LOCUS       NM_022179               3027 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus hexokinase 3 (Hk3), mRNA.
ACCESSION   NM_022179
VERSION     NM_022179.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3027)
  AUTHORS   Lin,Y.H., Wu,Y., Wang,Y., Yao,Z.F., Tang,J., Wang,R., Shen,L.,
            Ding,S.Q., Hu,J.G. and Lu,H.Z.
  TITLE     Spatio-temporal expression of Hexokinase-3 in the injured female
            rat spinal cords
  JOURNAL   Neurochem Int 113, 23-33 (2018)
   PUBMED   29196144
  REMARK    GeneRIF: HK3 may be involved in the pathologic process ofspinal
            cord injury by promoting glucose metabolism.
REFERENCE   2  (bases 1 to 3027)
  AUTHORS   Wyatt,E., Wu,R., Rabeh,W., Park,H.W., Ghanefar,M. and Ardehali,H.
  TITLE     Regulation and cytoprotective role of hexokinase III
  JOURNAL   PLoS One 5 (11), e13823 (2010)
   PUBMED   21072205
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3027)
  AUTHORS   Fujimoto,Y., Donahue,E.P. and Shiota,M.
  TITLE     Defect in glucokinase translocation in Zucker diabetic fatty rats
  JOURNAL   Am J Physiol Endocrinol Metab 287 (3), E414-E423 (2004)
   PUBMED   15138155
REFERENCE   4  (bases 1 to 3027)
  AUTHORS   Sui,D. and Wilson,J.E.
  TITLE     Interaction of insulin-like growth factor binding protein-4, Miz-1,
            leptin, lipocalin-type prostaglandin D synthase, and granulin
            precursor with the N-terminal half of type III hexokinase
  JOURNAL   Arch Biochem Biophys 382 (2), 262-274 (2000)
   PUBMED   11068878
REFERENCE   5  (bases 1 to 3027)
  AUTHORS   Cardenas,M.L., Cornish-Bowden,A. and Ureta,T.
  TITLE     Evolution and regulatory role of the hexokinases
  JOURNAL   Biochim Biophys Acta 1401 (3), 242-264 (1998)
   PUBMED   9540816
  REMARK    Review article
REFERENCE   6  (bases 1 to 3027)
  AUTHORS   Palma,F., Agostini,D., Mason,P., Dacha,M., Piccoli,G.,
            Biagiarelli,B., Fiorani,M. and Stocchi,V.
  TITLE     Purification and characterization of the carboxyl-domain of human
            hexokinase type III expressed as fusion protein
  JOURNAL   Mol Cell Biochem 155 (1), 23-29 (1996)
   PUBMED   8717435
REFERENCE   7  (bases 1 to 3027)
  AUTHORS   Chan,Y.L., Olvera,J., Gluck,A. and Wool,I.G.
  TITLE     A leucine zipper-like motif and a basic region-leucine zipper-like
            element in rat ribosomal protein L13a. Identification of the tum-
            transplantation antigen P198
  JOURNAL   J Biol Chem 269 (8), 5589-5594 (1994)
   PUBMED   8119894
REFERENCE   8  (bases 1 to 3027)
  AUTHORS   Schwab,D.A. and Wilson,J.E.
  TITLE     Complete amino acid sequence of the type III isozyme of rat
            hexokinase, deduced from the cloned cDNA
  JOURNAL   Arch Biochem Biophys 285 (2), 365-370 (1991)
   PUBMED   1897938
REFERENCE   9  (bases 1 to 3027)
  AUTHORS   Gonzalez,C., Ureta,T., Sanchez,R. and Niemeyer,H.
  TITLE     Multiple molecular forms of ATP:hexose 6-phosphotransferase from
            rat liver
  JOURNAL   Biochem Biophys Res Commun 16 (4), 347-352 (1964)
   PUBMED   5871820
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U73859.1.
            
            On Jul 3, 2003 this sequence version replaced NM_022179.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3027              U73859.1           1-3027
FEATURES             Location/Qualifiers
     source          1..3027
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..3027
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /note="hexokinase 3"
                     /db_xref="GeneID:25060"
                     /db_xref="RGD:2798"
     exon            1..57
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            58..176
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2855
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /EC_number="2.7.1.1"
                     /note="HK III; hexokinase type III; hexokinase 3 (white
                     cell); hexokinase-C"
                     /codon_start=1
                     /product="hexokinase-3"
                     /protein_id="NP_071515.1"
                     /db_xref="GeneID:25060"
                     /db_xref="RGD:2798"
                     /translation="MAAIEPSGLHPGERDSSCPQEGIPRPSGSLELAQEYLQQFKVTM
                     TQLQQIQASLLCSMEQALKGQDSPAPSVRMLPTYVRSTPHGTEQGDFLVLELGATGAS
                     LRVLWVTLTGTKEHSVETRSQEFVIPQEVILGAGQQLFDFAARCLSEFLDAYPVENQG
                     LKLGFNFSFPCHQTGLDKSTLISWTKGFRCSGVEGQDVVQLLRDAIQRQGTYNIDVVA
                     MVNDTVGTMMGCELGTRPCEVGLIVDTGTNACYMEEARHVAALDEDRGRTCVSIEWGS
                     FYDEEALGPVLTTFDDALDHESLVPGAQRFEKMIGGLYLGELVRLVLVHLSQHGVLFG
                     GCASPALLSQNSILLEHVAKMEDPATGIAHVHTVLQGLGLSPQASDAELVQRVCMAVC
                     TRAAQLCASALAAVLSRLQHSREQQTLHVAVATGGRVFEWHPRFLCILKETVMLLAPE
                     CDVSFIPSVDGGGRGVAMVTAVAARLATHRRILEETLAPFQLSLEQLTAVQAQMREAM
                     IRGLQGESSSLRMLPTYVRATPDGSERGDFLALDLGGTNFRVLLVRVAEGSVQITNQV
                     YSIPEYVAQGSGQKLFDHIVDCIVDFQKRQGLSGQSLPLGFTFSFPCKQLGLDQGILL
                     NWTKGFNASGCEGQDVVYLLREAIRRRQAVELNVVAIVNDTVGTMMSCGYDDPCCEMG
                     LIVGTGTNACYMEELRNVASVPGDSGHMCINMEWGAFGDDGSLSMLGTCFDASVDQAS
                     INPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQKTQCLQTRDIFKTKFLSEIE
                     SDSLALRQVRAILEDLGLTLTSDDALMVLEVCQAVSRRAAQLCGAGVAAVVEKIRENR
                     GLQELTVSVGVDGTLYKLHPHFSRLVSVTVRKLAPQCTVTFLQSEDGSGKGAALVTRV
                     ACRLTQMACV"
     exon            177..339
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            340..494
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            495..614
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            615..710
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            711..810
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            811..994
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1150
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1384
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1680
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1820
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1940
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2036
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2136
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2320
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2476
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2710
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..3027
                     /gene="Hk3"
                     /gene_synonym="RNU73859"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgtcttat ttgggagctg agacttgagg aaggtgataa cttctgaatc cccccaggta
       61 gtcaatacca ttgtggaaac atggccgcca ttgagccttc tggtctgcac ccgggagaaa
      121 gagactcaag ctgcccccag gagggcattc caaggccctc aggtagctta gaactggcac
      181 aggaatactt gcaacaattc aaggtgacca tgacacagct gcagcagatc caagccagtc
      241 ttctgtgttc catggagcag gcgctgaagg gacaggacag tcccgctcct tctgtccgga
      301 tgttgcccac atacgtgagg tccacaccac atggcaccga gcaaggagac ttcctggtgc
      361 tggagctggg ggccacagga gcctcactac gtgtgttgtg ggtaacactg acgggcacca
      421 aggaacacag cgtggagacc aggagccagg agtttgtgat ccctcaagag gtgatcctag
      481 gtgctggcca gcagctcttt gactttgctg cccgctgcct ctctgaattc ctggatgcat
      541 accccgtgga gaatcagggt ctgaagcttg ggtttaattt ctcttttcct tgtcaccaga
      601 caggcttgga caagagcacc ctcatttcct ggacaaaagg ttttaggtgc agtggtgtgg
      661 aaggccagga tgtggtccag ttgctaaggg atgccattca gaggcagggg acctacaata
      721 ttgatgtggt agccatggtg aatgacacag tgggtaccat gatgggctgt gagctgggca
      781 ccaggccatg tgaagtcggg cttattgtag acactggtac caatgcctgt tatatggagg
      841 aagcgaggca cgtggcagct ctggatgagg accgcggccg tacctgtgtc agcatcgagt
      901 ggggctcctt ctatgacgaa gaggccctag ggccagtact gaccaccttc gacgatgccc
      961 tggaccacga gtccctggtt cctggtgctc agaggtttga gaagatgatt ggtggccttt
     1021 acttgggtga gctggtaagg ctggtgctgg tccacttgtc ccagcatggg gtcctctttg
     1081 gtggctgcgc ctctcctgcg ttgctgagtc aaaacagcat cctcctggaa catgtggcca
     1141 aaatggagga ccctgccact gggatagccc acgtccacac agtcctgcag ggcttgggtc
     1201 tgagccctca ggcctcagat gctgagctcg tgcagcgcgt gtgcatggct gtgtgcacgc
     1261 gagctgccca gctctgtgcc tctgccctgg ctgcagtcct atcccgcctc cagcacagca
     1321 gggagcagca gacactgcac gtggccgtgg ccactggagg gcgagtgttc gaatggcacc
     1381 ccaggttcct ctgcatccta aaggagacgg taatgctctt ggccccagag tgtgatgtct
     1441 ccttcatccc ctctgtggat ggtggtggcc ggggtgtggc aatggtgact gctgtggcag
     1501 cccgcctggc tacccacagg cgcatcctgg aagagaccct ggcaccattt cagctgagct
     1561 tggagcagct gacagcggtg caggcacaaa tgcgggaagc catgatcagg gggcttcaag
     1621 gagagagctc ctccctccgc atgctgccca cttacgtccg agcaacgccc gatggcagcg
     1681 aacgaggtga cttcctggct ttggacctag ggggcaccaa cttccgtgtc ctgttggtac
     1741 gcgtggccga gggcagtgtt cagatcacca accaggtcta ctctattcct gagtatgtag
     1801 cccagggctc tggacagaag ctctttgatc atattgtgga ctgcatcgtg gacttccaga
     1861 agaggcaagg ccttagcgga cagagcctac ccctgggttt caccttctct tttccttgca
     1921 agcagcttgg cctggaccag ggcatcctcc tcaactggac taaggggttc aatgcatcag
     1981 gctgcgaggg ccaagatgtt gtgtatttat tacgggaagc cattaggcgc agacaggcag
     2041 tggagctgaa tgtggttgcc attgtcaatg acacggtggg gaccatgatg tcctgtggct
     2101 atgatgatcc ctgttgtgag atgggcctca ttgtcggaac cggtaccaac gcctgctata
     2161 tggaagaact ccggaatgtg gcgagtgtgc ccggggactc aggccacatg tgtatcaaca
     2221 tggagtgggg tgcctttggg gatgacggct cactgagcat gctcggcacc tgctttgatg
     2281 ctagcgtgga ccaggcatcc atcaacccag gcaaacagag gtttgagaaa atgatcagcg
     2341 gaatgtacct gggggagatc gtccgccata tcctcctgca cttaaccagt cttggagttc
     2401 tcttccgggg ccagaagacg caatgccttc agaccaggga catctttaag accaagtttc
     2461 tctccgagat tgagagcgac agcctggccc tgcgtcaggt ccgagccatc ctggaggacc
     2521 tggggctgac tctgacgtct gatgatgcct tgatggtcct agaggtgtgc caggctgtgt
     2581 cccgcagggc cgcccaactc tgcggggcag gtgtggctgc agtggtggaa aagatacggg
     2641 agaaccgggg cctgcaggag ctgacagtgt ctgtgggagt ggatgggacg ctctacaagc
     2701 tacatcccca cttctccagg ctggtgtcag tgacagttcg gaagctagcc cctcagtgca
     2761 cagtcacctt tttgcaatcg gaggatgggt ctgggaaagg ggcagcgttg gtcactcgtg
     2821 tcgcttgccg cctgacccag atggcctgcg tttgaggaaa atctccaaag agcaattggg
     2881 atctccctgg actaaggatt cagcccacac ggaccctctg gcgggcccag ccacccacaa
     2941 ctcccaaaga aacccacggg tggtgccctc ataactgtcc gcccacaccc aatggctttc
     3001 tgagagaagc accactctgg ttagcaa
//
