LOCUS       NM_024359               4003 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus hypoxia inducible factor 1 subunit alpha (Hif1a),
            mRNA.
ACCESSION   NM_024359
VERSION     NM_024359.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4003)
  AUTHORS   Kong,F., Xia,P., Shi,Y., Ye,Z., Zhang,X., Yu,C., Cheng,K. and Li,X.
  TITLE     Ultrasound-targeted microbubble destruction facilitates cartilage
            repair through increased the migration of mesenchymal stem cells
            via HIF-1alpha-mediated glycolysis pathway in rats
  JOURNAL   Biochem Biophys Res Commun 726, 150229 (2024)
   PUBMED   38908346
  REMARK    GeneRIF: Ultrasound-targeted microbubble destruction facilitates
            cartilage repair through increased the migration of mesenchymal
            stem cells via HIF-1alpha-mediated glycolysis pathway in rats.
REFERENCE   2  (bases 1 to 4003)
  AUTHORS   Kadekawa,K., Nishijima,S., Noguchi,K., Matsumoto,S. and Sugaya,K.
  TITLE     Elucidation of the pathophysiology of interstitial cystitis/bladder
            pain syndrome via experimental autoimmune cystitis rat model
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 327 (2), R250-R260 (2024)
   PUBMED   38842512
REFERENCE   3  (bases 1 to 4003)
  AUTHORS   Xiaoshan,Z., Huan,C., Zhilin,G., Liwen,M., Yan,Z. and Yue,C.
  TITLE     Hypoxia-inducible factor-1alpha attenuates renal podocyte injury in
            male rats in a simulated high-altitude environment by upregulating
            Kruppel-like factor 4 expression
  JOURNAL   Exp Physiol 109 (7), 1188-1198 (2024)
   PUBMED   38774964
  REMARK    GeneRIF: Hypoxia-inducible factor-1alpha attenuates renal podocyte
            injury in male rats in a simulated high-altitude environment by
            upregulating Kruppel-like factor 4 expression.
REFERENCE   4  (bases 1 to 4003)
  AUTHORS   Xu,L., Yang,M., Wei,A., Wei,Z., Qin,Y., Wang,K., Li,B., Chen,K.,
            Liu,C., Li,C. and Wang,T.
  TITLE     Aerobic exercise-induced HIF-1alpha upregulation in heart failure:
            exploring potential impacts on MCT1 and MPC1 regulation
  JOURNAL   Mol Med 30 (1), 83 (2024)
   PUBMED   38867145
  REMARK    GeneRIF: Aerobic exercise-induced HIF-1alpha upregulation in heart
            failure: exploring potential impacts on MCT1 and MPC1 regulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4003)
  AUTHORS   Mao,C., Huang,J., Liu,H., Liu,Y., Hu,Z. and Xu,R.
  TITLE     Nur77 induced by HIF-1alpha mediates vascular remodeling in hypoxic
            pulmonary hypertension
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (6), 233-237 (2024)
   PUBMED   38836656
  REMARK    GeneRIF: Nur77 induced by HIF-1alpha mediates vascular remodeling
            in hypoxic pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4003)
  AUTHORS   Wang,G.L., Jiang,B.H., Rue,E.A. and Semenza,G.L.
  TITLE     Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS
            heterodimer regulated by cellular O2 tension
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5510-5514 (1995)
   PUBMED   7539918
REFERENCE   7  (bases 1 to 4003)
  AUTHORS   Semenza,G.L., Roth,P.H., Fang,H.M. and Wang,G.L.
  TITLE     Transcriptional regulation of genes encoding glycolytic enzymes by
            hypoxia-inducible factor 1
  JOURNAL   J Biol Chem 269 (38), 23757-23763 (1994)
   PUBMED   8089148
REFERENCE   8  (bases 1 to 4003)
  AUTHORS   Wang,G.L. and Semenza,G.L.
  TITLE     General involvement of hypoxia-inducible factor 1 in
            transcriptional response to hypoxia
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 4304-4308 (1993)
   PUBMED   8387214
REFERENCE   9  (bases 1 to 4003)
  AUTHORS   Obara,N. and Takeda,M.
  TITLE     Expression of neural cell adhesion molecule (NCAM) during the first
            molar development in the mouse
  JOURNAL   Anat Embryol (Berl) 187 (3), 209-219 (1993)
   PUBMED   8470821
REFERENCE   10 (bases 1 to 4003)
  AUTHORS   Semenza,G.L. and Wang,G.L.
  TITLE     A nuclear factor induced by hypoxia via de novo protein synthesis
            binds to the human erythropoietin gene enhancer at a site required
            for transcriptional activation
  JOURNAL   Mol Cell Biol 12 (12), 5447-5454 (1992)
   PUBMED   1448077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 15, 2021 this sequence version replaced NM_024359.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF057308.1, SRR26643285.24954.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               JAXUCZ010000006.1  98359898-98360258
            362-555             JAXUCZ010000006.1  98383541-98383734
            556-701             JAXUCZ010000006.1  98384981-98385126
            702-786             JAXUCZ010000006.1  98385209-98385293
            787-899             JAXUCZ010000006.1  98387935-98388047
            900-1102            JAXUCZ010000006.1  98389252-98389454
            1103-1209           JAXUCZ010000006.1  98394685-98394791
            1210-1357           JAXUCZ010000006.1  98395953-98396100
            1358-1578           JAXUCZ010000006.1  98397770-98397990
            1579-1862           JAXUCZ010000006.1  98398576-98398859
            1863-1985           JAXUCZ010000006.1  98399808-98399930
            1986-2419           JAXUCZ010000006.1  98400038-98400471
            2420-2528           JAXUCZ010000006.1  98402235-98402343
            2529-2655           JAXUCZ010000006.1  98403068-98403194
            2656-4003           JAXUCZ010000006.1  98403721-98405068
FEATURES             Location/Qualifiers
     source          1..4003
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..4003
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /note="hypoxia inducible factor 1 subunit alpha"
                     /db_xref="GeneID:29560"
                     /db_xref="RGD:61928"
     exon            1..361
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..2807
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /note="hypoxia-inducible factor 1, alpha subunit (basic
                     helix-loop-helix transcription factor); hypoxia inducible
                     factor 1 alpha subunit; HIF1 alpha"
                     /codon_start=1
                     /product="hypoxia-inducible factor 1-alpha"
                     /protein_id="NP_077335.2"
                     /db_xref="GeneID:29560"
                     /db_xref="RGD:61928"
                     /translation="MEGAGGENEKKNRMSSERRKEKSRDAARSRRSKESEVFYELAHQ
                     LPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDEMKAQMNCFYLKALDGFVM
                     VLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGPVRKGK
                     EQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTSSNQPQCGYKKPPM
                     TCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSI
                     YEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQ
                     CIVCVNYVVSGIIQHDLIFSLQQTESVLKPVESSDMKMTQLFTKVESEDTSCLFDKLK
                     KEPDALTLLAPAAGDTIISLDFGSDDTETEDQQLEDVPLYNDVMFPSSNEKLNINLAM
                     SPLPASETPKPLRSSADPALNQEVALKLESSPESLGLSFTMPQIQDQPASPSDGSTRQ
                     SSPEPNSPSEYCFDVDSDMVNVFKLELVEKLFAEDTEAKNPFSAQDTDLDLEMLAPYI
                     PMDDDFQLRSFDQLSPLESNSPSPPSVSTVTGFQQTQLQKPTITVTAATATTATTTDE
                     SKAVTKDNIEDIKILIASPPSTQVPQEMTTAKASAYSGTHSRTTSPDRAGKRVIEKTD
                     KAHPRSLNLSVTLNQRNTVPEEELNPKTIALQNAQRKRKMEHDGSLFQAAGIGTLLQQ
                     PGDRAPTMSLSWKRVKGYISSEQDGMEQKTIFLIPSDLACRLLGQSMDESGLPQLTSY
                     DCEVNAPIQGSRNLLQGEELLRALDQVN"
     exon            362..555
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..701
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..786
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..899
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1102
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1209
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1357
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1578
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1862
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1985
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2419
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2528
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2655
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..4003
                     /gene="Hif1a"
                     /gene_synonym="HIF1-alpha; MOP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccttgccc gccccctgcc gctgcctcag cgcctcagtg cacagaggct cctcgtctga
       61 ggggacgcga ggactgtcct cgctaccgtc gcgagcagtg tctggccagg ccttgacaag
      121 ccagccggag gagcaactag gaacccgaac cagagcccgg cgagcgcagc ctgcagctcc
      181 cgcctcgccg tcccgggggg gtgtcccgcc tcacaccccg cctctggact tgcccctttc
      241 tctgcgcgtg aggacagagc cggcgcttag gccggagcga gcccaggggc tgccggccgg
      301 gaagacaccg cgggcaccga ttcgccatgg agggcgccgg cggcgagaac gagaagaaaa
      361 ataggatgag ttccgaacgt cgaaaagaaa agtctaggga tgcagcacga tctcggcgaa
      421 gcaaagagtc tgaagttttt tatgagcttg ctcatcagtt gccacttccc cacaacgtga
      481 gctcccatct tgataaagct tctgttatga ggctcaccat cagttactta cgtgtgagga
      541 aacttctaga tgctggtgat cttgacattg aagatgaaat gaaagcacag atgaactgct
      601 tttatctgaa agccctggat ggctttgtta tggtgctaac agatgatggt gacatgattt
      661 acatttctga taacgtgaac aaatacatgg ggttgactca gtttgaacta actggacaca
      721 gtgtgtttga ttttacccat ccatgtgacc atgaggaaat gagagaaatg cttacacaca
      781 gaaatggccc agtgagaaag gggaaagaac aaaacacgca gcgaagcttt tttctcagaa
      841 tgaaatgtac cctaacaagc cgggggagga cgatgaacat caagtcagca acgtggaagg
      901 tgctgcactg cacaggccac attcatgtgt atgataccag cagtaaccag ccgcagtgtg
      961 gctacaagaa accgcctatg acgtgcttgg tgctgatttg tgaacccatt cctcatccat
     1021 caaacattga aattccttta gacagcaaga catttctcag tcgacacagc ctcgatatga
     1081 aattttctta ctgtgatgaa aggattactg agttgatggg ttatgagcca gaagaacttt
     1141 tgggccgttc aatttatgaa tattatcatg ctttggactc tgatcatctg accaaaactc
     1201 atcatgacat gtttactaaa ggacaagtca ccacaggaca gtacaggatg cttgcaaaaa
     1261 gaggtggata tgtctgggtt gagactcaag caactgttat atataatacg aagaactctc
     1321 agccacagtg cattgtgtgt gtgaattatg ttgtaagtgg tattattcag cacgacttga
     1381 ttttctccct tcaacaaaca gaatctgtcc tcaaaccagt tgaatcttca gatatgaaaa
     1441 tgacccagct gttcactaaa gtggaatctg aggacacgag ctgcctcttc gacaagctta
     1501 agaaagagcc cgatgccctg actctgctag ctccagcggc tggggacacg atcatatcac
     1561 tggacttcgg cagcgatgac acggaaactg aagaccaaca acttgaagat gtcccgttgt
     1621 acaatgatgt aatgttcccc tcttctaatg agaaattaaa tataaatctg gcaatgtctc
     1681 cattacctgc ctctgaaact ccaaagccac ttcgaagtag tgctgatcct gcactgaatc
     1741 aagaggttgc attgaagtta gagtcaagcc cagagtcact gggactttct tttaccatgc
     1801 cccagattca agatcagcca gcaagtcctt ctgatggaag cactagacaa agctcacctg
     1861 agcctaacag tcccagtgag tactgctttg atgtggacag cgatatggtc aatgtattca
     1921 agttggaact ggtggaaaaa ctgtttgctg aagacacaga agcgaagaat ccattttcag
     1981 ctcaggacac tgatttagac ttggaaatgc tggctcccta tatcccaatg gatgatgatt
     2041 tccagttacg ttcctttgat cagttgtcac cattagagag caattctcca agccctccga
     2101 gtgtgagcac agttacagga ttccagcaga cccagttaca gaaacctacc atcactgtca
     2161 ctgccgcaac tgccaccacc gccaccacca ctgatgaatc aaaagcagtg acgaaggaca
     2221 atatagaaga cattaaaata ctgattgcat ctccaccttc tacccaagta cctcaagaaa
     2281 tgaccactgc taaggcatca gcatacagtg gtactcacag tcggacaacc tcaccagaca
     2341 gagcaggaaa gagagtcata gaaaaaacag acaaagctca tccaaggagc cttaacctat
     2401 ctgtcacttt gaatcaaaga aatactgttc ctgaagaaga attaaaccca aagacaatag
     2461 ctttgcagaa tgctcagagg aagcgaaaaa tggaacatga tggctccctt tttcaagcag
     2521 caggaattgg aacgttactg cagcaaccag gtgaccgtgc ccctactatg tcgctttctt
     2581 ggaaacgagt gaaaggatac atatctagtg aacaggatgg aatggagcag aagacaattt
     2641 ttttaatacc ctctgattta gcatgtagac tgctggggca gtcaatggat gagagtggat
     2701 taccacagct gaccagttac gattgtgaag ttaatgctcc catacaaggc agcagaaacc
     2761 tactgcaggg tgaagaatta ctcagagctt tggatcaagt taactgagct tttcctaatc
     2821 tcattccttt gattgttaat ttttgtgttc agttgttgtt gttgtctgtg gggtttcgtt
     2881 tctgttggtt gttttggaca ctggtggctc agcagtctat ttatattttc tatatctcat
     2941 ttagaggcct ggctacagta ctgcaccaac tcagatagtt tagtttgggc cccttcctcc
     3001 ttcattttca ctgatgctct ttttaccatg tccttcgaat gccagatcac agcacattca
     3061 cagctcccca gcatttcacc aatgcattgc tgtagtgtcg tttaaaatgc acctttttat
     3121 ttatttattt ttggtgaggg agtttgtccc ttattgaatt atttttaatg aaatgccaat
     3181 ataatttttt aagaaggcag taaatcttca tcatgatgat aggcagttga aaatttttta
     3241 ctcatttttt tcatgtttta catgaaaata atgctttgcc agcagtacat ggtagccaca
     3301 attgcacaat atattttctt aaaaatacca gcagttactc atgcatatat tctgcattta
     3361 taaaactagt ttttaagaag aaactttttt tggcctatgg aattgttaag cctggatcat
     3421 gatgctgttg atcttataat gattcttaaa ctgtatggtt tctttatatg ggtaaagcca
     3481 tttacatgat atagagagat atgcttatat ctggaaggta tatggcattt atttggataa
     3541 aattctcaat tgagaagtta tctggtgttt ctttacttta ccggctcaaa agaaaacagt
     3601 ccctatgtag ttgtggaagc ttatgctaat attgtgtaat tgatattaaa cattaaatgt
     3661 tctgcctatc ctgttggtat aaagacattt tgagcatact gtaaacaaaa aaatcatgca
     3721 ttgttagtaa aattgcctag tatgttaatt tgttgaaaat acgatgtttg gttttatgca
     3781 ctttgtcgct attaacatcc tttttttcat atagatttca ataattgagt aattttagaa
     3841 gcattatttt agaaatatag agttgtcata gtaaacatct tgtttttttt tctttttttc
     3901 tatgtacatt gtataaattt ttcattccct tgctctttgt agttgggtct aacactaact
     3961 gtactgtttt gttatatcaa ataaacatct tctgtggacc agg
//
