LOCUS       NM_012963               3444 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus high mobility group box 1 (Hmgb1), mRNA.
ACCESSION   NM_012963 XM_346045
VERSION     NM_012963.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3444)
  AUTHORS   Wang,R., Feng,W., Wang,Y., Jiang,Y., Lin,Y. and Chen,X.
  TITLE     Maternal obstructive sleep apnea aggravates metabolic
            dysfunction-associated fatty liver disease via HMGB1-TLR4
            signaling-mediated endoplasmic reticulum stress in male offspring
            rats
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166889 (2024)
   PUBMED   37730152
  REMARK    GeneRIF: Maternal obstructive sleep apnea aggravates metabolic
            dysfunction-associated fatty liver disease via HMGB1-TLR4
            signaling-mediated endoplasmic reticulum stress in male offspring
            rats.
REFERENCE   2  (bases 1 to 3444)
  AUTHORS   Qiu,R., Zhang,Y., Li,J., Wu,J. and He,R.
  TITLE     Influences of microRNA-451 on the expression of HMGB1 in myocardial
            cells and its mechanism in ischemia-reperfusion injury
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (15), 141-147 (2023)
   PUBMED   38279466
  REMARK    GeneRIF: Influences of microRNA-451 on the expression of HMGB1 in
            myocardial cells and its mechanism in ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3444)
  AUTHORS   Presto,P., Ji,G., Ponomareva,O., Ponomarev,I. and Neugebauer,V.
  TITLE     Hmgb1 Silencing in the Amygdala Inhibits Pain-Related Behaviors in
            a Rat Model of Neuropathic Pain
  JOURNAL   Int J Mol Sci 24 (15), 11944 (2023)
   PUBMED   37569320
  REMARK    GeneRIF: Hmgb1 Silencing in the Amygdala Inhibits Pain-Related
            Behaviors in a Rat Model of Neuropathic Pain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3444)
  AUTHORS   Zhang,Q., Chen,Y., Wang,Q., Wang,Y., Feng,W., Chai,L., Liu,J.,
            Li,D., Chen,H., Qiu,Y., Shen,N., Shi,X., Xie,X. and Li,M.
  TITLE     HMGB1-induced activation of ER stress contributes to pulmonary
            artery hypertension in vitro and in vivo
  JOURNAL   Respir Res 24 (1), 149 (2023)
   PUBMED   37268944
  REMARK    GeneRIF: HMGB1-induced activation of ER stress contributes to
            pulmonary artery hypertension in vitro and in vivo.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3444)
  AUTHORS   Huang,Y., Wang,A., Jin,S., Liu,F. and Xu,F.
  TITLE     Activation of the NLRP3 inflammasome by HMGB1 through inhibition of
            the Nrf2/HO-1 pathway promotes bleomycin-induced pulmonary fibrosis
            after acute lung injury in rats
  JOURNAL   Allergol Immunopathol (Madr) 51 (3), 56-67 (2023)
   PUBMED   37169561
  REMARK    GeneRIF: Activation of the NLRP3 inflammasome by HMGB1 through
            inhibition of the Nrf2/HO-1 pathway promotes bleomycin-induced
            pulmonary fibrosis after acute lung injury in rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3444)
  AUTHORS   Bianchi,M.E., Falciola,L., Ferrari,S. and Lilley,D.M.
  TITLE     The DNA binding site of HMG1 protein is composed of two similar
            segments (HMG boxes), both of which have counterparts in other
            eukaryotic regulatory proteins
  JOURNAL   EMBO J 11 (3), 1055-1063 (1992)
   PUBMED   1547772
REFERENCE   7  (bases 1 to 3444)
  AUTHORS   Merenmies,J., Pihlaskari,R., Laitinen,J., Wartiovaara,J. and
            Rauvala,H.
  TITLE     30-kDa heparin-binding protein of brain (amphoterin) involved in
            neurite outgrowth. Amino acid sequence and localization in the
            filopodia of the advancing plasma membrane
  JOURNAL   J Biol Chem 266 (25), 16722-16729 (1991)
   PUBMED   1885601
REFERENCE   8  (bases 1 to 3444)
  AUTHORS   Waga,S., Mizuno,S. and Yoshida,M.
  TITLE     Nonhistone proteins HMG1 and HMG2 suppress the nucleosome assembly
            at physiological ionic strength
  JOURNAL   Biochim Biophys Acta 1007 (2), 209-214 (1989)
   PUBMED   2465778
REFERENCE   9  (bases 1 to 3444)
  AUTHORS   Rauvala,H., Merenmies,J., Pihlaskari,R., Korkolainen,M.,
            Huhtala,M.L. and Panula,P.
  TITLE     The adhesive and neurite-promoting molecule p30: analysis of the
            amino-terminal sequence and production of antipeptide antibodies
            that detect p30 at the surface of neuroblastoma cells and of brain
            neurons
  JOURNAL   J Cell Biol 107 (6 Pt 1), 2293-2305 (1988)
   PUBMED   2461949
REFERENCE   10 (bases 1 to 3444)
  AUTHORS   Yoshida,M.
  TITLE     High glutamic and aspartic region in nonhistone protein HMG(1+2)
            unwinds DNA double helical structure
  JOURNAL   J Biochem 101 (1), 175-180 (1987)
   PUBMED   3571199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000224.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_012963.4.
            
            On Jan 31, 2022 this sequence version replaced NM_012963.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081839.1, FQ222862.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMD00132261,
                                           SAMD00132262 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JACYVU010000224.1  1939521-1939675
            156-319             JACYVU010000224.1  1941651-1941814
            320-465             JACYVU010000224.1  1941962-1942107
            466-640             JACYVU010000224.1  1942443-1942617
            641-3444            JACYVU010000224.1  1943426-1946229
FEATURES             Location/Qualifiers
     source          1..3444
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..3444
                     /gene="Hmgb1"
                     /gene_synonym="Ac2-008; Hmg1"
                     /note="high mobility group box 1"
                     /db_xref="GeneID:25459"
                     /db_xref="RGD:2802"
     exon            1..155
                     /gene="Hmgb1"
                     /gene_synonym="Ac2-008; Hmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            156..319
                     /gene="Hmgb1"
                     /gene_synonym="Ac2-008; Hmg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..817
                     /gene="Hmgb1"
                     /gene_synonym="Ac2-008; Hmg1"
                     /note="HMG-1; amphoterin; heparin-binding protein p30;
                     high mobility group protein 1; high mobility group 1;
                     Ac2-008-like"
                     /codon_start=1
                     /product="high mobility group protein B1"
                     /protein_id="NP_037095.1"
                     /db_xref="GeneID:25459"
                     /db_xref="RGD:2802"
                     /translation="MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKK
                     CSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAF
                     FLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIA
                     AYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE"
     exon            320..465
                     /gene="Hmgb1"
                     /gene_synonym="Ac2-008; Hmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..640
                     /gene="Hmgb1"
                     /gene_synonym="Ac2-008; Hmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..3444
                     /gene="Hmgb1"
                     /gene_synonym="Ac2-008; Hmg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggctgga gagtaatgtt acagagcgga gagagtgagg aggctgcgtc tggctcccgc
       61 tctcacagcc attgcagtac attgagctcc atagagacag cgccggggca agcgagagcc
      121 ggacgggcac tgggcgactc tgtgcctcgc ggaggaaaat caactaaaca tgggcaaagg
      181 agatcctaag aagccgagag gcaaaatgtc ctcatatgca ttctttgtgc aaacctgccg
      241 ggaggagcac aagaagaagc acccggatgc ttctgtcaac ttctcagagt tctccaagaa
      301 gtgctcagag aggtggaaga ccatgtctgc taaagaaaag gggaaatttg aagatatggc
      361 aaaggctgac aaggctcgtt atgaaagaga aatgaaaacc tacatccccc ccaaagggga
      421 gaccaaaaag aagttcaagg accccaatgc ccccaagagg cctccttcgg ccttcttctt
      481 gttctgttct gagtaccgcc caaaaatcaa aggcgagcat cctggcttat ccattggtga
      541 tgttgcgaag aaactaggag agatgtggaa caacactgct gcggatgaca agcagcccta
      601 tgaaaagaag gccgccaagc tgaaggagaa gtatgagaag gatattgctg cctacagagc
      661 taaaggaaaa cctgatgcag cgaaaaaggg ggtggtcaag gctgagaaga gcaagaaaaa
      721 gaaggaagag gaagacgacg aggaggatga agaggatgag gaagaggagg aagaggagga
      781 agacgaagat gaagaagaag atgatgatga tgaataagtt ggttctagcg cagttttttt
      841 ttcttgtcta taaagcattt aacccccctg tacacaactc actcctttta aagaaaaaaa
      901 ttgaaatgta aggctgtgta agatttgttt ttaaactgta cagtgtcttt ttttgtatag
      961 ttaacacact accgaatgtg tctttagcta gccctgtcct ggtggtattt tcaatagcca
     1021 ctaaccttgc ctggtacagt ctgggggttg taaattggca tggaaattaa agcaggttct
     1081 tgttggtgca cagcacaaat tagttatata tggggacagt agtttggttt ttggtttctt
     1141 tttttttttt tttttttgtt tttgtttttt tttccttttg tttttttttt tccatcttca
     1201 gttgtctctg atgcagctta tacgaaggta attgttgttc tgttaactga ataccactct
     1261 gtaattgcaa aaaaatggcg gctgttttgt tgacattctg aatgcttcta agtaaataca
     1321 atttttttta ttagtactgt tgtccttttc ataggtctga aagttttctt ctcaagggga
     1381 agctagtctt ttgcttttgc ccattttggg tcacatggat tattagtgtg tatcttcata
     1441 tagttggaaa aatcttttgt ccacacaccc tgcatattgt ggtaggggta acattttcat
     1501 ctacagttga agaattctcc aaaattgtga tcagttggat aagagatact ctacttagca
     1561 aagcaaggag tgatcaattc tgtcacacca tgggattatt agatcaaaca gtctgaaagt
     1621 ctgtccttga aggactaata gaaaagtatg ttctgctcct tacctgagga ctcctttaac
     1681 tgccattact gtgtaatgac agttatattt tgcagtttcc cctactaaag acctgagaat
     1741 gtatccccaa aagcgtgagc ttaaaataca agattgctgt actatttgtt gaccttagtc
     1801 ccagcgaagg ctatcatgag aagctggctg taatgccttt gcccttctat ctaaatacgg
     1861 attgctcagg aaacttgact gtttaaaggt atatttaatt agttgagcca gcttttaaaa
     1921 ttatgccaca tttaaaatga agggtatatt ttcctatatt gtggtttgtc cctttataaa
     1981 tcagatacaa ggaaagcgga taaactttgc atattagtac cagttgtcca agccatttgc
     2041 tttttcttta taaagcccga actcattcat taatcatgtt taatctgctt agtttaggga
     2101 acaatttggc aattttgtgg gttttctttt tttctttttc tttttttttt tttttttgag
     2161 attatcattc tcttaaagtg ccagtgtttt aaaatagcgt tcttgtaatt ttccgcgctt
     2221 ttgtgatgga gtgctgttat atcattttga cttgggttct ttacagttgc ctttgttctg
     2281 taatttgagg aggaatactg aacatgagtc ctggatgata ctaataaact aataattgca
     2341 gaggttttaa atattagtta aatgactttc actgaagaat aagctttttg tcacacttta
     2401 tagtagtgcc ttagagtaaa caacttaaag gcttttcccc attaacaaca cttggtgctg
     2461 ggcccagtga gggagagagt gggtaaaaag tgggtagaaa ggtggaagga ggggaccagc
     2521 ttccaaaatg gtttgaccac acaatcccta catttgtgta cacacaatac atttaaaaat
     2581 atgaggagcc aagatcagaa ggttaaggtt aatttaaaac ttggcacagt aagtgagaag
     2641 tgaggttggt ctcagattgc acatcagttc tcttaagccc tgggaggacc tcggcaggct
     2701 gtagtgttcc tgattaccaa cttaggaaca agtgactgac ttggactgtt gctttagaac
     2761 taccattgtg gacatctgtt gttagtaagt gatccattta aaagtgaact ctgcctccag
     2821 gaaacggctt tgtaactcta gtgggtgtgt cgtgacagct acccttctaa agatgttaag
     2881 agtgggaacg gtttgccttg cttaaccaac tttagatgtt caagaaatgg aacaaaaaaa
     2941 aaaaaaccct cttaaattag agaagttctg ttcagcatct aagcagtatc ctctggaact
     3001 aactctgtgg attgactctt aaatttgaaa tttacaggtt ttggtgttag gttcataagg
     3061 gtcttgtagc ccaggctttc ctgaagctca ctacgtagta ggttggatcc tgcctctgtc
     3121 aagtgctgtg attattggta tgtgtcacca tgcttgctag tatttctgtt ttaaaagtga
     3181 cacttgcggg gctggggatt tagctcagtg gtagagcgct tacctaggaa gcgcaaggcc
     3241 ctgggttcgg tccccagctc cgaaaagaac ccccccccaa aaaaaaagtg acacttgcca
     3301 ctatttctga taatcatttc ttacccccta gatgtatgcc tgaatgtcca tccacagaag
     3361 aagtgagaaa gttactgtct tccccacccc taacatttca tttcctaact tgtgaattaa
     3421 agaaagaact tggctggcct caaa
//
