LOCUS       NM_022243               1769 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus 3-hydroxyisobutyrate dehydrogenase (Hibadh),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_022243 XM_342686
VERSION     NM_022243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1769)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1769)
  AUTHORS   Murin,R., Schaer,A., Kowtharapu,B.S., Verleysdonk,S. and
            Hamprecht,B.
  TITLE     Expression of 3-hydroxyisobutyrate dehydrogenase in cultured neural
            cells
  JOURNAL   J Neurochem 105 (4), 1176-1186 (2008)
   PUBMED   18284611
  REMARK    GeneRIF: The expression of 3-hydroxyisobutyrate dehydrogenase in
            neural cells demonstrates their potential to utilize valine
            imported into the brain for the generation of energy.
REFERENCE   3  (bases 1 to 1769)
  AUTHORS   Loupatty,F.J., van der Steen,A., Ijlst,L., Ruiter,J.P., Ofman,R.,
            Baumgartner,M.R., Ballhausen,D., Yamaguchi,S., Duran,M. and
            Wanders,R.J.
  TITLE     Clinical, biochemical, and molecular findings in three patients
            with 3-hydroxyisobutyric aciduria
  JOURNAL   Mol Genet Metab 87 (3), 243-248 (2006)
   PUBMED   16466957
REFERENCE   4  (bases 1 to 1769)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1769)
  AUTHORS   Hawes,J.W., Harper,E.T., Crabb,D.W. and Harris,R.A.
  TITLE     Structural and mechanistic similarities of 6-phosphogluconate and
            3-hydroxyisobutyrate dehydrogenases reveal a new enzyme family, the
            3-hydroxyacid dehydrogenases
  JOURNAL   FEBS Lett 389 (3), 263-267 (1996)
   PUBMED   8766712
REFERENCE   6  (bases 1 to 1769)
  AUTHORS   Rougraff,P.M., Zhang,B., Kuntz,M.J., Harris,R.A. and Crabb,D.W.
  TITLE     Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate
            dehydrogenase. Evidence for its evolutionary relationship to other
            pyridine nucleotide-dependent dehydrogenases
  JOURNAL   J Biol Chem 264 (10), 5899-5903 (1989)
   PUBMED   2647728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            J04628.1 and AA859729.1.
            
            On Dec 24, 2005 this sequence version replaced XM_342686.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127442.1, J04628.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                J04628.1           1-62
            63-1725             J04628.1           64-1726
            1726-1769           AA859729.1         1-44                c
FEATURES             Location/Qualifiers
     source          1..1769
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1769
                     /gene="Hibadh"
                     /note="3-hydroxyisobutyrate dehydrogenase"
                     /db_xref="GeneID:63938"
                     /db_xref="RGD:708399"
     exon            1..120
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1040
                     /gene="Hibadh"
                     /EC_number="1.1.1.31"
                     /note="3-hydroxyisobutyrate dehydrogenase, mitochondrial"
                     /codon_start=1
                     /product="3-hydroxyisobutyrate dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_071579.1"
                     /db_xref="GeneID:63938"
                     /db_xref="RGD:708399"
                     /translation="MAASLGFRGAASGLRYWSGRRRPVGSLAAVCSRSMASKTPVGFI
                     GLGNMGNPMAKNLIKHGYPLILYDVFPDVCKEFKEAGEQVASSPADVAEKADRIITML
                     PSSMNSIEVYSGANGILKKVKKGSLLIDSSTIDPSVSKELAKEVEKMGAVFMDAPVSG
                     GVGAARSGNLTFMVGGVENEFAAAQELLGCMGSNVLYCGAVGSGQSAKICNNMLLAIS
                     MIGTAEAMNLGIRSGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSSNNYQGGF
                     GTTLMAKDLGLAQDSATSTKTPILLGSVAHQIYRMMCSKGYSKKDFSSVFQYLREEET
                     F"
     exon            121..281
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     exon            282..391
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     exon            392..513
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     exon            514..647
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     exon            648..724
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     exon            725..881
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1753
                     /gene="Hibadh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcacggcg cggaggcggg gcgtggggca gcatggcagc ctccttgggg ttccgggggg
       61 cagcctccgg cctccggtac tggagcggcc ggcggcggcc cgtgggcagc cttgcagcgg
      121 tgtgttctag gtcaatggct tctaagactc cagttggatt cattggactg ggaaacatgg
      181 gcaatccaat ggcaaaaaat ctcataaaac atggctaccc actcatcctc tatgatgtgt
      241 tccctgacgt atgcaaagag tttaaagagg ctggtgaaca ggtagcgtcc tccccagcag
      301 atgtagcgga aaaggctgac aggattatca caatgctgcc ctccagtatg aattcaatag
      361 aagtttattc tggagcaaat ggaattctaa aaaaagtgaa gaaaggctca ttattaatag
      421 attccagtac tattgatcct tcagtttcaa aagaattggc aaaagaagtt gagaaaatgg
      481 gagctgtttt catggacgcc cctgtttctg gtggcgtagg agctgctcgg tctggaaacc
      541 ttacattcat ggtgggagga gttgaaaatg agtttgctgc tgcccaagag ttgctggggt
      601 gcatgggctc caatgtattg tactgtggag ctgtcgggtc tgggcagtct gcaaagatct
      661 gtaacaacat gctgttggct ataagtatga tcggaactgc tgaagctatg aaccttggaa
      721 tcaggtcagg ccttgaccca aaactattgg ctaaaatcct gaatatgagc tcaggacgat
      781 gctggtccag cgacacttac aaccctgtac ctggggttat ggatggagtt ccctcatcta
      841 ataactacca aggtggattt gggacaacac tcatggccaa ggatctggga ttagctcaag
      901 actctgccac cagcaccaag accccaattc tcctcggaag cgtggcccat cagatataca
      961 ggatgatgtg ttcaaagggc tactcaaaga aagacttctc ctctgtgttc cagtatctgc
     1021 gggaggagga aaccttctga ctgccctgtg gtcatggaca ctgttaggaa ccaaactctg
     1081 tcctgagctt ccttctagct cattctagaa gtcatgggtt taatcaaagg tcatctgtct
     1141 gcttttgatt gtctacatta tagcaatccc tggggatttt tatccatttt aaatgctgct
     1201 gctttcatct gtttagcaaa cacacccaat ggtttccact gactagccca gttgaccttt
     1261 ttaagtttga accttgagca ccttaaacaa aattgagcac tctgatcagg atattttatt
     1321 tactctgctt tacaaataaa accaaatgtt ttgttaacaa gatggaaccc atggtaaaaa
     1381 aggaaagaaa tcagttacaa agacaaatta gagggaaatt tgtcctgtta accacgtgct
     1441 attattcctt cattctgggt tactgactta ctgtgcaggg gttgataggt aagacagctt
     1501 gctatacttg tcttcctgtc tcgattgtta cagtatctta gtgtaccctc ctgttacagc
     1561 ttcctcactc agccggcttg cttctgtatt tttgcttcct gtatatcctt ttactacatg
     1621 tttttgactc cagaaaaatg acaccgttag actgtttcag agccaatgat gatatttcct
     1681 ttagataatt attatattat tctaactata gtcatattat tttggattta aataaatttc
     1741 tatcctgata acaaaaaaaa aaaaaaaaa
//
