LOCUS       NM_024385               1602 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus hematopoietically expressed homeobox (Hhex),
            mRNA.
ACCESSION   NM_024385
VERSION     NM_024385.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1602)
  AUTHORS   Wadey,K.S., Brown,B.A., Sala-Newby,G.B., Jayaraman,P.S., Gaston,K.
            and George,S.J.
  TITLE     Protein kinase CK2 inhibition suppresses neointima formation via a
            proline-rich homeodomain-dependent mechanism
  JOURNAL   Vascul Pharmacol 99, 34-44 (2017)
   PUBMED   28927755
  REMARK    GeneRIF: Vascular smooth muscle protein kinase CK2 inhibition
            suppresses neointima formation via a proline-rich
            homeodomain-dependent mechanism.
REFERENCE   2  (bases 1 to 1602)
  AUTHORS   Simpson,M.T., Venkatesh,I., Callif,B.L., Thiel,L.K., Coley,D.M.,
            Winsor,K.N., Wang,Z., Kramer,A.A., Lerch,J.K. and Blackmore,M.G.
  TITLE     The tumor suppressor HHEX inhibits axon growth when prematurely
            expressed in developing central nervous system neurons
  JOURNAL   Mol Cell Neurosci 68, 272-283 (2015)
   PUBMED   26306672
  REMARK    GeneRIF: These findings suggest a role for HHEX in restricting axon
            growth in the developing central nervous system.
REFERENCE   3  (bases 1 to 1602)
  AUTHORS   Falix,F.A., Weeda,V.B., Labruyere,W.T., Poncy,A., de Waart,D.R.,
            Hakvoort,T.B., Lemaigre,F., Gaemers,I.C., Aronson,D.C. and
            Lamers,W.H.
  TITLE     Hepatic Notch2 deficiency leads to bile duct agenesis perinatally
            and secondary bile duct formation after weaning
  JOURNAL   Dev Biol 396 (2), 201-213 (2014)
   PUBMED   25446530
REFERENCE   4  (bases 1 to 1602)
  AUTHORS   Stuckey,D.W., Di Gregorio,A., Clements,M. and Rodriguez,T.A.
  TITLE     Correct patterning of the primitive streak requires the anterior
            visceral endoderm
  JOURNAL   PLoS One 6 (3), e17620 (2011)
   PUBMED   21445260
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1602)
  AUTHORS   Williams,H., Jayaraman,P.S. and Gaston,K.
  TITLE     DNA wrapping and distortion by an oligomeric homeodomain protein
  JOURNAL   J Mol Biol 383 (1), 10-23 (2008)
   PUBMED   18755198
REFERENCE   6  (bases 1 to 1602)
  AUTHORS   Keng,V.W., Yagi,H., Ikawa,M., Nagano,T., Myint,Z., Yamada,K.,
            Tanaka,T., Sato,A., Muramatsu,I., Okabe,M., Sato,M. and Noguchi,T.
  TITLE     Homeobox gene Hex is essential for onset of mouse embryonic liver
            development and differentiation of the monocyte lineage
  JOURNAL   Biochem Biophys Res Commun 276 (3), 1155-1161 (2000)
   PUBMED   11027604
  REMARK    Erratum:[Biochem Biophys Res Commun 2000 Dec 20;279(2):739]
REFERENCE   7  (bases 1 to 1602)
  AUTHORS   Pellizzari,L., D'Elia,A., Rustighi,A., Manfioletti,G., Tell,G. and
            Damante,G.
  TITLE     Expression and function of the homeodomain-containing protein Hex
            in thyroid cells
  JOURNAL   Nucleic Acids Res 28 (13), 2503-2511 (2000)
   PUBMED   10871399
  REMARK    Erratum:[Nucleic Acids Res. 2024 Jan 25;52(2):1001. PMID: 38109293]
REFERENCE   8  (bases 1 to 1602)
  AUTHORS   Martinez Barbera,J.P., Clements,M., Thomas,P., Rodriguez,T.,
            Meloy,D., Kioussis,D. and Beddington,R.S.
  TITLE     The homeobox gene Hex is required in definitive endodermal tissues
            for normal forebrain, liver and thyroid formation
  JOURNAL   Development 127 (11), 2433-2445 (2000)
   PUBMED   10804184
REFERENCE   9  (bases 1 to 1602)
  AUTHORS   Brickman,J.M., Jones,C.M., Clements,M., Smith,J.C. and
            Beddington,R.S.
  TITLE     Hex is a transcriptional repressor that contributes to anterior
            identity and suppresses Spemann organiser function
  JOURNAL   Development 127 (11), 2303-2315 (2000)
   PUBMED   10804173
REFERENCE   10 (bases 1 to 1602)
  AUTHORS   Tanaka,T., Inazu,T., Yamada,K., Myint,Z., Keng,V.W., Inoue,Y.,
            Taniguchi,N. and Noguchi,T.
  TITLE     cDNA cloning and expression of rat homeobox gene, Hex, and
            functional characterization of the protein
  JOURNAL   Biochem J 339 (Pt 1) (Pt 1), 111-117 (1999)
   PUBMED   10085234
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_024385.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86383.1, BC088135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               JAXUCZ010000001.1  244602945-244603319
            376-554             JAXUCZ010000001.1  244605270-244605448
            555-605             JAXUCZ010000001.1  244605640-244605690
            606-1602            JAXUCZ010000001.1  244607536-244608532
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..1602
                     /gene="Hhex"
                     /gene_synonym="Hex"
                     /note="hematopoietically expressed homeobox"
                     /db_xref="GeneID:79237"
                     /db_xref="RGD:619932"
     exon            1..375
                     /gene="Hhex"
                     /gene_synonym="Hex"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..827
                     /gene="Hhex"
                     /gene_synonym="Hex"
                     /codon_start=1
                     /product="hematopoietically-expressed homeobox protein
                     HHEX"
                     /protein_id="NP_077361.1"
                     /db_xref="GeneID:79237"
                     /db_xref="RGD:619932"
                     /translation="MQFPHPGPAAAPAVGVPLYAPTPLLQPAHPTPFYIDDILGRGPA
                     APTPTPTLPSPNSSFTSLVSSYRTPVYEPTPVHPAFSHHPAAALAAAYGPGGFGGPLY
                     PFPRTVNDYTHALLRHDPLGKPLLWNPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQ
                     KYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKDELDSLDTSCDQ
                     GQDLPSEQNKGASLDSSQCSPSPASPEDPESEISEDSDQEVDIEGDKGYFNAG"
     exon            376..554
                     /gene="Hhex"
                     /gene_synonym="Hex"
                     /inference="alignment:Splign:2.1.0"
     exon            555..605
                     /gene="Hhex"
                     /gene_synonym="Hex"
                     /inference="alignment:Splign:2.1.0"
     exon            606..1602
                     /gene="Hhex"
                     /gene_synonym="Hex"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggagcagc catgcagttc ccgcacccgg ggcccgcggc tgcgcccgcc gtcggagtcc
       61 cgctgtacgc gcccacgccg ctgctgcagc ccgctcaccc gacgcctttc tacatcgacg
      121 acatcctggg tcgcgggccc gccgctccca cgcccactcc cacgctgccg tcccccaact
      181 cctccttcac cagcctcgtg tcctcctacc ggaccccggt gtacgagccc acgccggtcc
      241 accccgcctt ctcgcatcac cccgccgccg cgctggccgc tgcctatggc cccggtggct
      301 tcggaggccc tctgtacccg ttcccgcgga cggtgaacga ctacacgcac gccctactcc
      361 gccacgaccc cctgggcaag cccttgctct ggaacccctt cctacagcga cctctgcaca
      421 aaaggaaagg cggtcaagtg aggttttcca acgaccagac catcgagctg gagaagaagt
      481 tcgagactca gaaatacctc tccccacctg agagaaagcg tctggccaag atgttgcagc
      541 tcagcgagag acaggtcaaa acctggtttc agaatcgcag agctaaatgg agacgactga
      601 agcaggagaa tcctcaaagc aataaaaagg atgagttgga cagtttggac acttcctgtg
      661 accagggcca agacttgccc agtgaacaga ataaaggtgc ctctttggac agttctcagt
      721 gttcaccctc cccagcctct ccggaagacc ctgaatcaga gatctcagag gattccgacc
      781 aggaagtgga catcgagggt gataaaggct attttaatgc tggatgacag tcatcggccg
      841 tgaccatgtt cagagactgg actttagaat accgttctgc tacagacaaa ctgggaaatt
      901 ctgagagaaa gaagtaccat tcttctagcg ttttgaaaat atttggcacg gcgtgcattg
      961 aaaccatact tttggtttag cgtacgtttt ccgtaccggt gttaagttgt tttgataaag
     1021 tggctaaatg tgacttcgtt tttaaaaagt gaattctttc tatttgtgag aagtaatttg
     1081 aacttttgcc tgaagcttaa actataactt taaaggtttt gggcggctgt tctcgaatga
     1141 cttttcccaa atgtgtagct gttccctcga cttcagaggt gcacttagaa agggggccag
     1201 catttgggga tccatggaat gctttcaaag agcacacttg gtttttacgt gacaccttac
     1261 attgctgcct taactccaaa gccggttcag agcacttggc ccctggtgtc tgttctcata
     1321 agcaagatag ttgataagat tcttacaatc ttgttttgct cggccagtgc ctctgaccct
     1381 ggtattaagg gatgacgcag tctctacagg cagggaaact gactcacttg tgactgatct
     1441 cacatgaact agaaatagca ggacaattaa atgtaagtag attgtagata gtgtgtttta
     1501 tagaaaccgt gtctatagca tgtgtataga attattcgtt gtaaaaaaaa ccctgcaaaa
     1561 atgtttgatt ttttttttaa tttaatgaat taactttcat at
//
