LOCUS       NM_053301               1670 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus homeostatic iron regulator (Hfe), transcript
            variant 1, mRNA.
ACCESSION   NM_053301
VERSION     NM_053301.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1670)
  AUTHORS   Tamosauskaite,J., Atkins,J.L., Pilling,L.C., Kuo,C.L., Kuchel,G.A.,
            Ferrucci,L. and Melzer,D.
  TITLE     Hereditary Hemochromatosis Associations with Frailty, Sarcopenia
            and Chronic Pain: Evidence from 200,975 Older UK Biobank
            Participants
  JOURNAL   J Gerontol A Biol Sci Med Sci 74 (3), 337-342 (2019)
   PUBMED   30657865
REFERENCE   2  (bases 1 to 1670)
  AUTHORS   Smith,D.J., Klein,K., Hartel,G., Wainwright,C.E., Bell,S.C.,
            Anderson,G.J. and Reid,D.W.
  TITLE     Mutations in the HFE gene can be associated with increased lung
            disease severity in cystic fibrosis
  JOURNAL   Gene 683, 12-17 (2019)
   PUBMED   30291871
REFERENCE   3  (bases 1 to 1670)
  AUTHORS   Pilling,L.C., Tamosauskaite,J., Jones,G., Wood,A.R., Jones,L.,
            Kuo,C.L., Kuchel,G.A., Ferrucci,L. and Melzer,D.
  TITLE     Common conditions associated with hereditary haemochromatosis
            genetic variants: cohort study in UK Biobank
  JOURNAL   BMJ 364, k5222 (2019)
   PUBMED   30651232
  REMARK    Erratum:[BMJ. 2019 Oct 23;367:l6157. doi: 10.1136/bmj.l6157.. PMID:
            31645331]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1670)
  AUTHORS   Frydlova,J., Rogalsky,D.W., Truksa,J., Traeger,L.,
            Steinbicker,A.U., Vokurka,M. and Krijt,J.
  TITLE     Liver HFE protein content is posttranscriptionally decreased in
            iron-deficient mice and rats
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 315 (4), G560-G568 (2018)
   PUBMED   29927322
REFERENCE   5  (bases 1 to 1670)
  AUTHORS   Lee,N.P., Wu,H., Ng,K.T.P., Luo,R., Lam,T.W., Lo,C.M. and Man,K.
  TITLE     Transcriptome Analysis of Acute Phase Liver Graft Injury in Liver
            Transplantation
  JOURNAL   Biomedicines 6 (2), 41 (2018)
   PUBMED   29642405
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1670)
  AUTHORS   Sanchez,M., Queralt,R., Bruguera,M., Rodes,J. and Oliva,R.
  TITLE     Cloning, sequencing and characterization of the rat hereditary
            hemochromatosis promoter: comparison of the human, mouse and rat
            HFE promoter regions
  JOURNAL   Gene 225 (1-2), 77-87 (1998)
   PUBMED   9931446
REFERENCE   7  (bases 1 to 1670)
  AUTHORS   Lebron,J.A., Bennett,M.J., Vaughn,D.E., Chirino,A.J., Snow,P.M.,
            Mintier,G.A., Feder,J.N. and Bjorkman,P.J.
  TITLE     Crystal structure of the hemochromatosis protein HFE and
            characterization of its interaction with transferrin receptor
  JOURNAL   Cell 93 (1), 111-123 (1998)
   PUBMED   9546397
REFERENCE   8  (bases 1 to 1670)
  AUTHORS   Feder,J.N., Penny,D.M., Irrinki,A., Lee,V.K., Lebron,J.A.,
            Watson,N., Tsuchihashi,Z., Sigal,E., Bjorkman,P.J. and
            Schatzman,R.C.
  TITLE     The hemochromatosis gene product complexes with the transferrin
            receptor and lowers its affinity for ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1472-1477 (1998)
   PUBMED   9465039
REFERENCE   9  (bases 1 to 1670)
  AUTHORS   George,D.K., Goldwurm,S., MacDonald,G.A., Cowley,L.L., Walker,N.I.,
            Ward,P.J., Jazwinska,E.C. and Powell,L.W.
  TITLE     Increased hepatic iron concentration in nonalcoholic
            steatohepatitis is associated with increased fibrosis
  JOURNAL   Gastroenterology 114 (2), 311-318 (1998)
   PUBMED   9453491
REFERENCE   10 (bases 1 to 1670)
  AUTHORS   Feder,J.N., Gnirke,A., Thomas,W., Tsuchihashi,Z., Ruddy,D.A.,
            Basava,A., Dormishian,F., Domingo,R. Jr., Ellis,M.C., Fullan,A.,
            Hinton,L.M., Jones,N.L., Kimmel,B.E., Kronmal,G.S., Lauer,P.,
            Lee,V.K., Loeb,D.B., Mapa,F.A., McClelland,E., Meyer,N.C.,
            Mintier,G.A., Moeller,N., Moore,T., Morikang,E., Prass,C.E.,
            Quintana,L., Starnes,S.M., Schatzman,R.C., Brunke,K.J.,
            Drayna,D.T., Risch,N.J., Bacon,B.R. and Wolff,R.K.
  TITLE     A novel MHC class I-like gene is mutated in patients with
            hereditary haemochromatosis
  JOURNAL   Nat Genet 13 (4), 399-408 (1996)
   PUBMED   8696333
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Mar 5, 2010 this sequence version replaced NM_053301.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ001517.1, SRR22582416.1465363.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000017.1  41841302-41841472
            172-435             JAXUCZ010000017.1  41844521-41844784
            436-735             JAXUCZ010000017.1  41845716-41846015
            736-1011            JAXUCZ010000017.1  41846954-41847229
            1012-1122           JAXUCZ010000017.1  41847343-41847453
            1123-1670           JAXUCZ010000017.1  41848806-41849353
FEATURES             Location/Qualifiers
     source          1..1670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..1670
                     /gene="Hfe"
                     /note="homeostatic iron regulator"
                     /db_xref="GeneID:29199"
                     /db_xref="RGD:2793"
     exon            1..171
                     /gene="Hfe"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1163
                     /gene="Hfe"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; hereditary hemochromatosis protein homolog;
                     RT1-CAFE"
                     /codon_start=1
                     /product="hereditary hemochromatosis protein homolog
                     isoform 1 precursor"
                     /protein_id="NP_445753.1"
                     /db_xref="GeneID:29199"
                     /db_xref="RGD:2793"
                     /translation="MDRSAGLPVRLLLLLLLLLLWSVAPQALRPGSHSLRYLFMGASK
                     PDLGLPFFEALGYVDDQLFVSYNHESRRAEPRAPWILGQTSSQLWLQLSQSLKGWDYM
                     FIVDFWTIMGNYNHSKVTKLRVVPESHILQVILGCEVHEDNSTSGFWKYGYDGQDHLE
                     FCPKTLNWSAAEPRAWATKMEWEEHRIRARQSRDYLQRDCPQQLKQVLELQRGVLGQQ
                     VPTLVKVTRHWASTGTSLRCQALNFFPQNITMRWLKDSQPLDAKDVNPENVLPNGDGT
                     YQGWLTLAVAPGEETRFSCQVEHPGLDQPLTATWEPSRSQDMIIGIISGITICAIFFV
                     GILILVLRKRKVSGGTMGDYVLTECE"
     exon            172..435
                     /gene="Hfe"
                     /inference="alignment:Splign:2.1.0"
     exon            436..735
                     /gene="Hfe"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1011
                     /gene="Hfe"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1122
                     /gene="Hfe"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1670
                     /gene="Hfe"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagcaatgg ctacagggtg acttcttgga tcctccacgt ttccaggtcc tagtgaaaac
       61 cggtggaccc agctggaggc atggaccgat cagctgggct ccctgtgcgg ctgctattgc
      121 tgctgctgtt gttgctgctg tggtccgtgg ccccgcaggc gctgcggccc ggttcacatt
      181 ctctacgata tctcttcatg ggtgcctcaa agccagacct cgggctgcct ttctttgagg
      241 ctctgggtta tgtggatgac cagctctttg tatcctacaa tcacgagagt cgccgtgctg
      301 agcccagggc cccatggatc ttggggcaga catcaagcca gctgtggctg cagctgagtc
      361 agagcctgaa agggtgggat tacatgttca tagtggactt ctggaccatc atgggcaact
      421 ataaccacag taaggtcacg aagttgagag tggtgcctga gtctcacatc ctgcaggtga
      481 tcctaggatg tgaggtgcat gaagacaaca gtaccagtgg cttctggaaa tatggctacg
      541 atgggcaaga tcaccttgaa ttctgcccca agacactgaa ctggagtgca gccgagccaa
      601 gggcctgggc caccaagatg gagtgggaag agcacaggat ccgtgccaga cagagcaggg
      661 actacctgca gagggactgc ccccagcagc tgaagcaggt cctggagctc cagagagggg
      721 ttctgggaca gcaagtgcct actttggtga aagtgactcg ccactgggcc tctacaggga
      781 cctctctaag gtgtcaggct ctgaatttct tcccccagaa catcactatg aggtggttga
      841 aggacagcca gcccctagat gccaaggatg tcaaccctga gaacgtgctg ccaaatgggg
      901 atgggaccta tcagggctgg ctgaccttgg ctgtggcccc tggagaagag acaaggttca
      961 gctgtcaagt ggagcaccca ggcctggatc agcctctcac tgccacttgg gagccctcac
     1021 ggtctcagga catgattatt ggaatcataa gtgggatcac catttgtgcc atcttctttg
     1081 ttggaattct gatcctagtc ttaaggaaaa ggaaggtttc aggaggaacc atgggtgact
     1141 atgtcttaac agagtgtgag tgacctgcag catgcagaag cacagaagag agaagactca
     1201 gccaaagact tggaggggac acacttgctc cattctagaa cacagctgga cctaacacac
     1261 agaaactgcc tgaggactct gcccttagct ttcctgtttg ctttcttaag gtgttttctc
     1321 cagttaagtt cagttcctga ataatagtga ctgccccagc tgcaacctct cccttcagaa
     1381 ccagtctcat gatctttaag ctgctacttg caggcatcct tcgttttctg catccaccta
     1441 gacttcgtat gtctacttaa aaagccccac taaatttggg ggacacatga ttcatttcca
     1501 catctgaaga agttatgaac cttcatcctg ggatgcacac attcttgtgc cagaattttt
     1561 catacatatc ctaggaccca ttcaattgtc atttgagcct ctctatctgt tagtgactac
     1621 tctgacttct ctgccattgg agtgttatgg caataaagct atgaacgtta
//
