LOCUS       NM_001108622            4851 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus homeodomain interacting protein kinase 2 (Hipk2),
            mRNA.
ACCESSION   NM_001108622 XM_001066598 XM_001066649 XM_001066707 XM_001066758
            XM_001066812 XM_001066856 XM_342662
VERSION     NM_001108622.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4851)
  AUTHORS   Zhou,Q., Meng,D., Li,F., Zhang,X., Liu,L., Zhu,Y., Liu,S., Xu,M.,
            Deng,J., Lei,Z., Sluijter,J.P.G. and Xiao,J.
  TITLE     Inhibition of HIPK2 protects stress-induced pathological cardiac
            remodeling
  JOURNAL   EBioMedicine 85, 104274 (2022)
   PUBMED   36182775
  REMARK    GeneRIF: Inhibition of HIPK2 protects stress-induced pathological
            cardiac remodeling.
REFERENCE   2  (bases 1 to 4851)
  AUTHORS   Li,R., Han,J., Chen,B. and Shang,J.
  TITLE     Homeodomain Interacting Protein Kinase 2-Modified Rat Spinal
            Astrocytes Affect Neurofunctional Recovery After Spinal Cord Injury
  JOURNAL   Curr Neurovasc Res 19 (2), 171-180 (2022)
   PUBMED   35652392
  REMARK    GeneRIF: Homeodomain Interacting Protein Kinase 2-Modified Rat
            Spinal Astrocytes Affect Neurofunctional Recovery After Spinal Cord
            Injury.
REFERENCE   3  (bases 1 to 4851)
  AUTHORS   Wu,C.G. and Huang,C.
  TITLE     MicroRNA-147 inhibits myocardial inflammation and apoptosis
            following myocardial infarction via targeting HIPK2
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 6279-6287 (2020)
   PUBMED   32572895
  REMARK    GeneRIF: MicroRNA-147 inhibits myocardial inflammation and
            apoptosis following myocardial infarction via targeting HIPK2.
REFERENCE   4  (bases 1 to 4851)
  AUTHORS   Cai,D.L., Chen,L.X., Wang,L.M. and Zhao,T.N.
  TITLE     Effects of homeodomain-interacting protein kinase 2 on renal
            tubular epithelial cells
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 6228-6236 (2020)
   PUBMED   32572889
  REMARK    GeneRIF: Effects of homeodomain-interacting protein kinase 2 on
            renal tubular epithelial cells.
REFERENCE   5  (bases 1 to 4851)
  AUTHORS   Li,R., Shang,J., Zhou,W., Jiang,L., Xie,D. and Tu,G.
  TITLE     Overexpression of HIPK2 attenuates spinal cord injury in rats by
            modulating apoptosis, oxidative stress, and inflammation
  JOURNAL   Biomed Pharmacother 103, 127-134 (2018)
   PUBMED   29649627
  REMARK    GeneRIF: overexpression of HIPK2 improved contusive spinal cord
            injury induced pain by modulating oxidative stress, Bcl2 and Bax
            signaling, and inflammation, and also regulating autophagy.
REFERENCE   6  (bases 1 to 4851)
  AUTHORS   Moller,A., Sirma,H., Hofmann,T.G., Staege,H., Gresko,E., Ludi,K.S.,
            Klimczak,E., Droge,W., Will,H. and Schmitz,M.L.
  TITLE     Sp100 is important for the stimulatory effect of
            homeodomain-interacting protein kinase-2 on p53-dependent gene
            expression
  JOURNAL   Oncogene 22 (54), 8731-8737 (2003)
   PUBMED   14647468
REFERENCE   7  (bases 1 to 4851)
  AUTHORS   Harada,J., Kokura,K., Kanei-Ishii,C., Nomura,T., Khan,M.M., Kim,Y.
            and Ishii,S.
  TITLE     Requirement of the co-repressor homeodomain-interacting protein
            kinase 2 for ski-mediated inhibition of bone morphogenetic
            protein-induced transcriptional activation
  JOURNAL   J Biol Chem 278 (40), 38998-39005 (2003)
   PUBMED   12874272
REFERENCE   8  (bases 1 to 4851)
  AUTHORS   Wang,Y., Marion Schneider,E., Li,X., Duttenhofer,I., Debatin,K. and
            Hug,H.
  TITLE     HIPK2 associates with RanBPM
  JOURNAL   Biochem Biophys Res Commun 297 (1), 148-153 (2002)
   PUBMED   12220523
REFERENCE   9  (bases 1 to 4851)
  AUTHORS   Wang,W., Link,V. and Green,J.M.
  TITLE     Identification and cloning of a CD43-associated serine/threonine
            kinase
  JOURNAL   Cell Immunol 205 (1), 34-39 (2000)
   PUBMED   11078605
REFERENCE   10 (bases 1 to 4851)
  AUTHORS   Kim,Y.H., Choi,C.Y., Lee,S.J., Conti,M.A. and Kim,Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            [WARNING] On Apr 12, 2024 this sequence was replaced by
            NM_001108622.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001066812.1, XM_001066856.1, XM_001066707.1, XM_001066598.1,
            XM_001066758.1, XM_342662.3, XM_001066649.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4851
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..4851
                     /gene="Hipk2"
                     /note="homeodomain interacting protein kinase 2"
                     /db_xref="GeneID:362342"
                     /db_xref="RGD:1309349"
     exon            1..108
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..3677
                     /gene="Hipk2"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="homeodomain-interacting protein kinase 2"
                     /protein_id="NP_001102092.1"
                     /db_xref="GeneID:362342"
                     /db_xref="RGD:1309349"
                     /translation="MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKVEPSSNWDMTGY
                     GSHSKVYSQSKNIPPSQPASTTVSTSLPIPNPSLPYEQTIIFPGSTGHIVVTSASSTS
                     VTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASG
                     ATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWK
                     RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV
                     FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVD
                     PSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIA
                     ELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT
                     PDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKML
                     TIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKT
                     PFITHVAPSTSTNLTMTFNNQLTTVHNQAPTSTSATLSLANPEVSILNYQSTLYQPSA
                     ASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENA
                     VPIVTQAPGAQPLQIQPGLLAQAWPGGAQQILLPPAWQQLTGVATHTSVQHAAVIPET
                     MAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTT
                     SSRKSKQHQSSARNVSTCEVTSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSLTC
                     GWGDGASSTTRDRQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNV
                     ISCVTVHDSPYSDSSSNTSPYSVQQRTGHNGTNTLDTKGGLENHCTGNPRTIIVPPLK
                     TQASEVLVECDSLGPAISTGHHSSSFKSKSSSTVTSTSGHSSGSSSGAIAYRQQRPGP
                     HFQQQQPLNLSQAQQHMAADRTGSHRRQQAYITPTMAQAPYTFPHSSPSHGTVHPHLA
                     AAAHLPAQPHLYTYTAPTALGSTSTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMG
                     PRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI"
     exon            109..1192
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1316
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1436
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1523
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1708
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1871
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2079
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2201
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2341
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2521
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2803
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..3051
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3215
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..4851
                     /gene="Hipk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcagatt cccactgagg ctgagggggc cgagctcgcg cgccgcgttc ccttctccgt
       61 tgccatgaac cgcggacacc ccggccccga tggcccccgt gtacgaaggt atggcctcac
      121 atgtgcaagt tttctcccct cacacccttc aatcaagtgc cttctgtagt gtgaagaaac
      181 taaaagtaga gccaagttcc aactgggaca tgactgggta cggctcccac agcaaagtgt
      241 acagccagag caagaacata ccaccttctc agccagcctc cacaaccgtc agcacctcct
      301 tgccaatccc aaacccaagc ctaccttacg agcagaccat catcttccca ggaagtactg
      361 gacacatagt tgtaacatca gcaagtagca cttctgtcac cgggcaagtc ctcggtggac
      421 cacataacct aatgcgtcga agcactgtga gcctccttga cacctaccaa aaatgtggac
      481 tcaagcgcaa gagtgaggag attgagaaca caagcagcgt gcagatcatt gaggagcatc
      541 cacccatgat tcagaataat gccagcgggg ccactgtcgc cactgccacc acatccactg
      601 ccacctccaa aaacagtggc tccaacagtg aaggtgacta tcagctggtg cagcatgaag
      661 tgctgtgctc tatgacaaac acctatgagg ttttagagtt cttggggcga gggacatttg
      721 ggcaagtggt caagtgctgg aaacggggca ccaatgaaat tgtggccatt aagatcctaa
      781 agaaccaccc atcctatgcc cggcaaggcc agattgaagt gagcatcctg gcccggctga
      841 gcacggagag cgctgatgac tacaattttg tgcgggccta tgagtgcttc cagcacaaga
      901 atcacacatg cttagtcttt gagatgttgg agcagaacct ctatgacttt ctgaaacaga
      961 acaagtttag tcccttgccc ctcaagtata ttcgcccagt cctccagcag gtagccacag
     1021 ccctgatgaa actcaaaagc ctgggtctta tccatgctga cctcaaacca gaaaacatca
     1081 tgctggtgga tccatccaga caaccatacc gagtgaaggt cattgacttt ggttcagcta
     1141 gtcatgtgtc caaagctgtc tgttctacgt acttgcaatc cagatactac agggcccctg
     1201 aaatcatcct tggtttgcca ttctgtgagg caattgacat gtggtccctg ggttgtgtca
     1261 ttgctgagct gttcctgggc tggccattat acccaggtgc ttctgagtat gatcagattc
     1321 ggtatatttc acaaacacag ggtttaccag ctgaatattt attaagtgca gggacaaaga
     1381 caactaggtt tttcaaccgt gacacagact caccgtatcc tttgtggagg ctaaagacac
     1441 cagatgacca tgaagcagag acggggatta aatcaaaaga agcaagaaag tacattttca
     1501 actgtttgga tgacatggcc caggtgaaca tgacaacaga tttggaaggg agtgacatgt
     1561 tagtagagaa ggcagaccgg cgggagttca ttgacctgtt aaagaagatg ctgaccatag
     1621 atgctgataa gaggatcact cccattgaaa ctctgaacca cccctttgtc accatgacgc
     1681 acctactgga ttttcctcat agtactcatg tcaaatcttg tttccaaaac atggagattt
     1741 gcaagcgccg ggtgaatatg tatgacacag tgaaccagag caaaacacct ttcatcacac
     1801 atgtggcccc cagcacatct accaacttga ccatgacctt taacaaccag ctgaccactg
     1861 tccacaacca ggctcccacc tccaccagtg ccactctttc cttagccaat cccgaagtct
     1921 ccatactaaa ctaccaatct acactctacc agccctcagc ggcatccatg gccgcagtgg
     1981 cccagcggag catgcccctg cagacgggaa cagcccaaat ttgtgcccgg cctgaccctt
     2041 tccagcaagc tctcatcgtg tgtccccctg gcttccaagg cctgcaggcc tctccctcca
     2101 agcacgctgg ctactcagtg cggatggaaa atgctgttcc catcgtcact caggctccgg
     2161 gcgctcagcc tcttcagatc cagccaggtc tgcttgctca ggcctggcca ggtggggccc
     2221 aacagatcct ccttcctcca gcatggcagc agctcactgg cgtggctacc cacacatccg
     2281 tacagcacgc agctgtgatt cccgagacca tggcaggcac tcagcaactg gctgactgga
     2341 gaaacacaca tgctcacgga agccattaca atcccatcat gcagcagcct gcactcttga
     2401 ctggtcatgt gacccttcca gctgcccagc ccttaaatgt gggtgtagcc cacgtgatga
     2461 gacagcaacc aaccagcacc acctcctcca ggaagagtaa gcagcaccaa tcatcagcga
     2521 gaaatgtctc cacctgtgaa gtgacctctt cccaggctat cagctcccct cagcgatcca
     2581 agcgtgtcaa ggagaacact cccccgaggt gtgcaatggt acacagcagc ccagcttgca
     2641 gcacctcact cacctgtggg tggggtgacg gggcctccag caccacccgg gaccgacagc
     2701 ggcagaccat tgtcatcccc gacaccccga gccccacagt cagtgtcatc accatcagca
     2761 gcgacacaga tgaggaggag gaacagaagc acgcccccac cagcacagtc tccaagcaaa
     2821 gaaaaaatgt catcagctgt gtcacagtcc atgattctcc ctactctgac tcctccagca
     2881 acaccagccc ctactcggtg cagcagcgca cagggcacaa cggcaccaac accttggaca
     2941 ccaagggggg cctagagaac cactgcaccg gcaacccccg caccatcatc gtacccccac
     3001 tgaagacgca ggccagtgaa gtgttggtag aatgtgacag cctagggcca gcaatcagta
     3061 ccggtcacca ttcatcctcc ttcaagtcca agtcctccag caccgtgacc tccaccagtg
     3121 gccactcttc agggagctcg tcaggagcca tcgcctaccg tcaacagcgg ccaggccccc
     3181 acttccagca gcagcagccc ctcaatctca gccaggctca gcagcacatg gctgcagacc
     3241 gcactgggag tcaccgtcgg cagcaggcct acatcactcc taccatggct caggctccgt
     3301 acaccttccc gcacagcagc cccagccatg gcactgttca cccccacctg gctgcggctg
     3361 cccacctccc tgcccagcct cacctctaca cctacacagc gcccacagcc ctaggctcca
     3421 ccagcactgt agcccacctg gtggcatccc aaggctcagc acgacacacc gtgcagcaca
     3481 ctgcctatcc ggccagcatc gtccaccagg tccccgtgag catggggccc cgggtcctgc
     3541 cctcgcccac cattcacccc agtcagtatc cggcccagtt tgcccaccag acctatatca
     3601 gcgcctcgcc agcctccacc gtctacactg gatatccact gagtcctgcc aaggtcaacc
     3661 aataccctta catataaaca ctggaggagg cccgccaggg aggagggtgg aggagctccc
     3721 agaccgacct ggggagctgg gaatttctac tgcaggtgcc gcacacaaac aatgcaaatg
     3781 gggcagggag gggggcagtt ggggcacaaa tgaaacttga actaggaagt gggaggactt
     3841 agagcggaaa agagaacatt ttaaaaggag gggtttaagg aggggaaatc tatgcttttt
     3901 attttaaaaa agaaaaagga aaaaagaaaa agaaaaatgt tagtaacaaa agaggaaaaa
     3961 aaagaaaaaa ccacagctca caaacccatt ctgcaccaaa ctggaaagga ggaggagtgg
     4021 aagactggaa gcaaggccca gtttttgaag aactttatga actttttaaa gattattttc
     4081 atatggcagc aagtgtcatt gaagaatttg ctgtcaggga cacctgatat ggaaatccaa
     4141 tagattttta attaattgaa cataaaaatt agggattttc ccagaactcc aaaagggtca
     4201 acatcccttt cacacgttag gccctggtct gaaaaggctc atatttgggg gttggtctgg
     4261 ggttggcaaa gcccagttct agcttgtttg tcagaaacgg tggggtcagg caaacaagtg
     4321 gaagatccct aagagaaagg cgggtttcct cttttggagc attctggata aatccctaag
     4381 caatgttagt cctcagatgt cattaatgat gtatgttgcc gtctttaatt tttttctttt
     4441 ctgagatttt ttttcttctc tttgaatcaa cccctagtcg tgtagcgtag ggctagtggt
     4501 tgtcctggac accctagaag aatgtagcac tgcacccttg tttcctacct tatgttcaac
     4561 tccagtgata ccaatagact attcctcagt ataattgcac aagcaaagtg atttaacata
     4621 ggcatggaac caatgtggtg gtccaggtta gcgagtgagt gtgcgtgagc acgtgtgggt
     4681 gtgaccgggg ctgccaccct ccccgtgtgt cccttggcac cgccgtcaca gcccttgcag
     4741 tcttgatttt acatcattcc ctcctagtgc cttaatgact gacagacaga gacacagcaa
     4801 agggtttact tccactggta ctccaagaaa ctggttgggg ctggtcattt g
//
