LOCUS       NM_032070                805 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus high mobility group AT-hook 2 (Hmga2), mRNA.
ACCESSION   NM_032070
VERSION     NM_032070.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 805)
  AUTHORS   Huang,S., Hong,Z., Zhang,L., Guo,J., Li,Y. and Li,K.
  TITLE     HMGA2 Promotes Brain Injury in Rats with Cerebral Infarction by
            Activating TLR4/NF-kappaB Signaling Pathway
  JOURNAL   Mediators Inflamm 2022, 1376959 (2022)
   PUBMED   35966335
  REMARK    GeneRIF: HMGA2 Promotes Brain Injury in Rats with Cerebral
            Infarction by Activating TLR4/NF-kappaB Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 805)
  AUTHORS   Frasson,L.T., Dalmaso,B., Akamine,P.S., Kimura,E.T., Hamassaki,D.E.
            and Del Debbio,C.B.
  TITLE     Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal
            Progenitor Cells
  JOURNAL   Invest Ophthalmol Vis Sci 62 (3), 31 (2021)
   PUBMED   33749722
  REMARK    GeneRIF: Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium
            and Retinal Progenitor Cells.
REFERENCE   3  (bases 1 to 805)
  AUTHORS   Yang,Z., Liu,X., Wang,L., Wang,T., Chen,Y., Teng,X., Li,J.,
            Shao,L., Hui,J., Ye,W. and Shen,Z.
  TITLE     The protective effects of HMGA2 in the senescence process of bone
            marrow-derived mesenchymal stromal cells
  JOURNAL   J Tissue Eng Regen Med 14 (4), 588-599 (2020)
   PUBMED   32068957
  REMARK    GeneRIF: The protective effects of HMGA2 in the senescence process
            of bone marrow-derived mesenchymal stromal cells.
REFERENCE   4  (bases 1 to 805)
  AUTHORS   Chen,X., Ding,Z., Li,T., Jiang,W., Zhang,J. and Deng,X.
  TITLE     MicroR-26b Targets High Mobility Group, AT-hook 2 to Ameliorate
            Myocardial Infarction-induced Fibrosis by Suppression of Cardiac
            Fibroblasts Activation
  JOURNAL   Curr Neurovasc Res 17 (2), 204-213 (2020)
   PUBMED   32370714
  REMARK    GeneRIF: MicroR-26b Targets High Mobility Group, AT-hook 2 to
            Ameliorate Myocardial Infarction-induced Fibrosis by Suppression of
            Cardiac Fibroblasts Activation.
REFERENCE   5  (bases 1 to 805)
  AUTHORS   Wong,L.L., Saw,E.L., Lim,J.Y., Zhou,Y., Richards,A.M. and Wang,P.
  TITLE     MicroRNA Let-7d-3p Contributes to Cardiac Protection via Targeting
            HMGA2
  JOURNAL   Int J Mol Sci 20 (7), 1522 (2019)
   PUBMED   30934671
  REMARK    GeneRIF: the anti-apoptotic effects of Let-7d-3p mimic during
            hypoxia challenge are due to direct targeting of HMGA2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 805)
  AUTHORS   Zhou,X., Benson,K.F., Ashar,H.R. and Chada,K.
  TITLE     Mutation responsible for the mouse pygmy phenotype in the
            developmentally regulated factor HMGI-C
  JOURNAL   Nature 376 (6543), 771-774 (1995)
   PUBMED   7651535
REFERENCE   7  (bases 1 to 805)
  AUTHORS   Ashar,H.R., Fejzo,M.S., Tkachenko,A., Zhou,X., Fletcher,J.A.,
            Weremowicz,S., Morton,C.C. and Chada,K.
  TITLE     Disruption of the architectural factor HMGI-C: DNA-binding AT hook
            motifs fused in lipomas to distinct transcriptional regulatory
            domains
  JOURNAL   Cell 82 (1), 57-65 (1995)
   PUBMED   7606786
REFERENCE   8  (bases 1 to 805)
  AUTHORS   Benson,K.F. and Chada,K.
  TITLE     Mini-mouse: phenotypic characterization of a transgenic insertional
            mutant allelic to pygmy
  JOURNAL   Genet Res 64 (1), 27-33 (1994)
   PUBMED   7958830
REFERENCE   9  (bases 1 to 805)
  AUTHORS   Sinha,Y.N., Wolff,G.L., Baxter,S.R. and Domon,O.E.
  TITLE     Serum and pituitary concentrations of growth hormone and prolactin
            in pygmy mice
  JOURNAL   Proc Soc Exp Biol Med 162 (1), 221-223 (1979)
   PUBMED   504232
REFERENCE   10 (bases 1 to 805)
  AUTHORS   Rimoin,D.L. and Richmond,L.
  TITLE     The pygmy (pg) mutant of the mouse--a model of the human pygmy
  JOURNAL   J Clin Endocrinol Metab 35 (3), 467-468 (1972)
   PUBMED   5051369
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_032070.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U89695.1, SRR22582416.1482092.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-526               JAXUCZ010000007.1  57879816-57880341   c
            527-613             JAXUCZ010000007.1  57877076-57877162   c
            614-664             JAXUCZ010000007.1  57866814-57866864   c
            665-694             JAXUCZ010000007.1  57777259-57777288   c
            695-805             JAXUCZ010000007.1  57765675-57765785   c
FEATURES             Location/Qualifiers
     source          1..805
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..805
                     /gene="Hmga2"
                     /gene_synonym="Hmgic"
                     /note="high mobility group AT-hook 2"
                     /db_xref="GeneID:84017"
                     /db_xref="RGD:620617"
     exon            1..526
                     /gene="Hmga2"
                     /gene_synonym="Hmgic"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..739
                     /gene="Hmga2"
                     /gene_synonym="Hmgic"
                     /note="non-histone chromosomal architectural protein
                     HMGI-C"
                     /codon_start=1
                     /product="high mobility group protein HMGI-C"
                     /protein_id="NP_114459.1"
                     /db_xref="GeneID:84017"
                     /db_xref="RGD:620617"
                     /translation="MSARGEGAGQPSTSAQGQPATPAPQKRGRGRPRKQPQEPTCEPS
                     PKRPRGRPKGSKNKSPSKAAQKKAETIGEKRPRGRPRKWPQQIVQKPAQETEETSSQE
                     SAEED"
     exon            527..613
                     /gene="Hmga2"
                     /gene_synonym="Hmgic"
                     /inference="alignment:Splign:2.1.0"
     exon            614..664
                     /gene="Hmga2"
                     /gene_synonym="Hmgic"
                     /inference="alignment:Splign:2.1.0"
     exon            665..694
                     /gene="Hmga2"
                     /gene_synonym="Hmgic"
                     /inference="alignment:Splign:2.1.0"
     exon            695..805
                     /gene="Hmga2"
                     /gene_synonym="Hmgic"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactcccgag ccgtagcgga gagaggaacc ctctccacct ccaactctcc ctctccctcg
       61 cttcccgcct cctctcgcta cctccacctc cacctccacc tccgccaccc accgcccgca
      121 gcgcctcctc ctttcctcct cctttcctcc tcctctcctc ctcctccact cttcctccct
      181 cccctctctc tttttggcag ctgctggacg tccggtgttg gtggtggcag cggcggcagc
      241 ctaagcagca gcagccccca gcgcgcgcca gctcgcccgc tctcgccgcc cctgccctct
      301 ccagctctct ccatcccgtc tcccgaaagg tgttgggcgg atccgaggca gcggaggccg
      361 agcggctgca gcggcggtac cggcggaggc agcggtagcg gcggcgggag gcaggatgag
      421 cgcacgcggt gagggcgccg ggcagccgtc cacatcagcc cagggacaac ctgccacccc
      481 ggcgccacag aagcgaggac gcggccgacc caggaagcag ccgcaagagc caacctgtga
      541 gccctctcct aagagaccca gaggaagacc caaaggcagc aagaacaaga gcccctcgaa
      601 agcagctcaa aagaaagcag agaccattgg agaaaaacgg ccaagaggca gacccaggaa
      661 atggccacaa caaattgttc agaagcctgc tcaggagact gaagagacat cctcgcaaga
      721 gtccgcagag gaagattagg gggcgccgac attcaatttc tacctcagca tcagtttgat
      781 ctttcgaagg gagaagacac tgcag
//
