LOCUS       NM_139327               1632 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus high mobility group AT-hook 1 (Hmga1), transcript
            variant 1, mRNA.
ACCESSION   NM_139327 XM_006256156
VERSION     NM_139327.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1632)
  AUTHORS   Egawa,N., Hamanaka,G., Chung,K.K., Ishikawa,H., Shindo,A., Maki,T.,
            Takahashi,R., Inoue,H., Lo,E.H. and Arai,K.
  TITLE     High Mobility Group A1 Regulates Transcription Levels of
            Oligodendrocyte Marker Genes in Cultured Oligodendrocyte Precursor
            Cells
  JOURNAL   Int J Mol Sci 23 (4), 2236 (2022)
   PUBMED   35216347
  REMARK    GeneRIF: High Mobility Group A1 Regulates Transcription Levels of
            Oligodendrocyte Marker Genes in Cultured Oligodendrocyte Precursor
            Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1632)
  AUTHORS   Kong,B., Qin,Z., Ye,Z., Yang,X., Li,L. and Su,Q.
  TITLE     microRNA-26a-5p affects myocardial injury induced by coronary
            microembolization by modulating HMGA1
  JOURNAL   J Cell Biochem 120 (6), 10756-10766 (2019)
   PUBMED   30652345
  REMARK    GeneRIF: microRNA-26a-5p affects myocardial injury induced by
            coronary microembolization by modulating HMGA1.
REFERENCE   3  (bases 1 to 1632)
  AUTHORS   Li,H.R., Li,Y., Liu,Y., Yu,J.J. and Li,F.X.
  TITLE     Expression and regulation of high mobility group AT-hook 1 (HMGA1)
            during ovulation and luteinisation in rat ovary
  JOURNAL   Reprod Fertil Dev 31 (4), 698-704 (2019)
   PUBMED   30414623
  REMARK    GeneRIF: the findings of this study suggest that induction of Hmga1
            may be important for theca and granulosa cell differentiation into
            luteal cells.
REFERENCE   4  (bases 1 to 1632)
  AUTHORS   Zhang,D.L., Liu,X., Wang,Q., Li,N., Wu,S.H. and Wang,C.
  TITLE     Downregulation of microRNA-196a attenuates ischemic brain injury in
            rats by directly targeting HMGA1
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (2), 740-748 (2019)
   PUBMED   30720182
  REMARK    GeneRIF: miR-196a expression in brain was significantly increased
            in rat cerebral ischemic injury model (middle cerebral artery
            occlusion) and in cultured neonatal rat cortical neurons after
            oxygen-glucose deprivation (OGD). HMGA1 was identified as the
            target gene of miR-196a. miR-196a overexpression promoted
            OGD-induced cortical neurons apoptosis possibly through negative
            regulation of HMGA1.
REFERENCE   5  (bases 1 to 1632)
  AUTHORS   Zhang,Q., Chen,L., Zhao,Z., Wu,Y., Zhong,J., Wen,G., Cao,R., Zu,X.
            and Liu,J.
  TITLE     HMGA1 Mediated High-Glucose-Induced Vascular Smooth Muscle Cell
            Proliferation in Diabetes Mellitus: Association Between PI3K/Akt
            Signaling and HMGA1 Expression
  JOURNAL   DNA Cell Biol 37 (4), 389-397 (2018)
   PUBMED   29634420
  REMARK    GeneRIF: High glucose increased HMGA1 expression and promoted
            proliferation of VSMCs, which could be blunted by Wortmannin and
            LY294002, inhibitors of PI3K/Akt pathway, and specificity protein 1
            (SP1) siRNA. Moreover, knockdown of HMGA1 could weaken the
            upregulation of cyclin D1 accompanied by high-glucose-induced HMGA1
            in VSMCs.
REFERENCE   6  (bases 1 to 1632)
  AUTHORS   Chieffi,P., Battista,S., Barchi,M., Di Agostino,S.,
            Pierantoni,G.M., Fedele,M., Chiariotti,L., Tramontano,D. and
            Fusco,A.
  TITLE     HMGA1 and HMGA2 protein expression in mouse spermatogenesis
  JOURNAL   Oncogene 21 (22), 3644-3650 (2002)
   PUBMED   12032866
REFERENCE   7  (bases 1 to 1632)
  AUTHORS   Berlingieri,M.T., Pierantoni,G.M., Giancotti,V., Santoro,M. and
            Fusco,A.
  TITLE     Thyroid cell transformation requires the expression of the HMGA1
            proteins
  JOURNAL   Oncogene 21 (19), 2971-2980 (2002)
   PUBMED   12082527
  REMARK    GeneRIF: Thyroid cell transformation requires the expression of the
            HMGA1 proteins
REFERENCE   8  (bases 1 to 1632)
  AUTHORS   Nagpal,S., Ghosn,C., DiSepio,D., Molina,Y., Sutter,M., Klein,E.S.
            and Chandraratna,R.A.
  TITLE     Retinoid-dependent recruitment of a histone H1 displacement
            activity by retinoic acid receptor
  JOURNAL   J Biol Chem 274 (32), 22563-22568 (1999)
   PUBMED   10428834
REFERENCE   9  (bases 1 to 1632)
  AUTHORS   Huth,J.R., Bewley,C.A., Nissen,M.S., Evans,J.N., Reeves,R.,
            Gronenborn,A.M. and Clore,G.M.
  TITLE     The solution structure of an HMG-I(Y)-DNA complex defines a new
            architectural minor groove binding motif
  JOURNAL   Nat Struct Biol 4 (8), 657-665 (1997)
   PUBMED   9253416
REFERENCE   10 (bases 1 to 1632)
  AUTHORS   Bussemakers,M.J., van de Ven,W.J., Debruyne,F.M. and Schalken,J.A.
  TITLE     Identification of high mobility group protein I(Y) as potential
            progression marker for prostate cancer by differential
            hybridization analysis
  JOURNAL   Cancer Res 51 (2), 606-611 (1991)
   PUBMED   1702360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Sep 21, 2022 this sequence version replaced
            XM_006256156.3, NM_139327.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.63079.1,
                                           SRR26643298.77809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000020.1  5613508-5613598
            92-268              JAXUCZ010000020.1  5616406-5616582
            269-352             JAXUCZ010000020.1  5617823-5617906
            353-403             JAXUCZ010000020.1  5618429-5618479
            404-1632            JAXUCZ010000020.1  5619368-5620596
FEATURES             Location/Qualifiers
     source          1..1632
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1632
                     /gene="Hmga1"
                     /gene_synonym="Hmgi; Hmgiy"
                     /note="high mobility group AT-hook 1"
                     /db_xref="GeneID:117062"
                     /db_xref="RGD:628699"
     exon            1..91
                     /gene="Hmga1"
                     /gene_synonym="Hmgi; Hmgiy"
                     /inference="alignment:Splign:2.1.0"
     exon            92..268
                     /gene="Hmga1"
                     /gene_synonym="Hmgi; Hmgiy"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..457
                     /gene="Hmga1"
                     /gene_synonym="Hmgi; Hmgiy"
                     /note="HMG-I(Y); high mobility group protein A1; high
                     mobility group AT-hook protein 1"
                     /codon_start=1
                     /product="high mobility group protein HMG-I/HMG-Y"
                     /protein_id="NP_647543.2"
                     /db_xref="GeneID:117062"
                     /db_xref="RGD:628699"
                     /translation="MSESVSKSSQPLASKQEKDGTEKRGRGRPRKQPSVSPGTALVGS
                     QKEPSEVPTPKRPRGRPKGSKNKGTAKTRKVTTTPGRKPRGRPKKLEKEEEEGISQES
                     SEEEQ"
     exon            269..352
                     /gene="Hmga1"
                     /gene_synonym="Hmgi; Hmgiy"
                     /inference="alignment:Splign:2.1.0"
     exon            353..403
                     /gene="Hmga1"
                     /gene_synonym="Hmgi; Hmgiy"
                     /inference="alignment:Splign:2.1.0"
     exon            404..1632
                     /gene="Hmga1"
                     /gene_synonym="Hmgi; Hmgiy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttttaagc tcccctgagc cggggctgcg ctcctctaat tgggactccg agtcgcggct
       61 atttctggtg ttggcgcggc tccaagaagg cagccagact cactctgtgc tgccccacac
      121 atagagaagc agaatgagcg agtcggtctc aaagtccagc cagcccctgg cctccaagca
      181 ggaaaaggat gggactgaga agcgaggccg gggcaggccg cgcaagcagc cttcggtgag
      241 tcctgggacg gcgctggtag ggagtcagaa ggagcccagt gaagtgccaa ccccgaagag
      301 accccggggc cggccgaagg gaagcaagaa caagggcaca gccaagacgc ggaaagttac
      361 cacaactccg gggaggaaac caaggggcag acccaagaaa ctggagaagg aggaagagga
      421 gggcatctcc caggagtcct cggaggagga gcagtgacca cttgcagtgc cgcctgctcc
      481 ttggccactg aggagcggcc ttcccctggg actggaagcc ctgctcccag gccccgcccc
      541 gcccccactg cacactaccg caccaggcac cagctgcagg ctctgcggca cccacgggag
      601 caggatttgg ctcagtccct gtgccctcct ccccaacaca cctgccccct cctgacaagg
      661 ttaacttccc atcaagccgc agcccagcct gctgcgtgcc tccctcagag ccctcgctct
      721 tagctctccg ggcgctttgt ttcgcaggtc cctcctgccc tgctgctcct ggcttccctg
      781 tagagggtcc ttggagcatt ccctggcctt aaggggccac agccccatct cattccgaca
      841 agccccgatg gctgacctgg cggcagcagt gtggtcagtg caggggaagc ttaggtccca
      901 gcatgtatgt cccccatcaa gcgtcaccgg gtgggtttct cagtccctcc tgccccaccc
      961 tactgagaat cctgcaccag gttggctgag ccccttggct ggacaacagg aagtaggatg
     1021 gtgttggctc cacccacttt gctgctcttc cctgggacaa gacagatggg cgctaccacc
     1081 catctcgagt gaggtcctga gcacttccac ctaaggcaga cggggctcca acaggcgcct
     1141 cccccactac actcttcctc tagcagggca ccaaggagct cgccttgccc cccctctcct
     1201 tttgctcctc cctgcccccc aaggttctgg ttccaccttt tcctctgttc acaaactacc
     1261 tctggacagt tgtgttgtgt tttttgttca atgttcattc ttagacaccc accattgctg
     1321 ctaccagcgc cagatgtcca tcctcccgat tttgcctgta ccccccacac aatacactct
     1381 aggggaaggg ggggctggtg tgcagcagca ggctggttac cgagtacccc acgctaggga
     1441 agatggggcc cccgccccgt ggatgctgca gcagagtgag gagggggggc ccacttggat
     1501 gggaaaaggg tataggacca cctccccttg ttgtggggga ggggtggcca gtatttgtcc
     1561 cagcctgggg ctccccctct ggtttcctat ttgcagttac ttgaataaaa aaaaaatagc
     1621 cttttctgga ca
//
