LOCUS       NM_001012080            2145 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus hemojuvelin BMP co-receptor (Hjv), mRNA.
ACCESSION   NM_001012080 XM_227467
VERSION     NM_001012080.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Kovac,S., Boser,P., Cui,Y., Ferring-Appel,D., Casarrubea,D.,
            Huang,L., Fung,E., Popp,A., Mueller,B.K. and Hentze,M.W.
  TITLE     Anti-hemojuvelin antibody corrects anemia caused by inappropriately
            high hepcidin levels
  JOURNAL   Haematologica 101 (5), e173-e176 (2016)
   PUBMED   26944476
  REMARK    GeneRIF: Anti-hemojuvelin antibody corrects anemia caused by
            inappropriately high hepcidin levels.
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Rausa,M., Pagani,A., Nai,A., Campanella,A., Gilberti,M.E.,
            Apostoli,P., Camaschella,C. and Silvestri,L.
  TITLE     Bmp6 expression in murine liver non parenchymal cells: a mechanism
            to control their high iron exporter activity and protect
            hepatocytes from iron overload?
  JOURNAL   PLoS One 10 (4), e0122696 (2015)
   PUBMED   25860887
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2145)
  AUTHORS   De Falco,L., Silvestri,L., Kannengiesser,C., Moran,E., Oudin,C.,
            Rausa,M., Bruno,M., Aranda,J., Argiles,B., Yenicesu,I.,
            Falcon-Rodriguez,M., Yilmaz-Keskin,E., Kocak,U., Beaumont,C.,
            Camaschella,C., Iolascon,A., Grandchamp,B. and Sanchez,M.
  TITLE     Functional and clinical impact of novel TMPRSS6 variants in
            iron-refractory iron-deficiency anemia patients and
            genotype-phenotype studies
  JOURNAL   Hum Mutat 35 (11), 1321-1329 (2014)
   PUBMED   25156943
REFERENCE   4  (bases 1 to 2145)
  AUTHORS   Gkouvatsos,K., Fillebeen,C., Daba,A., Wagner,J., Sebastiani,G. and
            Pantopoulos,K.
  TITLE     Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that
            hemojuvelin is dispensable for sensing body iron levels
  JOURNAL   PLoS One 9 (1), e85530 (2014)
   PUBMED   24409331
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2145)
  AUTHORS   Dokuyucu,R., Demir,T., Yumrutas,Onder., Erbagci,A.B., Orkmez,M.,
            Bahar,A.Y., Bayraktar,R., Bozgeyik,I., Kaplan,D.S., Cengiz,B. and
            Bagci,B.C.
  TITLE     The role of hepcidin and its related genes (BMP6, GDF-15, and HJV)
            in rats exposed to ischemia and reperfusion
  JOURNAL   Turk J Med Sci 44 (4), 576-581 (2014)
   PUBMED   25551924
  REMARK    GeneRIF: Expression levels of GDF-15, BMP6, and HJV genes increased
            in rats exposed to ischemia and reperfusion, but this increase was
            not statistically significant.
REFERENCE   6  (bases 1 to 2145)
  AUTHORS   Merle,U., Theilig,F., Fein,E., Gehrke,S., Kallinowski,B.,
            Riedel,H.D., Bachmann,S., Stremmel,W. and Kulaksiz,H.
  TITLE     Localization of the iron-regulatory proteins hemojuvelin and
            transferrin receptor 2 to the basolateral membrane domain of
            hepatocytes
  JOURNAL   Histochem Cell Biol 127 (2), 221-226 (2007)
   PUBMED   16932966
  REMARK    GeneRIF: hemojuvelin(HFE2)& transferrin receptor type 2 were
            predominantly localized to hepatocyte basolateral membrane domain;
            localization of HFE2 & TfR2 at the same membrane domain renders a
            functional interaction of these proteins in iron homeostasis
            possible
REFERENCE   7  (bases 1 to 2145)
  AUTHORS   Babitt,J.L., Huang,F.W., Wrighting,D.M., Xia,Y., Sidis,Y.,
            Samad,T.A., Campagna,J.A., Chung,R.T., Schneyer,A.L., Woolf,C.J.,
            Andrews,N.C. and Lin,H.Y.
  TITLE     Bone morphogenetic protein signaling by hemojuvelin regulates
            hepcidin expression
  JOURNAL   Nat Genet 38 (5), 531-539 (2006)
   PUBMED   16604073
REFERENCE   8  (bases 1 to 2145)
  AUTHORS   Niederkofler,V., Salie,R. and Arber,S.
  TITLE     Hemojuvelin is essential for dietary iron sensing, and its mutation
            leads to severe iron overload
  JOURNAL   J Clin Invest 115 (8), 2180-2186 (2005)
   PUBMED   16075058
REFERENCE   9  (bases 1 to 2145)
  AUTHORS   Niederkofler,V., Salie,R., Sigrist,M. and Arber,S.
  TITLE     Repulsive guidance molecule (RGM) gene function is required for
            neural tube closure but not retinal topography in the mouse visual
            system
  JOURNAL   J Neurosci 24 (4), 808-818 (2004)
   PUBMED   14749425
REFERENCE   10 (bases 1 to 2145)
  AUTHORS   Papanikolaou,G., Samuels,M.E., Ludwig,E.H., MacDonald,M.L.,
            Franchini,P.L., Dube,M.P., Andres,L., MacFarlane,J.,
            Sakellaropoulos,N., Politou,M., Nemeth,E., Thompson,J.,
            Risler,J.K., Zaborowska,C., Babakaiff,R., Radomski,C.C., Pape,T.D.,
            Davidas,O., Christakis,J., Brissot,P., Lockitch,G., Ganz,T.,
            Hayden,M.R. and Goldberg,Y.P.
  TITLE     Mutations in HFE2 cause iron overload in chromosome 1q-linked
            juvenile hemochromatosis
  JOURNAL   Nat Genet 36 (1), 77-82 (2004)
   PUBMED   14647275
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 2, 2021 this sequence version replaced NM_001012080.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089203.1, SRR26643289.6988.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JAXUCZ010000002.1  186754801-186754940
            141-344             JAXUCZ010000002.1  186755819-186756022
            345-892             JAXUCZ010000002.1  186756396-186756943
            893-2145            JAXUCZ010000002.1  186757456-186758708
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2145
                     /gene="Hjv"
                     /gene_synonym="Hfe2; Rgmc"
                     /note="hemojuvelin BMP co-receptor"
                     /db_xref="GeneID:310681"
                     /db_xref="RGD:1310195"
     exon            1..140
                     /gene="Hjv"
                     /gene_synonym="Hfe2; Rgmc"
                     /inference="alignment:Splign:2.1.0"
     exon            141..344
                     /gene="Hjv"
                     /gene_synonym="Hfe2; Rgmc"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1516
                     /gene="Hjv"
                     /gene_synonym="Hfe2; Rgmc"
                     /note="hemojuvelin; RGM domain family member C;
                     hemochromatosis type 2 protein homolog; hemochromatosis
                     type 2 (juvenile) (human homolog); hemojuvelin BMP
                     coreceptor"
                     /codon_start=1
                     /product="hemojuvelin precursor"
                     /protein_id="NP_001012080.1"
                     /db_xref="GeneID:310681"
                     /db_xref="RGD:1310195"
                     /translation="MGDRGRSPSLRSPHGSPPTLSTLTLLLLLCGQAHSQCKILRCNA
                     EYVSSTLSLRGGGSPDTPHGGGRGGPASGGLCRALRSYALCTRRTARTCRGDLAFHSA
                     VHGIEDLMIQHNCSRQGPTASPPARGPALPGAGPAPLTPDPCDYEARFSRLHGRTPGF
                     LHCASFGDPHVRSFHNHFHTCRVQGAWPLLDNDFLFVQATSSPVASGANATTIRKITI
                     IFKNMQECIDQKVYQAEVDNLPAAFEDGSVNGGDRPGGSSLSIQTANLGSHVEIRAAY
                     IGTTIIVRQTAGQLSFSIRVAEDVARAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAI
                     AIDTARRLCKEGLPVEDAYFQSCVFDVSVSGDPNFTVAAQSALDDARVFLTDLENLHL
                     FPVDAGPPLSPATCLVRLLSVLFVLWFCIQ"
     exon            345..892
                     /gene="Hjv"
                     /gene_synonym="Hfe2; Rgmc"
                     /inference="alignment:Splign:2.1.0"
     exon            893..2145
                     /gene="Hjv"
                     /gene_synonym="Hfe2; Rgmc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagattgc agccagtccg ggggatcggg gacagacatg gagaaggaga tggaggaccc
       61 cctggctgga gcagaccaac agaataggca actatggctg gagaaccggg tatcagagta
      121 atgcttgacc tcgggaaaca ccaaatttct tcttccgatc gcagaagtag tactcggcga
      181 aattcactag gtaggaggct cctcatctgg gaagaaccgg tgcctggggg gacctggctg
      241 gataggtatg ggggatcgag gccggtcccc tagtctccgg tccccccatg gcagtcctcc
      301 aactctaagc accctcactc tcctgctgct cctctgtgga caggctcact cccagtgcaa
      361 gatcctccgc tgcaatgccg agtacgtctc gtccactctg agccttcggg gagggggctc
      421 accggacacg ccacatggag gcggccgtgg tgggccggcc tcaggtggct tgtgtcgcgc
      481 cctgcgctcc tacgctctct gcacgcggcg caccgcccgc acctgccgcg gggacctcgc
      541 tttccactcc gcggtgcatg gcatagagga cctgatgatc cagcacaact gctcacgcca
      601 gggtcccacg gcctcgcccc cggcccgggg tcctgccctg cccggggccg gcccagcgcc
      661 cctgacccca gatccctgtg actatgaagc ccggttttcc aggctgcacg gtcgaacccc
      721 gggtttcttg cattgtgctt cctttggaga cccccatgtg cgcagcttcc acaatcactt
      781 tcacacatgc cgcgtccaag gagcttggcc cctactagat aacgacttcc tctttgtcca
      841 agccaccagc tccccggtag catcgggagc caacgctacc accatccgga agatcactat
      901 catatttaaa aacatgcagg aatgcattga ccagaaagtc taccaggctg aggtagacaa
      961 tcttcctgca gcctttgaag atggttctgt caatgggggc gaccgacctg ggggctcgag
     1021 tttgtccatt caaactgcta accttgggag ccacgtggag attcgagctg cctacattgg
     1081 aacaactata atcgttcgtc agacagctgg acagctctcc ttctccatca gggtagcgga
     1141 ggatgtggca cgggccttct ctgctgagca ggatctacag ctgtgtgttg ggggatgccc
     1201 tccgagccag cgactctctc gctcagagcg caatcgccgt ggggcgatag ccatagatac
     1261 tgccagaagg ttgtgtaagg aagggcttcc ggttgaagat gcctacttcc aatcctgcgt
     1321 ctttgatgtt tcagtctccg gtgaccccaa ctttactgtg gcagctcagt cagctctgga
     1381 cgatgcccga gtcttcttga ccgatttgga gaacttgcac cttttcccag tagatgcggg
     1441 gcctcccctc tctccagcca cctgcctagt ccggcttctt tcggtcctct ttgttctgtg
     1501 gttttgcatt cagtaagtag gccagcaacc cgtgactagt ttggaaacgg tttgaggaga
     1561 gaggttgatg tgagaaaaca caaagatgtg ccaaaggaaa cagtggggac aggagacaac
     1621 gaccttactc aatcacacga ggttgcagtc cagggctgaa atgaccctag aataaagatt
     1681 ctgagacagg gttttgcact ccagaccttg gtatgggctc cccatgaatt tccccattag
     1741 tgatttccca cttgtagtga aattctactc tctgtacacc tgatatcact cctgcaaggc
     1801 tagagattgt gagagcgcta agggccagca aaacattaaa gggctgagat atcttaaagg
     1861 cagaaactag aaaaggggaa accatgatta tctataagaa aatcaaaaga ggggtttggg
     1921 aatttagctc agtggtagag cacttgccta gcaagcgcaa ggccctgggt tcggtcccca
     1981 gctcctaaaa aagaaaaaaa aaatcaaaag agaaaaaact aattaaggca agctttttgg
     2041 ttcagaaatg aagtgggcat tgtctggcag aggaagtcag cttttggaga ctggcaccaa
     2101 catctccacc cttcctactc tgttattaaa gtgacgaatt cccca
//
