LOCUS       NM_001135760            4507 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus histone cell cycle regulator (Hira), mRNA.
ACCESSION   NM_001135760 XM_344057
VERSION     NM_001135760.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4507)
  AUTHORS   Ju,Z.R., Wang,H.J., Ma,X.J., Ma,D. and Huang,G.Y.
  TITLE     HIRA Gene is Lower Expressed in the Myocardium of Patients with
            Tetralogy of Fallot
  JOURNAL   Chin Med J (Engl) 129 (20), 2403-2408 (2016)
   PUBMED   27748330
REFERENCE   2  (bases 1 to 4507)
  AUTHORS   Valenzuela,N., Fan,Q., Fa'ak,F., Soibam,B., Nagandla,H., Liu,Y.,
            Schwartz,R.J., McConnell,B.K. and Stewart,M.D.
  TITLE     Cardiomyocyte-specific conditional knockout of the histone
            chaperone HIRA in mice results in hypertrophy, sarcolemmal damage
            and focal replacement fibrosis
  JOURNAL   Dis Model Mech 9 (3), 335-345 (2016)
   PUBMED   26935106
REFERENCE   3  (bases 1 to 4507)
  AUTHORS   Burgess,R.J. and Zhang,Z.
  TITLE     Histone chaperones in nucleosome assembly and human disease
  JOURNAL   Nat Struct Mol Biol 20 (1), 14-22 (2013)
   PUBMED   23288364
  REMARK    Review article
REFERENCE   4  (bases 1 to 4507)
  AUTHORS   Song,T.Y., Yang,J.H., Park,J.Y., Song,Y., Han,J.W., Youn,H.D. and
            Cho,E.J.
  TITLE     The role of histone chaperones in osteoblastic differentiation of
            C2C12 myoblasts
  JOURNAL   Biochem Biophys Res Commun 423 (4), 726-732 (2012)
   PUBMED   22705305
REFERENCE   5  (bases 1 to 4507)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   6  (bases 1 to 4507)
  AUTHORS   van der Heijden,G.W., Dieker,J.W., Derijck,A.A., Muller,S.,
            Berden,J.H., Braat,D.D., van der Vlag,J. and de Boer,P.
  TITLE     Asymmetry in histone H3 variants and lysine methylation between
            paternal and maternal chromatin of the early mouse zygote
  JOURNAL   Mech Dev 122 (9), 1008-1022 (2005)
   PUBMED   15922569
REFERENCE   7  (bases 1 to 4507)
  AUTHORS   Tagami,H., Ray-Gallet,D., Almouzni,G. and Nakatani,Y.
  TITLE     Histone H3.1 and H3.3 complexes mediate nucleosome assembly
            pathways dependent or independent of DNA synthesis
  JOURNAL   Cell 116 (1), 51-61 (2004)
   PUBMED   14718166
REFERENCE   8  (bases 1 to 4507)
  AUTHORS   Roberts,C., Sutherland,H.F., Farmer,H., Kimber,W., Halford,S.,
            Carey,A., Brickman,J.M., Wynshaw-Boris,A. and Scambler,P.J.
  TITLE     Targeted mutagenesis of the Hira gene results in gastrulation
            defects and patterning abnormalities of mesoendodermal derivatives
            prior to early embryonic lethality
  JOURNAL   Mol Cell Biol 22 (7), 2318-2328 (2002)
   PUBMED   11884616
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Oct 10, 2008 this sequence version replaced XM_344057.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.989891.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-743               JAXUCZ010000011.1  95636823-95637565   c
            744-806             JAXUCZ010000011.1  95619765-95619827   c
            807-917             JAXUCZ010000011.1  95618074-95618184   c
            918-1008            JAXUCZ010000011.1  95616901-95616991   c
            1009-1103           JAXUCZ010000011.1  95615220-95615314   c
            1104-1199           JAXUCZ010000011.1  95604876-95604971   c
            1200-1360           JAXUCZ010000011.1  95603410-95603570   c
            1361-1528           JAXUCZ010000011.1  95598403-95598570   c
            1529-1642           JAXUCZ010000011.1  95595976-95596089   c
            1643-1713           JAXUCZ010000011.1  95591192-95591262   c
            1714-1819           JAXUCZ010000011.1  95590601-95590706   c
            1820-2035           JAXUCZ010000011.1  95587747-95587962   c
            2036-2121           JAXUCZ010000011.1  95586396-95586481   c
            2122-2316           JAXUCZ010000011.1  95580134-95580328   c
            2317-2478           JAXUCZ010000011.1  95578258-95578419   c
            2479-2680           JAXUCZ010000011.1  95553660-95553861   c
            2681-2785           JAXUCZ010000011.1  95552752-95552856   c
            2786-2934           JAXUCZ010000011.1  95551010-95551158   c
            2935-3096           JAXUCZ010000011.1  95548937-95549098   c
            3097-3155           JAXUCZ010000011.1  95548581-95548639   c
            3156-3261           JAXUCZ010000011.1  95548102-95548207   c
            3262-3384           JAXUCZ010000011.1  95546402-95546524   c
            3385-3548           JAXUCZ010000011.1  95545745-95545908   c
            3549-3637           JAXUCZ010000011.1  95544323-95544411   c
            3638-4507           JAXUCZ010000011.1  95528831-95529700   c
FEATURES             Location/Qualifiers
     source          1..4507
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4507
                     /gene="Hira"
                     /note="histone cell cycle regulator"
                     /db_xref="GeneID:363849"
                     /db_xref="RGD:1584950"
     exon            1..743
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     CDS             707..3754
                     /gene="Hira"
                     /note="histone cell cycle regulation defective homolog A;
                     protein HIRA-like; HIR histone cell cycle regulation
                     defective homolog A"
                     /codon_start=1
                     /product="protein HIRA"
                     /protein_id="NP_001129232.1"
                     /db_xref="GeneID:363849"
                     /db_xref="RGD:1584950"
                     /translation="MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWN
                     MSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATY
                     IGPSTVFGSSGKLANVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNA
                     VKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDE
                     CGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKF
                     NPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDI
                     SWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLS
                     TAVIENPEMLKYQRRQQQQQLDQKNATTRETSSASSVTGVVNGESLEDIRKNLLKKQV
                     ETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPLSSSLAGTMLSSPSGQQLLPLDSST
                     PSFGASKPCTEPVAATSARPTGEPVSKDSMNATSTPAALSPSVLTTPSKIEPMKAFDS
                     RFTERSKATPGAPSLTSVIPTAVERLKEQNLVRELRSRELDSSSDSDEKVHLAKPSSL
                     SKRKLELEVETVEKKKKGRPRKDSRLLPVSLSVQSPAALSAEKEAMCLSAPALALKLP
                     IPGPQRAFTLQVSSDPSMYIEVENEVTTVGGIRLSRLKCNREGKEWETVLSSRVLTAA
                     GSCDVVCVACEKRMLSVFSTCGRRLLPPILLPSPISTLHCTGPYVMALTAAATLSVWD
                     VHRQVVVVKEESLHSILSGSDMTVSQILLTQHGIPVMNLSDGKAYCFNPSLSTWNLVS
                     DKQDSLAQCADFRNSLPSQDAMLCSGPLAIIQGRTSNSGRQAARLFSVPHVVQQESTL
                     AYLESQVAAALTLQSSHEYRHWLLLYARYLVNEGFEYRLREICQDLLGPVHCSTGSQW
                     ESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK"
     exon            744..806
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            807..917
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1008
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1103
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1199
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1360
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1528
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1642
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1713
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1819
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..2035
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2121
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2316
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2478
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2680
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2785
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2934
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3096
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3155
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3261
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3384
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3548
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3637
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..4507
                     /gene="Hira"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctctgctc tgcctggcct gtttctacgt ctatgcaaac gccccgctct tccaataaat
       61 gctccagtct ggccccctat ccttctccat taggctagct cctttatgca tgcaatcgag
      121 cccagcgtca ctgctgtcgg ccgctagccg catgctggcg cctgtctgtc tggcggtcgc
      181 gagatgccca atagctcgag ttgatggata gcggaacgta gttactaagc tggactcgga
      241 gccgcggatg tagaactaga gacctggaca ctgcattgcc tgacgggatc tcaagacttt
      301 gccagccttc ccacaccaag cctcatcagc gacagcgtcg gtgccagcag agtattcccg
      361 ccttcccccg cgtctacgga agaacggagg cggcccggtc cgcgtaggga gcggtttccc
      421 gccggggcga tttggcaggt gcgcgccgtg acttccggcg ttgtcccgga gccgccggag
      481 gaggagcggc gcaggggatg cggctgtggc ggcggcggcg gcggccgagc gcaggaggcg
      541 gctgtggcgg cggctggggg cgcgggccgg cgatggcgcg gcggcgctga gggaaagggt
      601 gggcggcggc cggagggcgg gcggcgcggg aggaagcagc ggcggctcca tggcccaggc
      661 gtgctgaggg acaccgctct ggcttcagcc cggcagcggc cgaacaatga agctcttgaa
      721 gccaacctgg gtcaaccaca atgggaagcc gattttttca gttgatattc accctgatgg
      781 gaccaagttt gcaactggag gacaagggca ggattctggg aaggttgtga tctggaatat
      841 gtctccagtc ctccaggagg atgacgagaa ggatgaaaat attcccaaga tgctttgcca
      901 gatggacaat cacttagcat gtgtgaactg tgtgcggtgg tcaaacagtg ggatgtattt
      961 agcttctggg ggagatgaca aactgattat ggtgtggaag cgggctacgt acattgggcc
     1021 cagcactgtg tttggctcca gtggtaagct tgccaatgtg gagcaatggc ggtgtgtctc
     1081 catcctccgg agtcactcag gcgatgtgat ggatgtagca tggtctcccc acgacgcctg
     1141 gctggcctca tgcagcgtgg ataacactgt cgtcatttgg aatgctgtga agttcccaga
     1201 aattcttgca actctgagag gtcattctgg cttagtgaaa ggcttgactt gggaccccgt
     1261 tggtaaatac attgcctctc aagctgatga tcgaagtttg aaggtatgga ggacgctgga
     1321 ctggcagcta gagactagca tcaccaaacc ttttgatgag tgtggaggaa caacacatgt
     1381 gctccggctt agttggtcac cagatggcca ttacctggta tctgctcatg ccatgaataa
     1441 ttctggcccc actgctcaga tcatcgaaag agagggctgg aagaccaaca tggacttcgt
     1501 gggtcaccgg aaagctgtga ccgttgtgaa attcaaccca aaaatcttca agaagaagca
     1561 gaagaatgga agttctgcaa agcccagctg cccatactgc tgctgtgctg ttggcagcaa
     1621 agaccgctca ctctccgttt ggctcacatg cttgaaacga cctctggttg tcatccatga
     1681 gctgtttgac aagtccatca tggatatttc ctggactctg aatgggttgg gtatcctggt
     1741 gtgctccatg gacggctctg tggcgttcct tgatttctct caggatgaac tcggagaccc
     1801 cctgagtgag gaggaaaaga gccgaattca tcagtccacc tatggcaaga gcctggcaat
     1861 aatgactgag gcccagcttt ccacagctgt tattgagaac cctgagatgc tcaagtacca
     1921 gcggagacag caacagcagc agctggatca gaagaacgcc actactaggg agacaagctc
     1981 agcatcctca gtcacgggtg tggtcaatgg ggaaagtcta gaagatatca gaaagaatct
     2041 tttgaagaaa caagtggaaa cacggacagc agatggtcgg aggagaatca cgcctctttg
     2101 catagcacag ctggacactg gggacttctc cacggcattc ttcaacagca tcccgctctc
     2161 cagctccctc gcaggcacca tgctctcctc tcctagtggt cagcagctac tgccactgga
     2221 ctccagtacc ccttccttcg gcgcctcaaa gccttgcaca gaaccagtgg cagccaccag
     2281 tgccaggcct acaggcgagc ctgtcagtaa ggacagtatg aatgctacct ctactcctgc
     2341 tgcattgtca ccctccgtgt taacaacccc atccaagatt gaacccatga aagcgtttga
     2401 ttcccggttc acagagcggt ccaaagccac cccaggtgct ccatccttga ccagtgtgat
     2461 tccaacggct gttgaaaggt tgaaagagca gaacctcgtc agggagctga ggtcccggga
     2521 gctggacagt agtagtgaca gcgatgagaa ggtccacctg gccaagccct cctcactgtc
     2581 caagcgcaaa cttgagcttg aggtggagac ggtggagaag aagaagaaag gccgccctag
     2641 gaaggactcc cgtcttctgc ccgtgtctct gtccgtccag tctccagctg ccctgtctgc
     2701 agagaaggag gccatgtgtc tgtctgcacc agcacttgca ctgaagctgc caattccagg
     2761 cccgcagaga gcattcaccc tccaggtgag ctctgacccc tccatgtaca ttgaggtgga
     2821 gaatgaagtg accactgttg gggggataag actgagtcgc ctgaagtgca accgtgaagg
     2881 gaaggagtgg gagacagtgc tcagcagccg tgtcctcact gctgccggca gctgtgatgt
     2941 ggtatgtgtt gcctgtgaaa agaggatgct gtcggtgttc tctacctgtg gtcgccgtct
     3001 ccttcccccc atcctccttc catctccaat ttctactttg cactgcacgg gcccctacgt
     3061 catggcactc accgctgcag ccacactgtc tgtctgggat gttcaccgac aggtggtggt
     3121 ggtgaaagaa gagtctctac actccatctt gtcaggaagt gatatgacgg tgtcacagat
     3181 cttgctaaca cagcatggaa tcccagtgat gaatttgtca gatgggaaag cctactgttt
     3241 taatccatcc ctgtctacat ggaacctggt ttctgacaag caagattcac tggcccagtg
     3301 tgcagacttc aggaacagcc tgccatccca ggatgccatg ctgtgttcag gaccattagc
     3361 cataattcaa ggccgtacct ccaactctgg aaggcaagct gcccggctct tctctgtgcc
     3421 tcacgtggtg cagcaggaga gcaccctggc ctacctagag agccaggttg ctgcggcact
     3481 cactctgcag tcaagccacg agtatcgcca ctggctcctc ctctacgctc ggtacctcgt
     3541 gaacgaaggg tttgaatacc gcctccggga aatatgccag gacttgctgg gtccagttca
     3601 ctgctccaca ggaagtcagt gggagtcaac agtagtgggt ctgcggaaaa gagaactgct
     3661 gaaggaactg ctgccagtca tcgggcagaa tcttcgattc cagcgcctct ttactgagtg
     3721 ccaggaacaa ctggacatcc tgagagacaa gtagcctgcc ctggcttgcc ccagctgctg
     3781 caagggcaga gccacacagt tgccactggc aggtgcccgg ggctagcccc gcctgtcatg
     3841 gtaggagtag gaagagagac cttggcaggt gtgttgtcct gcaccagcac tagcccagtt
     3901 ctctgggtgg acatggccta tatcccaggc ctcgatgact ccgaaagggg gcagcttgtt
     3961 cctccataca ggcccaactg tggacttggg gctgaaactg gggctctggc ttgctgccct
     4021 ggggccagca gggatctctt gagcctgtct ccagctcggc cccaaggtag atgctggctc
     4081 ctgccactgc aggtgctgtg ctgcttcagc tataacgaat gagccatttg tgagagcacg
     4141 agcctgggat cgttagggat gatgcagtct gcaaatggac ccgaagcctg tgtaaaagca
     4201 aagctcttct gacacatgga ctatttttgt actagaattt gctaacttgg aatatggagt
     4261 ttcttttggt cgatcaggat atccctataa gttacttgga cattggtcac ttataggaaa
     4321 tttaaactct aattatgaca gctacactga aaaaaataat tgtactgaaa ttaacttgtc
     4381 tatcttcatt tggtttaatt tttaatgttt gtaaaaagag atactttgtg tgggggtggg
     4441 gtgggacaaa ggggagggca atttcttttc taagtgtaaa ataaatgaac atgcattgga
     4501 taccaaa
//
