LOCUS       NM_001113749            1363 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus hypoxia inducible factor 1 subunit alpha
            inhibitor (Hif1an), mRNA.
ACCESSION   NM_001113749 XM_001062399 XM_219961
VERSION     NM_001113749.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Hu J, Chen C, Liu Q, Liu B, Song C, Zhu S, Wu C, Liu S, Yu H, Yao
            D, Kang J and Zhu L.
  TITLE     The role of the miR-31/FIH1 pathway in TGF-beta-induced liver
            fibrosis
  JOURNAL   Clin Sci (Lond) 129 (4), 305-317 (2015)
   PUBMED   25728779
  REMARK    GeneRIF: miR-31/FIH1 pathway associates with liver fibrosis,
            perhaps by participation in the TGF-beta/Smad3 signalling of
            hepatic stellate cells.
REFERENCE   2  (bases 1 to 1363)
  AUTHORS   Wan DY, Zhang Z and Yang HH.
  TITLE     Cardioprotective effect of miR-214 in myocardial ischemic
            postconditioning by down-regulation of hypoxia inducible factor 1,
            alpha subunit inhibitor
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 61 (2), 1-6 (2015)
   PUBMED   26025394
  REMARK    GeneRIF: The expression of HIF1AN remarkably decreased in the
            ischemia postconditioning group. This indicated that the
            downregulation of HIF1AN could protect cardiac cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1363)
  AUTHORS   Hirose,Y., Johnson,Z.I., Schoepflin,Z.R., Markova,D.Z., Chiba,K.,
            Toyama,Y., Shapiro,I.M. and Risbud,M.V.
  TITLE     FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in
            nucleus pulposus cells
  JOURNAL   J Biol Chem 289 (30), 20594-20605 (2014)
   PUBMED   24867948
  REMARK    GeneRIF: FIH-1 activity does not represent a major mechanism by
            which NP cells control HIF-1-dependent transcription, a testament
            to their adaptation to a unique hypoxic niche.
REFERENCE   4  (bases 1 to 1363)
  AUTHORS   Keith B, Johnson RS and Simon MC.
  TITLE     HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth
            and progression
  JOURNAL   Nat Rev Cancer 12 (1), 9-22 (2011)
   PUBMED   22169972
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1363)
  AUTHORS   Yang M, Chowdhury R, Ge W, Hamed RB, McDonough MA, Claridge TD,
            Kessler BM, Cockman ME, Ratcliffe PJ and Schofield CJ.
  TITLE     Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the
            post-translational hydroxylation of histidinyl residues within
            ankyrin repeat domains
  JOURNAL   FEBS J 278 (7), 1086-1097 (2011)
   PUBMED   21251231
REFERENCE   6  (bases 1 to 1363)
  AUTHORS   Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh
            CW, Ratcliffe PJ and Schofield CJ.
  TITLE     Structure of factor-inhibiting hypoxia-inducible factor (HIF)
            reveals mechanism of oxidative modification of HIF-1 alpha
  JOURNAL   J Biol Chem 278 (3), 1802-1806 (2003)
   PUBMED   12446723
REFERENCE   7  (bases 1 to 1363)
  AUTHORS   McNeill LA, Hewitson KS, Claridge TD, Seibel JF, Horsfall LE and
            Schofield CJ.
  TITLE     Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses
            hydroxylation at the beta-carbon of asparagine-803
  JOURNAL   Biochem J 367 (Pt 3), 571-575 (2002)
   PUBMED   12215170
REFERENCE   8  (bases 1 to 1363)
  AUTHORS   Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford
            RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ,
            Pugh CW and Schofield CJ.
  TITLE     Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical
            to factor inhibiting HIF (FIH) and is related to the cupin
            structural family
  JOURNAL   J Biol Chem 277 (29), 26351-26355 (2002)
   PUBMED   12042299
REFERENCE   9  (bases 1 to 1363)
  AUTHORS   Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML and Bruick RK.
  TITLE     FIH-1 is an asparaginyl hydroxylase enzyme that regulates the
            transcriptional activity of hypoxia-inducible factor
  JOURNAL   Genes Dev 16 (12), 1466-1471 (2002)
   PUBMED   12080085
REFERENCE   10 (bases 1 to 1363)
  AUTHORS   Mahon PC, Hirota K and Semenza GL.
  TITLE     FIH-1: a novel protein that interacts with HIF-1alpha and VHL to
            mediate repression of HIF-1 transcriptional activity
  JOURNAL   Genes Dev 15 (20), 2675-2686 (2001)
   PUBMED   11641274
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158810.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_001062399.1, XM_219961.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158810.1, SRR8487227.117258.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1363
                     /gene="Hif1an"
                     /note="hypoxia inducible factor 1 subunit alpha inhibitor"
                     /db_xref="GeneID:309434"
                     /db_xref="RGD:1308281"
     exon            1..188
                     /gene="Hif1an"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1061
                     /gene="Hif1an"
                     /EC_number="1.14.11.16"
                     /note="hypoxia-inducible factor 1, alpha subunit
                     inhibitor"
                     /codon_start=1
                     /product="hypoxia-inducible factor 1-alpha inhibitor"
                     /protein_id="NP_001107221.1"
                     /db_xref="GeneID:309434"
                     /db_xref="RGD:1308281"
                     /translation="MAATAAEVAASASGEAREEAEAPGPAWDESQLRSYSFPTRPIPR
                     LSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLY
                     YDEKKMANFQNFKPRSNREEIKFHEFVEKLQAIQQRGGEERLYLQQTLNDTVGRKIVM
                     DFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGHKRCIL
                     FPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFRNVVGYETVVGPGDVLYIPMY
                     WWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQ
                     EVGPLLNTMIKGRYN"
     exon            189..439
                     /gene="Hif1an"
                     /inference="alignment:Splign:2.1.0"
     exon            440..588
                     /gene="Hif1an"
                     /inference="alignment:Splign:2.1.0"
     exon            589..734
                     /gene="Hif1an"
                     /inference="alignment:Splign:2.1.0"
     exon            735..841
                     /gene="Hif1an"
                     /inference="alignment:Splign:2.1.0"
     exon            842..905
                     /gene="Hif1an"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1016
                     /gene="Hif1an"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1340
                     /gene="Hif1an"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagagtaga gatggcggcg acggcagccg aggttgcggc ctctgcctct ggagaggccc
       61 gggaagaagc tgaagctccg ggcccggcct gggatgagtc ccagctacga agttacagct
      121 ttccgaccag gcccatccca cgtttgagcc agagcgaccc tcgggcggaa gagctcatcg
      181 aaaatgagga gcccgtggtg ctgaccgaca caaaccttgt gtatcctgct ctgaagtggg
      241 acctcgaata cctgcaagag aatattggca acggagattt ctctgtgtac agtgccagca
      301 cccataagtt cttatactat gatgagaaga agatggccaa tttccagaac tttaagccaa
      361 ggtccaacag ggaggaaatt aaatttcatg agttcgttga gaaactacaa gctatccagc
      421 agcgcggggg agaagagcgg ttgtatctgc agcaaacact caatgacacc gtgggtagaa
      481 agattgtcat ggacttcttg ggttttaact ggaactggat taataaacaa caggggaaac
      541 gtggctgggg gcagctgacc tctaacctgt tgctcatcgg catggaaggg aatgtgacac
      601 ctgctcacta tgatgagcaa cagaactttt ttgcccagat aaaaggccat aagagatgca
      661 tcttatttcc tccggatcag ttcgagtgcc tctacccata ccctgtccat cacccctgtg
      721 acaggcagag ccaggtggac tttgacaatc ctgactatga gcgcttcccc aacttccgaa
      781 atgtggttgg ctatgaaaca gtggttggcc ctggtgacgt tctttacatc ccaatgtact
      841 ggtggcatca catagagtcg ttactaaatg ggggaattac catcactgtg aacttctggt
      901 ataagggggc tcccacccct aagagaattg aatatcctct caaagctcat cagaaagtag
      961 ccatcatgag aaacattgag aagatgcttg gagaggcctt ggggaaccca caagaggtgg
     1021 ggcctttgtt gaacaccatg attaaaggcc gctacaacta acctaccaga ggtcaaggcc
     1081 tcccgccagg tgactgctat cctgtccaca tgcttctgcg atgaggacgg gacactccaa
     1141 gcactagtat tgcacgctgc acttaatgga ctggactctt gccatggccc tggaggcagg
     1201 tgtctgaggc gaggcagggt agttgactcc acttcgattt ggaaaggttt ctcacccttg
     1261 cctcttgagc cccggacctt ccctcattgc cccctgaagt cctgcaatta gtgtgtggag
     1321 tcccagcttt ctggttgtaa aaaaaaaaaa aaaaaaaaaa aaa
//
