LOCUS       NM_001134763            4357 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus huntingtin interacting protein 1 related (Hip1r),
            transcript variant 1, mRNA.
ACCESSION   NM_001134763
VERSION     NM_001134763.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4357)
  AUTHORS   Catsburg,L.A., Westra,M., van Schaik,A.M. and MacGillavry,H.D.
  TITLE     Dynamics and nanoscale organization of the postsynaptic endocytic
            zone at excitatory synapses
  JOURNAL   Elife 11, e74387 (2022)
   PUBMED   35072626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4357)
  AUTHORS   Peng,L., Yang,Q., Xu,X., Du,Y., Wu,Y., Shi,X., Xu,J., Zhu,L. and
            Luo,J.
  TITLE     Huntingtin-Interacting Protein 1-Related Protein Plays a Critical
            Role in Dendritic Development and Excitatory Synapse Formation in
            Hippocampal Neurons
  JOURNAL   Front Mol Neurosci 10, 186 (2017)
   PUBMED   28663723
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4357)
  AUTHORS   Kim,J.H., Yoon,S., Won,M., Sim,S.H., Ko,J.J., Han,S., Lee,K.A.,
            Lee,K. and Bae,J.
  TITLE     HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces
            BAK-dependent cell death
  JOURNAL   Cell Physiol Biochem 23 (1-3), 43-52 (2009)
   PUBMED   19255499
REFERENCE   4  (bases 1 to 4357)
  AUTHORS   Wilbur,J.D., Chen,C.Y., Manalo,V., Hwang,P.K., Fletterick,R.J. and
            Brodsky,F.M.
  TITLE     Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R
            (Hip1-related protein) is regulated by clathrin light chain
  JOURNAL   J Biol Chem 283 (47), 32870-32879 (2008)
   PUBMED   18790740
REFERENCE   5  (bases 1 to 4357)
  AUTHORS   Jain,R.N., Al-Menhali,A.A., Keeley,T.M., Ren,J., El-Zaatari,M.,
            Chen,X., Merchant,J.L., Ross,T.S., Chew,C.S. and Samuelson,L.C.
  TITLE     Hip1r is expressed in gastric parietal cells and is required for
            tubulovesicle formation and cell survival in mice
  JOURNAL   J Clin Invest 118 (7), 2459-2470 (2008)
   PUBMED   18535670
REFERENCE   6  (bases 1 to 4357)
  AUTHORS   Hyun,T.S., Rao,D.S., Saint-Dic,D., Michael,L.E., Kumar,P.D.,
            Bradley,S.V., Mizukami,I.F., Oravecz-Wilson,K.I. and Ross,T.S.
  TITLE     HIP1 and HIP1r stabilize receptor tyrosine kinases and bind
            3-phosphoinositides via epsin N-terminal homology domains
  JOURNAL   J Biol Chem 279 (14), 14294-14306 (2004)
   PUBMED   14732715
REFERENCE   7  (bases 1 to 4357)
  AUTHORS   Okano,A., Usuda,N., Furihata,K., Nakayama,K., Bao Tian,Q.,
            Okamoto,T. and Suzuki,T.
  TITLE     Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is
            localized in the postsynaptic regions
  JOURNAL   Brain Res 967 (1-2), 210-225 (2003)
   PUBMED   12650982
  REMARK    GeneRIF: Localization of HIP1r at postsynaptic spines in rat brain
            suggests a role of HIP1r for vesicle trafficking through
            interaction with F-actin and working together with huntingtin and
            HIP1 at the synaptic sites.
REFERENCE   8  (bases 1 to 4357)
  AUTHORS   Legendre-Guillemin,V., Metzler,M., Charbonneau,M., Gan,L.,
            Chopra,V., Philie,J., Hayden,M.R. and McPherson,P.S.
  TITLE     HIP1 and HIP12 display differential binding to F-actin, AP2, and
            clathrin. Identification of a novel interaction with clathrin light
            chain
  JOURNAL   J Biol Chem 277 (22), 19897-19904 (2002)
   PUBMED   11889126
REFERENCE   9  (bases 1 to 4357)
  AUTHORS   Engqvist-Goldstein,A.E., Warren,R.A., Kessels,M.M., Keen,J.H.,
            Heuser,J. and Drubin,D.G.
  TITLE     The actin-binding protein Hip1R associates with clathrin during
            early stages of endocytosis and promotes clathrin assembly in vitro
  JOURNAL   J Cell Biol 154 (6), 1209-1223 (2001)
   PUBMED   11564758
REFERENCE   10 (bases 1 to 4357)
  AUTHORS   Engqvist-Goldstein,A.E., Kessels,M.M., Chopra,V.S., Hayden,M.R. and
            Drubin,D.G.
  TITLE     An actin-binding protein of the Sla2/Huntingtin interacting protein
            1 family is a novel component of clathrin-coated pits and vesicles
  JOURNAL   J Cell Biol 147 (7), 1503-1518 (1999)
   PUBMED   10613908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB005052.1 and BC169096.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB005052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AB005052.1         1-13
            14-1001             BC169096.1         1-988
            1002-1473           AB005052.1         1002-1473
            1474-4357           BC169096.1         1458-4341
FEATURES             Location/Qualifiers
     source          1..4357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..4357
                     /gene="Hip1r"
                     /note="huntingtin interacting protein 1 related"
                     /db_xref="GeneID:81917"
                     /db_xref="RGD:621615"
     exon            1..129
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..3246
                     /gene="Hip1r"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="huntingtin-interacting protein 1-related protein
                     isoform 1"
                     /protein_id="NP_001128235.1"
                     /db_xref="GeneID:81917"
                     /db_xref="RGD:621615"
                     /translation="MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINSQEA
                     PVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVL
                     HDCQRYRSNIREIGDLWGHLRDQYGHLVNIYTKLLLTKISFHLKHPQFPAGLEVTDEV
                     LEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQ
                     VIQDCSHLYHYTVKLMFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRL
                     IQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEEEEPENLIEISSGPPAGEPVQVV
                     ADLFDQTFGPPNGSMKDDRDLQIENLKREVETLRAELEKIKMEAQRYISQLKGQVNSL
                     EAELEEQRKQKQKALVDNEQLRHELAQLKALQLEGARNQGLREEAERKASATEARYSK
                     LKEKHNELINTHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQMEQVKRESEMKM
                     EEQSDQLEKLKRELVAKAGELAHAQEALSRTEQSGSELSSRLDTLNAEKEALSGAIRQ
                     REAELLAAQSLVREKEEALSQEQQRSAQEKGELQGRLAEKESQEQGLQQKLLDEQFAV
                     LRGAAAEAEAILQDAVSKLDDPLHLRCTSSPDYLVSRAQAALDSVSGLEKGHTQYLAS
                     SEDASALVAALTRFSHLAADTIVNGGATSHLAPTDPADRLIDTCRECGARALELMGQL
                     QDQTKLPRAQPSLMRAPLQGILQLGQDLKPKSLDVRQEELGAMVDKEMAATSAAIEDA
                     VRRIEDMMNQARHESSGVKLEVNERILNSCTDLMKAIRLLVMTSTSLQKEIVESGRGA
                     ATQQEFYAKNSRWTEGLISASKAVGWGATQLVESADKVVLHMGKYEELIVCSHEIAAS
                     TAQLVAASKVKANKNSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGL
                     SLIKLKKQEMETQVRVLELEKTLEAERVRLGELRKQHYVLAGGMGTPGEEEPSRPSPA
                     PRSGATKKPPLAQKPSIAPRPDNQLDKKDGVYPAQLVNY"
     exon            130..193
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            194..336
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            337..393
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            394..474
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            475..551
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            552..613
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            614..754
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            755..812
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            813..888
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1029
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1094
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1167
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1351
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1440
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1557
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1659
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1854
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2002
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2089
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2197
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2334
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2445
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2504
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2535
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2598
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2699
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2805
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2929
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..2991
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3198
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..4341
                     /gene="Hip1r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcggagc cgggccggga cagggtcggc ggcagcatga acagcatcaa gaatgtgccg
       61 gcgcgggtgc tgagccgcag gccgggccat agcctagagg ccgagcgcga gcagttcgac
      121 aagacgcagg ccatcagtat cagcaaagcc atcaacagcc aggaggcccc agtgaaggag
      181 aagcatgccc ggcgtatcat tctgggcact caccatgaga aaggagcctt taccttctgg
      241 tcctatgcca tcggcctgcc gctgcccagc agctccatcc tcagttggaa attctgtcac
      301 gtccttcaca aagtcctccg agatggacac cccaatgtgc tgcatgactg ccagcggtac
      361 cggagcaaca tacgtgagat tggcgacttg tggggccacc tacgtgacca gtatggacac
      421 ctggtgaata tctataccaa actgctgctg actaaaatct ccttccacct taagcacccc
      481 cagtttcctg cgggcttgga ggtaacagat gaagtgttgg agaaggcggc gggaactgat
      541 gttaataaca tttttcagct cactgtggag atgtttgact acatggactg tgaactgaag
      601 ctttctgagt cagttttccg gcagctcaac acagccatcg cagtgtcaca gatgtcttct
      661 ggccagtgtc gcctggcgcc gctcatccag gtcatccagg actgcagcca cctgtaccac
      721 tacacggtga agctcatgtt caagctccac tcctgtctcc cagcagacac cctgcaaggc
      781 cacagggatc ggttccacga gcagtttcac agtctcagaa acttcttccg ccgagcctcg
      841 gacatgctct acttcaagcg actcatccag atccccagac tgcctgaggg accccccaat
      901 ttcctgcggg cctcagccct ggctgagcac atcaagccgg tggtggtgat tccagaagag
      961 gccccggagg aggaggagcc tgagaaccta attgagatca gcagtgggcc ccctgctggg
     1021 gagccagtgc aggtggtggc tgacctcttt gatcagacct ttggaccccc caatggctcc
     1081 atgaaggatg acagggacct ccagattgag aacttgaaga gagaggtgga gaccctccgt
     1141 gctgagctgg agaagattaa gatggaggcc cagcggtaca tctcgcagct gaagggccag
     1201 gtgaacagcc tggaggcaga gctggaggag cagcggaagc agaagcagaa ggccctggtg
     1261 gacaacgagc agctgcgcca cgagctggcc cagctgaaag ccctgcagct ggaaggcgcg
     1321 cgcaaccagg gcctgcgaga ggaggcggag aggaaggcca gtgccactga ggcacgctac
     1381 agcaagctga aggagaagca caatgaactc attaacacgc atgccgagct gctcaggaag
     1441 aatgcagaca cagccaagca gctgacggtg acacagcaga gccaggagga ggtggcacgg
     1501 gtaaaggagc agctggcctt ccagatggag caagtgaagc gggagtctga gatgaagatg
     1561 gaggagcaga gtgaccagct ggagaagctc aagagggagc tggtggccaa ggcaggagag
     1621 ctggcccatg cccaggaggc cctgagccgc acggaacaga gtgggtcaga gctgagctca
     1681 cggctagata cactgaacgc agagaaggaa gcactgagcg gagccattcg gcagcgtgag
     1741 gcagagctgc tggctgccca gagcctggtg cgggagaagg aagaggctct tagccaagag
     1801 cagcagcgca gcgcccagga gaagggcgag ctacaggggc ggctggcaga aaaggagtct
     1861 caggagcagg ggctccagca gaagctgctg gatgaacagt ttgcagtgct gcgaggtgca
     1921 gccgccgagg cggaggccat cctgcaggac gcagtgagca agctggatga ccccctgcac
     1981 ctccgttgca ccagctcccc agactactta gtgagccggg ctcaggcagc cctggacagc
     2041 gtgagtggcc tggagaaggg ccacacccag tacctggctt cctctgagga tgcttccgcc
     2101 ctggtagcag cactgacccg cttctcccat ctggccgcgg acaccattgt caacggtggc
     2161 gccacctcgc acctggcccc cactgacccc gctgaccgcc tgatcgacac gtgcagggag
     2221 tgtggagccc gggctctgga gctcatggga cagctgcagg accagacaaa gctaccgagg
     2281 gcccagccca gcctgatgcg ggcccctctg cagggcattc ttcagttggg ccaggacctg
     2341 aagcctaaga gcctggacgt ccggcaagag gagctagggg ccatggttga caaggagatg
     2401 gcagccacct ctgcagccat tgaggacgct gtgcggagga tcgaggacat gatgaaccag
     2461 gcccgccacg agagctcagg ggtgaaacta gaggtgaacg agaggatcct caactcctgc
     2521 acagatctga tgaaggccat ccggctcctg gtgatgacgt ccaccagcct gcagaaggag
     2581 attgtggaga gcggcagggg ggcagcaaca cagcaggaat tttatgccaa gaattcacgg
     2641 tggactgaag gcctcatctc tgcctcgaag gcagtgggct ggggagccac acagctggtg
     2701 gagtcagctg acaaggttgt gcttcacatg ggcaaatatg aggaactcat cgtctgctca
     2761 cacgagattg cagccagcac tgcccagctg gtggcagcct cgaaggtaaa agccaacaag
     2821 aacagtcccc acctgagccg cctgcaggag tgttcccgca ctgtcaacga gagggctgcc
     2881 aatgtggtgg cctccaccaa gtctggccag gagcagatcg aggacagaga caccatggat
     2941 ttctctggcc tgtctctcat caagctgaag aagcaggaga tggagacaca ggtgcgagtc
     3001 ttggagctgg agaagacgct agaggcagag cgcgtacggc tcggggagct tcggaagcag
     3061 cactatgtac tggcgggggg catggggaca cctggcgaag aagaacccag cagacccagc
     3121 ccagctcccc gaagtggggc cactaagaag ccacctcttg cccagaaacc cagcatagcc
     3181 cccaggccgg acaaccagct cgacaagaag gatggtgtct acccagctca acttgtgaac
     3241 tactaggccc cctaaggtgt tcagcagttt ggctgggggc tatgcctggg cttcatgtgg
     3301 ctgtctggca gcggtcaagg ggcctctgaa aggcctccaa ctcctgcacc tggagcccaa
     3361 agcagtgtcc ctaaggcccc agccttcacc tgcccaaggg gcctggtctc tgtgggacag
     3421 ttcacgtgga tgtgactcta tttatctcta gtaggaactg cccagagcag ctgggaccca
     3481 gcaggcctga gccacaaatc tgcagcggac atctgagatg gcttgaacgc tgcgagttct
     3541 ttctttcctt gtaagtttag tcagcacact gggaaaaggc cacaagccag ggcctccttg
     3601 cctctggact caaaagtctg agaccacaag tgaacaacag aaagagggtc cctgctggct
     3661 atcggggata aggggatgac ctgtgacccc tgagccaggg agagcaggta ggctggctgg
     3721 ggtcatcatc tgggggcctg gtgctagggc acccatgctg ggagccccag gagagcaggc
     3781 tttgtgtggg tgccatggct gtgggcaacc cctgctcagg tgctgtctct agccttgaag
     3841 acctggaagc cgccctcacc cttgctgttt ccatccttct ggctactagt gtggcagtcc
     3901 actgcccacc tcgatggccg attcagccct cctaaagctg gggccttcca gccagttaga
     3961 agctaggaaa aaagcagatg tcacagccca tgtttctgga ggctcaggaa ttcctgctgc
     4021 agaggcccag gctcggaggc ccaggctcgg aggcctggcc tggcctggcc tgccctgctc
     4081 ctgacacttt gaataaattt gtgtttctag agcccgaggg ggagttgttg ggggtgggga
     4141 tatctaggcc accaataaag ccagcagctg gtctgggaca agtgcccagc ttcctccagc
     4201 tgcctgccct gagccctggg tggctaccaa ccatggggca aggtccgggc gtcgggaggg
     4261 agccaactcc tttgccctgg gcctagtatt cctgttgagt cctgttggca ataaaccctg
     4321 actgttgtta ccagtgccct aaaaaaaaaa aaaaaaa
//
