LOCUS       NM_001106868            1773 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Rattus norvegicus hedgehog acyltransferase-like (Hhatl), mRNA.
ACCESSION   NM_001106868 XM_001078610 XM_217299
VERSION     NM_001106868.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1773)
  AUTHORS   Xu,J., He,K., Ji,Y., Liu,X. and Dai,Q.
  TITLE     Downregulation of HHATL promotes cardiac hypertrophy via activation
            of SHH/DRP1
  JOURNAL   Exp Cell Res 439 (1), 114072 (2024)
   PUBMED   38719175
  REMARK    GeneRIF: Downregulation of HHATL promotes cardiac hypertrophy via
            activation of SHH/DRP1.
REFERENCE   2  (bases 1 to 1773)
  AUTHORS   Abe,Y., Kita,Y. and Niikura,T.
  TITLE     Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol
            uptake/transporter 1, acts as a negative regulator for N-terminal
            palmitoylation of Sonic hedgehog
  JOURNAL   FEBS J 275 (2), 318-331 (2008)
   PUBMED   18081866
REFERENCE   3  (bases 1 to 1773)
  AUTHORS   Soejima,H., Kawamoto,S., Akai,J., Miyoshi,O., Arai,Y., Morohka,T.,
            Matsuo,S., Niikawa,N., Kimura,A., Okubo,K. and Mukai,T.
  TITLE     Isolation of novel heart-specific genes using the BodyMap database
  JOURNAL   Genomics 74 (1), 115-120 (2001)
   PUBMED   11374908
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217299.4, XM_001078610.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1773
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1773
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /note="hedgehog acyltransferase-like"
                     /db_xref="GeneID:301073"
                     /db_xref="RGD:1311911"
     exon            1..149
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /inference="alignment:Splign:2.1.0"
     exon            150..268
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1674
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /note="Gup1, glycerol uptake/transporter homolog"
                     /codon_start=1
                     /product="protein-cysteine N-palmitoyltransferase
                     HHAT-like protein"
                     /protein_id="NP_001100338.1"
                     /db_xref="GeneID:301073"
                     /db_xref="RGD:1311911"
                     /translation="MGIKTALPAAELGLYSLVLSGALAYAGRGLLEASQDGAHRKAFR
                     ESVRPGWEYLGRKMDVADFEWVMWFTNFRNIIVFALSGHVLFAKLCTMVAPQLRSWMY
                     AVYGVLAVVGTMGPWYLLLLLGHCVVLYVASLLGQRWLCLALGLASLASFKMDPGISW
                     QSGFVTGTFDLQDVLFHGGSGFTVLRCTSFALESCAHPDRRYSLADLLKYNFYLPFFF
                     FGPIMTFDRFQAQVSQEPVRPEGELWRIQTQAGLSAAAIVAVDIFFHFFYILTIPSDL
                     KFASRLPDSALAGLAYSNLVYDWVKAAVLFGVVNTVARLDHLDPPQPPKCITALYVFG
                     ETHFDRGINDWLCKYVYDHIGGDHSAVIPELAASVATFVITTLWLGPCDIVYLWSVLN
                     CFGLNFELWAQKLAEHGPLAQIEARLSEQMSRRVRALCGAVNFWAIIMYNLVSLNSLE
                     FTELVARRLILTGFPQTTLAVLFVTYCGVQLVKERERSLALEEEQRQDKEKLE"
     exon            269..336
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /inference="alignment:Splign:2.1.0"
     exon            337..450
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /inference="alignment:Splign:2.1.0"
     exon            451..645
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /inference="alignment:Splign:2.1.0"
     exon            646..855
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1024
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1169
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1205
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1407
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1549
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1773
                     /gene="Hhatl"
                     /gene_synonym="Gup1; RGD1311911"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctggcctc cagggggtgg ggaccccaga gctggacaca ccccaccata gccccacagc
       61 tcagccagcc ggacagactc acggtcggac gcaggacccc ggagccctga ggtgggcagt
      121 gcgccagggt ccctctcagc ctcttcaagc cctctccagg ccatgggcat caaaacagcg
      181 ctgcctgcag ctgagctcgg cctctactcc ctggtgctaa gcggtgccct ggcttatgct
      241 ggccgtggtc tcctggaggc atcgcaagat ggagcacaca ggaaggcctt ccgggagtcc
      301 gtgcgacctg gctgggagta cctgggccgg aagatggatg tggctgactt cgagtgggtg
      361 atgtggttca ccaacttccg aaacatcatt gtctttgccc tctctggaca tgtgctgttt
      421 gctaaactct gcacaatggt ggccccccag ctccgctctt ggatgtatgc ggtgtatgga
      481 gtcctggcag tggtgggcac aatgggccca tggtacctgc tgctgctgct tggccactgc
      541 gtagtcctct atgtggcctc actcctgggc cagcgctggc tgtgccttgc ccttggcctt
      601 gccagcctgg cgtccttcaa gatggaccct gggatctctt ggcagagtgg gtttgtcaca
      661 ggcacttttg atcttcaaga tgtactgttc cacgggggca gcggcttcac agttctacgg
      721 tgcaccagct tcgcgctgga gagctgtgcc caccctgacc gccgctactc ccttgctgac
      781 ctgctcaagt acaatttcta cttgcccttc ttcttcttcg ggcccatcat gacctttgac
      841 cgcttccagg ctcaggtgag ccaggagcca gtgaggccag agggcgagct gtggcgcata
      901 caaacccagg caggactcag cgcggcagcc atagtggctg tcgacatctt cttccacttc
      961 ttctatatcc tcaccatccc cagcgatctc aagttcgcca gccgcctccc agacagtgcc
     1021 cttgcgggcc tggcctactc aaacctggtg tatgactggg tgaaggcagc agtcctgttt
     1081 ggtgtcgtca acactgtggc acgcctagac cacttggacc ctcctcagcc tccaaagtgc
     1141 attaccgcac tctacgtctt cggggagacg cactttgatc gtggcatcaa tgactggctt
     1201 tgcaaatacg tgtatgacca catcggcggg gatcattccg ccgtgatccc ggagctggcc
     1261 gcctctgtgg ccaccttcgt catcaccacc ctgtggctcg gaccttgtga catcgtctac
     1321 ctgtggtctg tccttaactg cttcggcctc aactttgagc tctgggcaca gaagctggca
     1381 gagcatgggc cactggcaca gatcgaggcc cggctatcgg agcagatgtc tcggagagtc
     1441 cgggccctct gtggggctgt aaacttctgg gctatcatca tgtacaatct cgtgagcctc
     1501 aacagccttg aattcacaga gctggttgcc cgacgcctga tacttacagg cttcccccag
     1561 accacactgg cggtcttgtt tgtcacctac tgtggtgtcc agctggtaaa agagcgtgag
     1621 agatccctgg cactggagga agagcagagg caggacaaag agaagctgga gtagaggtgg
     1681 ggacagagga ccaggctctg ctcagtggct tctgggccct aggcccagac catgaagcct
     1741 gaccaataga ataaaagact tttctaccac agt
//
