LOCUS       NM_001109607             583 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus histidine triad nucleotide binding protein 1
            (Hint1), mRNA.
ACCESSION   NM_001109607 XM_001073678
VERSION     NM_001109607.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 583)
  AUTHORS   Linde,C.I., Feng,B., Wang,J.B. and Golovina,V.A.
  TITLE     Histidine triad nucleotide-binding protein 1 (HINT1) regulates
            Ca(2+) signaling in mouse fibroblasts and neuronal cells via
            store-operated Ca(2+) entry pathway
  JOURNAL   Am J Physiol Cell Physiol 304 (11), C1098-C1104 (2013)
   PUBMED   23576580
REFERENCE   2  (bases 1 to 583)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 583)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 583)
  AUTHORS   Weiske,J. and Huber,O.
  TITLE     The histidine triad protein Hint1 triggers apoptosis independent of
            its enzymatic activity
  JOURNAL   J Biol Chem 281 (37), 27356-27366 (2006)
   PUBMED   16835243
REFERENCE   5  (bases 1 to 583)
  AUTHORS   Klein,M.G., Yao,Y., Slosberg,E.D., Lima,C.D., Doki,Y. and
            Weinstein,I.B.
  TITLE     Characterization of PKCI and comparative studies with FHIT, related
            members of the HIT protein family
  JOURNAL   Exp Cell Res 244 (1), 26-32 (1998)
   PUBMED   9770345
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001073678.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD568080.1, BC168732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..583
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..583
                     /gene="Hint1"
                     /gene_synonym="Pkci; Prkci"
                     /note="histidine triad nucleotide binding protein 1"
                     /db_xref="GeneID:690660"
                     /db_xref="RGD:1593411"
     exon            1..169
                     /gene="Hint1"
                     /gene_synonym="Pkci; Prkci"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..439
                     /gene="Hint1"
                     /gene_synonym="Pkci; Prkci"
                     /EC_number="3.-.-.-"
                     /note="protein kinase C, iota; PKCI-1; protein kinase C
                     inhibitor 1; adenosine 5'-monophosphoramidase; 17 kDa
                     inhibitor of protein kinase C; protein kinase
                     C-interacting protein 1; desumoylating isopeptidase HINT1"
                     /codon_start=1
                     /product="adenosine 5'-monophosphoramidase HINT1"
                     /protein_id="NP_001103077.1"
                     /db_xref="GeneID:690660"
                     /db_xref="RGD:1593411"
                     /translation="MADEIAKAQVAQPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDI
                     SPQAPTHFLVIPKKHISQISVADDDDESLLGHLMIVGKKCAADLGLKRGYRMVVNEGA
                     DGGQSVYHIHLHVLGGRQMNWPPG"
     exon            170..274
                     /gene="Hint1"
                     /gene_synonym="Pkci; Prkci"
                     /inference="alignment:Splign:2.1.0"
     exon            275..583
                     /gene="Hint1"
                     /gene_synonym="Pkci; Prkci"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctcgcggtt cctctcccca ccgtggccgc ggcgcgggaa ggacagcgac cggccgcgat
       61 ggctgacgag attgccaagg ctcaagtggc ccagcccggt ggcgacacga tcttcggcaa
      121 gatcatccgc aaagaaatcc cggccaagat cattttcgag gacgatcggt gtcttgcttt
      181 tcatgacatt tcccctcaag caccaacaca ctttctggtg atacccaaga agcacatatc
      241 ccagatttct gtggcagatg atgatgatga aagtcttcta ggacatttaa tgattgttgg
      301 caagaaatgt gctgcggatc tgggcctgaa gcgcgggtat cggatggtgg tgaatgaagg
      361 tgcagacggg gggcagtctg tctatcatat tcacctccac gtccttggag gtcggcagat
      421 gaactggcct cctggttaag caggttgggg ataagtatcc ttctctaggt agttggcaag
      481 ctccagtaat ttcaatggca cacatagttt tgcctgtgta tggagagatt gaagagatca
      541 tttaaaattc tgtgcctaat aaaagatatt gttgcacatc tct
//
