LOCUS       NM_001399536            1774 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus histocompatibility minor 13 (Hm13), transcript
            variant 1, mRNA.
ACCESSION   NM_001399536 XM_006235268
VERSION     NM_001399536.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1774)
  AUTHORS   Wang,S. and Ghiasi,H.
  TITLE     Absence of Signal Peptide Peptidase, an Essential Herpes Simplex
            Virus 1 Glycoprotein K Binding Partner, Reduces Virus Infectivity
            In Vivo
  JOURNAL   J Virol 93 (23), e01309-19 (2019)
   PUBMED   31511378
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1774)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1774)
  AUTHORS   Aizawa,S., Okamoto,T., Sugiyama,Y., Kouwaki,T., Ito,A., Suzuki,T.,
            Ono,C., Fukuhara,T., Yamamoto,M., Okochi,M., Hiraga,N., Imamura,M.,
            Chayama,K., Suzuki,R., Shoji,I., Moriishi,K., Moriya,K., Koike,K.
            and Matsuura,Y.
  TITLE     TRC8-dependent degradation of hepatitis C virus immature core
            protein regulates viral propagation and pathogenesis
  JOURNAL   Nat Commun 7, 11379 (2016)
   PUBMED   27142248
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1774)
  AUTHORS   Chen,C.Y., Malchus,N.S., Hehn,B., Stelzer,W., Avci,D., Langosch,D.
            and Lemberg,M.K.
  TITLE     Signal peptide peptidase functions in ERAD to cleave the unfolded
            protein response regulator XBP1u
  JOURNAL   EMBO J 33 (21), 2492-2506 (2014)
   PUBMED   25239945
REFERENCE   5  (bases 1 to 1774)
  AUTHORS   Allen,S.J., Mott,K.R. and Ghiasi,H.
  TITLE     Inhibitors of signal peptide peptidase (SPP) affect HSV-1
            infectivity in vitro and in vivo
  JOURNAL   Exp Eye Res 123, 8-15 (2014)
   PUBMED   24768597
REFERENCE   6  (bases 1 to 1774)
  AUTHORS   Urny,J., Hermans-Borgmeyer,I. and Schaller,H.C.
  TITLE     Cell-surface expression of a new splice variant of the mouse signal
            peptide peptidase
  JOURNAL   Biochim Biophys Acta 1759 (3-4), 159-165 (2006)
   PUBMED   16730383
REFERENCE   7  (bases 1 to 1774)
  AUTHORS   Krawitz,P., Haffner,C., Fluhrer,R., Steiner,H., Schmid,B. and
            Haass,C.
  TITLE     Differential localization and identification of a critical
            aspartate suggest non-redundant proteolytic functions of the
            presenilin homologues SPPL2b and SPPL3
  JOURNAL   J Biol Chem 280 (47), 39515-39523 (2005)
   PUBMED   15998642
REFERENCE   8  (bases 1 to 1774)
  AUTHORS   Friedmann,E., Lemberg,M.K., Weihofen,A., Dev,K.K., Dengler,U.,
            Rovelli,G. and Martoglio,B.
  TITLE     Consensus analysis of signal peptide peptidase and homologous human
            aspartic proteases reveals opposite topology of catalytic domains
            compared with presenilins
  JOURNAL   J Biol Chem 279 (49), 50790-50798 (2004)
   PUBMED   15385547
REFERENCE   9  (bases 1 to 1774)
  AUTHORS   Moliaka,Y.K., Grigorenko,A., Madera,D. and Rogaev,E.I.
  TITLE     Impas 1 possesses endoproteolytic activity against multipass
            membrane protein substrate cleaving the presenilin 1 holoprotein
  JOURNAL   FEBS Lett 557 (1-3), 185-192 (2004)
   PUBMED   14741365
REFERENCE   10 (bases 1 to 1774)
  AUTHORS   Urny,J., Hermans-Borgmeyer,I., Gercken,G. and Schaller,H.C.
  TITLE     Expression of the presenilin-like signal peptide peptidase (SPP) in
            mouse adult brain and during development
  JOURNAL   Gene Expr Patterns 3 (5), 685-691 (2003)
   PUBMED   12972007
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 10, 2022 this sequence version replaced XM_006235268.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1290676.1,
                                           SRR26643299.16474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               JAXUCZ010000003.1  161606059-161606343
            286-384             JAXUCZ010000003.1  161614151-161614249
            385-467             JAXUCZ010000003.1  161617152-161617234
            468-556             JAXUCZ010000003.1  161622441-161622529
            557-642             JAXUCZ010000003.1  161625106-161625191
            643-768             JAXUCZ010000003.1  161625283-161625408
            769-826             JAXUCZ010000003.1  161626221-161626278
            827-910             JAXUCZ010000003.1  161628265-161628348
            911-947             JAXUCZ010000003.1  161631072-161631108
            948-1050            JAXUCZ010000003.1  161631962-161632064
            1051-1136           JAXUCZ010000003.1  161636615-161636700
            1137-1336           JAXUCZ010000003.1  161640031-161640230
            1337-1774           JAXUCZ010000003.1  161640945-161641382
FEATURES             Location/Qualifiers
     source          1..1774
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1774
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /note="histocompatibility minor 13"
                     /db_xref="GeneID:311545"
                     /db_xref="RGD:1308946"
     exon            1..285
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1287
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /EC_number="3.4.99.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histocompatibility 13; minor histocompatibility antigen
                     H13"
                     /codon_start=1
                     /product="minor histocompatibility antigen H13 isoform 1"
                     /protein_id="NP_001386465.1"
                     /db_xref="GeneID:311545"
                     /db_xref="RGD:1308946"
                     /translation="MDSALSDPHNGSSEAGTPANGTTRPPSTPEGIALAYGSLLLMAL
                     LPIFFGALRSVRCARGKSSSDMPETITSRDAARFPIIASCTLLGLYLFFKLFSQEYIN
                     LLLSMYFFVLGILALSHTISPFMNKFFPANFPNRQYQLLFTQGSGENKEEIINYEFDT
                     KDLVCLGLSSVVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIY
                     DIFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEADNFAMLGLGDIVIPGIFIALL
                     LRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVA
                     LVKGEVAEMFSYESSAVILPHTPRLTHFPTVSGSPASLADSMQQKLAGPRRRRPQNPS
                     AM"
     exon            286..384
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
     exon            385..467
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
     exon            468..556
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
     exon            557..642
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
     exon            643..768
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
     exon            769..826
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
     exon            827..910
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
     exon            911..947
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1050
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1136
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1336
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1774
                     /gene="Hm13"
                     /gene_synonym="H13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttctttag gggaacgtgg ctttccccgc agtgcctctt ctccgtctgc gttcgtgctg
       61 cggcggccgg agctggagtc ggagcccgag cgcagcctcg ccatggattc ggccctcagc
      121 gacccgcaca acggcagcag cgaggctggc accccagcca acggcacgac gcggccgccc
      181 tccacacccg agggcattgc gctggcctac ggcagcctcc tgctcatggc gctgctgccc
      241 atcttcttcg gcgccctgcg ctcggtgcgc tgcgcccgcg gcaagagctc ttcggacatg
      301 ccagaaacca tcaccagccg agacgctgcc cgcttcccca tcatcgccag ctgtacactc
      361 ttggggctct acctcttttt caaactgttc tcccaggagt acatcaacct cttgctgtcc
      421 atgtatttct tcgtgctggg gatcctggcc ctgtcccaca ccatcagccc cttcatgaat
      481 aagttttttc cagccaactt cccaaatcgc cagtatcagc tgctcttcac acagggctct
      541 ggggaaaaca aggaagagat catcaactat gagtttgaca ctaaggacct ggtgtgcctg
      601 ggcctaagca gcgtcgttgg tgtctggtac cttctaagga agcattggat tgccaacaac
      661 ctgtttggcc tggccttctc ccttaatggg gtagagctcc tgcacctgaa caacgtgagc
      721 actggctgta ttctgcttgg aggactcttc atctatgaca tcttctgggt attcggcacc
      781 aacgtgatgg tgactgtggc caagtccttt gaggcaccaa taaaattggt gttcccccag
      841 gatctgctgg agaagggtct tgaagcagac aactttgcca tgctgggact tggagacatt
      901 gtcatcccag ggatcttcat cgccttgctg ctccgtttcg acatcagcct gaagaagaac
      961 acccacacct acttctacac cagcttcgct gcctacatct tcggcctggg tctcaccatc
     1021 ttcatcatgc acatcttcaa gcacgcccag ccggccctcc tgtacctggt ccctgcctgc
     1081 atcggttttc ctgtcctggt ggcactggtc aagggagaag tggcagagat gttcagctac
     1141 gagtcctcgg ccgtaatcct gcctcatacg ccgaggctca ctcactttcc cacagtctcg
     1201 ggctcccctg ccagcctggc cgactccatg cagcagaagc tagctggccc tcgtcgccgg
     1261 cgcccgcaga atcccagcgc catgtaatgc ccagcgggtg cccacctgcc cgcttcccca
     1321 ctgtcctggg cctaagttat gaggagtcta accctaaaga tccagcagcc gtgactgaat
     1381 ccaaagagga atcaacagag gcgtcggcat ccaagaggct agagaagaag gagaaatgag
     1441 gcggcgctgc ctgacccttg agggccagac caggcaggca ggggatgacc tgtaggcgac
     1501 aaagacaaga agacacctgc aggaggcgaa ggtggctcca ggatggggag cgggcctctg
     1561 ctgcctgtcc cctctcccct ttctctggct tcttctgctc ctcctcatcc cctgcaggca
     1621 aaggaaaccc tctgctgctt ccttccccag gagccaggtg ggaactgaat gtggttttta
     1681 gatttttgta ttgtggactg actttgcctc acattaaaac tcatcccatg gccacttagg
     1741 ccactgtgct cccagggagt tctcagcaac tcta
//
