LOCUS       NM_001012145            1698 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus homogentisate 1, 2-dioxygenase (Hgd), mRNA.
ACCESSION   NM_001012145 XM_340991
VERSION     NM_001012145.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1698)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 1698)
  AUTHORS   Fernandez-Canon JM, Granadino B, Beltran-Valero de Bernabe D,
            Renedo M, Fernandez-Ruiz E, Penalva MA and Rodriguez de Cordoba S.
  TITLE     The molecular basis of alkaptonuria
  JOURNAL   Nat Genet 14 (1), 19-24 (1996)
   PUBMED   8782815
REFERENCE   3  (bases 1 to 1698)
  AUTHORS   Montagutelli X, Lalouette A, Coude M, Kamoun P, Forest M and Guenet
            JL.
  TITLE     aku, a mutation of the mouse homologous to human alkaptonuria, maps
            to chromosome 16
  JOURNAL   Genomics 19 (1), 9-11 (1994)
   PUBMED   8188247
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078948.1.
            
            On Feb 11, 2005 this sequence version replaced XM_340991.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078948.1, FQ209622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1698
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1698
                     /gene="Hgd"
                     /note="homogentisate 1, 2-dioxygenase"
                     /db_xref="GeneID:360719"
                     /db_xref="RGD:1308757"
     exon            1..154
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1477
                     /gene="Hgd"
                     /EC_number="1.13.11.5"
                     /codon_start=1
                     /product="homogentisate 1,2-dioxygenase"
                     /protein_id="NP_001012145.1"
                     /db_xref="GeneID:360719"
                     /db_xref="RGD:1308757"
                     /translation="MAELKYISGFGNECASEDPRCPGSLPKGQNNPQICPYNLYAEQL
                     SGSAFTCPRNTNKRSWLYRILPSVSHKPFASIDQGHINHNWDEVGPDPNQLRWKPFEI
                     PKACQKKVDFVSGLHTLCGAGDIRSNNGLAVHIFLCNSPMENRCFYNSDGDFLIVPQK
                     GKLLIYTEFGKMFLQPNEICVIQRGMRFSVDVFEETRGYILEVYGVHFELPDLGPIGA
                     NGLANPRDFLIPVAWYEDRQVPGGFTVINKYQGKLFASKQDVSPFNVVAWHGNYTPYK
                     YNLENFMVINAVAFDHADPSIFTVLTAKSLRPGVAIADFVIFPPRWGVADKTFRPPYY
                     HRNCMSEFMGLIKGHYEAKQGGFLPGGGSLHSAMTPHGPDADCFEKASKAKLEPERIA
                     DGTMAFMFESSLSLAVTKWGLKTCGCLDEDYYKCWEPLQAHFTPTSRSPTEPK"
     exon            155..226
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     exon            227..315
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     exon            316..421
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     exon            422..481
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     exon            482..573
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     exon            574..608
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     exon            609..688
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     exon            689..788
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     exon            789..913
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1018
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1145
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1327
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1672
                     /gene="Hgd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgccctga gtgacctgct gaccaagaag aaagagagat ctggtaaaaa tcaacaacat
       61 ccagagagta gttttaaaga gacacaggaa cattcgtacc tcagctcctt ggcctgagtt
      121 tccttccagc agaagggaaa tggcagagtt aaagtacatt tctggatttg ggaatgagtg
      181 tgcttcagag gatcctcgct gcccaggctc cctgccgaaa ggacagaata atcctcagat
      241 ctgcccctac aatctctacg ctgagcagct ctcgggatcg gccttcactt gtccacggaa
      301 caccaataag agaagctggc tatacagaat tctcccttca gtttctcaca agccatttgc
      361 gtccattgac caaggccaca tcaaccacaa ctgggatgaa gttggccctg atcctaacca
      421 gcttagatgg aaaccgtttg agattccaaa agcatgtcag aagaaagtgg actttgtgag
      481 tggcttgcac accttatgtg gagcaggaga catcaggtct aacaatgggc ttgctgtgca
      541 tatcttcctg tgtaactccc ccatggagaa cagatgtttt tacaattcag atggggattt
      601 cctgattgtt ccccagaaag ggaagcttct catctacaca gagtttggca agatgttcct
      661 gcagcccaat gagatctgcg tcattcagag aggaatgaga ttcagtgttg atgtcttcga
      721 ggagaccagg ggttacatcc tggaagtcta cggtgtccac ttcgagctac ctgacctagg
      781 acccatcgga gcaaatggct tggccaatcc tcgagatttc ttgatccctg ttgcttggta
      841 tgaagatcgt caagtgccgg gtggtttcac cgtgattaat aaataccagg gaaagctgtt
      901 tgcttccaaa caggatgtct cccccttcaa tgtcgtggcc tggcatggaa actatacacc
      961 ctacaagtac aacctcgaga acttcatggt catcaatgcg gtggcctttg accatgcaga
     1021 tccttccatt ttcacagtgc tgaccgccaa gtctctccga cctggagtgg ccattgctga
     1081 ctttgtgatc ttcccacctc ggtggggggt tgcagataaa accttcagac ctccttatta
     1141 ccacaggaac tgcatgagtg agttcatggg actcatcaaa ggtcactatg aggcaaagca
     1201 aggtggattc ctgccagggg gaggcagtct gcacagtgcc atgacccctc atggccccga
     1261 cgcagactgc tttgagaagg ccagcaaggc caaactggaa cctgagagga tagcagacgg
     1321 caccatggca tttatgtttg aatcttcctt gagtttggca gtcaccaagt ggggactcaa
     1381 gacctgtggt tgtttggatg aggactacta caaatgctgg gagcctctcc aggcccactt
     1441 cacccccact tccaggagcc caacagagcc taagtgagac cggagccctc tacagtaatt
     1501 gagaacaggc tcgcatggct tcctcgagag cctcacacct ctggcgctat cagggactgc
     1561 gattagaatg agatttactc atcatattca agaaactcac aatgactgtg gacatgaatt
     1621 cagaagtgcc tatggctctc taatccatca ataaatttgt gtttctgtgg aaaaaaaaaa
     1681 aaaaaaaaaa aaaaaaaa
//
