LOCUS       NM_001412564            4951 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus helicase for meiosis 1 (Hfm1), mRNA.
ACCESSION   NM_001412564 XM_008769947
VERSION     NM_001412564.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4951)
  AUTHORS   Guiraldelli,M.F., Eyster,C., Wilkerson,J.L., Dresser,M.E. and
            Pezza,R.J.
  TITLE     Mouse HFM1/Mer3 is required for crossover formation and complete
            synapsis of homologous chromosomes during meiosis
  JOURNAL   PLoS Genet 9 (3), e1003383 (2013)
   PUBMED   23555294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Oct 6, 2022 this sequence version replaced XM_008769947.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000014.1  3002591-3002654
            65-162              JAXUCZ010000014.1  3005117-3005214
            163-275             JAXUCZ010000014.1  3009244-3009356
            276-579             JAXUCZ010000014.1  3010109-3010412
            580-842             JAXUCZ010000014.1  3016261-3016523
            843-890             JAXUCZ010000014.1  3016776-3016823
            891-961             JAXUCZ010000014.1  3023022-3023092
            962-1094            JAXUCZ010000014.1  3023480-3023612
            1095-1246           JAXUCZ010000014.1  3024388-3024539
            1247-1324           JAXUCZ010000014.1  3025279-3025356
            1325-1480           JAXUCZ010000014.1  3025572-3025727
            1481-1681           JAXUCZ010000014.1  3028321-3028521
            1682-1770           JAXUCZ010000014.1  3028604-3028692
            1771-1814           JAXUCZ010000014.1  3030953-3030996
            1815-1916           JAXUCZ010000014.1  3031142-3031243
            1917-2062           JAXUCZ010000014.1  3031574-3031719
            2063-2157           JAXUCZ010000014.1  3033238-3033332
            2158-2291           JAXUCZ010000014.1  3033999-3034132
            2292-2339           JAXUCZ010000014.1  3036941-3036988
            2340-2420           JAXUCZ010000014.1  3046320-3046400
            2421-2512           JAXUCZ010000014.1  3049737-3049828
            2513-2619           JAXUCZ010000014.1  3051125-3051231
            2620-2667           JAXUCZ010000014.1  3051313-3051360
            2668-2765           JAXUCZ010000014.1  3054102-3054199
            2766-2897           JAXUCZ010000014.1  3054278-3054409
            2898-2983           JAXUCZ010000014.1  3059454-3059539
            2984-3067           JAXUCZ010000014.1  3060085-3060168
            3068-3225           JAXUCZ010000014.1  3060295-3060452
            3226-3329           JAXUCZ010000014.1  3061645-3061748
            3330-3476           JAXUCZ010000014.1  3062115-3062261
            3477-3557           JAXUCZ010000014.1  3069029-3069109
            3558-3673           JAXUCZ010000014.1  3069647-3069762
            3674-3753           JAXUCZ010000014.1  3072205-3072284
            3754-3857           JAXUCZ010000014.1  3073868-3073971
            3858-4091           JAXUCZ010000014.1  3079090-3079323
            4092-4182           JAXUCZ010000014.1  3081448-3081538
            4183-4294           JAXUCZ010000014.1  3082623-3082734
            4295-4446           JAXUCZ010000014.1  3082818-3082969
            4447-4951           JAXUCZ010000014.1  3083897-3084401
FEATURES             Location/Qualifiers
     source          1..4951
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..4951
                     /gene="Hfm1"
                     /note="helicase for meiosis 1"
                     /db_xref="GeneID:690161"
                     /db_xref="RGD:1584010"
     exon            1..64
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            65..162
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..4516
                     /gene="Hfm1"
                     /EC_number="3.6.4.12"
                     /note="HFM1, ATP-dependent DNA helicase homolog"
                     /codon_start=1
                     /product="probable ATP-dependent DNA helicase HFM1"
                     /protein_id="NP_001399493.1"
                     /db_xref="GeneID:690161"
                     /db_xref="RGD:1584010"
                     /translation="MLESNDCILSMDSLFFSSPGETESFPVEEKSLDWFLPPAPLISE
                     IPDIQELEEEIENYKLLGERKMPNILTSNLKIINEDTNCISPTQKFHFPYNIHEQDYL
                     NLGGLNNNDMSHTAGKLVYGSSQKYKNHMGDESPPTKSGPGDAKLHTAAEDREGTSAL
                     KTRLSRTCGSVQECDYANGNLSLNSHISPARLTQTKVSKEKPWNCSNRKQKLQYSTDK
                     SKANDAFSASGIEKDIFEAPSFSAASQPRDIQGITSNGLGSLKAVTEIPAKFRSVFKE
                     FPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEAPLPWLNMKVVY
                     MAPIKALCSQRFDDWKEKFGPIGLTCKELTGDTVMDDLFEIQHANIIMTTPEKWDSMT
                     RKWRDNSFIQLVRLFLIDEVHVIKDENRGPTLEVVVSRMKTVQSLSKTLENASPAPVR
                     FVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPSSSNQTEFKFD
                     LALNYKVYSVIRTYSDQKPTLVFCATRKGVQQAASVLVKDAKFIITVEQKLRLQKSAY
                     SIRDSKLKDTLVYGVGYHHAGMELSDRKLVEELFTSGDLPVLFTTSTLAMGVNLPAHL
                     VVIKSTMHYTGGAFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTREKYVQMLAC
                     NDTVESSLHRHLIEHLNAEIVLHTITDVSIALDWIRSTLLYIRALKNPSHYGFISGLN
                     KDGIEAKLQELCLKNLKDLSSLDLIKMDEDLNFRSTEAGRLMAWYYITFETVKKFCAI
                     SGKETLSDLISMISSCSEFLDVQLRISEKRTLNTLNKDPNRITIRFPMEGRIKTREMK
                     VNCLIQAQLGCIPIQDFALTQDTSKIFRNGSRIAKWLSDFVTAQEQKFAVLLNSVILA
                     KCFKCKLWENSQHVSKQLDKIGISLSNTMVNAGLTSFKKIEEANARELELILNRHPPF
                     GTQIKEAVMYLPKYELEAEQIARYSDTKAEILVTIILRNFEQLQTKRTAPDFHYATLI
                     IGDADNQVVCKHKIMDSVLLKSGNWVKKIDVKRALISEDLSINLISSDYVGLDIHQKF
                     TVFYLGPRKFVNQTVTERSSGTGLSHSECSDRATAAGSSKRTATCRNPGNRECHHHCK
                     NKHICGHDCCKIGVAQKPEAKVSAVSSYLSDLKSRDAVSSFPPAKRLKIQMNKSQNVD
                     LKEFGFVPRPSLSSIARSEYLNIHKLPILEQRTQHEIYGEVEEGASECRDEDFPGWDY
                     CAASNKRTPVMLSRHANTPGNHGVAVAEKSKSSDGPHVNSELGDEVWDDFDDESLIEV
                     MSFSADAEEMAVSGFGDTRDSSLGRSKLHFGRSSSRFQRDISNSFVSSPEKPDVCLSD
                     CSVSNFGLSSVAEFPQQAGNASLVNLQERKQLTLSPVIERMCFTHSEKIPQSPSFKEV
                     DIFIGNSDSKKEIDLSKYYPDDAAEEMKALLGIFNGIF"
     exon            163..275
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..579
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..842
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..890
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..961
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1094
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1246
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1324
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1480
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1681
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1770
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1814
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1916
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2062
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2157
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2291
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2339
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2420
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2512
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2619
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2667
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2765
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2897
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..2983
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3067
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3225
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3329
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3476
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3557
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3673
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..3753
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3857
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3858..4091
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            4092..4182
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4294
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            4295..4446
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            4447..4951
                     /gene="Hfm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggcttccgt cttccacctc tcaagtgtag ggattactgt tgggagccac tggcgtctga
       61 ctaaatttca gacaaagtct gtttttcagc aatgctggaa tcaaacgatt gcattttatc
      121 catggattct ttgtttttca gtagcccagg tgaaactgaa agctttccag ttgaggaaaa
      181 atcactggat tggtttctcc ctccagctcc actgatctca gaaattccag atattcaaga
      241 gttagaggaa gaaattgaaa attataagct attaggagaa agaaagatgc ccaatatatt
      301 aacatcaaac ttgaagatca ttaatgaaga cacaaattgt atttcaccaa cacagaaatt
      361 ccattttccc tataacatac atgaacagga ttacctaaat ttaggaggat taaataacaa
      421 tgacatgtca catacagctg gcaagctagt gtacggttct tctcaaaaat ataaaaacca
      481 catgggggat gagagtccac cgacaaagag tggtcctggt gatgcaaagc tgcatactgc
      541 tgctgaggac agagagggca catcagcact caaaaccaga ttatctagaa catgtggcag
      601 tgtgcaggaa tgtgactatg ctaatggaaa tttaagcttg aattctcata ttagcccagc
      661 gagactcacc caaacaaaag taagcaaaga gaaaccatgg aactgtagca atagaaaaca
      721 gaaactgcag tattctacag acaaatccaa agcaaacgat gctttttctg cttctggaat
      781 tgaaaaagac atattcgaag caccatcgtt ttctgctgca tctcagcctc gtgacattca
      841 aggcataacc tcaaatggct taggttcgtt gaaggctgtc acagaaatcc ctgcaaaatt
      901 tagaagtgta ttcaaagaat tcccttactt caactatata cagtccaaag cctttgatga
      961 tcttctttac acagatcgga attttgtgat ttgtgccccc actggttctg ggaaaactgt
     1021 ggtgtttgag ctagcaataa caagattgtt aatggaagca ccattgccgt ggctgaacat
     1081 gaaagttgtt tacatggcac caataaaagc cctttgtagt cagcggtttg atgactggaa
     1141 agaaaaattt ggaccgatag gcttgacctg taaagaactt actggagata cagtaatgga
     1201 tgacctgttt gagattcagc atgccaatat aattatgaca actccagaga agtgggacag
     1261 tatgactagg aagtggagag acaactcctt catccaactg gttcgcctgt ttctcattga
     1321 tgaggtgcat gttattaaag atgaaaaccg tggtccaact cttgaggttg tagtaagcag
     1381 aatgaaaact gtccagtctt tatctaagac cttagaaaac gccagccctg ctccagtgag
     1441 gtttgtagct gtatcagcaa caattcccaa tgctgaggat atcgcagaat ggctttcaga
     1501 tggggagaga cctgctgtgt gtctgaaaat ggatgagagc cacagacctg tgaaacttca
     1561 gaaagtggtc ctgggtttcc ccagtagtag taaccaaact gaattcaagt ttgatttagc
     1621 cctcaactat aaagtgtaca gtgttatacg aacgtactcc gatcagaagc ccacactcgt
     1681 gttttgtgca acgaggaaag gtgtgcagca ggctgcttct gttcttgtga aggacgctaa
     1741 gtttatcatc accgtggagc agaaactacg gttgcagaag tctgcatatt ctataaggga
     1801 ttcaaagcta aaagatacct tggtgtacgg tgttggttac catcatgctg gaatggagct
     1861 gtcagataga aaattggttg aagagttgtt tacttctgga gatctaccag ttctttttac
     1921 tacaagtact ctagctatgg gagtgaactt gccggctcac ctggtcgtta taaagtccac
     1981 catgcactac actggaggtg cctttgaaga gtacagcgag acagacatcc tgcagatgat
     2041 tggaagagct ggcaggcccc agtttgacac cacagctact gcagttatta tgacccgact
     2101 aagtacaaga gagaagtacg ttcagatgct agcttgtaat gacactgtgg aaagcagttt
     2161 gcacagacat cttattgagc acctgaacgc agagatagtg ctgcacacca tcacagatgt
     2221 gagcatcgcc ctggactgga tccggtccac actgctgtat atcagagctc tgaaaaaccc
     2281 atctcactat ggttttatat ctggattgaa caaagatgga attgaagcaa aattacaaga
     2341 gttatgtttg aagaatctga aagatttatc atcgctagac ctaataaaga tggatgaaga
     2401 ccttaatttc agatcaacag aggcaggaag actaatggca tggtattata ttacatttga
     2461 gacagtgaag aaattttgtg caatcagtgg aaaagaaact ttatcagatt tgatttcaat
     2521 gatatccagc tgcagtgagt ttctagatgt gcagctgagg ataagcgaaa agagaacact
     2581 gaacacacta aacaaagacc caaaccggat aaccatcaga tttccaatgg aggggagaat
     2641 taaaaccaga gagatgaaag taaactgtct tattcaggct cagctaggat gcatccctat
     2701 acaagatttt gctttgacac aagatacctc gaagattttc agaaatggct cacgaattgc
     2761 aaaatggttg tcagattttg tgactgctca ggaacagaag tttgctgtgc ttttaaacag
     2821 tgtgatttta gctaaatgtt ttaagtgtaa actctgggaa aactctcaac atgtttcaaa
     2881 acagctggat aaaattggca tatcattgtc aaataccatg gtaaatgcag gcttgacgtc
     2941 ttttaaaaaa atagaagaag caaatgcgag agaacttgaa ctgattttaa atagacaccc
     3001 gccattcggg acccagataa aggaagctgt gatgtatctg ccaaagtatg aacttgaggc
     3061 agagcagatt gcaagatata gtgataccaa ggcagaaata ctggtgacca ttatattaag
     3121 aaactttgag cagctgcaga ccaaaagaac agcgccagac tttcactatg ccaccttaat
     3181 cataggtgat gcagataacc aagtcgtttg taagcacaaa attatggatt ctgtcttgtt
     3241 aaaaagtgga aattgggtta aaaaaattga tgtgaagaga gctcttatat cagaagatct
     3301 cagcataaat ctaattagct ctgattatgt tggtcttgat attcaccaga aatttacagt
     3361 cttttattta ggacccagga agtttgtaaa tcaaacagtt acggaaagaa gctcaggaac
     3421 aggtctttct cattccgaat gctcagacag agctactgca gcaggatcca gtaaaagaac
     3481 ggctacctgc agaaaccctg ggaaccgaga atgccatcat cactgtaaaa ataagcacat
     3541 atgtgggcat gactgctgta aaattggagt tgcacaaaag ccagaagcta aagtgtcagc
     3601 agtgtcctca tatctgtctg acctaaaaag cagagatgct gtttcttctt ttcccccagc
     3661 taagcgactc aagatacaga tgaacaaatc tcaaaatgtg gaccttaaag aatttggttt
     3721 tgttccaagg ccttcccttt ccagtatagc aaggtcagaa tatttaaaca tccataaatt
     3781 gccaatatta gaacagagga ctcagcatga gatctatggc gaagttgaag agggagcgtc
     3841 tgaatgccga gacgaagact ttcccggatg ggactattgt gcagcttcaa acaaaaggac
     3901 cccagtgatg ctcagcagac atgctaacac acctggaaac cacggtgtcg cagttgcaga
     3961 gaagagcaag tcttcagacg gcccacatgt gaactcagag ctgggagatg aagtttggga
     4021 tgactttgat gatgaaagct taatagaagt tatgagcttt tcagctgacg ccgaggagat
     4081 ggctgtgtca gggtttggag acactcgtga ttcaagtcta ggcagaagta agctacactt
     4141 cggaagatca agcagcaggt tccaaagaga catctcaaac agttttgttt catcacccga
     4201 gaagccagat gtttgtttgt cagattgttc cgtgtctaat ttcgggctgt cctctgtggc
     4261 agagttccct caacaagctg gaaatgcaag tcttgtcaat ttacaagaga gaaaacagct
     4321 gaccctctca ccagtgattg agaggatgtg ctttacccac tctgagaaaa taccacagtc
     4381 tcccagtttt aaggaagtgg atatttttat tggaaacagt gactctaaaa aggaaattga
     4441 tcttagtaag tattatcctg atgatgcagc cgaggaaatg aaggcccttc tgggaatatt
     4501 taatggcatt ttctaaagat aaaaaataca gttaataagg caaagtatga atatgtgtta
     4561 tgactaaaaa tgctttttat ttgtaaagat aattggtaat tgttcagaat ttttctctta
     4621 agtttgattc attctttgac tttgttatta taaaatatat ggactgatac attttttatt
     4681 gtaacttctg aaagaatggt tttgtatcag taaactgata atttatcatc ataaataatt
     4741 tgttattaaa ccaattttaa tagaaactta tacttcattt ttatattttc ttgagaaagc
     4801 aaagcaatgc tgtgagtgga cctgtgtagt ggctgtgtat tttttgatgt tcttgtgtct
     4861 gttctgttgc ttgctcgtct ggattgtcaa gaatccagta gcctttgaat ctgttctttc
     4921 acttcgagcg gtaacaaatg aaatgctaat c
//
