LOCUS       NM_017187               1225 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus high mobility group box 2 (Hmgb2), mRNA.
ACCESSION   NM_017187 XM_001054623 XM_573903
VERSION     NM_017187.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   Kong,D., Liu,J., Lu,J., Zeng,C., Chen,H., Duan,Z., Yu,K., Zheng,X.,
            Zou,P., Zhou,L., Lv,Y., Zeng,Q., Lu,L., Li,J. and He,Y.
  TITLE     HMGB2 Release Promotes Pulmonary Hypertension and Predicts Severity
            and Mortality of Patients With Pulmonary Arterial Hypertension
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (6), e172-e195 (2024)
   PUBMED   38572649
  REMARK    GeneRIF: HMGB2 Release Promotes Pulmonary Hypertension and Predicts
            Severity and Mortality of Patients With Pulmonary Arterial
            Hypertension.
REFERENCE   2  (bases 1 to 1225)
  AUTHORS   Yang,P., He,J., Wang,C., Yang,C. and Jian,F.
  TITLE     Downregulation of High mobility group box 2 relieves spinal cord
            injury by inhibiting microglia-mediated neuroinflammation
  JOURNAL   Exp Anim 72 (2), 199-208 (2023)
   PUBMED   36503880
  REMARK    GeneRIF: Downregulation of High mobility group box 2 relieves
            spinal cord injury by inhibiting microglia-mediated
            neuroinflammation.
REFERENCE   3  (bases 1 to 1225)
  AUTHORS   Lee,D., Taniguchi,N., Sato,K., Choijookhuu,N., Hishikawa,Y.,
            Kataoka,H., Morinaga,H., Lotz,M. and Chosa,E.
  TITLE     HMGB2 is a novel adipogenic factor that regulates ectopic fat
            infiltration in skeletal muscles
  JOURNAL   Sci Rep 8 (1), 9601 (2018)
   PUBMED   29942000
  REMARK    GeneRIF: the enhance expression of HMGB2 induces the adipogenesis
            of MSCs and the fat infiltration into skeletal muscles through the
            cascade of HMGB2-PDGFRA
            Erratum:[Sci Rep. 2020 Mar 10;10(1):4647. doi:
            10.1038/s41598-020-61550-w.. PMID: 32157195]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1225)
  AUTHORS   Lee,S., Nam,Y., Koo,J.Y., Lim,D., Park,J., Ock,J., Kim,J., Suk,K.
            and Park,S.B.
  TITLE     A small molecule binding HMGB1 and HMGB2 inhibits
            microglia-mediated neuroinflammation
  JOURNAL   Nat Chem Biol 10 (12), 1055-1060 (2014)
   PUBMED   25306442
REFERENCE   5  (bases 1 to 1225)
  AUTHORS   Abraham,A.B., Bronstein,R., Reddy,A.S., Maletic-Savatic,M.,
            Aguirre,A. and Tsirka,S.E.
  TITLE     Aberrant neural stem cell proliferation and increased adult
            neurogenesis in mice lacking chromatin protein HMGB2
  JOURNAL   PLoS One 8 (12), e84838 (2013)
   PUBMED   24391977
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1225)
  AUTHORS   Beliavtseva,L.M., Kozlov,S.V., Kulikova,O.G., Surkova,E.A. and
            Fedorova,N.A.
  TITLE     [Effect of HMG proteins and their phosphorylated forms on the
            process of transcription in neuronal nuclei of the rat brain (data
            from an immunochemical analysis)]
  JOURNAL   Biokhimiia 57 (2), 214-219 (1992)
   PUBMED   1525238
REFERENCE   7  (bases 1 to 1225)
  AUTHORS   Mosevitsky,M.I., Novitskaya,V.A., Iogannsen,M.G. and
            Zabezhinsky,M.A.
  TITLE     Tissue specificity of nucleo-cytoplasmic distribution of HMG1 and
            HMG2 proteins and their probable functions
  JOURNAL   Eur J Biochem 185 (2), 303-310 (1989)
   PUBMED   2583185
REFERENCE   8  (bases 1 to 1225)
  AUTHORS   Waga,S., Mizuno,S. and Yoshida,M.
  TITLE     Nonhistone proteins HMG1 and HMG2 suppress the nucleosome assembly
            at physiological ionic strength
  JOURNAL   Biochim Biophys Acta 1007 (2), 209-214 (1989)
   PUBMED   2465778
REFERENCE   9  (bases 1 to 1225)
  AUTHORS   Kuehl,L.
  TITLE     Synthesis of high mobility group proteins in regenerating rat liver
  JOURNAL   J Biol Chem 254 (15), 7276-7281 (1979)
   PUBMED   457681
REFERENCE   10 (bases 1 to 1225)
  AUTHORS   Chiou,W.L. and Niazi,S.
  TITLE     Pharmaceutical applications of solid dispersion systems:
            dissolution of griseofulvin-succinic acid eutectic mixture
  JOURNAL   J Pharm Sci 65 (8), 1212-1214 (1976)
   PUBMED   978439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089854.1.
            
            On or before Oct 27, 2007 this sequence version replaced
            XM_573903.2, XM_001054623.1, NM_017187.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089854.1, FQ225084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132300, SAMD00132302
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..1225
                     /gene="Hmgb2"
                     /gene_synonym="Hmg2"
                     /note="high mobility group box 2"
                     /db_xref="GeneID:29395"
                     /db_xref="RGD:69291"
     exon            1..132
                     /gene="Hmgb2"
                     /gene_synonym="Hmg2"
                     /inference="alignment:Splign:2.1.0"
     exon            133..302
                     /gene="Hmgb2"
                     /gene_synonym="Hmg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..785
                     /gene="Hmgb2"
                     /gene_synonym="Hmg2"
                     /note="HMG-2; high mobility group protein 2"
                     /codon_start=1
                     /product="high mobility group protein B2"
                     /protein_id="NP_058883.1"
                     /db_xref="GeneID:29395"
                     /db_xref="RGD:69291"
                     /translation="MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKK
                     CSERWKTMSAKEKSKFEDLAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAF
                     FLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIA
                     AYRAKGKSEVGKKGPGRPTGSKKKNEPEDEEEEEEEEDDEDEEEEDEDEE"
     exon            303..448
                     /gene="Hmgb2"
                     /gene_synonym="Hmg2"
                     /inference="alignment:Splign:2.1.0"
     exon            449..623
                     /gene="Hmgb2"
                     /gene_synonym="Hmg2"
                     /inference="alignment:Splign:2.1.0"
     exon            624..1153
                     /gene="Hmgb2"
                     /gene_synonym="Hmg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcaagttg ccgtggcgcg gagaactctg caaaacaaga ggctggggat tgcgttagtg
       61 ataagccagt tctcgccgga gcttggggaa ggaagtctct ctgtggaggt ctgagggaag
      121 agctcgcgcc aggtagacgc tgcgccgtca tcatgggcaa gggggacccc aacaagccgc
      181 ggggcaagat gtcctcgtac gccttcttcg tgcagacctg ccgggaggag cacaagaaga
      241 agcatcccga ctcgtcggtc aacttcgccg agttctcgaa gaaatgttcg gagagatgga
      301 agaccatgtc tgccaaggaa aagtcgaagt ttgaggattt ggccaagagc gacaaagctc
      361 gttatgacag ggagatgaag aactatgttc ctcccaaagg tgataagaaa ggaaagaaaa
      421 aagatccaaa tgctcccaag agaccaccgt ctgccttctt cctgttttgc tctgaacatc
      481 gcccaaagat caaaagtgaa caccccggcc tgtctattgg agatactgca aagaaactgg
      541 gggagatgtg gtctgagcaa tctgccaaag ataaacaacc gtatgagcag aaagcagcta
      601 aactaaagga gaagtatgaa aaggatattg ctgcataccg tgccaagggc aaaagtgaag
      661 taggaaagaa gggtcctggt aggccaacag gctcaaagaa gaagaatgaa ccagaagatg
      721 aggaagagga ggaggaggag gaagatgatg aagatgaaga ggaggaagat gaggatgaag
      781 aataagtatc tgtcctaaag tgtggagtat atgtgctcag gcaattattt tgctaagaat
      841 gtgaaattca agtgcagctc aacattagct tcagtataaa aactgtacag atttttgtat
      901 agctgatgag attctttgta gagaaaatac tttttaaaaa gggtttgtag ctttttcagg
      961 ggctacaacg tacagttaga tttaaagctt ttgatgttga atgtttctaa atatttaatg
     1021 gtttctttaa tttcttatga tagcaaaaaa aaaacttcat aggaatttgt attaccagta
     1081 aaagaatttt tttttttagg atgttgcatt tttgtttttt ttaaatttgt aataaaataa
     1141 tgtatattac ttgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1201 aaaaaaaaaa aaaaaaaaaa aaaaa
//
