LOCUS       NM_001395080            7437 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus homeodomain interacting protein kinase 3 (Hipk3),
            transcript variant 2, mRNA.
ACCESSION   NM_001395080 XM_006234658
VERSION     NM_001395080.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7437)
  AUTHORS   Wang,X., Zhang,T., Zhai,J., Wang,Z., Wang,Y., He,L., Ma,S., Xing,H.
            and Guo,Y.
  TITLE     MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by
            regulating HIPK3 expression
  JOURNAL   Biosci Rep 43 (9) (2023)
   PUBMED   37581369
  REMARK    GeneRIF: MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by
            regulating HIPK3 expression.
REFERENCE   2  (bases 1 to 7437)
  AUTHORS   Ma,Z.F., Wang,N., Zhang,J., Wan,Y.F., Xiao,N. and Chen,C.
  TITLE     Overexpression of miR-431 inhibits cardiomyocyte apoptosis
            following myocardial infarction via targeting HIPK3
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (4), 2056-2064 (2021)
   PUBMED   33660818
  REMARK    GeneRIF: Overexpression of miR-431 inhibits cardiomyocyte apoptosis
            following myocardial infarction via targeting HIPK3.
REFERENCE   3  (bases 1 to 7437)
  AUTHORS   Liu,B., Hou,Q., Ma,Y. and Han,X.
  TITLE     HIPK3 Mediates Inflammatory Cytokines and Oxidative Stress Markers
            in Monocytes in a Rat Model of Sepsis Through the JNK/c-Jun
            Signaling Pathway
  JOURNAL   Inflammation 43 (3), 1127-1142 (2020)
   PUBMED   32356246
  REMARK    GeneRIF: HIPK3 Mediates Inflammatory Cytokines and Oxidative Stress
            Markers in Monocytes in a Rat Model of Sepsis Through the JNK/c-Jun
            Signaling Pathway.
REFERENCE   4  (bases 1 to 7437)
  AUTHORS   Lan,H.C., Li,H.J., Lin,G., Lai,P.Y. and Chung,B.C.
  TITLE     Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through
            homeodomain-interacting protein kinase 3-mediated Jun N-terminal
            kinase and c-Jun phosphorylation
  JOURNAL   Mol Cell Biol 27 (6), 2027-2036 (2007)
   PUBMED   17210646
REFERENCE   5  (bases 1 to 7437)
  AUTHORS   Curtin,J.F. and Cotter,T.G.
  TITLE     JNK regulates HIPK3 expression and promotes resistance to
            Fas-mediated apoptosis in DU 145 prostate carcinoma cells
  JOURNAL   J Biol Chem 279 (17), 17090-17100 (2004)
   PUBMED   14766760
REFERENCE   6  (bases 1 to 7437)
  AUTHORS   Rochat-Steiner,V., Becker,K., Micheau,O., Schneider,P., Burns,K.
            and Tschopp,J.
  TITLE     FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that
            induces FADD phosphorylation and inhibits fas-mediated Jun
            NH(2)-terminal kinase activation
  JOURNAL   J Exp Med 192 (8), 1165-1174 (2000)
   PUBMED   11034606
REFERENCE   7  (bases 1 to 7437)
  AUTHORS   Ebling,F.J., Brooks,A.N., Cronin,A.S., Ford,H. and Kerr,J.B.
  TITLE     Estrogenic induction of spermatogenesis in the hypogonadal mouse
  JOURNAL   Endocrinology 141 (8), 2861-2869 (2000)
   PUBMED   10919273
REFERENCE   8  (bases 1 to 7437)
  AUTHORS   Moilanen,A.M., Karvonen,U., Poukka,H., Janne,O.A. and Palvimo,J.J.
  TITLE     Activation of androgen receptor function by a novel nuclear protein
            kinase
  JOURNAL   Mol Biol Cell 9 (9), 2527-2543 (1998)
   PUBMED   9725910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jun 3, 2021 this sequence version replaced XM_006234658.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100068.1, SRR26360176.2301527.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               JAXUCZ010000003.1  111320725-111321192 c
            469-1567            JAXUCZ010000003.1  111299022-111300120 c
            1568-1691           JAXUCZ010000003.1  111271396-111271519 c
            1692-1811           JAXUCZ010000003.1  111266080-111266199 c
            1812-1898           JAXUCZ010000003.1  111265071-111265157 c
            1899-2083           JAXUCZ010000003.1  111264221-111264405 c
            2084-2240           JAXUCZ010000003.1  111262939-111263095 c
            2241-2364           JAXUCZ010000003.1  111262301-111262424 c
            2365-2486           JAXUCZ010000003.1  111260138-111260259 c
            2487-2614           JAXUCZ010000003.1  111259792-111259919 c
            2615-2776           JAXUCZ010000003.1  111259538-111259699 c
            2777-3067           JAXUCZ010000003.1  111258754-111259044 c
            3068-3208           JAXUCZ010000003.1  111258353-111258493 c
            3209-3444           JAXUCZ010000003.1  111256555-111256790 c
            3445-3572           JAXUCZ010000003.1  111256140-111256267 c
            3573-7437           JAXUCZ010000003.1  111251863-111255727 c
FEATURES             Location/Qualifiers
     source          1..7437
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q32"
     gene            1..7437
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /note="homeodomain interacting protein kinase 3"
                     /db_xref="GeneID:83617"
                     /db_xref="RGD:619884"
     exon            1..468
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            469..1567
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             471..4049
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     androgen receptor-interacting nuclear protein kinase;
                     nuclear serine/threonine protein kinase"
                     /codon_start=1
                     /product="homeodomain-interacting protein kinase 3 isoform
                     2"
                     /protein_id="NP_001382009.1"
                     /db_xref="GeneID:83617"
                     /db_xref="RGD:619884"
                     /translation="MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSGCVFQERACPQIH
                     VNGRHFGNPLPSTKGSAFQTKIPFSKPRGHSFSLQAGAIVVKDTAGATKVIAAQAQQA
                     GVEAPRAVVWRNRLHFLGGPQRCGLKRKSEELDNHSGAMQIVDELSILPAMLQTNMGN
                     PVTVVTATTGSKQNCTSGEGDYQLVQHEVLCSVKNTYEVLDFLGRGTFGQVVKCWKRG
                     TNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFE
                     MLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPV
                     RQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAEL
                     FLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSGWRLKTLE
                     EHEAETGMKSKEARKYIFNSLDDIVHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLI
                     DADLRITPIETLNHPFVSMKHLLDFPHSSHVKSCFHIMDICKSPSSCETNNHSKMSLL
                     RPVASNGTAALAANFTKVGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFHQTLI
                     ICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQQTWSGRTQQM
                     LIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMIPHSNHYNSVMPPPLLTNQITLS
                     APQPISVGIAHVVWPQPATTKKNKLCQNRSNSLQNTNVPHSAFISPKIISGKEVEEVS
                     CVETQDNHTSEGEARTCHEASVRQDSSVSDKQRQTIIIADSPSPAVSVITISSDTDDE
                     ETSPRPSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSM
                     SDDEQESGCETVDGSPTSDSSGHDSPFAESSFVEDTPQNPELGTCAGTEAKPALSTAV
                     EPPVGTERGLNVDAHMANTDSTCQPLTKGQPAPGKLNQPSASAARQQKPTSAFQQQHL
                     NLSQVQHFGTGHQEWNGNLGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGSAH
                     LGGQPTLLPYPPSTALSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGIN
                     PRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM"
     exon            1568..1691
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1811
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1898
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2083
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2240
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2364
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2486
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2614
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2776
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..3067
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3208
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3444
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3572
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
     exon            3573..7437
                     /gene="Hipk3"
                     /gene_synonym="ANPK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggttgcgc aacggctctt cccagcaacc gaagttttgt ttggtcccac ggggggcccc
       61 ctctttcagc tcggtggctc taggccgtca ctacggagac ctcgttcctt tcattgatgg
      121 gagcgaacac caacgtgcac acacgccgcc ggagcgccca gccccgtggc tgtgccgcgg
      181 aggcttggtg gccctgtcac cggcgtcgcg gggcggcggg tttggagggt gtcaactctg
      241 gggacgtgcg tgcgtgtgat tgttggggag gagaaatgtg atccgcggct tcgcgtcccc
      301 agcggcggcg ggaggaaggc gtggcggccg cgcggcgggg ctgttgccgg cttctctcgt
      361 tacggcggcg gcggccctct tcccttcgcg ctgggggaga tcagcggaaa ggactcggga
      421 ccagaatgtc tgttttcctg tctgagggga gacggctgtt gtaaaatggt atggcctcac
      481 aagtcttggt ctacccacca tatgtttatc aaactcagtc aagtgccttt tgtagtgtga
      541 agaaactgaa agtagagccc agcggttgtg ttttccagga aagagcctgc cctcagatcc
      601 atgtgaatgg tagacacttt ggaaatcctc ttccttccac gaagggtagt gctttccaga
      661 caaagatacc attctctaaa cctcgaggac acagcttttc actgcaggca ggggccattg
      721 ttgtcaaaga cactgccggt gctacaaagg tcatagcagc tcaggcgcag caggctggag
      781 tggaggcacc tcgggccgtg gtgtggagaa acaggctaca tttcctagga ggtccccagc
      841 gatgcgggtt aaagcgcaag agtgaggagt tggataatca cagcggcgcg atgcagattg
      901 tcgatgaact gtccatactt cctgcaatgt tgcaaaccaa catgggaaac ccagtgacag
      961 ttgtgacagc gaccacagga tcgaaacaga actgtaccag tggggaaggt gactatcagt
     1021 tagtgcagca cgaagtcttg tgctctgtga aaaacacata tgaagtcctg gattttcttg
     1081 gtcgtggcac tttcggccag gttgttaaat gctggaagag agggacaaat gaaattgtag
     1141 ccattaaaat tttgaagaat cacccttcgt atgcacgtca agggcagata gaagtgagca
     1201 tcttagcaag gctcagtact gagaacgctg atgagtataa ctttgtgcga gcctatgagt
     1261 gcttccagca ccgcaaccat acctgcctgg tctttgagat gctggagcag aacctgtatg
     1321 acttcctgaa acagaataaa ttcagtccct tgcccctaaa ggtgatccgg cccgttcttc
     1381 agcaagtggc cactgcactg aagaaattaa aaagtcttgg tttaattcat gctgacctta
     1441 aaccagagaa tattatgttg gtggatcctg ttcgacagcc atacagggtt aaagtgatag
     1501 actttggatc ggccagtcat gtatcaaaga ctgtttgctc aacgtatcta caatctcggt
     1561 actatagagc tccagagatt atattggggt tgccgttttg tgaagccata gacatgtggt
     1621 cactgggatg cgtgattgca gagttattcc ttggatggcc actctacccg ggagccttgg
     1681 agtatgacca gattcgatac atttctcaga ctcaaggttt accaggagaa caattgttga
     1741 atgtgggtac aaaatccaca agattttttt gcagagaaac agatatgtct cattctggtt
     1801 ggaggttaaa gacactggaa gagcatgaag cagagacagg aatgaagtct aaagaggcca
     1861 gaaagtacat attcaacagt ctggacgata tagtgcatgt gaacacagtg atggacttgg
     1921 aaggaagtga tctcttggct gagaaagctg atagaagaga atttgttagt ctgttgaaga
     1981 aaatgttgct gattgatgca gatttaagaa ttactccgat cgagactctg aaccacccat
     2041 tcgttagtat gaagcaccta ctagattttc ctcacagcag ccatgtaaag tcctgttttc
     2101 atatcatgga tatttgtaag tctccgagtt catgtgaaac aaacaaccac agtaaaatgt
     2161 cactcttacg accagttgca tccaatggca ctgctgctct agcggcaaac tttactaaag
     2221 tcggaacatt aagaagtcag gcgttgacca catctgctca ctcggtcgtg caccatggta
     2281 tacctctgca ggcggggacc gcacagttcg gttgtggtga tgcttttcat cagaccctga
     2341 ttatctgtcc cccagctatt caaggtattc ccgcagcaca tggtaagccc accagttatt
     2401 ccataagggt ggacaacaca gttccgcttg tgactcaggc cccagctgta cagcctctgc
     2461 agatccgacc aggagtcctt tcacagcaga catggtctgg tcgaacacag cagatgctaa
     2521 tacctgcctg gcagcaggta acacccatgg ctcctgctgc tgcaacacta acttctgaag
     2581 gcatggctgg ttcacagagg cttggagact gggggaaaat gattccacac agcaatcatt
     2641 ataactccgt gatgccgcca cctcttctga ccaaccagat aacattgtcg gcccctcagc
     2701 ctatcagcgt aggcatcgca catgttgtct ggcctcagcc tgccactacc aagaaaaata
     2761 agctgtgcca gaacaggagt aattcattgc agaacaccaa tgtcccacat tcagcattta
     2821 tttctccaaa gataatcagt gggaaagaag ttgaggaagt aagttgtgta gaaacacagg
     2881 acaatcatac ctcagaagga gaggcaagaa cttgccatga agcgtctgtc agacaggatt
     2941 cttcagtttc agacaaacag cggcaaacca tcatcattgc cgactcccca agtcctgccg
     3001 tgagtgtgat caccattagc agtgacactg atgacgaaga gacctcaccc agaccttcac
     3061 tccgagagtg taaaggtagt ctggattgtg aagcttgcca aagcactttg aatattgatc
     3121 ggatgtgttc actcagcagt cccgacagca ctctgagtac cagctcctca gggcagtcca
     3181 gcccatcccc ttgcaaaaga ccgaacagta tgtcagatga tgaacaggaa agtgggtgtg
     3241 agactgtgga cggctctcca acgtcagact cctcggggca tgacagtcca tttgcagaga
     3301 gcagttttgt ggaagacact cctcaaaacc cagagctggg gacttgtgct ggcacagagg
     3361 ccaagccagc tcttagcact gctgtggagc caccagtggg gacagagcgt ggcctgaacg
     3421 tcgatgcgca catggccaac acagattcta catgccagcc attgacaaaa ggccagcccg
     3481 cccctggaaa gctgaaccag ccctctgcct cggctgctcg tcagcaaaag cccacatcag
     3541 cattccagca gcagcatttg aacctgagcc aggttcagca tttcggaact gggcatcaag
     3601 aatggaatgg aaacttgggg catcgaagac agcaagcata tattcctact agtgttacca
     3661 gtaatccatt cactctttct cacggaagtc ccaaccacac agcagtgcat gcccatctgg
     3721 ctggaagtgc gcacctcgga ggacagccca ctctgcttcc gtacccgcca tcaactgccc
     3781 tcagtagtgc tgcacccgtg gcccacctcc tagcctctcc gtgtacctca agacctatgt
     3841 tacagcatcc aacttataat atctcccatc ccagtggcat agttcaccaa gtccccgtgg
     3901 gcataaatcc ccgcctgtta ccatccccga ccattcatca gactcagtac aaaccaatct
     3961 tccctccaca ttcttacatt gcagcatcgc ctgcatatac tggatttcca ttgagtccaa
     4021 caaaactcag ccagtatcca tatatgtgaa aactcgaaag cagtttattg aggaagctca
     4081 atgatacaaa cgtttgatta aaaataaaaa catggtattt aataaatatt agccatggca
     4141 caagaaaatt atttttgaat catgtagact tgggtgcaat ttaaacaact ttgagcttta
     4201 aaaaactcac ttttaatgtg ttttgcacat ttggtataac ttgtctttgg tcatgtatct
     4261 tcttatgtag taactctata gacaggtgac ttatgggagc aaaattccag ttttgctcct
     4321 gctatttttt ataaaattgc cttctaacta gtgcaagaca cgtccacctt tgggaagcca
     4381 ttctgtgtct agacttagag caacagatgc acatgtgtca gaattccagc ctatgagtga
     4441 agtgtatcgt ctgtgtcttc gtgtgtacat gttggggcac ttaacctaag caattgagct
     4501 attgttcttt acattgcatg tgtcttttgc atgggcaaaa tgttgcctag acttggctct
     4561 taatgttgtt gtaataatct cagctgcatt gtaaaccgtt cccacacata gtgccttaaa
     4621 tatttgaggt tgttgaagtt attacctatc tgtaaatgtt ggactgcagc acttaaaatt
     4681 cagacctact cctgagttct ctttcagtag agtaatgttc cttttggttt tgtgtggtat
     4741 gatttcagat agtagctgct ttttccttat taagagggca gcatgtttgc tatagctgaa
     4801 ttctgctgcc tgattttttt cagaatgatc tagcttcaag aaaagcaagc cgttcgtagt
     4861 gcttaagaaa acttgattca gtaactaatg gatagttgat acctgtcaca cacagcacag
     4921 cattttatat acttttaagg gaaactgcaa tacaacctaa gtttattttg ggagtgtttg
     4981 ctgtataatt ggacttgata aaatggttag aggtgcagta ggcatgactt gagtagataa
     5041 tgaaagaaaa tgcaaatgct catcgaccca tgatgtgctc tttcttgctt gggcagacca
     5101 tgcagtattt aacacattag tagcagaata tttactattg aagcttgaaa agatgtgagt
     5161 tctttgtgtg caatttttca tttatgcatg tgaggaggtt ttggttttgg ttattcttaa
     5221 gtatttttac attgtagtac tcgtttttgc ttgttggtgg tgtttgctta tttaatacat
     5281 tccgtcaggg acagaaatta catgcttttt ctcttaggaa gtgtgtattg ggtttttccc
     5341 tccccctctc cccttggtgg tgatggtggt gatgtttaaa tgaagttgct tttacagcac
     5401 caaagactta atcatccatt tcttatataa aaggtagcta cattttgcat agacctcaag
     5461 tatattgtag tgtagaggtg gaatttaagg aaaggtatta aaccaaggct gtgttttagc
     5521 ttacaggcaa gtaataaatt gtatcattta tcttgaatgt atcatagata agctgctata
     5581 taacgattgc cacttcagat agctgtgaaa ttaggtgatt aactagttgt tatttagctt
     5641 tctaatttct gtataagtct aattacacaa gatagaagct ggggttttga tttttttttt
     5701 tactttgctt ttctgtttgg agtgtcattg taactactgt attgtaaatg atggaaacaa
     5761 ttgcctatgt tattttgggg tgtgttattt gcatcagtat tttatctatt aatgtttgtg
     5821 ttcattacgg catatacaaa cttggatgta tcaatgtaac ttaatttttt tattttcata
     5881 ctggcattgt agacacatga gaaagctgta tcttgcaggc ttgacttaac tttttttttt
     5941 tccttaaaag tctggaatat aatcttacag catttactgg aataaacagt acaaaacatt
     6001 tgagtgtaga actccaaatg ttttggactg acagcatttc cttcctaagc acgttgcata
     6061 ccacaagtac agttctagta tgcgctgatg gtaagctaag agtgataaca tttttcttta
     6121 ctccatgaca caagcagtgt tttatttaac aatcatccat gacataaacg tgcctgaagt
     6181 tgattttaaa aattacagta ttagatcata agataaaaac cagcagcaca tttttagtca
     6241 ctgaaaatga aggacttgat tcccccacag gtctcagtgt ttttagtaat tgattctatg
     6301 cattttatat aaatagaaat atatataaca cacgttacaa aaaggagtgg actgagatta
     6361 acttaaagac gatttacagg cgacacgtct gtggagtcag taagtaactg ctgcccgcca
     6421 cggcctcctc atgcgagcta atggcctcac ttcttggaaa agattcagtg ctggcgatgg
     6481 atggatgttt cagaatcacc aagtccacag attgattatg tcacaacagg gagaaaagtg
     6541 gcctgtaagc tgtgcttact gcctaagaag atgctctttc tttctgcttt taagttcatg
     6601 agtggagcag ccttgttaag ttgactgtag agggtgacag tcagcatttt cataccgcag
     6661 taatgctttc taaaggcatg tcactgtcga gtgcactgct cttaattcac tgcaatcatg
     6721 ggctttttaa tgtatttcaa aacttaagac ttcaagatcc ccctgaagtc taattttagc
     6781 aaattggcag aaggatctgg attttacccc ctctaaaact attttaatag ttttatttta
     6841 atgttttctt aaataaaaca ctgcatgatt tccaagttgc atatttgtgt gctaattttg
     6901 caagtgaatt tttaatcagt tattttgata tttaggtttt ttccttcagg gtatttaata
     6961 tattactcta ttagcaaatc ttttcatttt aatatctcta ctgctgattt taaacttggc
     7021 ttgtgttctg taaaagttaa atcatacact gcaaggtgta ggaagattca ttttaatgat
     7081 cccaatgaca gattcgatga cttagtttga actattaact gttgaacagt tttactcgcg
     7141 tggcttctgt cttggtttga tttgctttga cttctgtgct acactagttt gccatgtagc
     7201 agttgcactg tgcaatatta caataaggac tgggaaaact tttatggatg taatgtctat
     7261 tacagtttgc gatagtattt ctctctagtt ctcagtgatt taaatgtgac caagccttct
     7321 gtactttgtc acaaaaagcg ggttttccag gtgactattt tggtgagtgt caaaataaga
     7381 atttatggtg tattactgtt gattcacttt gaattaaaat atatatattg cagcaaa
//
