LOCUS       NP_445772                653 aa            linear   ROD 20-MAR-2023
DEFINITION  hepatocyte growth factor activator precursor [Rattus norvegicus].
ACCESSION   NP_445772 XP_341241
VERSION     NP_445772.1
DBSOURCE    REFSEQ: accession NM_053320.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 653)
  AUTHORS   Iida I, Johkura K, Teng R, Kubota S, Cui L, Zhao X, Ogiwara N,
            Okouchi Y, Asanuma K, Nakayama J and Sasaki K.
  TITLE     Immunohistochemical localization of hepatocyte growth factor
            activator (HGFA) in developing mouse liver tissues. Heterogeneous
            distribution of HGFA protein
  JOURNAL   J Histochem Cytochem 51 (9), 1139-1149 (2003)
   PUBMED   12923239
REFERENCE   2  (residues 1 to 653)
  AUTHORS   Kaibori M, Inoue T, Oda M, Naka D, Kawaguchi T, Kitamura N,
            Miyazawa K, Kwon AH, Kamiyama Y and Okumura T.
  TITLE     Exogenously administered HGF activator augments liver regeneration
            through the production of biologically active HGF
  JOURNAL   Biochem Biophys Res Commun 290 (1), 475-481 (2002)
   PUBMED   11779195
REFERENCE   3  (residues 1 to 653)
  AUTHORS   Tapper J, Kettunen E, El-Rifai W, Seppala M, Andersson LC and
            Knuutila S.
  TITLE     Changes in gene expression during progression of ovarian carcinoma
  JOURNAL   Cancer Genet Cytogenet 128 (1), 1-6 (2001)
   PUBMED   11454421
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089871.1.
            
            On Apr 19, 2005 this sequence version replaced XP_341241.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     Protein         1..653
                     /product="hepatocyte growth factor activator precursor"
                     /note="hepatocyte growth factor activator"
                     /calculated_mol_wt=67323
     sig_peptide     1..30
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=3432
     Region          99..145
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(109,111,116,129,136,142,144)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          159..194
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          197..237
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     Region          242..274
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          283..364
                     /region_name="Kringle"
                     /note="Kringle domain; pfam00051"
                     /db_xref="CDD:395005"
     Site            292
                     /site_type="active"
                     /note="putative domain interaction site [active]"
                     /db_xref="CDD:238056"
     Site            order(307,319,345,347,356)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:238056"
     Region          406..641
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            406
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(445,495,596)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(590,615,617)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..653
                     /gene="Hgfac"
                     /coded_by="NM_053320.1:12..1973"
                     /db_xref="GeneID:58947"
                     /db_xref="RGD:70909"
ORIGIN      
        1 mrqrawlpsv ssrpcpflll llllvvprva qpqagrnhte ppgpnvtatr mtpmipatsg
       61 nfstsigsdp egeaetegpq seryllssss splggqvlte sgqpcrfpfr yggrmlhscs
      121 segsayrkwc atthnydrdr awgycaeatl pvegpavldp casgpclngg tcsstqdhvs
      181 yhcacplaft gkdcgtekcf detryeyfev gdhwarvseg hveqcscieg qarcedthht
      241 aclsspclng gtchlivgtg tsicacplgy agrfcnivpt ercflgngte yrgvastsas
      301 glsclawnsd llyqelhvds vgaaallglg phaycrnpdk derpwcyvvk dsalsweycr
      361 laaceslarv hsripevlat lpeststarp tcgkrhkkrt flrpriiggs sslpgshpwl
      421 aaiyigngfc agslvhtcwv vsaahcfsss pprdsitvvl gqhffnrttd vtqtfaieky
      481 vpytlysvfn pndhdlvlir lkkkgercav rsqfvqpicl peagssfptg hkcqiagwgh
      541 mdenvsgysn sllealvplv adhkcsspev ygadispnml cagyfdcksd acqgdsggpl
      601 vcekngvayl ygiiswgdgc grlnkpgvyt rvsnyvdwin drirppkrpa aas
//
