LOCUS       NM_001398668            1874 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus 3-hydroxyisobutyryl-CoA hydrolase (Hibch),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001398668 XM_006244895
VERSION     NM_001398668.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1874)
  AUTHORS   Hawes,J.W., Jaskiewicz,J., Shimomura,Y., Huang,B., Bunting,J.,
            Harper,E.T. and Harris,R.A.
  TITLE     Primary structure and tissue-specific expression of human
            beta-hydroxyisobutyryl-coenzyme A hydrolase
  JOURNAL   J Biol Chem 271 (42), 26430-26434 (1996)
   PUBMED   8824301
REFERENCE   2  (bases 1 to 1874)
  AUTHORS   Shimomura,Y., Murakami,T., Fujitsuka,N., Nakai,N., Sato,Y.,
            Sugiyama,S., Shimomura,N., Irwin,J., Hawes,J.W. and Harris,R.A.
  TITLE     Purification and partial characterization of
            3-hydroxyisobutyryl-coenzyme A hydrolase of rat liver
  JOURNAL   J Biol Chem 269 (19), 14248-14253 (1994)
   PUBMED   8188708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Dec 21, 2021 this sequence version replaced XM_006244895.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.31078.1,
                                           SRR26643298.48687.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000009.1  56161653-56161796   c
            145-187             JAXUCZ010000009.1  56144563-56144605   c
            188-325             JAXUCZ010000009.1  56140450-56140587   c
            326-410             JAXUCZ010000009.1  56138660-56138744   c
            411-491             JAXUCZ010000009.1  56135602-56135682   c
            492-544             JAXUCZ010000009.1  56128373-56128425   c
            545-623             JAXUCZ010000009.1  56110557-56110635   c
            624-769             JAXUCZ010000009.1  56100834-56100979   c
            770-856             JAXUCZ010000009.1  56098538-56098624   c
            857-915             JAXUCZ010000009.1  56096445-56096503   c
            916-997             JAXUCZ010000009.1  56095679-56095760   c
            998-1117            JAXUCZ010000009.1  56088967-56089086   c
            1118-1151           JAXUCZ010000009.1  56086178-56086211   c
            1152-1874           JAXUCZ010000009.1  56082082-56082804   c
FEATURES             Location/Qualifiers
     source          1..1874
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..1874
                     /gene="Hibch"
                     /note="3-hydroxyisobutyryl-CoA hydrolase"
                     /db_xref="GeneID:301384"
                     /db_xref="RGD:1308392"
     exon            1..144
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1267
                     /gene="Hibch"
                     /EC_number="3.1.2.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     3-hydroxyisobutyryl-CoA hydrolase, mitochondrial;
                     HIBYL-CoA-H; HIB-CoA hydrolase;
                     3-hydroxyisobutyryl-Coenzyme A hydrolase"
                     /codon_start=1
                     /product="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
                     isoform 1"
                     /protein_id="NP_001385597.1"
                     /db_xref="GeneID:301384"
                     /db_xref="RGD:1308392"
                     /translation="MGQQFVWRLQSRFSSIRRASVILQHLRMSKHTETAEVLLERRGC
                     AGVITLNRPKLLNALSLNMIRQIYPQLKKWERDPDTFLIIIKGAGGKAFCAGGDIKAL
                     SEAKKAGQTLSQDLFREEYILNNAIASCQKPYVALIDGITMGGGVGLSVHGQFRVATE
                     RSLFAMPETGIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVHRAGIATHFVDS
                     EKLHVLEEELLALKSPSAEDVAGVLESYHAKSKMGQDKSIIFEEHMDKINSCFSANTV
                     EQILENLRQDGSPFAMEQIKVINKMSPTSLKITLRQLMEGSTKTLQEVLTMEYRLTQA
                     CMEGHDFHEGVRAVLIDKDQTPKWKPADLKDVTDEDLNSYFKSLGSRDLKF"
     exon            145..187
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     exon            188..325
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     exon            326..410
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     exon            411..491
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     exon            492..544
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     exon            545..623
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     exon            624..769
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     exon            770..856
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     exon            857..915
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     exon            916..997
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1117
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1151
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1874
                     /gene="Hibch"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaattgtcag tgaccctggc tcttctaggt tctggtcggc ggtgggcggg tctgagaagt
       61 gcaggtggag ttgctacgtt ctgctaattc atctctaggg ttttaggcca tggggcagca
      121 gtttgtgtgg cggctccagt cgaggttcag ctcaatcaga agagccagtg ttattctgca
      181 acatctgaga atgtccaagc acacagagac tgcagaagtg ctgctggaga ggagaggctg
      241 tgcaggggtc ataacgctca acagacccaa gttactcaac gctctgagtc tgaatatgat
      301 ccggcagatc tatccgcagc taaagaagtg ggaacgagac ccagatacat tcctgatcat
      361 cataaaggga gctggaggaa aggccttctg tgctggaggg gacatcaaag cactctcaga
      421 agctaaaaaa gcagggcaga ctttgagtca agatttattc agagaagaat atatcctgaa
      481 caatgccatt gcgtcttgtc agaaaccgta tgttgccctt attgatggaa tcacaatggg
      541 tgggggagtt ggtctttcag tccatggtca attccgagtg gctacagaaa gatctctctt
      601 tgctatgcca gaaacgggaa taggactgtt tcctgatgtg ggcggaggtt atttcttgcc
      661 aagacttcaa ggaaaactgg gttacttcct tgcactgaca ggattcagac taaaaggaag
      721 agatgtgcac agagcgggaa tcgccacaca ctttgtagat tcagaaaagt tgcatgtact
      781 ggaggaggag ttgttagcct taaagtcccc ttcagctgag gatgttgctg gtgtcttaga
      841 aagctatcat gccaagtcca agatgggtca agacaagtct atcatatttg aggaacacat
      901 ggacaaaata aacagttgtt tttcagccaa tactgtggaa cagattcttg aaaacttacg
      961 gcaagatggt tcaccttttg ctatggaaca gattaaggtt attaataaaa tgtctccaac
     1021 gtcactaaag atcacactaa ggcagctcat ggagggctct acaaagacct tgcaagaagt
     1081 actgaccatg gagtaccggt taactcaagc gtgtatggaa ggtcatgact ttcatgaagg
     1141 tgttagagct gttctcattg acaaagacca gactccaaaa tggaaaccag ctgatctaaa
     1201 agatgttact gatgaagatt tgaatagtta ttttaaatct ctgggaagca gggatttgaa
     1261 attctgaggt ttattttgga gcaagggtca gcacaccata gcagagacgc caggcctggc
     1321 atcttggccc atttttgtgc aacctgcaag ctggaaatag ttttcttgtt tttaaatgct
     1381 tgggaaagaa atgaaaagac taatgtttca taatacagtg gttgcctgaa gtttaagcac
     1441 cagtgtttat aacttttcct gatgtgacag ctaaagttca aacaccaatg ttttatggag
     1501 ccttcctgca gtggagcgga acttgttccc tatggcttgg agtggccatg gcacagactt
     1561 catgacccac agcacctcaa gtatctaagt atctactgtg atcttcgtca gaaacggttt
     1621 gctggtccct ggtttataag aaaattaaga gctccagaga atcccaagtc atttctcatt
     1681 aaaacaatga ctgtaatttc tactttatca gtaattaacc aaattatgta cagattatca
     1741 gaatccaaac cttgaaattt ggagagggta tattgatgcc ttataaattt tctttttaaa
     1801 catttcctac tttaaaacaa tattgtagca gaagaattac tttgtaaaca ttaaaaatct
     1861 catgcaaaaa acaa
//
