LOCUS       NM_001388512            2107 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus hypoxia inducible factor 3 subunit alpha (Hif3a),
            transcript variant 2, mRNA.
ACCESSION   NM_001388512
VERSION     NM_001388512.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2107)
  AUTHORS   Xu,Y., Hu,T., Ding,H., Yuan,Y. and Chen,R.
  TITLE     miR-485-5p alleviates obstructive sleep apnea syndrome with
            hypertension by inhibiting PI3K/AKT signaling pathway via
            downregulating HIF3A expression
  JOURNAL   Sleep Breath 27 (1), 109-119 (2023)
   PUBMED   35132534
  REMARK    GeneRIF: miR-485-5p alleviates obstructive sleep apnea syndrome
            with hypertension by inhibiting PI3K/AKT signaling pathway via
            downregulating HIF3A expression.
REFERENCE   2  (bases 1 to 2107)
  AUTHORS   Yang,M., Yan,X., Yuan,F.Z., Ye,J., Du,M.Z., Mao,Z.M., Xu,B.B.,
            Chen,Y.R., Song,Y.F., Fan,B.S. and Yu,J.K.
  TITLE     MicroRNA-210-3p Promotes Chondrogenic Differentiation and Inhibits
            Adipogenic Differentiation Correlated with HIF-3alpha Signalling in
            Bone Marrow Mesenchymal Stem Cells
  JOURNAL   Biomed Res Int 2021, 6699910 (2021)
   PUBMED   33937412
  REMARK    GeneRIF: MicroRNA-210-3p Promotes Chondrogenic Differentiation and
            Inhibits Adipogenic Differentiation Correlated with HIF-3alpha
            Signalling in Bone Marrow Mesenchymal Stem Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2107)
  AUTHORS   Coelho,N.R., Tomkiewicz,C., Correia,M.J., Goncalves-Dias,C.,
            Barouki,R., Pereira,S.A., Coumoul,X. and Monteiro,E.C.
  TITLE     First evidence of aryl hydrocarbon receptor as a druggable target
            in hypertension induced by chronic intermittent hypoxia
  JOURNAL   Pharmacol Res 159, 104869 (2020)
   PUBMED   32416216
REFERENCE   4  (bases 1 to 2107)
  AUTHORS   Drevytska,T., Gonchar,E., Okhai,I., Lynnyk,O., Mankovska,I.,
            Klionsky,D. and Dosenko,V.
  TITLE     The protective effect of Hif3a RNA interference and HIF-prolyl
            hydroxylase inhibition on cardiomyocytes under anoxia-reoxygenation
  JOURNAL   Life Sci 202, 131-139 (2018)
   PUBMED   29660430
  REMARK    GeneRIF: Hif3a RNA interference and HIF-prolyl hydroxylase
            inhibition protect cardiomyocytes against anoxia-reoxygenation
            injury via the HIF signaling pathway
REFERENCE   5  (bases 1 to 2107)
  AUTHORS   Cuomo,F., Coppola,A., Botti,C., Maione,C., Forte,A., Scisciola,L.,
            Liguori,G., Caiafa,I., Ursini,M.V., Galderisi,U., Cipollaro,M.,
            Altucci,L. and Cobellis,G.
  TITLE     Pro-inflammatory cytokines activate hypoxia-inducible factor 3alpha
            via epigenetic changes in mesenchymal stromal/stem cells
  JOURNAL   Sci Rep 8 (1), 5842 (2018)
   PUBMED   29643458
  REMARK    GeneRIF: Study in human mesenchymal stromal/stem cells revealed
            robust hypermethylation of histone H3 across HIF3A locus driven by
            pro-inflammatory cytokines. Experiments in a murine model of
            arteriotomy highlighted the activation of Hif3alpha expression in
            infiltrated inflammatory cells, suggesting a new role for Hif3alpha
            in inflammation in vivo.
            Erratum:[Sci Rep. 2020 Apr 17;10(1):6776. doi:
            10.1038/s41598-020-62861-8.. PMID: 32303693]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2107)
  AUTHORS   Li,Q.F. and Dai,A.G.
  TITLE     Differential expression of three hypoxia-inducible factor-alpha
            subunits in pulmonary arteries of rat with hypoxia-induced
            hypertension
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 37 (10), 665-672 (2005)
   PUBMED   16215633
  REMARK    GeneRIF: HIF-1alpha, HIF-2alpha and HIF-3alpha may not only confer
            different target genes, but also play key pathogenetic roles in
            hypoxic-induced pulmonary hypertension.
REFERENCE   7  (bases 1 to 2107)
  AUTHORS   Heidbreder,M., Frohlich,F., Johren,O., Dendorfer,A., Qadri,F. and
            Dominiak,P.
  TITLE     Hypoxia rapidly activates HIF-3alpha mRNA expression
  JOURNAL   FASEB J 17 (11), 1541-1543 (2003)
   PUBMED   12824304
  REMARK    GeneRIF: Hypoxia rapidly activates HIF-3alpha mRNA expression
REFERENCE   8  (bases 1 to 2107)
  AUTHORS   Hara,S., Hamada,J., Kobayashi,C., Kondo,Y. and Imura,N.
  TITLE     Expression and characterization of hypoxia-inducible factor
            (HIF)-3alpha in human kidney: suppression of HIF-mediated gene
            expression by HIF-3alpha
  JOURNAL   Biochem Biophys Res Commun 287 (4), 808-813 (2001)
   PUBMED   11573933
REFERENCE   9  (bases 1 to 2107)
  AUTHORS   Kietzmann,T., Cornesse,Y., Brechtel,K., Modaressi,S. and
            Jungermann,K.
  TITLE     Perivenous expression of the mRNA of the three hypoxia-inducible
            factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat
            liver
  JOURNAL   Biochem J 354 (Pt 3), 531-537 (2001)
   PUBMED   11237857
REFERENCE   10 (bases 1 to 2107)
  AUTHORS   Gu,Y.Z., Moran,S.M., Hogenesch,J.B., Wartman,L. and Bradfield,C.A.
  TITLE     Molecular characterization and chromosomal localization of a third
            alpha-class hypoxia inducible factor subunit, HIF3alpha
  JOURNAL   Gene Expr 7 (3), 205-213 (1998)
   PUBMED   9840812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000001.1  86877774-86877838   c
            66-256              JAXUCZ010000001.1  86871770-86871960   c
            257-402             JAXUCZ010000001.1  86870256-86870401   c
            403-487             JAXUCZ010000001.1  86867879-86867963   c
            488-600             JAXUCZ010000001.1  86866999-86867111   c
            601-809             JAXUCZ010000001.1  86866431-86866639   c
            810-916             JAXUCZ010000001.1  86864244-86864350   c
            917-1064            JAXUCZ010000001.1  86863842-86863989   c
            1065-1177           JAXUCZ010000001.1  86860356-86860468   c
            1178-1368           JAXUCZ010000001.1  86859373-86859563   c
            1369-1470           JAXUCZ010000001.1  86857163-86857264   c
            1471-1742           JAXUCZ010000001.1  86855165-86855436   c
            1743-1854           JAXUCZ010000001.1  86853682-86853793   c
            1855-1936           JAXUCZ010000001.1  86852083-86852164   c
            1937-2107           JAXUCZ010000001.1  86850554-86850724   c
FEATURES             Location/Qualifiers
     source          1..2107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2107
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /note="hypoxia inducible factor 3 subunit alpha"
                     /db_xref="GeneID:64345"
                     /db_xref="RGD:70332"
     exon            1..65
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..2034
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /note="isoform 2 is encoded by transcript variant 2;
                     HIF3-alpha; HIF-3-alpha; HIF3-alpha-1; hypoxia inducible
                     factor 3, alpha subunit; hypoxia inducible factor 3a;
                     Inhibitory PAS (Per/Arnt/Sim) domain protein;
                     hypoxia-inducible factor 3-alpha"
                     /codon_start=1
                     /product="hypoxia-inducible factor 3-alpha isoform 2"
                     /protein_id="NP_001375441.1"
                     /db_xref="GeneID:64345"
                     /db_xref="RGD:70332"
                     /translation="MALGLQRVRSSTELRKEKSRDAARSRRSQETEVLYQLAHTLPFA
                     RGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVGKEGEPLDACYLKALEGFVMVLTA
                     EGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPRPSLSKKKSEAAT
                     GRHFSLRMKSTLTSRGRTLNLKAATWKVLHCSGHMRAYKPPAQTSPAGSPRSEPPLQC
                     LVLICEAIPHPASLEPPLGRGAFLSRHSLDMKFTYCDERIAEVAGYSPDDLIGCSAYE
                     YIHALDSDAVSRSIHTLLSKGQAVTGQYRFLARTGGYLWTQTQATVVSGGRGPQSESI
                     ICVHFLISRVEENGVVLSLEQTEQHTRRPPQLGTSSKKGIPGNSLDPPAPRILAFLHP
                     PALSEASLAADPRRFCSPDLRRLMAPILDGPPTAATPSTPQAARRPQSPLPADLPDQL
                     AVGLENAHRLSTARKNKTMETDLDIAQDPDTLDLEMLAPYISMDDDFQLNSSEQLPKV
                     HRRPPRTARRPRARSFHGLSPPIPEATLLPRWGSDPRLNCSSSSKGDPPTAPLTPRTR
                     KRALAQSSEDKGLELLETKPPKRSPRLEPGSVLLPPLSLSFLLQGRQLPGNQPDPRAP
                     LVDSHEPLGLAPSLLSLYQHEETIQPRNHFLPAAGLAQTH"
     exon            66..256
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            257..402
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            403..487
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            488..600
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            601..809
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            810..916
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1064
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1177
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1368
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1470
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1742
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1854
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1936
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2107
                     /gene="Hif3a"
                     /gene_synonym="Ipas; Mop7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgggcatc gagggctctg gaaccgcgaa gggcgagcca tggcgttggg gctgcagcgc
       61 gtgaggtcga gcaccgagct gcggaaggag aagtcgcggg atgcggcccg cagcaggcgc
      121 agccaggaga cggaggtgct gtaccaactg gcgcacaccc tgccctttgc gcgcggcgtc
      181 agcgcgcacc tggacaaggc ctccatcatg cgcctcacaa tcagctactt gcgcatgcac
      241 cgcctctgcg ctgcagggga gtggaaccag gtgggaaaag agggagaacc actggacgcc
      301 tgctacctga aggccctgga gggtttcgtc atggtgctca ccgctgaggg agacatggct
      361 tacctgtcgg aaaatgtcag caagcacctg ggcctcagtc agctggagct cattggacac
      421 agtatctttg attttatcca tccctgtgac caagaggaac tccaggatgc cctgaccccg
      481 agaccaagcc tgtcaaagaa gaagtcagaa gcagcaacag gacgccactt ttccctgcga
      541 atgaagagca cactcaccag cagggggcgc acgctgaacc tcaaagcggc cacctggaag
      601 gtgctgcact gctcaggaca tatgagggcc tacaagcccc ctgcacagac ttcccccgcc
      661 gggagccctc gctccgagcc tcccctgcaa tgcctggtgc ttatctgtga agccatcccc
      721 cacccagcca gtctggagcc cccactgggc cgaggggcct ttctcagtcg ccacagcctg
      781 gacatgaagt tcacatactg cgacgagagg attgcagaag ttgctggcta cagccccgat
      841 gacctgattg gctgttctgc ctatgaatac atccacgctt tggactctga tgcagtcagc
      901 aggagcatcc acactttgct gagcaagggc caggcagtaa cagggcagta tcgcttcctg
      961 gcccggactg gaggctatct gtggactcag actcaggcta cagtggtgtc aggggggcgg
     1021 ggcccccagt cggaaagtat catctgcgtc cacttcctga tcagccgtgt agaagagaac
     1081 ggagtggtgc tgtccctgga acaaacggag caacatactc gcagaccccc tcagctgggt
     1141 acctcctcga agaagggtat cccaggcaac agtctagacc ctcccgctcc acggatcctg
     1201 gccttcctgc accctccagc cctgagtgag gcctccctgg ctgctgaccc tcgccgtttt
     1261 tgtagcccag acctgcgccg cctcatggca cccatcctgg atggacctcc cacagccgct
     1321 acccccagca ccccgcaagc tgcacggaga ccccaaagtc ctcttccggc tgatctccca
     1381 gatcagttgg ctgtgggctt ggagaatgca cacagactct ccactgcccg gaaaaacaag
     1441 accatggaga cagatctaga tatagctcag gaccctgaca ctctggactt ggagatgttg
     1501 gctccgtaca tctccatgga tgatgacttc cagctcaact ccagcgagca attgcccaaa
     1561 gtccaccgca gacctcccag gacggcccgc aggcctcgtg ctcggagctt ccatggcctg
     1621 tcgcctccca tccctgaggc caccctgctg ccccgctggg ggagtgatcc acgactgaac
     1681 tgttccagct cctccaaggg ggatcccccc acagcccccc tgacgcctag aactcggaag
     1741 agggccttgg cccagagctc agaggacaaa gggttggagc tgctggaaac gaagcccccc
     1801 aagcggtccc caagactaga acctggaagt gtcctgctgc ctccgctcag cctgagtttc
     1861 cttctgcaag gtcgacaact tccagggaac cagccggatc ccagagcccc actcgtggat
     1921 tcgcatgagc ccttgggcct agctccctcg ctgctctctc tctaccagca tgaggaaact
     1981 atccagccca ggaaccactt cctcccagca gcaggcttgg cccagacaca ctgagtcagc
     2041 cttcctctca gccctcttct tctaccccag aaaggactca gccgcactcc acaccagcag
     2101 cctacac
//
