LOCUS       NM_001109565             797 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus histone linker H1 domain, spermatid-specific 1
            (Hils1), mRNA.
ACCESSION   NM_001109565 XM_001072107
VERSION     NM_001109565.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 797)
  AUTHORS   Mishra,L.N., Shalini,V., Gupta,N., Ghosh,K., Suthar,N., Bhaduri,U.
            and Rao,M.R.S.
  TITLE     Spermatid-specific linker histone HILS1 is a poor condenser of DNA
            and chromatin and preferentially associates with LINE-1 elements
  JOURNAL   Epigenetics Chromatin 11 (1), 43 (2018)
   PUBMED   30068355
  REMARK    GeneRIF: Results show that HILS1 possesses significantly lower
            alpha-helicity compared to other linker histones but also show that
            HILS1 is a poor condenser of chromatin which demonstrate the idea
            that this particular linker histone variant may have distinct role
            in histone to protamine replacement.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 797)
  AUTHORS   Mishra,L.N., Gupta,N. and Rao,S.M.
  TITLE     Mapping of post-translational modifications of spermatid-specific
            linker histone H1-like protein, HILS1
  JOURNAL   J Proteomics 128, 218-230 (2015)
   PUBMED   26257145
  REMARK    GeneRIF: Immunofluorescence studies demonstrate the presence of
            linker histone HILS1 and HILS1Y78p during different steps of
            spermiogenesis from early elongating to condensing spermatids.
REFERENCE   3  (bases 1 to 797)
  AUTHORS   Iguchi,N., Tanaka,H., Yomogida,K. and Nishimune,Y.
  TITLE     Isolation and characterization of a novel cDNA encoding a
            DNA-binding protein (Hils1) specifically expressed in testicular
            haploid germ cells
  JOURNAL   Int J Androl 26 (6), 354-365 (2003)
   PUBMED   14636221
REFERENCE   4  (bases 1 to 797)
  AUTHORS   Yan,W., Ma,L., Burns,K.H. and Matzuk,M.M.
  TITLE     HILS1 is a spermatid-specific linker histone H1-like protein
            implicated in chromatin remodeling during mammalian spermiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10546-10551 (2003)
   PUBMED   12920187
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001072107.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..797
                     /gene="Hils1"
                     /gene_synonym="H1-9"
                     /note="histone linker H1 domain, spermatid-specific 1"
                     /db_xref="GeneID:690026"
                     /db_xref="RGD:1585185"
     exon            1..797
                     /gene="Hils1"
                     /gene_synonym="H1-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..731
                     /gene="Hils1"
                     /gene_synonym="H1-9"
                     /note="histone H1-like protein in spermatids 1;
                     spermatid-specific linker histone H1-like protein"
                     /codon_start=1
                     /product="histone H1.9"
                     /protein_id="NP_001103035.1"
                     /db_xref="GeneID:690026"
                     /db_xref="RGD:1585185"
                     /translation="MSLVSPSPDSNAVMAGDQDASTSQVPSQSESKIGPNVATQTLRK
                     PTMSKVILRTVADKGVHSRVSLAALKKAVSITGYNMAQNTWRFKRVLQNLVKKGMLKQ
                     VTGKGASGSFRLGKKQAFKSKCKAKRRQRRQKPGQRRTGSRRSLLGSKKSNNRLFKGV
                     RRVAKGRRH"
ORIGIN      
        1 gcacaagtct gctgaggcca atcgtgggtg atcatccttg gtcctctctc tggccgaggt
       61 gtggcccaga ccccccttac agaggctcct ctgagggaag cagaaggcag aacacagccc
      121 acccactacc gagaggaacc gggtggactt ttccagccgc caccctggag atcctagcgc
      181 ctagtgctct acagccatct ccggaagaga atcagagaga tatgtcgctg gtgtcaccat
      241 ctccagactc aaatgctgtg atggctggag accaagatgc cagcacatca caggtcccaa
      301 gccagagtga gagcaagatt gggcccaacg tcgccaccca aaccctgcgg aagcccacca
      361 tgtcgaaggt gattctgagg actgtggctg ataagggggt tcatagccgt gtgtcccttg
      421 ctgccttgaa gaaagctgtg tctatcacag ggtacaatat ggcccaaaac acctggcgct
      481 tcaagcgtgt gctccagaat ctagtcaaga aaggcatgct caagcaggtg accggcaagg
      541 gtgcctcggg ctccttccgc ctgggcaaga agcaggcctt caagtccaag tgcaaggcca
      601 agagacgcca gcggaggcag aagcctgggc agcgccggac tggatcacgc cgatcactac
      661 taggctccaa aaagagcaat aaccggcttt tcaaaggagt tcgtagggtg gctaaaggcc
      721 gccgccatta atacggcagg tcaggcgggg tgccaggctt gtcacgaagt gggaataaaa
      781 cccagcttat ttcacaa
//
