LOCUS       NM_001173435            1106 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus homeostatic iron regulator (Hfe), transcript
            variant 3, mRNA.
ACCESSION   NM_001173435
VERSION     NM_001173435.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1106)
  AUTHORS   Tamosauskaite,J., Atkins,J.L., Pilling,L.C., Kuo,C.L., Kuchel,G.A.,
            Ferrucci,L. and Melzer,D.
  TITLE     Hereditary Hemochromatosis Associations with Frailty, Sarcopenia
            and Chronic Pain: Evidence from 200,975 Older UK Biobank
            Participants
  JOURNAL   J Gerontol A Biol Sci Med Sci 74 (3), 337-342 (2019)
   PUBMED   30657865
REFERENCE   2  (bases 1 to 1106)
  AUTHORS   Smith,D.J., Klein,K., Hartel,G., Wainwright,C.E., Bell,S.C.,
            Anderson,G.J. and Reid,D.W.
  TITLE     Mutations in the HFE gene can be associated with increased lung
            disease severity in cystic fibrosis
  JOURNAL   Gene 683, 12-17 (2019)
   PUBMED   30291871
REFERENCE   3  (bases 1 to 1106)
  AUTHORS   Pilling,L.C., Tamosauskaite,J., Jones,G., Wood,A.R., Jones,L.,
            Kuo,C.L., Kuchel,G.A., Ferrucci,L. and Melzer,D.
  TITLE     Common conditions associated with hereditary haemochromatosis
            genetic variants: cohort study in UK Biobank
  JOURNAL   BMJ 364, k5222 (2019)
   PUBMED   30651232
  REMARK    Erratum:[BMJ. 2019 Oct 23;367:l6157. doi: 10.1136/bmj.l6157.. PMID:
            31645331]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1106)
  AUTHORS   Frydlova,J., Rogalsky,D.W., Truksa,J., Traeger,L.,
            Steinbicker,A.U., Vokurka,M. and Krijt,J.
  TITLE     Liver HFE protein content is posttranscriptionally decreased in
            iron-deficient mice and rats
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 315 (4), G560-G568 (2018)
   PUBMED   29927322
REFERENCE   5  (bases 1 to 1106)
  AUTHORS   Lee,N.P., Wu,H., Ng,K.T.P., Luo,R., Lam,T.W., Lo,C.M. and Man,K.
  TITLE     Transcriptome Analysis of Acute Phase Liver Graft Injury in Liver
            Transplantation
  JOURNAL   Biomedicines 6 (2), 41 (2018)
   PUBMED   29642405
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1106)
  AUTHORS   Sanchez,M., Queralt,R., Bruguera,M., Rodes,J. and Oliva,R.
  TITLE     Cloning, sequencing and characterization of the rat hereditary
            hemochromatosis promoter: comparison of the human, mouse and rat
            HFE promoter regions
  JOURNAL   Gene 225 (1-2), 77-87 (1998)
   PUBMED   9931446
REFERENCE   7  (bases 1 to 1106)
  AUTHORS   Lebron,J.A., Bennett,M.J., Vaughn,D.E., Chirino,A.J., Snow,P.M.,
            Mintier,G.A., Feder,J.N. and Bjorkman,P.J.
  TITLE     Crystal structure of the hemochromatosis protein HFE and
            characterization of its interaction with transferrin receptor
  JOURNAL   Cell 93 (1), 111-123 (1998)
   PUBMED   9546397
REFERENCE   8  (bases 1 to 1106)
  AUTHORS   Feder,J.N., Penny,D.M., Irrinki,A., Lee,V.K., Lebron,J.A.,
            Watson,N., Tsuchihashi,Z., Sigal,E., Bjorkman,P.J. and
            Schatzman,R.C.
  TITLE     The hemochromatosis gene product complexes with the transferrin
            receptor and lowers its affinity for ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1472-1477 (1998)
   PUBMED   9465039
REFERENCE   9  (bases 1 to 1106)
  AUTHORS   George,D.K., Goldwurm,S., MacDonald,G.A., Cowley,L.L., Walker,N.I.,
            Ward,P.J., Jazwinska,E.C. and Powell,L.W.
  TITLE     Increased hepatic iron concentration in nonalcoholic
            steatohepatitis is associated with increased fibrosis
  JOURNAL   Gastroenterology 114 (2), 311-318 (1998)
   PUBMED   9453491
REFERENCE   10 (bases 1 to 1106)
  AUTHORS   Feder,J.N., Gnirke,A., Thomas,W., Tsuchihashi,Z., Ruddy,D.A.,
            Basava,A., Dormishian,F., Domingo,R. Jr., Ellis,M.C., Fullan,A.,
            Hinton,L.M., Jones,N.L., Kimmel,B.E., Kronmal,G.S., Lauer,P.,
            Lee,V.K., Loeb,D.B., Mapa,F.A., McClelland,E., Meyer,N.C.,
            Mintier,G.A., Moeller,N., Moore,T., Morikang,E., Prass,C.E.,
            Quintana,L., Starnes,S.M., Schatzman,R.C., Brunke,K.J.,
            Drayna,D.T., Risch,N.J., Bacon,B.R. and Wolff,R.K.
  TITLE     A novel MHC class I-like gene is mutated in patients with
            hereditary haemochromatosis
  JOURNAL   Nat Genet 13 (4), 399-408 (1996)
   PUBMED   8696333
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            Transcript Variant: This variant (3) lacks two alternate in-frame
            exons compared to variant 1. The resulting protein (isoform 3) is
            shorter compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF176535.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000017.1  41841302-41841472
            172-447             JAXUCZ010000017.1  41846954-41847229
            448-558             JAXUCZ010000017.1  41847343-41847453
            559-1106            JAXUCZ010000017.1  41848806-41849353
FEATURES             Location/Qualifiers
     source          1..1106
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..1106
                     /gene="Hfe"
                     /note="homeostatic iron regulator"
                     /db_xref="GeneID:29199"
                     /db_xref="RGD:2793"
     exon            1..171
                     /gene="Hfe"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..599
                     /gene="Hfe"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; hereditary hemochromatosis protein homolog;
                     RT1-CAFE"
                     /codon_start=1
                     /product="hereditary hemochromatosis protein homolog
                     isoform 3 precursor"
                     /protein_id="NP_001166906.1"
                     /db_xref="GeneID:29199"
                     /db_xref="RGD:2793"
                     /translation="MDRSAGLPVRLLLLLLLLLLWSVAPQALRPVPTLVKVTRHWAST
                     GTSLRCQALNFFPQNITMRWLKDSQPLDAKDVNPENVLPNGDGTYQGWLTLAVAPGEE
                     TRFSCQVEHPGLDQPLTATWEPSRSQDMIIGIISGITICAIFFVGILILVLRKRKVSG
                     GTMGDYVLTECE"
     exon            172..447
                     /gene="Hfe"
                     /inference="alignment:Splign:2.1.0"
     exon            448..558
                     /gene="Hfe"
                     /inference="alignment:Splign:2.1.0"
     exon            559..1106
                     /gene="Hfe"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagcaatgg ctacagggtg acttcttgga tcctccacgt ttccaggtcc tagtgaaaac
       61 cggtggaccc agctggaggc atggaccgat cagctgggct ccctgtgcgg ctgctattgc
      121 tgctgctgtt gttgctgctg tggtccgtgg ccccgcaggc gctgcggccc gtgcctactt
      181 tggtgaaagt gactcgccac tgggcctcta cagggacctc tctaaggtgt caggctctga
      241 atttcttccc ccagaacatc actatgaggt ggttgaagga cagccagccc ctagatgcca
      301 aggatgtcaa ccctgagaac gtgctgccaa atggggatgg gacctatcag ggctggctga
      361 ccttggctgt ggcccctgga gaagagacaa ggttcagctg tcaagtggag cacccaggcc
      421 tggatcagcc tctcactgcc acttgggagc cctcacggtc tcaggacatg attattggaa
      481 tcataagtgg gatcaccatt tgtgccatct tctttgttgg aattctgatc ctagtcttaa
      541 ggaaaaggaa ggtttcagga ggaaccatgg gtgactatgt cttaacagag tgtgagtgac
      601 ctgcagcatg cagaagcaca gaagagagaa gactcagcca aagacttgga ggggacacac
      661 ttgctccatt ctagaacaca gctggaccta acacacagaa actgcctgag gactctgccc
      721 ttagctttcc tgtttgcttt cttaaggtgt tttctccagt taagttcagt tcctgaataa
      781 tagtgactgc cccagctgca acctctccct tcagaaccag tctcatgatc tttaagctgc
      841 tacttgcagg catccttcgt tttctgcatc cacctagact tcgtatgtct acttaaaaag
      901 ccccactaaa tttgggggac acatgattca tttccacatc tgaagaagtt atgaaccttc
      961 atcctgggat gcacacattc ttgtgccaga atttttcata catatcctag gacccattca
     1021 attgtcattt gagcctctct atctgttagt gactactctg acttctctgc cattggagtg
     1081 ttatggcaat aaagctatga acgtta
//
