LOCUS       NM_001398579            3032 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus hedgehog acyltransferase (Hhat), mRNA.
ACCESSION   NM_001398579 XM_039091514
VERSION     NM_001398579.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3032)
  AUTHORS   Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang
            C, Heman-Ackah SM, Hessa T, Guha R, Martin SE and Youle RJ.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   2  (bases 1 to 3032)
  AUTHORS   Chen MH, Li YJ, Kawakami T, Xu SM and Chuang PT.
  TITLE     Palmitoylation is required for the production of a soluble
            multimeric Hedgehog protein complex and long-range signaling in
            vertebrates
  JOURNAL   Genes Dev 18 (6), 641-659 (2004)
   PUBMED   15075292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000246.1 and JACYVU010000245.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001398579.2.
            
            On Dec 20, 2021 this sequence version replaced XM_039091514.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487230.91924.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               JACYVU010000246.1  70188-70453         c
            267-396             JACYVU010000246.1  56489-56618         c
            397-464             JACYVU010000246.1  44768-44835         c
            465-578             JACYVU010000246.1  35646-35759         c
            579-773             JACYVU010000246.1  18673-18867         c
            774-989             JACYVU010000246.1  17490-17705         c
            990-1161            JACYVU010000246.1  8506-8677           c
            1162-1312           JACYVU010000245.1  20732540-20732690   c
            1313-1348           JACYVU010000245.1  20700266-20700301   c
            1349-1550           JACYVU010000245.1  20632853-20633054   c
            1551-1695           JACYVU010000245.1  20605119-20605263   c
            1696-3032           JACYVU010000245.1  20563246-20564582   c
FEATURES             Location/Qualifiers
     source          1..3032
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..3032
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /note="hedgehog acyltransferase"
                     /db_xref="GeneID:289344"
                     /db_xref="RGD:1311746"
     exon            1..266
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /inference="alignment:Splign:2.1.0"
     exon            267..396
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..1787
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /note="protein-cysteine N-palmitoyltransferase HHAT"
                     /codon_start=1
                     /product="protein-cysteine N-palmitoyltransferase HHAT
                     precursor"
                     /protein_id="NP_001385508.1"
                     /db_xref="GeneID:289344"
                     /db_xref="RGD:1311746"
                     /translation="MLSRWELTLCLLVSLGFHFRSFYEVYKVSREHEEELDQEFELEM
                     DTLFGGLKKDPTDFEWNFWLEWGKQRLVWLLLGHMAVSQLATLLTKKHRPWIIMIYGM
                     WACWCVLGAPGVVMVLLHTTIAFCVAQFRSMLLSWLCSLLLLSTLRLQSVEEVKRRWY
                     KTESEYYLLQFTLTVRCLYYTSFSLELCRQPPSAQRACFSFPWLLTYVFYYPVFHNGP
                     ILNFPEFFRQMQQPELSSLQHSLCILAKGLGRLLCWWWLAELMVHLMYMHALYSSIPL
                     LESVSCWTLGGLALAQVLFFYVKYLVLFGAPALLMRLDGLTPPPLPRCVSTMFSFTGM
                     WRYFDVGLHNFLIRYVYIPLGGSQHGLLGTLLSTAMTFAFVSYWHGSYEDLWCWAALN
                     WLGVTVESGVRRLLQTPCVRETLARHLSPQARRRLHALLASCSTSMLILFNLVFLEGI
                     QVGKTYWNRIFLQGWPWVTLSVLGFLYCYSHVGIAWAQTYTVL"
     exon            397..464
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /inference="alignment:Splign:2.1.0"
     exon            465..578
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /inference="alignment:Splign:2.1.0"
     exon            579..773
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /inference="alignment:Splign:2.1.0"
     exon            774..989
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1161
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1312
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1348
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1550
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1695
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..3032
                     /gene="Hhat"
                     /gene_synonym="RGD1311746"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcctttggg gaccggaaga atccagaagc ctgaggttct aatgggaccc tgggtgatga
       61 ttctgctccg gtaaatgtac agagcgccgg ccaatcccct gtcccggcag ccgggagcaa
      121 catctcaggc caaggcgttc acccccgcgg cctccgaccg gcgcagcccg cagccctcgc
      181 gagtccttcc cgggccgggg ctccgcgcgg cggggtgcag ggacgccttc ttccctgcgc
      241 actcagctct gcacgctgcg attcagaaac tctccacact acactgggaa gcagagtctc
      301 cagctatgct gtcccgttgg gaactgactc tctgcctgct tgtttccttg ggcttccact
      361 tccgctcttt ctatgaagtt tacaaagtct ccagggagca tgaagaggaa ctggaccagg
      421 agtttgaact ggagatggat actctatttg gaggactgaa gaaggacccg actgattttg
      481 agtggaactt ctggctggag tgggggaagc agaggctggt gtggctcctc cttggccata
      541 tggctgtgtc tcagttggcc acactgctca caaagaagca tagaccctgg attatcatga
      601 tctatggaat gtgggcctgc tggtgtgtgc tgggggctcc gggcgtggtc atggtccttc
      661 tccacaccac catcgccttc tgcgtggctc agttccgatc aatgctcctc tcctggctgt
      721 gttctctgct tctactctcc accctaagac tgcaaagtgt ggaggaagtt aagagaaggt
      781 ggtacaagac agagagcgag tactacctgc tgcagttcac gctcacagtt cgctgcctgt
      841 actacaccag cttcagcctg gagctgtgcc ggcagcctcc gtccgcccag cgtgcctgct
      901 tttccttccc gtggctgctg acctatgtct tctattatcc tgtcttccac aacgggccca
      961 tccttaactt cccggagttc ttcagacaga tgcagcagcc agagctcagc tctctgcagc
     1021 acagcctctg cattctagcc aagggcctgg gccgcctgct gtgctggtgg tggctggctg
     1081 aattgatggt acacctcatg tacatgcatg ccctctacag cagcatcccc ctcctggaga
     1141 gtgtttcctg ctggacctta ggaggactgg cgctggctca ggtgctcttc ttctatgtga
     1201 agtacttggt gctcttcggt gccccggctc tgctcatgcg cctggacgga ctcacaccac
     1261 caccccttcc ccgctgcgtg agcaccatgt tcagcttcac agggatgtgg aggtattttg
     1321 atgttggact acacaatttc ttaatcaggt atgtgtatat cccactgggt gggtcccagc
     1381 atggcctgct ggggacgctg ctttctaccg cgatgacgtt tgcgtttgtg agctactggc
     1441 acggcagcta tgaggacctc tggtgctggg cagcgctcaa ctggctggga gtcactgtgg
     1501 agagtggggt ccggaggctg ctacagacac cctgtgtccg ggagactttg gcccggcacc
     1561 tctccccaca agctcgccgt cgactacacg ctctgctggc ctcctgctct acctccatgc
     1621 tgatcctctt caacctggtg ttcctcgagg gaattcaagt tggaaaaacc tactggaaca
     1681 ggatcttcct gcaagggtgg ccatgggtga ccctgtctgt cctgggattc ctgtactgct
     1741 attcacacgt gggcattgcc tgggctcaga catacacagt tctttaactg tgtggctgct
     1801 gggccaggac agcctccaag ggacatagca tttcatcccg acctctcact ctgagaccat
     1861 ccccaaaaga ctaccttcta ctccaggacc atctccaagg aaccacccta cactgagacc
     1921 atccctgaag aaccaccttc caatctccag tccctaaggg accatcttat actccaaggc
     1981 aatccctgag aaaccaactt ctactcccgg tgcaatctct gagggaccac ctttcactcc
     2041 aggacagtcc ctgagggact gccttccact catcttctgc tgacgatact tcattccaag
     2101 actggcagct tggtctatca tagtacatat acaaccccaa aatcttctag ctttggagcc
     2161 tcaaagtgtt ttttttttta ataaccccat aagcttcctg atgcataagt tacagcccag
     2221 agcagtctca ggtctttccc acgatacctg tgacatttgt tttagaacct cccttagaca
     2281 tgtttgggtt gttttttcct tctctaccaa agattcagta tggcagacat gtgttttgac
     2341 atggaagtcc tggttagaga taggcctgcc atccctggga tgccttttgg ggaaatttct
     2401 gtgatacttt gacgacccct ttctatgtgc tgcactggag gctctggact aaccttctca
     2461 tgaatgatcc tcagatgggg ggaacagcaa aaccatattt cacgtttcaa gtgacctagc
     2521 tagagtgggt gatgtacagc tggggcattc caaagagttc tgtaatttga acttttttgg
     2581 actccacgca tggctgctga tttctgagac cttttgtcat gaagagacat ggtcatttct
     2641 ctcacagatg ttctgcacag aagtggagtt taaaagccag agaatagggt gtccacaggt
     2701 gtactgggca aggcctcagg ggacagtggc atctcagggt cctgtgtgtt ttactcagtg
     2761 ggttttattg ccttagtgtc tctctctctc tctctctctc tctctctctc tctctctctc
     2821 tctctctttt aaagcagaac cctttttgct acatagataa ttctgatttt ttttctaggc
     2881 ttattttgga tttttttttt ttttttggtt ctttttttcg gagctgggga ccgaacccag
     2941 ggccttgtgc ttcctaggta agcgctctac cactgagcta aatccccagc ccctattttg
     3001 gatattttta aataaaaatt ttgagatcta aa
//
