LOCUS       XM_039106171           15591 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus hemicentin 2 (Hmcn2), transcript
            variant X1, mRNA.
ACCESSION   XM_039106171
VERSION     XM_039106171.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051338.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039106171.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15591
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..15591
                     /gene="Hmcn2"
                     /note="hemicentin 2; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 19 ESTs, 2 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 7 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:686132"
                     /db_xref="RGD:1585467"
     CDS             1..15228
                     /gene="Hmcn2"
                     /codon_start=1
                     /product="hemicentin-2 isoform X1"
                     /protein_id="XP_038962099.1"
                     /db_xref="GeneID:686132"
                     /db_xref="RGD:1585467"
                     /translation="MTPGAQLLPLLLATYTVVAAAVTSDEPTKTLSPATGDATLAFVF
                     DVTGSMWDDLMQVIDGASRILERSLSSRSRVIANYALVPFHDPDIGPVTLTADPVVFQ
                     RELRQLYVQGGGDCPEMSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKNELLQLLQL
                     KQSQVVFVLTGDCGDRTHPGYLAFEEIASTSSGQVFQLDKQQVSEVLKWVESAIQASK
                     VHLLSADHEEEGEHTWRIPFDPSLKEVTISLSGPGPEIEVRDPLGRVLQTDEGLNVLL
                     NIPDSAKVVAFKPEHPGLWAIKVYSSGRHSVRISGISNINFRAGFSVQPSLDLNHTIE
                     WPLQGVPISLVINSTGLQAPGHLESVELSHSSGRSLLTLPTQLLSNGSTHQLWAGPPF
                     HVPKERFYLKVKGKDQEGNPLLRVSGVSYSGVAPGVPLVSMAPKIHGYLQQPLLVSCS
                     VYSTLPFQLQLQRDGERLGEERYFQESGNSSWEIPRASKAEEGVYQCIAVSRAGTGRA
                     SAQIVITDPPPQLVPGPNVTVSPGETAILSCQVLGETPYNLTWVRDWRALPVKTGRVS
                     QLRDLSLEVSSVVPSDGGQYQCVASNPNGLTRASTWLLVREPPQVSINARSQRFSQGV
                     EVRVSCSASGYPKPHVSWSREGLALPEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAAN
                     EVGTDEETVTLYYTDPPSVSAINAVVLTAVGEEAVLLCAASGVPPPRVIWYRGGLEVI
                     LAPEGSRSGTLRIPEAQERDAGLYTCKAVNELGDASAEIQLLVGYAPRLTDPPQDVTV
                     ELGKSVFLTCRATGRPPPTVTWRRGDGQALEPGRRSRTGQRDSGVLVFERVSLEDQAP
                     YVCEARNVFGKAQAEAQLVVTGHAPPQIASSASVVRVLEGQPVSLTCVILAGRPLPER
                     RWLKAGRPLPPGNRHAVRADGSLHLDRALQEDAGRYSCVATNVAGSQHRDVELVVQVP
                     PRIHPTATHHITKEGVPASLPCMASGVPTPTITWTKETNTLTTSDHYSVSRNGTLVIV
                     QPSPQDAGAYVCTATNSVGFSSQEMWLSVNTKPRIKINDSQATDAPLRVTVKAGEEAT
                     LDCEAQGSPTPLVTWTKDAHPLLPVTNRYELLSSGSLRLVQTQVGDSGLYECTASNPA
                     GATFRRYILGVQVPPQVQPGPRVLKVLAGEALDLNCVAEGNPQPQLNWFKDGMVLMGE
                     GPPGSVHFAAVKTSDTGLYHCEASSSSGTDTWKLELQVLEPPHWGVNETNDLLERVVG
                     ENASLLCPAQGSPKPRITWRRVPSSEALNGRPDVAVLNEGSLFLSSVSLADSGEYECQ
                     ATNEVGSASRRVKLVVYVPPSIREEGRTANMSGLAGQPLTLECDASGFPVPEVVWLKD
                     GQQIPEASAHRFLDGARSLHFPRIQENHSGLYSCQAENQAGRAQRDFNLAVFIPPSLL
                     GAGAAQEVLGLAGADVKLECQTSGVPTPQVEWIKDGQPLLPGDSHILLQEDGQVLRII
                     SSHLGDEGRYQCVAFSPAGQQAKDFQLSIHSPPTIWGSNETGEVTVLEGHTAQLLCEA
                     RGMPAPDITWYKDGTLLAPSSEVIYSKGGRQLQLGKAQHSDAGLYTCQASNSAGITKK
                     STNLEVYVPPTIEGAVGGPYLVQAVAGRPVALECVARGHPPPTLSWQHEGLPVVDSNG
                     TWLEAGGALQLENPGEASGGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGVGQVTA
                     IVGQSLDLPCQASGSPVPTIQWLQNGRPAEELAGVQLASQGTKLHISQVELNHSGLFS
                     CQATNEAGTAGAEVEVSVHELPSVNIIGGENLTAPFLQPVTLQCTGTGVPTPSLRWWK
                     DGVAVATSGGNLQIEKADLRDEGVYTCSATNLAGESKKDVTLKVLVPPNIEPGPVNKA
                     VLENASVTLECLASGVPPPDISWFKGRQPISTQRHLIVSTDGRVLHIERAQLSDAGSY
                     RCVATNVVGSAALQYGLRVNVPPRITLPPSLPGPVVLGTPFRLTCNATGTPSPMLLWL
                     KDGNPVSPEGTPGLKVFPGGQVLTVASARASDAGGYSCVAVSAVGEDRRDIVLQVHMP
                     PSILGEELNISVVVNESVALECRSHAVPPPVLRWQKDGRPLEPHPGIRLSADKALLEV
                     DRVAVWDAGHYTCEAINQAGRSEKHFNLHVWVPPAFPSKEPYTLTVTEGQTARLSCDC
                     QGIPFPKISWRKDGQPLPGDGDSQEQVLAVGRLLYLGQAQSAQEGTYTCECSNVAGTS
                     SQEQQLEVLVPPQVTGLWEPLTTVSVIQDGNATLDCNATGKPLPVVTWERDGQPVRME
                     LGIWLQNQNHSLHVDRAQASHAGGYSCVAENIAGRAERRFALSVLAPPHLTGDSDSLT
                     NVTATLHGSLTLLCEAEGIPPPTVQWFREGQPISPGEGTYLLAGGWMLKMTQAQEQDK
                     GLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVPEGQTAQLLCNATGYPPPK
                     VTWFKDGQSLAVGDPYEMSPDGAFLWIPQANLSNAGHYSCIATNAVGEKTKHTQLSVL
                     VVPTILGEPEKNANEEVTVTINNPISLICEALAFPSPNITWMKDGLPFEASKNIQLLP
                     GTHGLQILNAQKEDAGQYTCIVTNELGEATKNYHVEVLIPPSISKDDPLGEVSVKEVK
                     TKVNSSLTLECECWAVPPPSISWYKDGRPVTPSQRLSVLGEGRLLQIQPTKVSDSGRY
                     LCVATNVAGEDDQDFNVLIQVPPMFQKMGDADAGFELLPHEEEAQGRVTEYREVVENN
                     PAYLYCDTNAIPPPELTWYREGQPLSAVDGVSVLQGGRILQLPLVQAEDAGRYSCKAS
                     NEVGEDWLHYELLVLTPPVIPGDTQELVEEVTVNASSAVSLECPALGNPAPALSWFQN
                     GLPVSPSPRLQVLEEGQVLKVSTAEVTDAANYMCVAENQAGSAEKLFTLRVQVPPQIS
                     NWNAGQLTATLNSSVSLPCEVHAHPSPEVTWYKDGQPLSLGQEVFLLPGTHTLRLARA
                     QPADSGTYLCEALNPAGRDQKMVQLSVLVPPSFKQAPGGPQEAVQVRAGDKATLNCET
                     DSLPEPAVTWFKDQQPLALGQRIQGLQGGQKLEILDSQVSDKGVYSCKVSNTAGEATR
                     TFELNIQVPPTFEKPERETVNQVAGRPLVLACDVSGVPAPTVTWLKDRLPVESSMGQG
                     VVSRGGRLQLSHLQPAQAGTYTCMAENAQAEARKDFVVSVLVPPQIQNSGMTQEHNVL
                     EGQEVRLGCEAEGQPPPDIAWLKEGGPLDQHVGPHLRFYLDGSTLVLKGLRAADSGAY
                     TCVAHNPAGEDARLHTVNVLVPPTIKQQASDTGTLVSRTGELVTMMCPVQGSPPIHVS
                     WLKDGLPLALSQRTLLHNSGRTLRISQVQLADSGVFTCVASSPAGVANRNFTLLVLVP
                     PILEPEEFQNDVMAAQGSEVVLPCEARGSPLPLVSWMKDGEPLLPQSLEQGPGLKLEA
                     VSIGDSGTYSCMAASEAGEARRHFQLTVMDPPHIEASGETSELSLTPGAHLELLCEAR
                     GIPPPNIIWHKDGQALSRVENDSQVGRVLRVRNVQVDNAGLYTCLAESPAGEVEKSFR
                     VRVQAPPNVVGPRGPRSVVGLAPGQLILECSVEAEPAPEIEWHRGGVLLQADAHTHFP
                     EKGRFLKLQALSTADGGDYSCTARNTAGSTSVAFHVEIHMAPTIQPGPNAVNVSVNRT
                     TLLPCQAHGVPTPLVSWRKDGIPLDPGSPRLEFLLEGSLRIHPVLAQDAGHYLCLASN
                     SAGSDRKGLDLRVFEPPAIAPGPSNLTLTAHSPASLPCEASGSPKPLVTWWKDGQKLD
                     FRLQQGAYRLLPSSALLLTAPSPEDSAQFECVASNEMGESRRRYQVTVHVPPTIADDQ
                     THFTVTRMAPVVLTCHSTGSPAPAVSWSKAGTQLGARGSGYRVLPSGALEIEQALPIH
                     AGRYTCTARNSVGVARKHMVLTVQASPVVKPLPSMVQVVASEEVLLPCEASGIPQPMI
                     IWQKEGFSIPEGAHMQVLPSGQLRIMHASPEDAGNYFCIAQNSVGSAMAKTRLVVQVP
                     PVIENGLPDLSTTEGSHALLPCTAKGSPKPAITWEKDGHLVSGPEGKFTLQPSGELLV
                     KNSEGQDAGTYICTAENAVGRARRRVHLTILTLPVLTTLPGDRSLHLGDRLWLRCAAR
                     GSPTPRIGWTINDQPVTEGVSEQDGGSTLQRAAVTKEDSGVYMCWAENRVGRVQAVSF
                     VHVKEAPVLQGEAFSYLVEPVGGSIQLHCVVRGDPAPDIHWTKDGLPLPNSRLHLQLQ
                     NGSLTIPRTKMDDAGRYQCLATNEMGSVEKVVTLVLQSAPVFQVEPRDMTVRSGVDVE
                     LRCRATGEPVPTIEWLRAGRPLQASRRLRALPDGSLWLERVEAGDAGVYECVAHNLLG
                     SATAKALLAVRGEPRGSRGSMIGVINGQELGMATLNISVRQQGGSELPTIWSSISHVP
                     ASVGPLMRVLVVTISPIYWALARESGEALNGYSLTGGNFQQESQMEFSTGELLTMTQV
                     ARGLDPDGFLLVNMKISGMIPESLADADLHVQDFQEHYVQTGPGQLFVGSTQRFLHDR
                     LPASLSCNHSIQYDETRGPQPQLVQHLRASSISSAFDPEAEALSFQLTTALQTEENEL
                     GCPEGFELDAQGAFCVDKDECSGGPSPCSHTCRNAPGRFSCSCPTGFSLAWDRRNCRD
                     VDECAGDTHLCQEGQHCVNLLGSYNCLPSCRPGFRVTADGSNCEDVDECLEQLDECHY
                     NQVCENTPGGYHCGCPRRYRQQGHGLPCLDINECLQLPMPCVYQCHNLQGSYRCLCPP
                     GQTLLQDGRTCNPLGRNGQNITIVSHRNPSLPWLRSRIPRPNGSYHAWVSLRPGSRAL
                     SSVGRAWCPPGFIRQDGVCTDLDECSVRSLCQHACQNTEGSYYCLCPSGYRLLPSGKN
                     CQDINECEEDGIECGPGQMCFNTRGSFQCVDTPCPATYRQGSSPGTCFRRCSQDCSAS
                     GPSTLQYRLLPLPLGVRAHHDVARLAAFSEAGIPANRTELTVLEPDPRSPFALRQLRA
                     GQGAVYTRRALTRAGLYRLTVRAAAPRHQSLYVLLIAVSPYPY"
ORIGIN      
        1 atgacgcctg gggcgcagct cctgccgctg ctcctggcga cctacacagt agtggcggcg
       61 gcggtcacat ctgatgagcc cacgaagacg ctgtcccccg ccacaggaga cgccaccctg
      121 gccttcgtct tcgatgtcac cggctccatg tgggacgatc tgatgcaggt gatcgacggc
      181 gcctcacgca ttctggagcg cagtctgagc agccgcagcc gggtcatcgc caactatgcg
      241 ctggtgcctt tccacgaccc agacattggc ccagtgaccc tcacggcgga cccagtggtg
      301 tttcagagag agctgagaca actctatgtt cagggaggtg gtgactgccc agaaatgagt
      361 gtgggggcca tcaaggctgc tgtggaggtt gccaaccccg gctccttcat ctacgtcttc
      421 tcggatgccc gtgccaagga ctaccacaag aagaatgagc tcctgcagct cctgcagctg
      481 aagcagtcgc aggtggtctt cgtgctgact ggggactgcg gtgaccgcac ccaccctggc
      541 tacctggctt ttgaggagat cgcctccacc agttctggcc aggtgttcca gctggacaag
      601 cagcaggtgt cggaggtgtt aaagtgggtg gagtccgcca tccaggcctc caaagttcat
      661 ctgctgtcag cagaccacga ggaggagggc gaacacacat ggagaatccc ttttgacccc
      721 agcttgaagg aagtcaccat ctcactgagc gggccagggc ctgagatcga agtccgggac
      781 ccactgggaa gggtcctgca gacggacgaa ggcctcaatg tgctcctcaa cattccagac
      841 tcagccaagg tcgtagcctt taagcccgag cacccaggac tgtgggccat caaggtgtac
      901 agtagcggcc gccactcagt gagaatatcg ggcatcagca acatcaactt ccgagccggc
      961 ttctccgtgc agccctccct ggacctcaac cacaccatcg agtggccttt gcaaggcgta
     1021 cccatctccc tggtgatcaa ctctacgggt ctgcaggcac ctggccacct tgagtctgtg
     1081 gagctctcac acagctcggg gaggtccctt ctcactctgc ctacacaact cctctccaat
     1141 gggtccactc atcagctctg ggctgggcca cccttccacg taccaaagga gcgcttttat
     1201 ctcaaggtga agggcaaaga ccaggagggg aatcccctcc tccgtgtctc tggagtttcc
     1261 tacagcgggg tggccccagg tgtgccactg gtcagcatgg ctcccaagat ccacggttac
     1321 ctacagcagc ccctgctggt gtcctgttct gtgtatagca ccctcccctt ccagctgcag
     1381 ctacagcgag atggagagag gctgggcgag gagcgatact ttcaagagtc aggaaacagc
     1441 agctgggaga tcccacgggc ctccaaggct gaggaaggcg tgtaccagtg catagctgtc
     1501 agcagagctg ggacaggccg agccagcgcc cagattgtca tcacagaccc tccaccacag
     1561 ctggtccctg gccccaatgt gaccgtgtcc ccaggggaaa ccgccatcct gtcatgccaa
     1621 gtcctaggtg aaactcctta caacttgaca tgggtccggg actggcgagc cttaccagtc
     1681 aaaacaggcc gagtctccca gctgcgtgac ctgtctctgg aagtgagcag cgttgtcccc
     1741 agtgatggtg ggcagtacca gtgtgtggcc agcaatccga atgggctcac aagggcatct
     1801 acctggctcc tggtgcgaga gccccctcaa gtcagcatca atgccaggtc ccagcgtttc
     1861 tcccagggtg tggaggtgag ggtcagctgc tcagcttctg ggtaccccaa accccatgtc
     1921 tcctggagcc gtgagggcct cgccttgcca gaggacagca ggatccatgt ggatgcccaa
     1981 ggcacactca tcattcaggg agtggcccca gaggatgctg ggaactacag ctgccaggcc
     2041 gctaatgaag taggcacaga cgaggaaaca gtcaccctct attacacaga cccaccatcc
     2101 gtgtctgcta tcaacgctgt ggttctcaca gctgttgggg aagaggccgt gctactgtgt
     2161 gcggcgtctg gggtcccccc accacgggtc atctggtatc gaggaggtct ggaagtgatt
     2221 ctggctcctg aaggctccag gtctgggaca ctgcggatcc ctgaagctca ggaaagagac
     2281 gctggcctct atacctgcaa ggctgtaaac gaactgggtg atgcctctgc tgaaatccag
     2341 ctgctggttg gatatgcgcc caggctgacg gatcctcccc aggacgtcac cgtggagcta
     2401 ggcaagagtg tcttcctcac ctgccgggcc acaggccgcc cacccccaac cgtcacctgg
     2461 aggcgtggag acggccaagc cctggagcct gggaggagga gcagaactgg acaacgagat
     2521 tcaggagtct tggtctttga aagagtctcc ctggaagacc aagccccgta cgtgtgcgaa
     2581 gctcgtaacg tattcgggaa ggcccaggct gaggctcagc tggtggtcac tggacacgca
     2641 cccccacaga tcgccagcag tgcttctgtc gtacgtgtcc tggagggaca gcccgtgtcc
     2701 ctgacctgtg tcatcctggc agggaggccc ctccctgaga gacgctggct caaggctggc
     2761 aggcctctcc ctccaggcaa ccggcatgct gtccgtgctg atggcagcct ccaccttgac
     2821 cgggccctgc aagaagatgc tgggagatac agctgtgtgg ccaccaatgt ggcaggctct
     2881 cagcaccgag atgtggagct ggtggtccag gtgccaccta gaatccatcc aactgccacc
     2941 caccacatca ccaaggaagg agtgccagct tccctcccct gcatggcttc gggggtccct
     3001 acccctacca tcacctggac caaggaaacc aacaccctga ctaccagcga ccattacagt
     3061 gtgagcagaa atggtaccct ggtcattgtt cagccatccc cacaggatgc aggtgcctat
     3121 gtgtgcacag ccactaacag cgtgggcttc tccagccagg agatgtggct gtccgttaat
     3181 accaagccca ggatcaagat aaatgactct caggctacag atgcccctct gagagtgaca
     3241 gtcaaggctg gtgaagaggc aaccctggac tgcgaggccc aaggctctcc gactccactg
     3301 gtcacctgga ccaaggatgc ccaccctctg ctgcctgtca ccaacaggta tgagctcctc
     3361 tcatcaggct ccctgcgcct ggtgcagacc caggtgggtg acagcggcct ttatgagtgt
     3421 acagccagca accccgcagg ggccacattt cgccgctaca tcctcggagt tcaagttccc
     3481 cctcaggtgc agcctggccc gagggtcctg aaggtactgg ctggagaagc tcttgatctg
     3541 aactgtgtgg ccgagggcaa cccccagcct cagctgaact ggttcaagga tgggatggtc
     3601 ctgatgggtg agggaccccc aggctccgtt cactttgctg ctgtcaagac ctctgacact
     3661 gggctgtacc actgcgaggc ctccagtagc tctggcacag atacctggaa gctagagctc
     3721 caagtgctgg agccaccaca ctggggcgtc aatgagacca acgacctgct ggagcgagtg
     3781 gttggggaga atgccagtct gctgtgcccc gcccaaggtt ctccaaagcc acgaatcaca
     3841 tggaggaggg tcccatcctc agaggccctg aatggccggc cagacgtggc ggtgctgaac
     3901 gaagggtcgc tattcctgtc ctcagtctct cttgcggaca gcggagagta cgagtgccag
     3961 gccaccaatg aggtgggctc tgcttccagg agagtcaagc tggtggtcta tgtgcccccc
     4021 agcatccggg aagagggccg cacagccaac atgtcaggcc tagctgggca gcctctaaca
     4081 ctggagtgtg acgcaagcgg gtttccagtc cctgaggtgg tgtggctcaa ggatgggcag
     4141 cagatcccag aggcaagtgc ccatcgcttc ctggatggtg ctcggtccct ccacttccca
     4201 aggatccaag agaaccattc tggcctctat tcctgccagg ctgagaatca ggcagggcgc
     4261 gcccagagag acttcaatct tgccgtgttc atccctcctt ccttgctggg agctggggct
     4321 gctcaggagg tgctgggcct ggctggtgcg gatgtgaagt tggagtgtca gacctcaggg
     4381 gtccccacgc cccaggtgga gtggatcaag gatgggcagc ccctccttcc aggggactct
     4441 cacatcctgc tgcaggagga tggccaggtt ctcagaatca tcagcagtca cttgggtgat
     4501 gaaggacggt atcagtgtgt ggccttcagc ccagccggcc agcaggccaa ggactttcag
     4561 ctcagcattc actcacctcc caccatctgg ggctctaatg agacaggtga ggtgactgtc
     4621 ctggagggcc acacagcaca gctcctgtgt gaggcccgag gaatgccagc tcctgacatc
     4681 acctggtaca aagatgggac cctactggcc cccagctctg aagtgattta cagcaagggt
     4741 ggccggcagc tccagctggg gaaggcccag cactccgatg ctggcctcta tacctgccag
     4801 gccagcaact ctgcagggat caccaagaaa tccaccaatc tggaggttta tgttccacct
     4861 accattgagg gtgctgttgg agggccatac ctggtgcagg ctgtggctgg gagacccgtg
     4921 gcactggagt gtgtggccag aggccatcca ccccctaccc tctcctggca gcatgaaggg
     4981 ctgccagtgg tggatagcaa tgggacgtgg ctggaggcag gaggtgccct gcagctggag
     5041 aacccaggag aggcgtccgg tggcctctac agctgtgtgg ccagcagccc cgctggagag
     5101 gccgtactgc agtactcggt ggaggtgcaa gtgcccccac agctgctggt ggctgaaggt
     5161 gtgggccagg tgactgccat cgtgggacag tctctggatc ttccctgcca ggcatcaggc
     5221 tccccggtgc ccaccatcca atggctacaa aatggccgcc cagccgagga gctggctggg
     5281 gtgcagctgg cctcacaggg aaccaaactg cacatcagcc aggtggagct gaaccactcg
     5341 ggcctcttct cctgccaggc caccaatgag gcaggaacag ccggggctga ggtggaggtc
     5401 tctgtgcatg aacttccttc agtgaacatc atcggtggtg agaatctcac agcccctttc
     5461 ctgcagcctg taaccctgca gtgtacaggt actggagtgc ccaccccaag ccttcgctgg
     5521 tggaaagatg gcgtggccgt ggcaacctca gggggcaacc ttcagatcga gaaggcagac
     5581 ctgagagatg aaggtgtcta cacgtgttca gccaccaacc tggcagggga gagcaagaag
     5641 gatgttacac taaaagttct ggttcccccc aacattgaac caggaccagt caacaaggcg
     5701 gttctggaga atgcctcagt gaccttggag tgtctggctt cgggtgtgcc ccctccagac
     5761 atctcctggt tcaagggtcg ccagcccatc tctacccaga gacacctgat agtgtcaact
     5821 gacggtagag ttcttcacat tgagcgagcc cagctctctg atgcagggag ctaccgctgt
     5881 gtggcgacca atgtggtggg cagtgcagcg ctgcagtatg gcttacgggt caatgtgcca
     5941 ccccgaatca ccctgccacc cagcctacca ggcccagtag tacttggcac acccttccgc
     6001 ctgacctgta atgccactgg cacccccagc cccatgctgc tatggctgaa ggatgggaac
     6061 cctgtgtccc ctgaaggaac ccctggcctc aaggtcttcc ccggaggcca agtcctcaca
     6121 gtggccagcg cccgtgcctc tgatgcgggc ggctactcct gcgtagcagt gagtgctgtg
     6181 ggtgaggatc gccgggacat tgtcctgcaa gttcacatgc cccccagcat cctcggagaa
     6241 gagctgaaca tatccgtggt ggtaaatgag tcagtggctc tggagtgccg gagccatgcc
     6301 gtgccgccac ccgtgctgag atggcagaag gatgggagac ccttggagcc tcaccctggc
     6361 atacgcctct ctgcagacaa ggccttgctg gaggtggacc gagtggcggt gtgggacgca
     6421 ggtcactata cctgtgaggc cattaaccag gcaggccgct ctgagaagca cttcaactta
     6481 catgtctggg ttcctccagc cttcccctca aaggagccct acactctcac tgtgactgag
     6541 ggtcagactg ccagactgtc ctgtgactgc caaggcattc ccttccccaa gatctcatgg
     6601 aggaaagacg gtcagcccct gcctggggat ggggacagcc aggaacaggt attagcggtc
     6661 gggaggctgc tgtacctggg acaggcccag tcggcccagg aggggacata cacctgtgaa
     6721 tgcagcaacg tggctggcac cagcagccag gagcagcagc tggaagttct ggttcctcct
     6781 caggtcactg gcctttggga gcccctcacg acagtctccg tgatccagga tggaaatgcc
     6841 accctggact gcaatgccac agggaagcca ctgccggtgg tgacgtggga gagggatggt
     6901 cagcctgtca ggatggaact cggcatatgg cttcagaatc agaaccacag cctacacgtg
     6961 gaccgggctc aggcctccca cgctggtggc tacagctgtg tggctgagaa tatagctggg
     7021 cgcgccgaga ggaggtttgc actgtccgtg ctggcacctc ctcaccttac tggagactcg
     7081 gactcattaa ccaatgtcac tgctacctta cacggctcct tgacactgct ctgtgaagcc
     7141 gaagggatcc cgcccccgac agtccaatgg tttcgggaag gacagccaat cagccccgga
     7201 gagggcacct acctcttggc aggtggctgg atgctgaaga tgacccaggc acaggagcag
     7261 gacaaaggcc tctactcgtg cttggccagc aatgaggctg gggaggcacg gaggaacttc
     7321 agtgtagagg tcctggttcc tcccagcatt gaaaatgaag acttggagga agtgatcaag
     7381 gtgcctgagg gacagactgc ccagctgttg tgcaatgcca cgggctaccc accacccaag
     7441 gtcacctggt tcaaagatgg ccagtccctg gctgttggag acccttatga gatgtcccca
     7501 gatggcgcct tcctgtggat cccccaggcc aatctgtcca acgccggcca ctactcttgc
     7561 atcgctacca atgcagtggg ggagaagacc aaacacacac agctcagtgt cctggtggtt
     7621 cccaccatcc tgggagagcc tgagaagaat gccaatgagg aagtgaccgt gaccatcaac
     7681 aatcctatct ccttgatctg cgaggcacta gcctttccat cccccaatat cacctggatg
     7741 aaggatgggt tgccctttga ggcctcgaaa aacatccagc tcctcccagg tacccacgga
     7801 ctacagatcc tgaatgccca gaaggaagat gccggccagt acacctgtat agtcaccaac
     7861 gagctggggg aggccacaaa gaactaccat gtggaagtac tcatcccccc ctccatctcc
     7921 aaagatgacc ctttggggga ggtcagcgtg aaggaagtga agaccaaagt caacagctct
     7981 ctgaccctgg agtgtgaatg ctgggccgtg cccccgcctt ccatcagctg gtacaaggac
     8041 ggaaggcctg tgacccccag ccagcggctc agtgtcctgg gggaggggcg gctgctccag
     8101 atccaaccca cgaaggtgtc tgactctggc cgatacctgt gtgtggccac caatgtggct
     8161 ggcgaggatg accaggactt caatgttctc atccaagtgc ccccaatgtt ccagaagatg
     8221 ggtgatgctg atgcaggctt tgaactcctg ccccatgagg aagaggccca gggcagggtg
     8281 acagagtacc gggaggttgt ggagaacaac ccagcttatc tgtactgtga taccaatgct
     8341 attccaccac cagaactcac gtggtacagg gagggccagc ccctgtcagc tgtcgatggg
     8401 gtctctgtgc tgcaaggagg ccgaatcctg cagctgcctc tcgtgcaggc agaggatgcg
     8461 ggcaggtatt cctgcaaggc ttccaacgaa gtgggcgagg actggctaca ctatgaacta
     8521 ctggtgttga caccgccagt gatcccggga gacacacagg agctggtaga ggaggtgact
     8581 gtgaatgcca gcagtgccgt cagcctagag tgcccagccc tggggaaccc agcacctgct
     8641 ctatcatggt tccagaatgg gcttcctgtg tcccccagcc cacggctgca ggtcctagag
     8701 gaaggacagg tcttgaaggt ttccactgcg gaagtgactg acgctgccaa ctacatgtgc
     8761 gttgcggaga accaggcggg ctctgcagag aaactcttta ccctcagggt ccaagtgcca
     8821 ccacaaatct ccaactggaa cgccggccag ctcaccgcca ccctcaacag cagtgtttcc
     8881 ctcccctgtg aagttcatgc tcacccaagc cctgaggtca catggtacaa ggatggccag
     8941 cctctctcct tgggacaaga ggttttcctc cttcctggta cccacacact gcggctggcg
     9001 cgggcacagc cagctgactc cgggacctac ctgtgtgaag ccctcaaccc tgcaggccga
     9061 gaccaaaaga tggtacagct cagtgttctg gttcccccca gctttaaaca ggctcctgga
     9121 ggcccccagg aggctgtcca ggtcagagca ggtgacaaag ccaccctaaa ctgtgagaca
     9181 gactcactcc cagagccagc tgtgacctgg ttcaaggatc agcagcccct agccctgggg
     9241 cagcggattc agggtctaca aggaggacaa aaactggaaa tcctcgactc acaggtatca
     9301 gataagggcg tatacagctg caaagttagc aacacagctg gagaggccac ccggaccttt
     9361 gaactcaaca tccaagtgcc cccaacattt gagaaacctg agagggagac agtgaaccag
     9421 gtagctgggc gtcccctagt cctggcttgt gatgtgtctg gagtcccagc tcccactgtg
     9481 acttggctga aggacagact gcccgtggag agcagcatgg ggcagggcgt ggtctcccga
     9541 ggtggccgcc tccagctgag tcacctgcag ccagcccagg ctggtaccta cacgtgcatg
     9601 gctgagaacg cccaagcaga agcccgtaaa gactttgtgg tgtctgtact agtgcctcct
     9661 cagatccaga actcgggcat gacacaagaa cacaacgtgt tggagggaca ggaggtccgg
     9721 ctgggctgtg aggctgaggg ccagccacca ccagatatag cctggctgaa ggaaggtggc
     9781 ccattggacc agcacgtggg gcctcacctc cggttctatc tggatggcag caccctggtg
     9841 ctgaagggcc taagagcagc ggactcgggt gcctacacct gtgtggccca caacccagct
     9901 ggggaggatg ccaggctaca cacggtgaat gtactggttc cccccaccat caagcaacaa
     9961 gccagtgaca cagggaccct ggtgagcagg actggagaac tggtgaccat gatgtgccct
    10021 gtccaagggt ccccacccat tcacgtgagc tggctcaagg atggcctgcc ccttgcactc
    10081 tcccagcgca ccctcctcca caactctggc cgcaccctca ggatctctca ggtgcagctg
    10141 gcagattcgg gcgtcttcac ctgcgtggct tcgagtccag ccggtgtggc taacaggaac
    10201 ttcaccttgc tggtactcgt gccccctatc ctggaaccag aggaatttca gaacgacgtg
    10261 atggctgccc aaggctctga agtagtcctt ccgtgtgagg cccggggaag ccccctgccc
    10321 ctcgtgtcct ggatgaaaga cggggagccc ttgttacccc agagccttga gcagggtcct
    10381 ggcctgaaac tggaagccgt gagcattggt gactcgggaa cctactcctg catggcagca
    10441 agtgaggcag gggaggccag gaggcacttc cagctgaccg tgatggatcc cccccacatt
    10501 gaggcgtctg gtgagacttc agagctgtca ctgacacctg gtgcccacct ggaactcctg
    10561 tgtgaagccc gcggcatccc cccacccaac atcatttggc acaaagatgg gcaggccctg
    10621 agccgggtgg aaaatgacag ccaagtcggc cgggtgctcc gggtgcggaa tgtgcaggtg
    10681 gacaatgctg ggctgtacac ctgcctggct gagagccctg caggtgaagt cgagaagagc
    10741 ttccgggtca gggttcaagc ccctccaaat gttgttgggc cccggggccc ccgctctgtg
    10801 gttggcttgg ctccagggca gctgatcctg gagtgttccg tggaagcaga accagcacca
    10861 gagattgagt ggcatcgagg tggtgtcctg cttcaggcag atgcccacac tcactttcca
    10921 gagaagggca gattcctcaa gctgcaggca ttgagcacag cagacggcgg ggactacagc
    10981 tgcacagccc gcaacacagc aggcagcacc agcgtggctt tccacgtgga gattcacatg
    11041 gcacccacca tccagccagg accgaatgct gtgaacgtct cagtgaaccg cacaaccctg
    11101 ctgccctgcc aggcccacgg tgtgcccacg cctctcgtga gctggcggaa ggacgggatc
    11161 cctctggacc ctgggagccc caggctagag tttctgcttg agggctcact gaggatccat
    11221 ccagtcctgg cacaggatgc tggacactac ctctgcctag catctaactc tgctggctct
    11281 gaccggaaag gcctagacct tagagtcttt gagcccccag ccattgcccc tggtccctcc
    11341 aacctgaccc tgactgccca cagcccggcc tcactgccct gcgaggccag cggctctccc
    11401 aagcccctgg tgacctggtg gaaggatggg cagaagctgg acttccgcct gcagcaaggc
    11461 gcctaccggc tcctgccttc cagtgccctg ctcctcacag ctcccagccc tgaggactca
    11521 gcccagtttg agtgtgtggc gagcaatgag atgggcgagt cccgcaggcg ctaccaggtg
    11581 actgtccacg tgcctcccac cattgcggac gaccagacgc atttcacagt gaccaggatg
    11641 gcacctgtgg tcctcacttg ccacagcaca gggtcaccag ctccagcagt gtcttggagc
    11701 aaggcaggca ctcagctggg agcaaggggc agtggttacc gagtcttgcc ctccggagcc
    11761 ctggagattg agcaggccct ccctatccat gctggccgat acacctgcac agctcgaaac
    11821 tctgtggggg tagcccgcaa gcacatggtc ctcacagtgc aagcctcccc tgtggtaaag
    11881 ccgctcccca gcatggttca ggtcgtggca tcggaggagg tgctgctgcc ctgtgaggcc
    11941 tctggcatcc ctcagccaat gatcatctgg cagaaggagg ggttcagcat tcctgaagga
    12001 gctcatatgc aggtcctccc cagcggccag ctgcggatca tgcatgccag cccagaggat
    12061 gccgggaact acttctgcat tgcccagaac agcgtgggca gtgccatggc aaaaaccagg
    12121 ctggtggtgc aagtcccacc tgtgattgag aatggtctcc cagatttgtc caccactgag
    12181 ggctcccatg ccctcctgcc ctgcacagcc aagggcagcc ccaagccagc catcacctgg
    12241 gaaaaggatg gccacctggt atctggacct gagggcaagt ttacgctgca gccttctggg
    12301 gagctcctgg taaagaactc tgagggccag gatgcaggca cgtacatctg caccgcagag
    12361 aacgccgtgg gccgtgcccg ccgccgtgtg catctcacta tcctgacgct gcctgtcctt
    12421 accaccttgc ccggggaccg cagtctgcac cttggggaca ggttatggct tcgctgtgca
    12481 gccaggggca gcccaacacc ccgcattggc tggaccatca acgaccagcc tgtcacagag
    12541 ggggtgtctg agcaggatgg gggcagcacc ctgcagcggg cagccgtcac caaagaggac
    12601 agcggagtgt acatgtgttg ggctgagaac agagttggcc gtgtgcaggc tgtcagcttc
    12661 gtccatgtga aagaggctcc ggtcctacaa ggggaagcct tctcctacct ggtagaacct
    12721 gtagggggca gcatccagct acactgtgtg gttcgtggag acccagctcc agacatccac
    12781 tggaccaaag atggccttcc actgcccaac agccgcctcc acttgcagct gcagaacggc
    12841 tccctgacta tccccaggac caagatggac gacgcaggac ggtaccagtg cctggccacg
    12901 aacgagatgg gctctgtgga gaaagtggtg acccttgtgc ttcagagtgc cccagtgttc
    12961 caggtggagc ctcgggacat gacagtgagg tccggagtgg atgtggaact cagatgccgg
    13021 gccactggag agcctgtgcc cacaatcgag tggctacggg caggccgacc actacaggct
    13081 agccggaggc tgcgggccct gccagacggg agcctgtggc ttgaacgtgt ggaagctgga
    13141 gatgctggag tatatgagtg tgttgctcac aaccttctgg gctctgccac agccaaggcg
    13201 ttgctggccg tgagagggga gccccggggc agtcggggca gcatgatcgg agtcatcaat
    13261 ggccaggaat tgggaatggc tactctcaac atcagtgtgc gacagcaggg cggttctgag
    13321 ctccctacca tctggagcag catcagtcat gtcccagcaa gtgtggggcc tctgatgcgg
    13381 gtgctggtgg tcactatttc tcccatctac tgggccctgg ctagagagag cggagaggcc
    13441 ttaaacggtt actccctgac cggcggcaac ttccagcagg agtcacaaat ggagttttct
    13501 acaggggagc tgctcacaat gacccaggtg gctcggggac tggatcctga tgggttcctt
    13561 cttgtgaaca tgaaaatcag tggcatgatc ccagagagcc tggccgacgc agatctacac
    13621 gtgcaggact tccaggagca ctacgtgcag accgggcctg gccagctatt cgtgggctcc
    13681 acacagcgct tcctccacga caggctcccg gcctcactga gctgcaatca cagcatccag
    13741 tatgatgaga cccggggccc ccagccccag ctggtgcagc accttcgggc ctcatctatc
    13801 agctcggcct tcgaccctga ggcagaggcc ctgagcttcc agctcaccac agccctgcaa
    13861 actgaagaaa atgaacttgg ctgtcccgag ggctttgagc tggatgccca gggagcgttt
    13921 tgtgtggaca aggacgaatg ctcagggggt cccagtccct gctcccatac ctgccgtaat
    13981 gctcccggcc gtttctcctg ctcctgcccc actggcttct ccctggcttg ggaccgcagg
    14041 aactgtagag atgtggacga gtgtgcagga gacacccacc tctgccagga ggggcagcac
    14101 tgtgtgaacc tgctcggctc ctataactgc ctcccttcct gtaggcctgg cttccgggta
    14161 actgctgacg gaagcaactg cgaagatgtg gacgaatgcc tggaacagct ggatgagtgc
    14221 cactacaatc aagtctgtga gaacactcca ggtggctacc actgtggttg tcccagaagg
    14281 taccgccaac aaggtcacgg cctgccttgc ctagacatca atgagtgcct acagctgccc
    14341 atgccctgtg tctaccagtg ccataacctc cagggcagct accgatgcct gtgcccacca
    14401 ggccagaccc tcctacagga tggcaggacc tgtaaccccc tgggacggaa cggtcaaaac
    14461 attaccattg tcagccaccg gaacccatct ttgccctggc tgcgatctcg gatacccagg
    14521 cccaatggtt cctaccatgc ctgggtctcc ctccggcctg gttctagagc cctgagtagt
    14581 gtgggacggg cctggtgccc acctggcttc ataaggcagg atggcgtgtg tacagacctt
    14641 gatgagtgca gtgtgagaag cctgtgtcag catgcctgcc aaaacacgga gggtagctac
    14701 tactgtctct gcccctctgg ctaccgcctc cttcccagcg ggaagaactg ccaggacatc
    14761 aacgagtgtg aggaagatgg catcgagtgt gggcctggcc agatgtgctt caacacccga
    14821 ggcagcttcc agtgtgtaga cacgccctgt cctgccacct accggcaggg ctccagccct
    14881 gggacctgtt tccgccgctg ctctcaggac tgcagcgcca gcggtccgtc cacactgcag
    14941 taccgcctgc tgccgctgcc cctcggcgtg cgcgcccacc atgacgtggc ccgcctggcc
    15001 gccttctccg aggctggcat ccctgccaac cgtacggagc tcaccgtgct ggagcccgac
    15061 ccacgtagtc cctttgctct ccgccagctg cgcgctggac aaggagcggt ctacacccgc
    15121 agagcgctca cccgcgccgg gctctaccgc ctgacggtgc gcgcagcggc accccgccac
    15181 cagagcctct acgtcctgct aattgcagtg tcgccctacc cgtactgaag ctggcgaggc
    15241 cagagctgca gatccaccgt gacctcgcag agaggacagg gtggcccttg cccgtgacac
    15301 ctacagtgac agagaacatc ctcttctccc gcccccgtgc gtcagcgaga tcttcggtaa
    15361 acactgctgt gcgcagggcc ttgaccccag ggcaaggacc gctgcccctt tggtggcaaa
    15421 gccgatgggg caggcctgag tcctgtcctt cctcaagtct cagggggaag ctgggcaagg
    15481 tctcagggga ccaggactcc aaggagttca gaccccaagt agagggggca gcggctggca
    15541 ctgccctgac cacatggaat gcagtaatat aaaaactttt ttttaactga c
//
