LOCUS       NM_001398776            1616 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus high mobility group box 3 (Hmgb3), transcript
            variant 2, mRNA.
ACCESSION   NM_001398776 XM_003751682
VERSION     NM_001398776.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1616)
  AUTHORS   Sun,D., Cao,H., Yang,L., Lin,L., Hou,B., Zheng,W., Shen,Z. and
            Song,H.
  TITLE     MiR-200b in heme oxygenase-1-modified bone marrow mesenchymal stem
            cell-derived exosomes alleviates inflammatory injury of intestinal
            epithelial cells by targeting high mobility group box 3
  JOURNAL   Cell Death Dis 11 (6), 480 (2020)
   PUBMED   32587254
  REMARK    GeneRIF: MiR-200b in heme oxygenase-1-modified bone marrow
            mesenchymal stem cell-derived exosomes alleviates inflammatory
            injury of intestinal epithelial cells by targeting high mobility
            group box 3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1616)
  AUTHORS   Zheng,W.J., Yao,M., Fang,M., Wang,L., Dong,Z.Z. and Yao,D.F.
  TITLE     Abnormal expression of HMGB-3 is significantly associated with
            malignant transformation of hepatocytes
  JOURNAL   World J Gastroenterol 24 (32), 3650-3662 (2018)
   PUBMED   30166860
  REMARK    GeneRIF: HMGB3 is involved in malignant transformation of
            hepatocytes and could be a useful biomarker for diagnosis and a
            potential target for therapy of liver cancer.
REFERENCE   3  (bases 1 to 1616)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 1616)
  AUTHORS   Yanai,H., Ban,T., Wang,Z., Choi,M.K., Kawamura,T., Negishi,H.,
            Nakasato,M., Lu,Y., Hangai,S., Koshiba,R., Savitsky,D., Ronfani,L.,
            Akira,S., Bianchi,M.E., Honda,K., Tamura,T., Kodama,T. and
            Taniguchi,T.
  TITLE     HMGB proteins function as universal sentinels for
            nucleic-acid-mediated innate immune responses
  JOURNAL   Nature 462 (7269), 99-103 (2009)
   PUBMED   19890330
REFERENCE   5  (bases 1 to 1616)
  AUTHORS   Nemeth,M.J., Curtis,D.J., Kirby,M.R., Garrett-Beal,L.J.,
            Seidel,N.E., Cline,A.P. and Bodine,D.M.
  TITLE     Hmgb3: an HMG-box family member expressed in primitive
            hematopoietic cells that inhibits myeloid and B-cell
            differentiation
  JOURNAL   Blood 102 (4), 1298-1306 (2003)
   PUBMED   12714519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 23, 2021 this sequence version replaced XM_003751682.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FN804369.1, SRR26643287.38464.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAXUCZ010000021.1  154341171-154341329
            160-314             JAXUCZ010000021.1  154343631-154343785
            315-454             JAXUCZ010000021.1  154344023-154344162
            455-629             JAXUCZ010000021.1  154344774-154344948
            630-1616            JAXUCZ010000021.1  154345101-154346087
FEATURES             Location/Qualifiers
     source          1..1616
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..1616
                     /gene="Hmgb3"
                     /gene_synonym="RGD1564407"
                     /note="high mobility group box 3"
                     /db_xref="GeneID:305373"
                     /db_xref="RGD:1564407"
     exon            1..159
                     /gene="Hmgb3"
                     /gene_synonym="RGD1564407"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..767
                     /gene="Hmgb3"
                     /gene_synonym="RGD1564407"
                     /note="isoform 2 is encoded by transcript variant 2; high
                     mobility group protein B3"
                     /codon_start=1
                     /product="high mobility group protein B3 isoform 2"
                     /protein_id="NP_001385705.1"
                     /db_xref="GeneID:305373"
                     /db_xref="RGD:1564407"
                     /translation="MFRSCSGAHTTFHPRLHSRVLATPSPFSLLGGREGRRHSVRMAK
                     GDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKKCSERWKTMSSKEKSKFD
                     EMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFLFCSEFRPKIKSANPGIS
                     IGDVAKKLGEMWNNLSDSEKQPYMTKAAKLKEKYEKDVADYKSKGKFDGAKGPAKVAR
                     KKVEEEEEEEEEEEEEEEEEEDE"
     exon            160..314
                     /gene="Hmgb3"
                     /gene_synonym="RGD1564407"
                     /inference="alignment:Splign:2.1.0"
     exon            315..454
                     /gene="Hmgb3"
                     /gene_synonym="RGD1564407"
                     /inference="alignment:Splign:2.1.0"
     exon            455..629
                     /gene="Hmgb3"
                     /gene_synonym="RGD1564407"
                     /inference="alignment:Splign:2.1.0"
     exon            630..1616
                     /gene="Hmgb3"
                     /gene_synonym="RGD1564407"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atacaggtac ggcccgcacc gcagcccgcg cccctagcca gatgttccgc agctgcagcg
       61 gcgcccacac aactttccac ccgcgcctcc actcccgcgt ccttgctacc ccttctcctt
      121 tttcgctgct cggcggcagg gaaggaagac gccattcagt caggatggct aaaggtgatc
      181 ccaagaaacc aaagggcaag atgtccgcct atgccttctt cgtgcagacg tgcagggaag
      241 aacacaagaa gaaaaaccca gaggttccag tcaactttgc tgagttttcc aagaagtgct
      301 ctgagaggtg gaagacgatg tctagcaaag agaaatcaaa gtttgacgaa atggccaagg
      361 cggataaggt acgctacgat cgtgaaatga aagattatgg gccagctaaa ggaggcaaaa
      421 agaagaagga cccgaatgcc cccaaaagac ctccgtctgg atttttcttg ttctgctctg
      481 aattccgccc gaagatcaaa tctgcaaacc ctggcatctc tattggagat gtggccaaaa
      541 agctgggtga gatgtggaat aacttaagtg acagtgaaaa gcagccttac atgaccaagg
      601 cagcaaagct gaaggagaag tatgagaagg atgttgctga ctataagtct aaagggaagt
      661 ttgatggtgc caagggtcct gctaaagttg cccggaaaaa ggtggaagaa gaggaggagg
      721 aggaggaaga agaagaggag gaggaggaag aggaagaaga tgaataaaaa ctctgtctcc
      781 ttgtgaatac cttagagtag gagagcgctg tgattgacac atctcttatt tgagtcgtgt
      841 ctattgccct tgttaggttt aattacaaaa tttgatcacg atcatattgt agtttctcaa
      901 agtgtcagtg gtttacatga agtggccgtg ggtgtccgga gcgccctgaa actgtatcaa
      961 agttgtacat agctccaaac atttttaaaa agaaaaggca ctctctcgtc ctcctcactt
     1021 cagtgcactt tgctgttggg gtgacaaggc attcgaagat ttttttctgg cattttgttc
     1081 tcaactcgta aggtagtgtt aactctatgg ctattggcta gaaatcctga gttatcagct
     1141 gtacatatct atagtttgta aagagaacaa aacagcccag acagattctt gatgctcctt
     1201 gtttggcgtg gacgttgtga ggggagatgc ctttcagagg gggccgtagc tcagggcgtg
     1261 cactgtgagg ctggacctgt tgatactgcg gtgggcatcc atttagcttc aggtagtctt
     1321 gtttttgtac atagtggcat agcattctgc tgacattctt agttgtggag gcggggggag
     1381 gggtcagctg gcatgagaag tgtttggagt ttttccttta gttaagtgca gtagatttta
     1441 aactttttaa agcaactgta gaactcatcg ttgtcagcaa agtgaagaac tactgcatca
     1501 atggaaggtc aagaaccctc tgtacctaaa cccaatttgc aacattctgt tattttttgt
     1561 atgtttagaa tgctgaaatg tttttgaagt taaataaaca gtattacatt tttaaa
//
