LOCUS       NM_001100986            7996 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus homeodomain interacting protein kinase 1 (Hipk1),
            mRNA.
ACCESSION   NM_001100986 XM_001064683 XM_345267
VERSION     NM_001100986.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7996)
  AUTHORS   Kulkarni,P., Jolly,M.K., Jia,D., Mooney,S.M., Bhargava,A.,
            Kagohara,L.T., Chen,Y., Hao,P., He,Y., Veltri,R.W., Grishaev,A.,
            Weninger,K., Levine,H. and Orban,J.
  TITLE     Phosphorylation-induced conformational dynamics in an intrinsically
            disordered protein and potential role in phenotypic heterogeneity
  JOURNAL   Proc Natl Acad Sci U S A 114 (13), E2644-E2653 (2017)
   PUBMED   28289210
REFERENCE   2  (bases 1 to 7996)
  AUTHORS   Mooney,S.M., Qiu,R., Kim,J.J., Sacho,E.J., Rajagopalan,K.,
            Johng,D., Shiraishi,T., Kulkarni,P. and Weninger,K.R.
  TITLE     Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation,
            is phosphorylated by homeodomain-interacting protein kinase 1, a
            component of the stress-response pathway
  JOURNAL   Biochemistry 53 (10), 1670-1679 (2014)
   PUBMED   24559171
REFERENCE   3  (bases 1 to 7996)
  AUTHORS   Shang,Y., Doan,C.N., Arnold,T.D., Lee,S., Tang,A.A., Reichardt,L.F.
            and Huang,E.J.
  TITLE     Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis
            via TGF-beta-TAK1-dependent mechanism
  JOURNAL   PLoS Biol 11 (4), e1001527 (2013)
   PUBMED   23565059
REFERENCE   4  (bases 1 to 7996)
  AUTHORS   Inoue,T., Kagawa,T., Inoue-Mochita,M., Isono,K., Ohtsu,N.,
            Nobuhisa,I., Fukushima,M., Tanihara,H. and Taga,T.
  TITLE     Involvement of the Hipk family in regulation of eyeball size, lens
            formation and retinal morphogenesis
  JOURNAL   FEBS Lett 584 (14), 3233-3238 (2010)
   PUBMED   20579985
REFERENCE   5  (bases 1 to 7996)
  AUTHORS   Isono,K., Nemoto,K., Li,Y., Takada,Y., Suzuki,R., Katsuki,M.,
            Nakagawara,A. and Koseki,H.
  TITLE     Overlapping roles for homeodomain-interacting protein kinases hipk1
            and hipk2 in the mediation of cell growth in response to
            morphogenetic and genotoxic signals
  JOURNAL   Mol Cell Biol 26 (7), 2758-2771 (2006)
   PUBMED   16537918
  REMARK    Erratum:[Mol Cell Biol. 2014 Jul;34(14):2772]
REFERENCE   6  (bases 1 to 7996)
  AUTHORS   Li,X., Zhang,R., Luo,D., Park,S.J., Wang,Q., Kim,Y. and Min,W.
  TITLE     Tumor necrosis factor alpha-induced desumoylation and cytoplasmic
            translocation of homeodomain-interacting protein kinase 1 are
            critical for apoptosis signal-regulating kinase 1-JNK/p38
            activation
  JOURNAL   J Biol Chem 280 (15), 15061-15070 (2005)
   PUBMED   15701637
REFERENCE   7  (bases 1 to 7996)
  AUTHORS   Kondo,S., Lu,Y., Debbas,M., Lin,A.W., Sarosi,I., Itie,A.,
            Wakeham,A., Tuan,J., Saris,C., Elliott,G., Ma,W., Benchimol,S.,
            Lowe,S.W., Mak,T.W. and Thukral,S.K.
  TITLE     Characterization of cells and gene-targeted mice deficient for the
            p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)
  JOURNAL   Proc Natl Acad Sci U S A 100 (9), 5431-5436 (2003)
   PUBMED   12702766
REFERENCE   8  (bases 1 to 7996)
  AUTHORS   Ecsedy,J.A., Michaelson,J.S. and Leder,P.
  TITLE     Homeodomain-interacting protein kinase 1 modulates Daxx
            localization, phosphorylation, and transcriptional activity
  JOURNAL   Mol Cell Biol 23 (3), 950-960 (2003)
   PUBMED   12529400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 20, 2007 this sequence version replaced
            XM_001064683.1, XM_345267.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF460311.1, SRR22582416.290191.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               JAXUCZ010000002.1  193987160-193987344 c
            186-1263            JAXUCZ010000002.1  193974087-193975164 c
            1264-1387           JAXUCZ010000002.1  193966578-193966701 c
            1388-1507           JAXUCZ010000002.1  193962165-193962284 c
            1508-1594           JAXUCZ010000002.1  193961357-193961443 c
            1595-1779           JAXUCZ010000002.1  193959253-193959437 c
            1780-1942           JAXUCZ010000002.1  193958799-193958961 c
            1943-2168           JAXUCZ010000002.1  193956377-193956602 c
            2169-2290           JAXUCZ010000002.1  193952048-193952169 c
            2291-2425           JAXUCZ010000002.1  193951160-193951294 c
            2426-2568           JAXUCZ010000002.1  193948512-193948654 c
            2569-2751           JAXUCZ010000002.1  193947923-193948105 c
            2752-2958           JAXUCZ010000002.1  193947059-193947265 c
            2959-3200           JAXUCZ010000002.1  193944727-193944968 c
            3201-3334           JAXUCZ010000002.1  193942829-193942962 c
            3335-7996           JAXUCZ010000002.1  193937261-193941922 c
FEATURES             Location/Qualifiers
     source          1..7996
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..7996
                     /gene="Hipk1"
                     /note="homeodomain interacting protein kinase 1"
                     /db_xref="GeneID:365895"
                     /db_xref="RGD:1304941"
     exon            1..185
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            186..1263
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..3823
                     /gene="Hipk1"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="homeodomain-interacting protein kinase 1"
                     /protein_id="NP_001094456.1"
                     /db_xref="GeneID:365895"
                     /db_xref="RGD:1304941"
                     /translation="MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYT
                     HSKTLPATQGQASSSHQVANFNIPAYDQGLLLQAPAVEHIVVTAADSSGSAATATFQS
                     SQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTT
                     TVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAI
                     KILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLY
                     DFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVK
                     VIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLY
                     PGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETG
                     IKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRVT
                     PLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPS
                     TSTNLTMSFSNQLSTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPPSAAPV
                     PGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPL
                     VPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVE
                     QTAAVLQAWPGGTQQILLPSAWQQLPGVALHNSVQPTAVIPEAMGSSQQLADWRNAHS
                     HGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSRKNKQSAPVSSTS
                     SLEVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDE
                     EEDNKFKPSSSSLKARSNVISYVTVNDSPDSDSSLSSPYPTDTLSALRGNSGTLLEGP
                     GRTAADGIGTRTIIVPPLKTQLGDCTGATQASGLLSSSKTKPVASVSGQSSGCCITPT
                     GYRAQRGGASAVQPLNLSQNQQSSSASTSQERSSNPAPRRQQAFVAPLSQAPYAFQHG
                     SPLHSTGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAY
                     TTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTK
                     ISQYSYL"
     exon            1264..1387
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1507
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1594
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1779
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1942
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2168
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2290
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2425
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2568
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2751
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2958
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3200
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3334
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..7996
                     /gene="Hipk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggaggct ggcgagactc cggccgcagg acgggcgcgg ggacggctcc ggggggcggg
       61 ggccggggcc cgggccggct cgtgcggggg gtatgatgac ccggcggcgg ggccccggat
      121 cgcctctcct ccgccgcctc ctcgcggcgg ccccgactcg aggctgagaa ctacacacac
      181 cggcggtatg gcatcacagc tgcaggtgtt ttcccctcca tcagtgtcgt cgagtgcctt
      241 ctgcagtgcg aagaaactga aaatagagcc ctctggctgg gatgtttcag gacagagcag
      301 caacgacaaa tattataccc acagcaaaac cctcccagct acacaagggc aagccagctc
      361 ctctcaccag gtagcaaatt tcaatattcc tgcttacgac cagggcctcc tcctccaggc
      421 tcctgcagtg gagcatattg tggtaacagc tgctgacagc tcaggcagtg ccgccacggc
      481 aaccttccaa agcagccaga ccctgactca caggagcaac gtttctttgc ttgagccata
      541 tcaaaaatgt ggattgaaaa gaaaaagtga ggaagtcgac agcaacggta gcgtgcagat
      601 catagaagaa catccccctc tcatgctgca aaacagaact gtggtgggtg ctgctgccac
      661 gaccaccact gtgaccacga agagtagcag ttctagcgga gaaggggatt accagctggt
      721 ccagcatgag atcctgtgct ctatgaccaa tagttatgaa gtcttggagt tcctaggccg
      781 agggacattt ggacaggtgg caaagtgctg gaagcggagc accaaggaaa ttgtggccat
      841 taagatcttg aagaaccacc cctcctatgc cagacaagga cagatcgaag tgagcatcct
      901 ttctcgccta agcagtgaga atgctgatga gtataatttt gtccgatctt atgagtgttt
      961 tcagcacaag aatcatacct gccttgtgtt tgagatgttg gagcagaatt tgtatgattt
     1021 tctaaagcag aacaagttta gcccactgcc actcaagtac ataagaccaa tcttgcagca
     1081 ggtggccaca gccctgatga agctgaagag tcttggtctg attcatgctg acctcaaacc
     1141 tgagaacatc atgctggttg atccagttcg ccaaccctac cgagtgaagg tcattgactt
     1201 tggttctgcg agtcatgttt ccaaagccgt atgttcaacc tacctgcaat cacgctacta
     1261 cagagctcct gaaattatcc ttgggttgcc attctgtgag gctattgaca tgtggtcgct
     1321 gggctgtgta atagctgagc tgttcctggg ctggcctctt tatcctggtg cttcagaata
     1381 cgatcagatt cgttatatct cacaaacaca aggcctgcca gctgaatatc tcctcagtgc
     1441 cggaacaaaa acaactaggt ttttcaacag agatcctaat ttggggtacc cactgtggag
     1501 gcttaagaca ccagaagaac atgaattaga gactggaata aagtcaaaag aagctcggaa
     1561 gtacattttt aactgtttag atgacatggc tcaggtaaat atgtctacag acttagaggg
     1621 aacagacatg ttggcagaaa aggcagaccg gagagaatac attgatctcc taaagaaaat
     1681 gctgacgatt gatgcagaca agagagtcac gcctctgaaa actcttaacc accagttcgt
     1741 gacaatgacc caccttctgg actttccaca cagtaaccat gttaagtctt gtttccagaa
     1801 catggagatc tgcaagcgga gggttcacat gtatgacaca gtgagtcaga tcaagagtcc
     1861 cttcactacc catgtggctc caagtacaag cacaaatcta accatgagct tcagcaacca
     1921 gctcagcaca gtgcacaacc aggccagtgt tttagcctcc agctctactg cagcagctgc
     1981 tactctttct ctggctaact cagacgtctc gctgctaaac taccagtcag ctttgtaccc
     2041 tccgtccgca gcgcccgttc ctggagttgc ccagcagggt gtttccttac agcctggaac
     2101 cacccagatc tgcacccaga cggacccatt ccagcaaaca ttcatagtgt gtccacctgc
     2161 ctttcagact gggctacaag caacaacaaa gcattctgga ttccctgtga ggatggataa
     2221 tgctgtgcca cttgtccccc aggcgcccgc agcccagcca ctgcagatac agtcaggagt
     2281 gctcacacag ggaagctgta caccactaat ggtagcaact ctccaccctc aagtagccac
     2341 catcacaccg cagtatgcgg tgccctttac cctgagctgc gcagccggcc ggccggcgct
     2401 ggttgaacag actgctgctg tactgcaagc ttggcctgga ggaacccaac agattctcct
     2461 gccttcagca tggcagcagc tgcctggggt cgctctacac aactctgtcc agcctactgc
     2521 agtgattcca gaggccatgg ggagcagcca gcagctagcc gactggagga atgcccactc
     2581 tcatggcaac cagtacagca ctatcatgca acagccatct ttgctgacta accatgtgac
     2641 gttggccact gcgcagcctc tgaatgttgg tgttgctcat gttgtcagac aacagcagtc
     2701 tagttccctc ccttcaagga agaataaaca gtctgctcca gtctcatcca catcttctct
     2761 ggaagttctg ccttcccaag tttattctct ggttggaagt agtcctcttc gtaccacatc
     2821 ttcttataat tccctagtcc ctgtccaaga ccagcatcag ccaatcatca ttccagacac
     2881 tcccagccct cctgtgagtg tcatcactat ccgtagtgac accgatgaag aagaggacaa
     2941 caaattcaag cccagcagct cgagcctgaa ggcgaggtct aatgtcatca gttatgtgac
     3001 tgtcaatgat tctccagact ctgactcctc cctgagcagc ccatacccca cagacactct
     3061 gagtgctctg cggggcaaca gcgggacact tctggaggga cctggcagaa ctgcagcaga
     3121 tggcattggc acccgtacga tcattgtgcc tcctttaaaa acacagcttg gcgactgtac
     3181 tggagcaaca caggcctcag gtctccttag cagtagtaag accaagccag tggcctcagt
     3241 gagtgggcag tcatctggat gctgtatcac tcccacaggg taccgagctc aacgaggggg
     3301 agccagcgcg gtgcagccac tcaaccttag ccagaaccag cagtcatcgt cagcttcaac
     3361 ctcgcaggaa agaagcagca accctgctcc ccgcagacag caggcatttg tggccccgct
     3421 ctcccaagcc ccctacgcct tccagcatgg cagcccactg cactcgacgg ggcacccaca
     3481 tttggcccca gcccctgctc acctgccaag ccagcctcac ctgtatacgt acgctgcccc
     3541 cacttctgct gctgcattgg gttccaccag ttccattgct catcttttct ccccccaggg
     3601 ttcctcaagg catgctgcag cttataccac ccaccccagc actctggtgc atcaggttcc
     3661 tgtcagtgtt gggcctagcc tcctcacctc tgccagtgtg gcccctgctc agtaccaaca
     3721 ccagtttgcc actcagtcct atattgggtc ttcccgaggc tcaacaattt acactggata
     3781 cccgctgagt cctaccaaga tcagtcagta ttcttatttg tagttgatga gcacgaggga
     3841 ggctcctggc tgcctgctac tagccctgag ttcttcatgg gctctgctga gagcctccat
     3901 tgtctcctct tggaagttac tagccagcag ctcgttgttc tgcaggggcc cactgaagca
     3961 gaaggctttt ctctgggaaa cagctctcag tcagtgttga ctgcattgtt gtagtctccc
     4021 aagtctgccc tggtttttaa ttctttattc ttgtgacagc aattttggac gttggaagag
     4081 ctcagaagcc cgtcttctgc agttacggag gaagaaaggt cgctctgaag tcacctgtca
     4141 tacatttggt ctcgttgacc tggtttttat aaatgttttc agaagaagta aagcccttta
     4201 tgagggaaaa tgctgataaa agatttgaaa tcttgtaaca gatgagaaag agtcattact
     4261 ttttgtttgt ttaaaaaaac taaaaaagga agacttcctt gccttttgtt ttaaaagcag
     4321 cttcggcaag gctgtacttt actgtcaggc atttctcctc aagagctgat ctttgctcgt
     4381 ggcacatcga cacatatatt gctttagttt tcgtgttgtg ctatccctgt cggacagttg
     4441 tcaggagttc agtggcccta gccgagccct gggacctgaa cagcagctgc tgcactcgtt
     4501 agagcagcac tgaaaagcag cccagtgctt gctggtgact cgtgcgagga ctgtgcccac
     4561 cacgattcat tttaaatgaa gcaccgtgaa ttctttctta gattattgtt ttaaagtcct
     4621 ccttctctct ctggtttaac ttatcttgta ctagaaaagc cagggaggtg gtaaatgtat
     4681 ggtggtgttt tgcttacaat agttcacaaa aatctctctc taggatgaga tgctggcact
     4741 gacgaacatt gcctaagatt tctatgaatt ttgaacaata cacttctgtg ttttcctcat
     4801 ctctcccttc tgtttcatgt ggcttattgg aggggaaagc taaagaaact aaaaccagat
     4861 aagtagtgta tagcttttat actttaaagt agcttccttt gtatgccaac agcaaattga
     4921 atgctctctt actaagactt atataataag tgcatgtagg aactgcagaa aatattttaa
     4981 aagtttatta ctgaatttaa aaatatttta gaagttttgt aatggtggtg ttttaatatt
     5041 ttgcataatt aaatatgtac atattgatta gaagaaatat aacaattttt cctctaaccc
     5101 aaaatgttat ttgtaatcag atgtgtagtg attacacttg aactgtgtat tagtgtgtat
     5161 ctgatcctgc agtgttaccc cggagatgga ttctgtctcc attgtattta aaccaaaatg
     5221 aactgatact tgttggaatg tgtgtgatct aactgcagtt ctgttagagc gtattactgt
     5281 agtgctgagt gaggggcatt gccgcagaga ggagacccgt ggggttgttt tgcacaggtg
     5341 tgtctggtga ggagttgttc agtgtgtgtc ttttccttcc tcctctcctc tcttccctta
     5401 ttgtagtgcc ttatatgata atgtagtggt taatagagtt tacagtgagc ttgccttagg
     5461 atgaccagca agccccagcg gaccccaagc tgttcactgg gatttaccag aacaggttta
     5521 gtagctgtgt tgtgtaactg cgttgttctc agtctcccta ccgacagtga gacatcaagg
     5581 ctgcagcttt tctcctttcc tgccacctct gtcctggtcc actttggacc ttcagctcag
     5641 ttctcacaga agcatcccca atatggctct ctcactgtgc cttgctacct ggcttctgtg
     5701 agagttcagg aagcaggtga gagcagtgaa gccagtgcta aatatgcata tttgaagatt
     5761 tgtgcaatca cttaggatgg gattcctctt tctcttttcc atgtgatagt cctttttgtg
     5821 catagttggt tgttgttact ggtaaacttt gccttttttt ttaaagcatg taacagatgt
     5881 gtttatacca aagagcctgt tgtattgctt aatatgcccc catattacaa gaagggtttt
     5941 gtagaatatc tggtgacaag aagctcacag agaggtttct taatcaatga caaatatgac
     6001 aaagaaagca aagcctcttg agtcaccaag actcccgagg tttctttgta acatgtatgt
     6061 tcttggggcc cttcaagctg tgaaattgtc ctagtactca actccttcat ggatttgggt
     6121 caagttgaag gtactaggga tggggacagt cttgcccatg aaggatttgt ggggagaagg
     6181 ttaaccctaa gctacagatg tggtccacct gaactgaaaa ctatatttga gtggtaattc
     6241 taggattggt gttgtgtaga gatggtgtca gggaggtgca ggatggagat ggggggtttc
     6301 atggagcctg ggcaaggaag ctctgaacca ggagaaacac cgaggagctg tcaacgaact
     6361 tggagtttct tcatcatggg gagtaagggt ttccagggca gggcaggtag tcagtacagc
     6421 ctgccaggaa catggtgtgt gttgttgtct ttcctttaat cattatatta agctgtgcat
     6481 tcagcagtct gttggttgag ataaccacgc atctgtgtag ttcgtcacta gtgttgtaca
     6541 gtttaagtca atctgtgtgc gatctttgtg tcttcttccc cccagcattc tggttttcct
     6601 atttaaatac agttcttgtt tctagtcaaa catttttttg taccttatct tttctctaca
     6661 agggacaaga tttattattg tttttgtagg aatgagatgc agggaaaaaa ccaaccaacc
     6721 ctgcccctgc cccctaactc atccaataag cagttattga agatgggagt cttaaattca
     6781 tgggaaaaga ggatgcctag gagtttgcat cattccctga agcatcggct agcagtgcct
     6841 gtacagactc tgaggttgtc actctgtaag tgacatctca gattcctaga taacccactg
     6901 tgtctgctga atgtgtatgt gccacacatg gctttacatt cattccgtcc tggggcttaa
     6961 cattcactgc ttgccctgat ggcatggagg gaaaccctat gaacatagcg agcgggtgag
     7021 ctgggtcagc attgcctgac cttggaactg tttaaggctt taaaccctct cttagaactt
     7081 gcatttccag tttctccctc cccaggtgag aaaggcagtg gaaagggttg catagccgca
     7141 ccaggacact aagtcactgc agagttccct gttgcaacta ggagatggtt acccttgtca
     7201 tgtcccactg aaatgccacc ccctggaatt agaaccccat ttcaaacaat tctggccatt
     7261 cacagcctgc tttgtggttt ctcattcacc atcctccact agaggggctt agccaggcca
     7321 gcacggaaca cgtgttttat tctgcagaaa tctattagtt gagatggttt gttttagggt
     7381 aggaaatgaa attgcccctc ggtgacagga atggccaagc ctgctttgta ttttgacttt
     7441 ttttaactga tggatggtgc agcatgtctc catgtttcca tggttgtttg ttggtaaact
     7501 ttatataatg tgtggtttca attcagcttg aaaaataatc tcactatatg tagcagtaca
     7561 ttatatgtac attatatgta atgttagtat ttctgctttg aatccttgat attgcaatgg
     7621 aattcctact ttattaaatg tatttgatat gctagttact gtgtgtggtt taaacttttt
     7681 tctttctccc ttttctggtt gtgtgcttcc ttttacaaca agcttctaga aacaggtagt
     7741 tctgagaatt actgatctat gttcgtaatg caggtgtact tagggagtat gtaaaataat
     7801 cattttaaca aaagaaatag ctatttaaaa tttaatacta actgggaaaa gggtccattg
     7861 tgtaaaacat agtttatctt tggatttgtt gttgtctttg gttttacaaa gtagcttgta
     7921 ttttcagtat tttctacata atatggtaaa aaaaagtaga gcaattgcaa tgcatcaata
     7981 aaatgggtaa attttc
//
