P., Marques,C.V., Scomazzon,S.P., Schroeder,H.T.,
            Fernandes,J.R., da Silva Rossato,J. and Homem de Bittencourt,P.I.
            Jr.
  TITLE     A-family anti-inflammatory cyclopentenone prostaglandins: A novel
            class of non-statin inhibitors of HMG-CoA reductase
  JOURNAL   Biochimie 182, 37-50 (2021)
   PUBMED   33412161
  REMARK    GeneRIF: A-family anti-inflammatory cyclopentenone prostaglandins:
            A novel class of non-statin inhibitors of HMG-CoA reductase.
REFERENCE   4  (bases 1 to 4319)
  AUTHORS   Hao,C.L., Lin,H.L., Ke,L.Y., Yen,H.W. and Shen,K.P.
  TITLE     Pre-germinated brown rice extract ameliorates high-fat diet-induced
            metabolic syndrome
  JOURNAL   J Food Biochem 43 (3), e12769 (2019)
   PUBMED   31353547
REFERENCE   5  (bases 1 to 4319)
  AUTHORS   Khamis,A.A., Salama,A.F., Kenawy,M.E. and Mohamed,T.M.
  TITLE     Regulation of hepatic hydroxy methyl glutarate - CoA reductase for
            controlling hypercholesterolemia in rats
  JOURNAL   Biomed Pharmacother 95, 1242-1250 (2017)
   PUBMED   28938515
  REMARK    GeneRIF: This study is aiming to investigate the inhibition role of
            quercetin on hydroxy methyl glutarate - CoA reductase activity and
            its gene for attenuating hypercholesterolemia.
REFERENCE   6  (bases 1 to 4319)
  AUTHORS   Gillespie,J.G. and Hardie,D.G.
  TITLE     Phosphorylation and inactivation of HMG-CoA reductase at the
            AMP-activated protein kinase site in response to fructose treatment
            of isolated rat hepatocytes
  JOURNAL   FEBS Lett 306 (1), 59-62 (1992)
   PUBMED   1628744
REFERENCE   7  (bases 1 to 4319)
  AUTHORS   Hwa,J.J., Zollman,S., Warden,C.H., Taylor,B.A., Edwards,P.A.,
            Fogelman,A.M. and Lusis,A.J.
  TITLE     Genetic and dietary interactions in the regulation of HMG-CoA
            reductase gene expression
  JOURNAL   J Lipid Res 33 (5), 711-725 (1992)
   PUBMED   1352323
REFERENCE   8  (bases 1 to 4319)
  AUTHORS   McPherson,R., Bedard,J., Connelly,P., Curnew,G., Davignon,J.,
            Echenberg,D., Lavin,P., Leiter,L., Lenis,J., McQueen,M. et al.
  TITLE     Comparison of the short-term efficacy and tolerability of
            lovastatin and pravastatin in the management of primary
            hypercholesterolemia
  JOURNAL   Clin Ther 14 (2), 276-291 (1992)
   PUBMED   1611649
REFERENCE   9  (bases 1 to 4319)
  AUTHORS   Clarke,P.R. and Hardie,D.G.
  TITLE     Regulation of HMG-CoA reductase: identification of the site
            phosphorylated by the AMP-activated protein kinase in vitro and in
            intact rat liver
  JOURNAL   EMBO J 9 (8), 2439-2446 (1990)
   PUBMED   2369897
REFERENCE   10 (bases 1 to 4319)
  AUTHORS   Luskey,K.L. and Stevens,B.
  TITLE     Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved
            domains responsible for catalytic activity and sterol-regulated
            degradation
  JOURNAL   J Biol Chem 260 (18), 10271-10277 (1985)
   PUBMED   2991281
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC064654.1.
            
            On Jan 1, 2004 this sequence version replaced NM_013134.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4319
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..4319
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /note="3-hydroxy-3-methylglutaryl-CoA reductase"
                     /db_xref="GeneID:25675"
                     /db_xref="RGD:2803"
     exon            1..27
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            28..215
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2714
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /EC_number="1.1.1.34"
                     /note="HMG-CoA reductase"
                     /codon_start=1
                     /product="3-hydroxy-3-methylglutaryl-coenzyme A reductase"
                     /protein_id="NP_037266.2"
                     /db_xref="GeneID:25675"
                     /db_xref="RGD:2803"
                     /translation="MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKIC
                     GWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFS
                     SFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARG
                     MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSL
                     VLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIAD
                     PSPQNSTAEQSKVSLGLAEDVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAV
                     KYIFFEQAETESTLSLKNPITSPVVTPKKAQDNCCRREPLLVRRNQKLSSVEEDPGVN
                     QDRKVEVIKPLVAEAETSGRATFVLGASAASPPLALGAQEPGIELPSEPRPNEECLQI
                     LESAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSAKLAEPSSL
                     QYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEYQVPMATTEGCLVASTN
                     RGCRAISLGGGASSRVLADGMSRGPVVRLPRACDSAEVKSWLETPEGFAVVKEAFDST
                     SRFARLQKLHVTLAGRNLYIRLQSKTGDAMGMNMISKGTEKALLKLQEFFPELQILAV
                     SGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMVDVNINKNLVGSA
                     MAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPS
                     IEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAAL
                     AAGHLVRSHMVHNRSKINLQDLQGTCTKKAA"
     exon            216..327
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            328..415
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            416..500
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            501..606
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            607..713
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            714..830
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            831..991
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1239
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1415
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1610
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1769
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1927
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2033
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2204
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2345
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2504
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2659
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..4305
                     /gene="Hmgcr"
                     /gene_synonym="3H3M"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttggtggcc tccattgaga tccggaggat ccaaggactg tgtagctaca atgttgtcaa
       61 gacttttccg tatgcatggc ctctttgtgg cctcccatcc ctgggaggta attgtgggaa
      121 cggtgacact tactatctgt atgatgtcca tgaacatgtt caccggcaac aacaagatct
      181 gtggttggaa ttatgagtgc ccaaaatttg aagaggacgt gctgagcagc gacatcatca
      241 tcctcacgat aacccggtgc atcgccatcc tgtacatcta cttccagttc cagaacctgc
      301 gtcagcttgg gtcaaagtac attttgggta ttgccggcct cttcacaatt ttctcaagtt
      361 tcgtcttcag cactgtcgtc attcatttcc tcgacaaaga attgacaggc ttaaatgaag
      421 ctttgccctt ttttctgctc ttgattgacc tttctagagc gagtgcattg gccaagtttg
      481 ccctgagttc aaactcacag gatgaagtaa gggagaatat agcgcgtggg atggcgatcc
      541 tgggccccac gttcaccctt gacgctctgg tggaatgtct tgtgattgga gttggcacca
      601 tgtcaggggt gcggcagctt gagatcatgt gctgctttgg ctgtatgtcc gtgcttgcca
      661 actactttgt cttcatgaca ttcttcccag cctgcgtgtc cctggtccta gagctttctc
      721 gggaaagccg tgagggtcgt ccaatttggc agctcagcca ttttgccaga gttttagaag
      781 aagaagagaa taaaccaaac ccagtaaccc aaagggtcaa gatgatcatg tctttaggcc
      841 tggttcttgt tcacgctcac agtcgctgga tagctgatcc ttctcctcag aacagcacag
      901 cagaacagtc taaggtttcc ttgggtctgg ctgaagatgt gtccaagaga attgagccga
      961 gtgtttctct ctggcagttt tacctctcca agatgatcag catggacatc gagcaagtga
     1021 ttaccctgag cttagcgttg cttttggctg tcaagtatat tttctttgaa caagcagaga
     1081 cagaatcaac actctcatta aaaaatccta tcacatctcc tgtcgtgacc ccaaagaaag
     1141 ctcaagacaa ctgttgtaga cgtgagcctc tgcttgtgag gaggaaccag aagctttcgt
     1201 cagtggagga ggatccagga gtgaaccaag acagaaaagt tgaggttata aaacctttag
     1261 tggcagaagc cgagacttcg ggcagagcta cgtttgtgct tggcgcctct gcagccagcc
     1321 ctccattggc cctgggggca caggagcctg ggatcgaact ccccagcgag cctcgaccta
     1381 atgaagagtg tctacagata ctggagagtg cagagaaagg tgcgaagttc cttagtgatg
     1441 cagagatcat ccagttggtc aatgctaagc acatcccagc ctacaaactg gaaaccctca
     1501 tggagacgca cgagcgtggt gtgtctattc gccggcagct cctctccgcc aagcttgcag
     1561 agccatcttc tctgcagtac ctgccttaca gagactataa ttactccttg gtgatgggag
     1621 cttgctgtga gaacgtgatc ggatatatgc ccatccctgt tggagtggca ggacctctgt
     1681 gcctggatgg aaaagagtac caggtgccaa tggcaacaac agaaggttgt cttgtggcca
     1741 gcacgaacag aggctgcaga gcgatcagtc ttggtggagg tgccagcagc cgggtccttg
     1801 cagatgggat gagccgaggc ccagtggtgc gtcttcctcg tgcttgtgac tcagcagagg
     1861 tgaagagctg gcttgaaaca cctgaagggt ttgcagtggt aaaggaggcc ttcgacagca
     1921 cgagcagatt tgcacgtcta cagaaacttc acgtgacgct ggcaggacgc aacctctaca
     1981 tccgtctcca gtccaaaacg ggggacgcca tggggatgaa catgatttcc aagggtacgg
     2041 agaaagcact tctgaagctt caagagttct ttcctgagct gcagattctg gcggtcagtg
     2101 gtaactattg caccgacaag aaacctgctg ccataaactg gatcgaaggg agaggaaaga
     2161 ctgtggtttg tgaagctgtc attccagcca aggtggtgag agaagtatta aagacgacta
     2221 cggaagctat ggttgacgta aacattaaca agaatcttgt gggctctgcc atggctggta
     2281 gcataggagg ctacaacgcc catgctgcca acatcgtcac tgccatctac attgcatgtg
     2341 gccaggatgc agcacagaat gtggggagtt caaactgtat tacgttaatg gaagcaagtg
     2401 gtcccacaaa tgaagactta tacatcagct gtaccatgcc gtctatagag atcggaaccg
     2461 tgggtggtgg gaccaacctt ctacctcagc aagcctgcct gcagatgcta ggtgttcaag
     2521 gggcgtgcaa agacaatcct ggagaaaatg cacggcagct tgcccgaatt gtgtgtggca
     2581 ctgtgatggc tggtgagttg tccttgatgg cagcattggc agcaggacat cttgtcagaa
     2641 gtcacatggt tcacaacaga tcaaagataa atttacaaga tctgcaggga acatgcacca
     2701 agaaggcagc ttgagcatcc tgacatactg gactgaaaca cgggcattgg gttctccagg
     2761 actaacatga aatctgtgaa ttaaaaatgt cagtgcagtg tcttgtggaa gatgaacgtg
     2821 atcagtgagg caggcacctg cttggtttct ggctctttag agacgtctgc ggtcctttgc
     2881 acagactcct cagacgtggg aactatggtt ctttccgtgc cgtgttctag aaagatctca
     2941 tgtggatgtc atggtgctct gagcaccaca gatgtgactg cagctcgttt ctgaaagctg
     3001 ccacaagctg gaagctggtg ttttgacgaa atgatggatc ctggtgatca gtgtggggct
     3061 cacctccaat gggttaaaat ggagttttaa atgacactgt agctgacaga acttctgatt
     3121 tttatttatt cagtctgggt tgtagaactt tgcaatctaa gtttattttt tgtaaactaa
     3181 taattcattt ggtgctggtc tattgatttt tggggaccta cttcttcatg gaagaattac
     3241 ttttattctc aaactacaga ataatgtgct aagtagtgct aaatagttct cgacgaagaa
     3301 aagagtcgct gtgttcatct cagtctttgt tcagagaggc ctttagctgt gccacagtct
     3361 gcactaaaga cacagagctc ttagtgttag agcagagtac aagcaggtcg gacctctcag
     3421 gacttagagt gtgggagcag tttttaaaga aaacaaccat tgctctaagc caactttctt
     3481 tggagacatt ttaacttatt tagctgaatt ctagatttct tggtaaacta tcaaatctgt
     3541 atatgttgta ataaagtgtc taatgctagg agtttattgg aagtgtttaa gaaataaaag
     3601 tactcagctt ttacacggat aaaatgctct agcttgggcc agagaagacc tcgctcagga
     3661 gcattggtcc gggaaagcct ggcttgcttg ccgagcctaa tgaagggaag tcagcctaca
     3721 gagccagtga tggagccaca tgaatggccc tggagctgtg tgccttgttc ctgtggccag
     3781 gagttgggtg actgaatcat ttatgggctc ctttggtgga cccataaaag ctcttagctt
     3841 cctcaggggg tcagcagagt tgttgaatct taattttttt ttaatgtacc agttttgtat
     3901 aaataataat aaagagctcc ttattttgta ttctatctaa tgcttcgttt ggtcttggaa
     3961 gcggacgtct gtgtagaaga cggactctga aagacattcc gagtgaggcg gcggcggcgg
     4021 cggcggcacg ggagctcagt gattgtgtca gtattattgt ggaaggttga ctttgctgtt
     4081 gtatgtaaag tttccagttg cgcctcttgt gacttttcag ccagtaccat tttatttacc
     4141 tgagcttgtc gtggaagtgg tagtaaaccg cattgagtgt tgatgctggt gactgtgatc
     4201 agtgtcatcg tgctaagtcc atgttttgta caattactaa attgtataca ttttgttata
     4261 gaatactttt tccagttgag taaattatga aaggaagtta acattaaaaa aaaaaaaaa
//
