LOCUS       NM_017017               2532 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hepatocyte growth factor (Hgf), mRNA.
ACCESSION   NM_017017
VERSION     NM_017017.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2532)
  AUTHORS   Elgaabari,A., Imatomi,N., Kido,H., Nakashima,T., Okuda,S.,
            Manabe,Y., Sawano,S., Mizunoya,W., Kaneko,R., Tanaka,S., Maeno,T.,
            Matsuyoshi,Y., Seki,M., Kuwakado,S., Zushi,K., Daneshvar,N.,
            Nakamura,M., Suzuki,T., Sunagawa,K., Anderson,J.E., Allen,R.E. and
            Tatsumi,R.
  TITLE     Age-related nitration/dysfunction of myogenic stem cell activator
            HGF
  JOURNAL   Aging Cell 23 (2), e14041 (2024)
   PUBMED   37985931
  REMARK    GeneRIF: Age-related nitration/dysfunction of myogenic stem cell
            activator HGF.
REFERENCE   2  (bases 1 to 2532)
  AUTHORS   Zhang,S., Sun,L., Chen,B., Lin,S., Gu,J., Tan,L. and Lin,M.
  TITLE     Telocytes protect against lung tissue fibrosis through hexokinase
            2-dependent pathway by secreting hepatocyte growth factor
  JOURNAL   Clin Exp Pharmacol Physiol 50 (12), 964-972 (2023)
   PUBMED   37715611
  REMARK    GeneRIF: Telocytes protect against lung tissue fibrosis through
            hexokinase 2-dependent pathway by secreting hepatocyte growth
            factor.
REFERENCE   3  (bases 1 to 2532)
  AUTHORS   Johnston,J.L., Reda,S.M., Setti,S.E., Taylor,R.W., Berthiaume,A.A.,
            Walker,W.E., Wu,W., Moebius,H.J. and Church,K.J.
  TITLE     Fosgonimeton, a Novel Positive Modulator of the HGF/MET System,
            Promotes Neurotrophic and Procognitive Effects in Models of
            Dementia
  JOURNAL   Neurotherapeutics 20 (2), 431-451 (2023)
   PUBMED   36538176
  REMARK    GeneRIF: Fosgonimeton, a Novel Positive Modulator of the HGF/MET
            System, Promotes Neurotrophic and Procognitive Effects in Models of
            Dementia.
REFERENCE   4  (bases 1 to 2532)
  AUTHORS   Takasawa,S., Itaya-Hironaka,A., Makino,M., Yamauchi,A.,
            Sakuramoto-Tsuchida,S., Uchiyama,T., Shobatake,R., Takeda,Y. and
            Ota,H.
  TITLE     Upregulation of Reg IV and Hgf mRNAs by Intermittent Hypoxia via
            Downregulation of microRNA-499 in Cardiomyocytes
  JOURNAL   Int J Mol Sci 23 (20), 12414 (2022)
   PUBMED   36293268
  REMARK    GeneRIF: Upregulation of Reg IV and Hgf mRNAs by Intermittent
            Hypoxia via Downregulation of microRNA-499 in Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2532)
  AUTHORS   Du,T., Ju,G., Zhou,J., Zhong,L., Rong,L., Chen,W., Zhang,X.,
            Zhou,R., Ding,D. and Ji,T.
  TITLE     Microvesicles derived from human umbilical cord mesenchyme promote
            M2 macrophage polarization and ameliorate renal fibrosis following
            partial nephrectomy via hepatocyte growth factor
  JOURNAL   Hum Cell 34 (4), 1103-1113 (2021)
   PUBMED   33860459
  REMARK    GeneRIF: Microvesicles derived from human umbilical cord mesenchyme
            promote M2 macrophage polarization and ameliorate renal fibrosis
            following partial nephrectomy via hepatocyte growth factor.
REFERENCE   6  (bases 1 to 2532)
  AUTHORS   Kadoya,A., Okada,J. and Kondo,H.
  TITLE     [Serum hepatocyte growth factor (HGF) in patients with inflammatory
            myopathies]
  JOURNAL   Nihon Rinsho Meneki Gakkai Kaishi 19 (5), 488-497 (1996)
   PUBMED   8952317
REFERENCE   7  (bases 1 to 2532)
  AUTHORS   Asami,O., Ihara,I., Shimidzu,N., Shimizu,S., Tomita,Y., Ichihara,A.
            and Nakamura,T.
  TITLE     Purification and characterization of hepatocyte growth factor from
            injured liver of carbon tetrachloride-treated rats
  JOURNAL   J Biochem 109 (1), 8-13 (1991)
   PUBMED   1826679
REFERENCE   8  (bases 1 to 2532)
  AUTHORS   Okajima,A., Miyazawa,K. and Kitamura,N.
  TITLE     Primary structure of rat hepatocyte growth factor and induction of
            its mRNA during liver regeneration following hepatic injury
  JOURNAL   Eur J Biochem 193 (2), 375-381 (1990)
   PUBMED   2146117
REFERENCE   9  (bases 1 to 2532)
  AUTHORS   Tashiro,K., Hagiya,M., Nishizawa,T., Seki,T., Shimonishi,M.,
            Shimizu,S. and Nakamura,T.
  TITLE     Deduced primary structure of rat hepatocyte growth factor and
            expression of the mRNA in rat tissues
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 3200-3204 (1990)
   PUBMED   2139229
REFERENCE   10 (bases 1 to 2532)
  AUTHORS   Nakamura,T., Nishizawa,T., Hagiya,M., Seki,T., Shimonishi,M.,
            Sugimura,A., Tashiro,K. and Shimizu,S.
  TITLE     Molecular cloning and expression of human hepatocyte growth factor
  JOURNAL   Nature 342 (6248), 440-443 (1989)
   PUBMED   2531289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D90102.1 and X54400.1.
            
            On Mar 24, 2010 this sequence version replaced NM_017017.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90102.1, X54400.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00155321,
                                           SAMD00155336 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2473              D90102.1           1-2473
            2474-2532           X54400.1           2373-2431
FEATURES             Location/Qualifiers
     source          1..2532
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q12"
     gene            1..2532
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /note="hepatocyte growth factor"
                     /db_xref="GeneID:24446"
                     /db_xref="RGD:2794"
     exon            1..233
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2329
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /note="SF; scatter factor; hepatopoeitin-A;
                     hepatopoietin-A"
                     /codon_start=1
                     /product="hepatocyte growth factor preproprotein"
                     /protein_id="NP_058713.1"
                     /db_xref="GeneID:24446"
                     /db_xref="RGD:2794"
                     /translation="MMWGTKLLPVLLLQHVLLHLLLLPVTIPYAEGQKKRRNTLHEFK
                     KSAKTTLTKEDPLVKIKTKKVNSADECANRCIRNKGFPFTCKAFVFDKSRKRCYWYPF
                     NSMSSGVKKGFGHEFDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWNSMIPHE
                     HSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGE
                     SYRGPMDHTESGKTCQRWDQQTPHRHKFLPERYPDKGFDDNYCRNPDGKPRPWCYTLD
                     PDTPWEYCAIKMCAHSAVNETDVPMETTECIKGQGEGYRGTTNTIWNGIPCQRWDSQY
                     PHKHDITPENFKCKDLRENYCRNPDGAESPWCFTTDPNIRVGYCSQIPKCDVSSGQDC
                     YRGNGKNYMGNLSKTRSGLTCSMWDKNMEDLHRHIFWEPDASKLTKNYCRNPDDDAHG
                     PWCYTGNPLVPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTQTTVGW
                     MVSLKYRNKHICGGSLIKESWVLTARQCFPARNKDLKDYEAWLGIHDVHERGEEKRKQ
                     ILNISQLVYGPEGSDLVLLKLARPAILDNFVSTIDLPSYGCTIPEKTTCSIYGWGYTG
                     LINADGLLRVAHLYIMGNEKCSQHHQGKVTLNESELCAGAEKIGSGPCEGDYGGPLIC
                     EQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKVILTYKL"
     exon            234..399
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            400..512
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            513..627
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            628..770
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            771..891
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1010
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1185
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1313
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1416
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1550
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1589
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1686
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1761
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1908
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2015
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2161
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2532
                     /gene="Hgf"
                     /gene_synonym="HPTA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttagtcct agatctttcc agttaatcac acaacaaact tagctcatcg caataaaagc
       61 agctcagaac cgaccggctt gcaacaggat tctttcagcc cggcatctcc tgcagaggga
      121 tcagcctgct cgaactgcaa gcatgatgtg ggggaccaaa cttctgccgg tcctgttgct
      181 gcagcatgtc ctgctgcacc tcctcctgct tcctgtcacc atcccctatg cagaaggaca
      241 gaagaagaga agaaatactc ttcatgaatt caaaaagtca gcaaaaacta ctcttaccaa
      301 ggaagaccca ttagtgaaga ttaaaaccaa aaaagtgaac tctgcagatg agtgtgccaa
      361 caggtgcatc agaaacaagg gctttccatt cacttgcaag gcctttgttt ttgataagtc
      421 gagaaaacga tgctactggt atcctttcaa tagtatgtca agtggagtga aaaaagggtt
      481 tggccatgaa tttgacctct atgaaaacaa agactatatt agaaattgca tcattggtaa
      541 aggaggcagc tataagggga cagtatccat cactaagagt ggcatcaagt gccagccttg
      601 gaattccatg atcccccatg aacacagctt tttgccttcg agctatcgcg gtaaagacct
      661 acaggaaaac tactgtcgaa atcctcgagg ggaagaaggg ggaccctggt gtttcacaag
      721 caatccagag gtacgctacg aagtctgtga cattcctcag tgttcagaag ttgaatgcat
      781 gacctgcaac ggtgaaagct acagaggtcc catggatcac acagaatcag gcaagacatg
      841 tcagcgctgg gatcagcaga caccacaccg gcacaaattc ttgccggaaa gatatcccga
      901 caagggcttt gatgataatt attgccgcaa tcccgatggc aagccgaggc catggtgcta
      961 cactcttgac cctgacaccc cttgggagta ttgtgcaatt aaaatgtgcg ctcacagtgc
     1021 tgtgaatgag actgatgttc ccatggaaac aactgaatgt ataaaaggcc aaggagaagg
     1081 ttacagggga accaccaata ccatttggaa tggaattccg tgtcagcgtt gggattcgca
     1141 gtacccccac aagcatgaca tcactcccga gaacttcaaa tgcaaggacc ttagagaaaa
     1201 ttattgccgc aatccggatg gggctgaatc accatggtgt tttaccactg atccaaacat
     1261 ccgagttggt tactgctctc aaattcccaa atgtgacgtg tcaagtggac aagattgtta
     1321 tcgtggcaat gggaaaaact acatgggcaa cttatccaaa acaaggtctg gactcacatg
     1381 ttccatgtgg gacaagaata tggaggattt acaccgtcat atcttctggg agccagacgc
     1441 tagcaagttg actaagaatt actgccggaa ccccgatgac gacgcccatg gaccttggtg
     1501 ctacacaggg aatcctctcg ttccttggga ttattgccct atttcccgtt gtgaaggaga
     1561 tactacacct acaattgtca atttggacca tcctgtaata tcctgtgcca aaacaaaaca
     1621 actgcgagtt gtaaatggca ttccaacaca aacaacagta gggtggatgg ttagtttgaa
     1681 atacaggaat aaacacatct gtgggggatc attgataaag gaaagttggg ttcttactgc
     1741 aaggcaatgt tttccagcta gaaacaaaga cttgaaagac tatgaagctt ggcttggaat
     1801 ccatgatgtc catgagagag gcgaggagaa acgcaaacag atcttaaaca tttcccagct
     1861 agtctatgga cctgaaggct cagatttggt tttactgaag cttgctcgcc ctgcaatcct
     1921 ggataacttt gtcagtacaa ttgatttacc tagttatggc tgtacaatcc ctgaaaagac
     1981 tacttgcagt atttacggct ggggctacac tggattgatc aacgcagatg gtttattacg
     2041 agtagctcat ctgtatatta tggggaatga gaaatgcagt cagcaccatc aaggcaaggt
     2101 gactttgaat gagtctgaat tatgtgctgg ggctgaaaag attggatcag gaccttgtga
     2161 gggagattat ggtggcccac tcatttgtga acaacacaaa atgagaatgg ttcttggtgt
     2221 cattgttcct ggtcgtggat gtgccatccc aaatcgtcct ggtatttttg ttcgagtagc
     2281 atattatgca aaatggatac acaaagtaat tttgacatac aagttgtaat agccatagaa
     2341 gaggccagtg tatttgaagc atccatggat acaggaagat ttccaagact tcaggattaa
     2401 aatgtcacct aaaacaatcc taaaacaact acttgagtgt tgtgagtgtt cagatactca
     2461 ttaatatatg tgggcgtttt ctgttgtatt gtttgtcagt gtccttttgt aaatgttgaa
     2521 gtgagttagg gt
//
