LOCUS       NM_001399165            1018 bp    mRNA    linear   ROD 07-JUL-2024
DEFINITION  Rattus norvegicus hypoxia inducible lipid droplet-associated
            (Hilpda), mRNA.
ACCESSION   NM_001399165 XM_006236238
VERSION     NM_001399165.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1018)
  AUTHORS   Wang,T., Dai,L., Shen,S., Yang,Y., Yang,M., Yang,X., Qiu,Y. and
            Wang,W.
  TITLE     Comprehensive Molecular Analyses of a Macrophage-Related Gene
            Signature With Regard to Prognosis, Immune Features, and Biomarkers
            for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and
            the LASSO Algorithm
  JOURNAL   Front Immunol 13, 843408 (2022)
   PUBMED   35693827
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1018)
  AUTHORS   Cui,C., Fu,K., Yang,L., Wu,S., Cen,Z., Meng,X., Huang,Q. and Xie,Z.
  TITLE     Hypoxia-inducible gene 2 promotes the immune escape of
            hepatocellular carcinoma from nature killer cells through the
            interleukin-10-STAT3 signaling pathway
  JOURNAL   J Exp Clin Cancer Res 38 (1), 229 (2019)
   PUBMED   31142329
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1018)
  AUTHORS   Mattijssen,F., Georgiadi,A., Andasarie,T., Szalowska,E., Zota,A.,
            Krones-Herzig,A., Heier,C., Ratman,D., De Bosscher,K., Qi,L.,
            Zechner,R., Herzig,S. and Kersten,S.
  TITLE     Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel
            peroxisome proliferator-activated receptor (PPAR) target involved
            in hepatic triglyceride secretion
  JOURNAL   J Biol Chem 289 (28), 19279-19293 (2014)
   PUBMED   24876382
  REMARK    GeneRIF: data uncover HILPDA as a novel PPAR target that raises
            hepatic triglyceride storage via regulation of triglyceride
            secretion.
REFERENCE   4  (bases 1 to 1018)
  AUTHORS   Kim,S.H., Wang,D., Park,Y.Y., Katoh,H., Margalit,O., Sheffer,M.,
            Wu,H., Holla,V.R., Lee,J.S. and DuBois,R.N.
  TITLE     HIG2 promotes colorectal cancer progression via hypoxia-dependent
            and independent pathways
  JOURNAL   Cancer Lett 341 (2), 159-165 (2013)
   PUBMED   23916472
REFERENCE   5  (bases 1 to 1018)
  AUTHORS   Gimm,T., Wiese,M., Teschemacher,B., Deggerich,A., Schodel,J.,
            Knaup,K.X., Hackenbeck,T., Hellerbrand,C., Amann,K., Wiesener,M.S.,
            Honing,S., Eckardt,K.U. and Warnecke,C.
  TITLE     Hypoxia-inducible protein 2 is a novel lipid droplet protein and a
            specific target gene of hypoxia-inducible factor-1
  JOURNAL   FASEB J 24 (11), 4443-4458 (2010)
   PUBMED   20624928
REFERENCE   6  (bases 1 to 1018)
  AUTHORS   Togashi,A., Katagiri,T., Ashida,S., Fujioka,T., Maruyama,O.,
            Wakumoto,Y., Sakamoto,Y., Fujime,M., Kawachi,Y., Shuin,T. and
            Nakamura,Y.
  TITLE     Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for
            renal cell carcinoma and potential target for molecular therapy
  JOURNAL   Cancer Res 65 (11), 4817-4826 (2005)
   PUBMED   15930302
REFERENCE   7  (bases 1 to 1018)
  AUTHORS   Denko,N., Schindler,C., Koong,A., Laderoute,K., Green,C. and
            Giaccia,A.
  TITLE     Epigenetic regulation of gene expression in cervical cancer cells
            by the tumor microenvironment
  JOURNAL   Clin Cancer Res 6 (2), 480-487 (2000)
   PUBMED   10690527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006236238.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ233481.1, FQ232409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               JAXUCZ010000004.1  58836463-58836648
            187-1018            JAXUCZ010000004.1  58838592-58839423
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..1018
                     /gene="Hilpda"
                     /note="hypoxia inducible lipid droplet-associated"
                     /db_xref="GeneID:100361568"
                     /db_xref="RGD:2319900"
     exon            1..186
                     /gene="Hilpda"
                     /inference="alignment:Splign:2.1.0"
     exon            187..1018
                     /gene="Hilpda"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..440
                     /gene="Hilpda"
                     /note="hypoxia-inducible protein 2-like"
                     /codon_start=1
                     /product="hypoxia-inducible lipid droplet-associated
                     protein"
                     /protein_id="NP_001386094.1"
                     /db_xref="GeneID:100361568"
                     /db_xref="RGD:2319900"
                     /translation="MKYMLNLYVLGVMLTLLSIFVRLMESLGGLLENPLPGSSWITRG
                     HLANTQPPRGLPDHPSRGVQ"
ORIGIN      
        1 ctccgagggc ggagcctcgc ccagaaaggg cggggcttca ggaggtccgt ttctctttgc
       61 tacttatttc tatccggagc ggtgcctgcg tggagcttcc acgttgcgac tcagccgacc
      121 gtcatcctta cgcctgcacg atctagtgtg actctgagca gccgtctccc gactcttctt
      181 cctaaggatc tagaagcaga aagcagcagc tccacttccc tgcaaaggag ctgggcggcg
      241 gcaccatgaa gtacatgcta aacctctacg tgctgggggt catgttgacc ctgctttcca
      301 tctttgttag actgatggag tcactgggag gattgttgga gaacccattg cccgggagct
      361 cctggattac gagaggtcac ctagccaaca cacagcctcc caggggcctt ccagaccatc
      421 catccagagg agtgcaataa aacctccccc caggcatcag ccatgctttg acacactgac
      481 ttcagcatgt ccgaccacat gtttcatttc ccaagaggca acatcaagtg tctccaaaga
      541 actgttacta ggcctggcag ggcagttttc ttttggatgt tcccttacac gggaaaagag
      601 cctgtttact ggagaggtgt gagtggcttg tctgtggctc tgagatggtg gtgtaccgtt
      661 ttcagctgtt gggagaacgt ttttttggtt ttgtttgttt gtttaagtcc tccgtcctaa
      721 aggactcttt tggacctaag catcttctgt tgtttacgat tgagcctctc ttccaggaga
      781 gttttgtttg gacagcatct aaggggttgt gggttggcca cgaagacagg gtggaccatc
      841 cggtgtttag gtctaagttc tgcgtttaag ttctttctcc agtgtaatgc acatgtgttt
      901 gtacataatg tctaaagggc tatgggatga tcaggcctgc tagggtatag gcattccagc
      961 cactgtgtgg cttacatgag tttttctaat gcaataaatg tgaatatatg tgtatgta
//
