LOCUS       NM_080902               1443 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus HIG1 hypoxia inducible domain family, member 1A
            (Higd1a), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_080902 XM_346838
VERSION     NM_080902.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1443)
  AUTHORS   Lopez,L., Zuluaga,M.J., Lagos,P., Agrati,D. and Bedo,G.
  TITLE     The Expression of Hypoxia-Induced Gene 1 (Higd1a) in the Central
            Nervous System of Male and Female Rats Differs According to Age
  JOURNAL   J Mol Neurosci 66 (3), 462-473 (2018)
   PUBMED   30302618
  REMARK    GeneRIF: Hgd1a expression in central nervous system varies
            according to age.
REFERENCE   2  (bases 1 to 1443)
  AUTHORS   Ameri,K., Jahangiri,A., Rajah,A.M., Tormos,K.V., Nagarajan,R.,
            Pekmezci,M., Nguyen,V., Wheeler,M.L., Murphy,M.P., Sanders,T.A.,
            Jeffrey,S.S., Yeghiazarians,Y., Rinaudo,P.F., Costello,J.F.,
            Aghi,M.K. and Maltepe,E.
  TITLE     HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK
            Activity during Glucose Deprivation to Modulate Cell Survival and
            Tumor Growth
  JOURNAL   Cell Rep 10 (6), 891-899 (2015)
   PUBMED   25683712
REFERENCE   3  (bases 1 to 1443)
  AUTHORS   Ameri,K., Rajah,A.M., Nguyen,V., Sanders,T.A., Jahangiri,A.,
            Delay,M., Donne,M., Choi,H.J., Tormos,K.V., Yeghiazarians,Y.,
            Jeffrey,S.S., Rinaudo,P.F., Rowitch,D.H., Aghi,M. and Maltepe,E.
  TITLE     Nuclear localization of the mitochondrial factor HIGD1A during
            metabolic stress
  JOURNAL   PLoS One 8 (4), e62758 (2013)
   PUBMED   23646141
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1443)
  AUTHORS   Bedo,G., Lagos,P. and Agrati,D.
  TITLE     Temporal distribution of Hig-1 (hypoxia-induced gene 1) mRNA and
            protein in rat spinal cord: changes during postnatal life
  JOURNAL   J Mol Neurosci 47 (3), 666-673 (2012)
   PUBMED   22350989
  REMARK    GeneRIF: We found an interesting change in the protein expression
            pattern, shifting from neurons at P1 to glial cells at P90, which
            points towards a functional role for this protein in the spinal
            cord throughout development.
REFERENCE   5  (bases 1 to 1443)
  AUTHORS   An,H.J., Shin,H., Jo,S.G., Kim,Y.J., Lee,J.O., Paik,S.G. and Lee,H.
  TITLE     The survival effect of mitochondrial Higd-1a is associated with
            suppression of cytochrome C release and prevention of caspase
            activation
  JOURNAL   Biochim Biophys Acta 1813 (12), 2088-2098 (2011)
   PUBMED   21856340
REFERENCE   6  (bases 1 to 1443)
  AUTHORS   Wang,J., Cao,Y., Chen,Y., Chen,Y., Gardner,P. and Steiner,D.F.
  TITLE     Pancreatic beta cells lack a low glucose and O2-inducible
            mitochondrial protein that augments cell survival
  JOURNAL   Proc Natl Acad Sci U S A 103 (28), 10636-10641 (2006)
   PUBMED   16815968
REFERENCE   7  (bases 1 to 1443)
  AUTHORS   Bedo,G., Vargas,M., Ferreiro,M.J., Chalar,C. and Agrati,D.
  TITLE     Characterization of hypoxia induced gene 1: expression during rat
            central nervous system maturation and evidence of antisense RNA
            expression
  JOURNAL   Int J Dev Biol 49 (4), 431-436 (2005)
   PUBMED   15968589
  REMARK    GeneRIF: Hig-1 protein and human- and murine-predicted sequences,
            as well as its characteristic expression in the Central Nervous
            System, are indicative of a specific role which could be related to
            apoptosis signaling during postnatal maturation.
REFERENCE   8  (bases 1 to 1443)
  AUTHORS   Jin,K., Mao,X.O., Eshoo,M.W., del Rio,G., Rao,R., Chen,D.,
            Simon,R.P. and Greenberg,D.A.
  TITLE     cDNA microarray analysis of changes in gene expression induced by
            neuronal hypoxia in vitro
  JOURNAL   Neurochem Res 27 (10), 1105-1112 (2002)
   PUBMED   12462408
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC059118.1.
            
            On Aug 31, 2012 this sequence version replaced NM_080902.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059118.1, CF977525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1443              BC059118.1         5-1447
FEATURES             Location/Qualifiers
     source          1..1443
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1443
                     /gene="Higd1a"
                     /gene_synonym="Hig1"
                     /note="HIG1 hypoxia inducible domain family, member 1A"
                     /db_xref="GeneID:140937"
                     /db_xref="RGD:620215"
     exon            1..56
                     /gene="Higd1a"
                     /gene_synonym="Hig1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..175
                     /gene="Higd1a"
                     /gene_synonym="Hig1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..360
                     /gene="Higd1a"
                     /gene_synonym="Hig1"
                     /note="hypoxia-inducible gene 1 protein; HIG1 domain
                     family, member 1A; hypoxia induced gene 1"
                     /codon_start=1
                     /product="HIG1 domain family member 1A, mitochondrial"
                     /protein_id="NP_543178.2"
                     /db_xref="GeneID:140937"
                     /db_xref="RGD:620215"
                     /translation="MSTNTDLSLSSYDEGQGSKFIRKARETPFVPIGMAGFAAIVAYG
                     LYKLKSRGNTKMSIHLIHMRVAAQGFVVGAMTLGMGYSMYQEFWAKRKP"
     exon            176..310
                     /gene="Higd1a"
                     /gene_synonym="Hig1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..1415
                     /gene="Higd1a"
                     /gene_synonym="Hig1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcactcggg ggtggaggcc agaagccggc tggactgaaa gggacgtctc ctctccgaag
       61 actcttcaag aaatcacaat gtcaaccaac acagaccttt ctctctcttc atacgatgaa
      121 ggtcaggggt ccaagtttat tcggaaagct agggagacac cgtttgtccc cattggaatg
      181 gccggcttcg cagcgattgt tgcatatggg ctctacaagc tgaagagcag gggaaacacg
      241 aagatgtcta ttcacttgat ccacatgcgt gtggcagccc agggctttgt tgtgggggcc
      301 atgactcttg gtatgggcta ttccatgtat caagaattct gggccaagcg taagccttag
      361 aagagctgct gccttggtct gggaagtgct tgctttagtt agacgtctca tattgaggtt
      421 acatgtttgt gtctgcaata aataacatat ggtttagaca aaacacagta ttgaatgttg
      481 gtttactttc tggccaactt gatttgcctg gtgaccagat tgttagtgac tgattcacta
      541 actaggtcgc taagggggtc agggtaacac agaagaaatc tgtcacctga aagtacttgg
      601 tcacagtgct ttccttacac ccttatgatg aaagtcactg taagaagggc tgctggcagt
      661 ccaggcacac cctgtgtgca gagtcggcca tgctttggga gggtgtcagg aaagagtcat
      721 ttactttgtc tgcctgtggg ctgacttcag aacttcaggt cttaaggttt gctggcttct
      781 gaaaacactt tctaaagagc ccatgaaata taaatataac taacttagaa agccctgtac
      841 ctcagtagga gggagcgcgt gtgtgtgtgt gtgcgcgtgt gtgagtgtgt gtaacaaccc
      901 agaaagctgg taagagctgc agagaggcag tgtttattag attcacactt agacactgat
      961 tgtgggttct ggtttagctc ttttataatt gtaaagttat atttttgctg ctttgtaata
     1021 ggataattct taagcatcat cttaaaatag aggtattttg tttctttttt gtggtgctgg
     1081 gcattaagtg cagggtctca cataggctaa gcaagtgctg tgcactgagt tgaaccccag
     1141 cagaagtagg tgctgcaagt gtaaaacaag gctaaagggc ctaatgcaca cagcctgtgc
     1201 aggccgcgtg gccaccgtct ataaggccat ggctattaaa gtaccgaagg tgagaggtga
     1261 acggtgggcg ggctggtttt tccaatattt acatacaaat ttggatacac agaatattaa
     1321 atgcactgta aaatccccct gtccaacctg aacttacatt ccatccacag tgccaagatg
     1381 gtgtatgtat tgttattaaa ataagtctga acataaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaa
//
