LOCUS       NM_001393711            3915 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hexokinase 1 (Hk1), transcript variant 1, mRNA.
ACCESSION   NM_001393711 XM_039098433
VERSION     NM_001393711.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3915)
  AUTHORS   Bridgeman,S., Ellison,G., Newsholme,P. and Mamotte,C.
  TITLE     The HDAC Inhibitor Butyrate Impairs beta Cell Function and
            Activates the Disallowed Gene Hexokinase I
  JOURNAL   Int J Mol Sci 22 (24), 13330 (2021)
   PUBMED   34948127
  REMARK    GeneRIF: The HDAC Inhibitor Butyrate Impairs beta Cell Function and
            Activates the Disallowed Gene Hexokinase I.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3915)
  AUTHORS   Dehghani,Z., Meratan,A.A., Saboury,A.A. and Nemat-Gorgani,M.
  TITLE     alpha-Synuclein fibrillation products trigger the release of
            hexokinase I from mitochondria: Protection by curcumin, and
            possible role in pathogenesis of Parkinson's disease
  JOURNAL   Biochim Biophys Acta Biomembr 1862 (6), 183251 (2020)
   PUBMED   32113849
  REMARK    GeneRIF: alpha-Synuclein fibrillation products trigger the release
            of hexokinase I from mitochondria: Protection by curcumin, and
            possible role in pathogenesis of Parkinson's disease.
REFERENCE   3  (bases 1 to 3915)
  AUTHORS   Ramirez-Perez,G., Sanchez-Chavez,G. and Salceda,R.
  TITLE     Mitochondrial bound hexokinase type I in normal and streptozotocin
            diabetic rat retina
  JOURNAL   Mitochondrion 52, 212-217 (2020)
   PUBMED   32283307
  REMARK    GeneRIF: Mitochondrial bound hexokinase type I in normal and
            streptozotocin diabetic rat retina.
REFERENCE   4  (bases 1 to 3915)
  AUTHORS   Nedvedova,I., Kolar,D., Elsnicova,B., Hornikova,D., Novotny,J.,
            Kalous,M., Pravenec,M., Neckar,J., Kolar,F. and Zurmanova,J.M.
  TITLE     Mitochondrial genome modulates myocardial Akt/Glut/HK salvage
            pathway in spontaneously hypertensive rats adapted to chronic
            hypoxia
  JOURNAL   Physiol Genomics 50 (7), 532-541 (2018)
   PUBMED   29676955
REFERENCE   5  (bases 1 to 3915)
  AUTHORS   Liu,X., Salokas,K., Tamene,F., Jiu,Y., Weldatsadik,R.G., Ohman,T.
            and Varjosalo,M.
  TITLE     An AP-MS- and BioID-compatible MAC-tag enables comprehensive
            mapping of protein interactions and subcellular localizations
  JOURNAL   Nat Commun 9 (1), 1188 (2018)
   PUBMED   29568061
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3915)
  AUTHORS   Gelb,B.D., Adams,V., Jones,S.N., Griffin,L.D., MacGregor,G.R. and
            McCabe,E.R.
  TITLE     Targeting of hexokinase 1 to liver and hepatoma mitochondria
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 202-206 (1992)
   PUBMED   1309605
REFERENCE   7  (bases 1 to 3915)
  AUTHORS   Adams,V., Griffin,L.D., Gelb,B.D. and McCabe,E.R.
  TITLE     Protein kinase activity of rat brain hexokinase
  JOURNAL   Biochem Biophys Res Commun 177 (3), 1101-1106 (1991)
   PUBMED   2059200
REFERENCE   8  (bases 1 to 3915)
  AUTHORS   Schwab,D.A. and Wilson,J.E.
  TITLE     Complete amino acid sequence of rat brain hexokinase, deduced from
            the cloned cDNA, and proposed structure of a mammalian hexokinase
  JOURNAL   Proc Natl Acad Sci U S A 86 (8), 2563-2567 (1989)
   PUBMED   2704734
REFERENCE   9  (bases 1 to 3915)
  AUTHORS   Kottke,M., Adam,V., Riesinger,I., Bremm,G., Bosch,W., Brdiczka,D.,
            Sandri,G. and Panfili,E.
  TITLE     Mitochondrial boundary membrane contact sites in brain: points of
            hexokinase and creatine kinase location, and control of Ca2+
            transport
  JOURNAL   Biochim Biophys Acta 935 (1), 87-102 (1988)
   PUBMED   2457393
REFERENCE   10 (bases 1 to 3915)
  AUTHORS   Belfiore,F., Borzi,V., Napoli,E. and Rabuazzo,A.M.
  TITLE     Enzymes related to lipogenesis in the adipose tissue of obese
            subjects
  JOURNAL   Metabolism 25 (5), 483-493 (1976)
   PUBMED   131232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Mar 5, 2021 this sequence version replaced XM_039098433.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.82612.1,
                                           SRR26643294.61448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000020.1  30874721-30874814   c
            95-276              JAXUCZ010000020.1  30862586-30862767   c
            277-371             JAXUCZ010000020.1  30856718-30856812   c
            372-419             JAXUCZ010000020.1  30852707-30852754   c
            420-582             JAXUCZ010000020.1  30818834-30818996   c
            583-731             JAXUCZ010000020.1  30808173-30808321   c
            732-851             JAXUCZ010000020.1  30803259-30803378   c
            852-947             JAXUCZ010000020.1  30800331-30800426   c
            948-1047            JAXUCZ010000020.1  30799668-30799767   c
            1048-1231           JAXUCZ010000020.1  30799377-30799560   c
            1232-1387           JAXUCZ010000020.1  30796148-30796303   c
            1388-1621           JAXUCZ010000020.1  30792819-30793052   c
            1622-1926           JAXUCZ010000020.1  30789604-30789908   c
            1927-2075           JAXUCZ010000020.1  30787990-30788138   c
            2076-2195           JAXUCZ010000020.1  30787597-30787716   c
            2196-2291           JAXUCZ010000020.1  30785388-30785483   c
            2292-2391           JAXUCZ010000020.1  30784637-30784736   c
            2392-2575           JAXUCZ010000020.1  30779556-30779739   c
            2576-2731           JAXUCZ010000020.1  30778406-30778561   c
            2732-2965           JAXUCZ010000020.1  30775834-30776067   c
            2966-3915           JAXUCZ010000020.1  30773224-30774173   c
FEATURES             Location/Qualifiers
     source          1..3915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..3915
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /note="hexokinase 1"
                     /db_xref="GeneID:25058"
                     /db_xref="RGD:2796"
     exon            1..94
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            95..276
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            277..371
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..3113
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /EC_number="2.7.1.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hexokinase type I; hexokinase-A; brain form hexokinase"
                     /codon_start=1
                     /product="hexokinase-1 isoform 1"
                     /protein_id="NP_001380640.1"
                     /db_xref="GeneID:25058"
                     /db_xref="RGD:2796"
                     /translation="MGQNCQRGQAVDIEPQIRPPLTEDKIDKYLYAMRLSDEILIDIL
                     TRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVN
                     HEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSF
                     PCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTM
                     MTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLED
                     IRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLT
                     RGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICTIVSFRSANLVAA
                     TLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFLLSE
                     SGSGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETN
                     SKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSI
                     PLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWT
                     KGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIV
                     GTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNS
                     GKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDR
                     LALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLD
                     HLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKGAALITAVGVR
                     LRGDPSIA"
     exon            372..419
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            420..582
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            583..731
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            732..851
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            852..947
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1047
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1231
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1387
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1621
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1926
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2075
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2195
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2291
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2391
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2575
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2731
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2965
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3915
                     /gene="Hk1"
                     /gene_synonym="HEXOKIN; HKI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attccatgac tgcaggagtc cctgaaccac ctgggaccat ggagggtccc cctcttctca
       61 aggctcgcta ggcaagacca gtaactacat caaggactcc aacccaccag ctcaagactg
      121 ttcctcagac acctgggaag gtagaactca ccccagtccc acatactttt ccatcaagaa
      181 cccagtcacc tctaaaagat ggcaaatgat gttctttggg gaaaatgaga gtgaactcaa
      241 gtaaggattg tcagaggtga ctcaggctct cccaaggatc aggagaccca gcttcggagg
      301 acagaagacc cctgggaaaa cagcatagcc agaacctcta cattatggga cagaactgcc
      361 agcgaggaca ggctgtagac attgaaccac aaatacgacc ccctctcaca gaggataaga
      421 ttgacaagta tctgtacgcc atgcggctct ctgatgagat tctgatagat atcctgacac
      481 gattcaagaa agagatgaag aatggcctct cccgggatta taatccaaca gcctccgtca
      541 agatgctgcc caccttcgtc cggtccattc cggacggctc agaaaagggg gatttcattg
      601 ccctggatct cggcgggtct tcctttcgaa tcctgcgggt gcaggtgaac cacgagaaga
      661 accagaacgt cagcatggag tctgagatct acgacacccc agagaacatc gtgcatggca
      721 gtggaaccca gcttttcgat catgtcgctg actgcctggg agacttcatg gagaaaaaga
      781 agatcaagga caagaagtta cccgtgggat tcacattttc cttcccctgc cgacaatcca
      841 agatagatga ggctgtactg atcacgtgga caaagcggtt caaagccagt ggcgtggaag
      901 gagcggatgt ggtcaagttg ctgaataaag ccattaagaa gcgaggggac tatgatgcta
      961 acattgtcgc cgtggtgaat gacacagtag ggaccatgat gacctgcggt tatgatgacc
     1021 aacagtgtga agtcggcctg atcattggca caggcaccaa tgcttgctac atggaggaac
     1081 tgcgacacat cgacctggtg gaaggcgacg aggggaggat gtgtattaac acggaatggg
     1141 gagcctttgg ggatgatggg tccctggaag acatccgaac cgagtttgac agagagttag
     1201 accgtggatc tctcaaccct gggaagcagc tgttcgagaa gatggtgagc ggcatgtaca
     1261 tgggggagct ggtccggcta atcctggtga agatggccaa ggaaggcctc ttattcgaag
     1321 ggcgcatcac tccagagctg ctcacgaggg gaaagttcaa cactagtgac gtgtccgcca
     1381 ttgaaaagga taaggaaggc attcaaaatg ccaaggaaat cttaacccgc ttgggagtgg
     1441 agccgtctga tgttgactgt gtgtcggtcc agcacatctg cacgatcgtc tccttccgat
     1501 cagccaacct ggtggccgcc acgctcggtg ccatcttgaa ccgcctgcgg gacaacaagg
     1561 gcacacccag gctgcggacc acggttggcg tggacggttc tctctacaag atgcacccac
     1621 agtactcccg gcggttccac aagaccctga ggcgcctggt gcctgactcc gacgtccgtt
     1681 tcctcctctc agagagtggc agcggcaagg gggccgccat ggtgacggca gtagcctacc
     1741 gcctggctga gcagcaccgg cagattgagg aaaccctggc ccacttccgc ctcagcaagc
     1801 agacgctgat ggaggtgaag aagaggctac ggacagagat ggaaatgggg ctgaggaagg
     1861 agaccaacag caaagctact gtcaaaatgc tgccttcttt tgtccggagc atcccggatg
     1921 ggactgaaca cggtgacttc ctggccttgg atcttggagg aacgaatttc cgggttctgc
     1981 tggtaaagat ccgcagtggg aaaaagagaa cagtggaaat gcacaacaag atctactcca
     2041 ttcccctgga aatcatgcag ggcaccgggg atgagctgtt tgaccacatc gtctcctgca
     2101 tctctgactt cctggactac atggggatca aaggcccccg gatgcctctg ggcttcacct
     2161 tctcatttcc ctgccatcag acgaacctgg actgtggaat cttgatctca tggacaaagg
     2221 gtttcaaagc cactgactgt gagggccatg atgtagcctc cttactgagg gatgcggtga
     2281 agaggagaga ggaatttgac ttggatgtgg tggctgtggt caacgacacc gtgggcacca
     2341 tgatgacctg tgcgtatgaa gaacccactt gcgaaattgg actcatcgtg gggacgggca
     2401 ccaatgcctg ctacatggag gagatgaaga atgtggagat ggtggagggg aaccagggcc
     2461 agatgtgcat caacatggag tggggcgcct tcggtgacaa tgggtgtctg gatgacatca
     2521 gaacagactt tgacaaagtg gtggacgaat attctctaaa ctctgggaaa caaaggtttg
     2581 agaaaatgat cagtgggatg tacctgggtg agatcgtccg taacatcctg attgacttca
     2641 ccaagaaagg cttcctcttc cggggacaga tctccgaacc actcaagacc cgaggcatct
     2701 ttgagaccaa gtttctctct cagattgaga gtgaccggtt agcgctgctc caggtgcggg
     2761 ccatccttca gcagctgggt ttgaacagca cgtgtgacga cagtatcctg gtcaagaccg
     2821 tgtgtggggt ggtgtccaag agggcggctc agctgtgtgg tgccggcatg gccgccgtgg
     2881 tggaaaagat cagagagaac agaggcctag accatctgaa tgtaactgtg ggagtggatg
     2941 ggacgctcta caaacttcat ccacacttct ccagaatcat gcaccaaact gtgaaggaac
     3001 tgtcaccaaa gtgtaccgtg tccttcctcc tgtctgaaga cggcagcggc aagggggccg
     3061 cccttatcac agctgtgggc gtgcggctca gaggagaccc ttcgatcgcc taaaagccag
     3121 gatcctccca gcccccagcc cgccaccctt ccagcactcc tctctagaac cgacgaccac
     3181 acccccgtgt tccacccagc aagccccgct gggagaccca gcgccagcgc ccactccgcc
     3241 gcagcagagg gaggaagggg accgcagtaa cggagcacca cgtagaatac cacccagagc
     3301 gcgtgtgctg ttgatctgat ctctcgcctg gacccctaat ccctgccctg ccactctgca
     3361 tgattcaagt tcgacctggc catgcattgc ccatgcgtga acgtagcggc acccgcgtgc
     3421 gtctactgca gatgtccagc taggaaagag tcccctctct tggacagtct tctgggccct
     3481 tccaagccca tccgtggagt cgcctctcct cccctctccc ccgtgtgaag tgtgttatca
     3541 ccagcagaca ctgccggact cctgcccaca ggggcgtggc ctgaagggcg agtgtggaca
     3601 tggcactgct gttccgttcc cttcccctcc cagcacccgc cgcagcctgc catcccgtct
     3661 ggatgtatcg atgccacaga attgtgaatt gtgtgtccgt ccgtggagcc agtcctagcc
     3721 acattattga cagtcttgca ttttgttttg tctcctggtg gtgggggtgg aggtggtagg
     3781 ggtgcgctaa ggtgggcagt cctgtgggag aacatcttgc tagaaggaac caacccacga
     3841 aacaacacca tcactggaat ttcccatcgc tttagtgagc cattgttgta cgtctagtaa
     3901 actttgtact gattc
//
