LOCUS       NM_001107977            4658 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus hes-related family bHLH transcription factor with
            YRPW motif-like (Heyl), mRNA.
ACCESSION   NM_001107977 XM_001055126 XM_233495
VERSION     NM_001107977.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4658)
  AUTHORS   Rajan S, Chu Pham Dang H, Djambazian H, Zuzan H, Fedyshyn Y, Ketela
            T, Moffat J, Hudson TJ and Sladek R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   2  (bases 1 to 4658)
  AUTHORS   Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf
            E, Eilers M, Wei CL and Gessler M.
  TITLE     Target gene analysis by microarrays and chromatin
            immunoprecipitation identifies HEY proteins as highly redundant
            bHLH repressors
  JOURNAL   PLoS Genet 8 (5), e1002728 (2012)
   PUBMED   22615585
REFERENCE   3  (bases 1 to 4658)
  AUTHORS   Lavery DN, Villaronga MA, Walker MM, Patel A, Belandia B and Bevan
            CL.
  TITLE     Repression of androgen receptor activity by HEYL, a third member of
            the Hairy/Enhancer-of-split-related family of Notch effectors
  JOURNAL   J Biol Chem 286 (20), 17796-17808 (2011)
   PUBMED   21454491
REFERENCE   4  (bases 1 to 4658)
  AUTHORS   Kanno K and Ishiura S.
  TITLE     Differential effects of the HESR/HEY transcription factor family on
            dopamine transporter reporter gene expression via variable number
            of tandem repeats
  JOURNAL   J Neurosci Res 89 (4), 562-575 (2011)
   PUBMED   21290414
REFERENCE   5  (bases 1 to 4658)
  AUTHORS   Jalali A, Bassuk AG, Kan L, Israsena N, Mukhopadhyay A, McGuire T
            and Kessler JA.
  TITLE     HeyL promotes neuronal differentiation of neural progenitor cells
  JOURNAL   J Neurosci Res 89 (3), 299-309 (2011)
   PUBMED   21259317
REFERENCE   6  (bases 1 to 4658)
  AUTHORS   Fischer A, Klattig J, Kneitz B, Diez H, Maier M, Holtmann B,
            Englert C and Gessler M.
  TITLE     Hey basic helix-loop-helix transcription factors are repressors of
            GATA4 and GATA6 and restrict expression of the GATA target gene ANF
            in fetal hearts
  JOURNAL   Mol Cell Biol 25 (20), 8960-8970 (2005)
   PUBMED   16199874
REFERENCE   7  (bases 1 to 4658)
  AUTHORS   Chen L and Al-Awqati Q.
  TITLE     Segmental expression of Notch and Hairy genes in nephrogenesis
  JOURNAL   Am J Physiol Renal Physiol 288 (5), F939-F952 (2005)
   PUBMED   15821257
REFERENCE   8  (bases 1 to 4658)
  AUTHORS   Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JM, Gardner
            KA, Gerard RD, Olson EN, Srivastava D and Nakagawa O.
  TITLE     Hairy-related transcription factors inhibit GATA-dependent cardiac
            gene expression through a signal-responsive mechanism
  JOURNAL   J Biol Chem 279 (52), 54937-54943 (2004)
   PUBMED   15485867
REFERENCE   9  (bases 1 to 4658)
  AUTHORS   Wang W, Campos AH, Prince CZ, Mou Y and Pollman MJ.
  TITLE     Coordinate Notch3-hairy-related transcription factor pathway
            regulation in response to arterial injury. Mediator role of
            platelet-derived growth factor and ERK
  JOURNAL   J Biol Chem 277 (26), 23165-23171 (2002)
   PUBMED   11971902
REFERENCE   10 (bases 1 to 4658)
  AUTHORS   Maier MM and Gessler M.
  TITLE     Comparative analysis of the human and mouse Hey1 promoter: Hey
            genes are new Notch target genes
  JOURNAL   Biochem Biophys Res Commun 275 (2), 652-660 (2000)
   PUBMED   10964718
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001055126.1, XM_233495.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB581434.1, FM048125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4658
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4658
                     /gene="Heyl"
                     /note="hes-related family bHLH transcription factor with
                     YRPW motif-like"
                     /db_xref="GeneID:313575"
                     /db_xref="RGD:1305022"
     exon            1..391
                     /gene="Heyl"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1292
                     /gene="Heyl"
                     /codon_start=1
                     /product="hairy/enhancer-of-split related with YRPW
                     motif-like protein"
                     /protein_id="NP_001101447.1"
                     /db_xref="GeneID:313575"
                     /db_xref="RGD:1305022"
                     /translation="MKRPRAPSGSDGESDGPIDVGQENDLSQMARPLTTPSPSQMQAR
                     KKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHASG
                     GAGFFDARALAVDFRSIGFRECLTEVVRYLGVLEGPSSHADPVRIRLLSHLNSYAAEM
                     EPSPTTTGALAFPVWPWSFLHSCPGLPSLSSQLAILGRVPGPVLPNVSSPPYPISALR
                     SAPVHRVPGTIPPAQRNLLPSRGVTSSQRAHPPERPAAPPPTALGVRAARSIVPILPC
                     SSPAAPGAGKSDDSASGSISSPSPLGPTGRPAGAVFYHSWVSEITEIGAF"
     exon            392..458
                     /gene="Heyl"
                     /inference="alignment:Splign:2.1.0"
     exon            459..542
                     /gene="Heyl"
                     /inference="alignment:Splign:2.1.0"
     exon            543..624
                     /gene="Heyl"
                     /inference="alignment:Splign:2.1.0"
     exon            625..4658
                     /gene="Heyl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgggctt ccccgtgggg cctcccaggg cacctgccca aggccaccca gcgcgccagc
       61 ccaggcagcg ccggtggagc ggagccggac ctcccagcgg ccgatggggg cggtgaccgc
      121 ccggggcctt cccacggttc ggtggcgcgt caccgcgggg gcgagggggc gccggggcgc
      181 cctgggctgc ggtgcaggaa agggccctgg gaaagggcgg cgttggctcc tgggccgggg
      241 cggggctgag gcggggccca gagaccaact ccagggatcg cagggctggg accccgcagc
      301 cagctttcgc catgaagcgg cccagggcgc ccagtggctc cgacggcgag tctgatggac
      361 ccatcgacgt gggtcaggag aacgatctta gccagatggc cagaccgctg accaccccca
      421 gcccttcgca gatgcaagcc cggaagaagc gcagagggat catagagaaa cggcgccgag
      481 accgcatcaa cagcagcctg tctgaactgc gacgattggt ccccactgcc tttgagaaac
      541 agggctcctc taagctggag aaagctgagg ttttgcagat gaccgtggat cacttgaaga
      601 tgctccatgc ctctggtggc gcagggttct ttgatgcccg agccctggct gttgacttcc
      661 ggagcattgg ttttcgggaa tgccttactg aggtcgtaag atacctgggg gtcctggaag
      721 gacccagcag ccatgcagac cccgtccgga ttcgcctcct ctcccacctc aacagctatg
      781 cagcagagat ggaaccctcg cccacaacca ccggtgccct ggcctttccc gtgtggccct
      841 ggtccttcct ccatagctgt ccaggcttgc cttccctgag cagtcagcta gccatcctgg
      901 gaagagtgcc cggccccgtc cttcccaatg tctcttctcc cccttacccg atctcagccc
      961 tgcggtccgc accagtgcac agagttcctg gtaccattcc cccagcccag cggaatttgc
     1021 tgcccagccg aggggtgact tcctcccaga gagcccaccc tcctgagagg ccagctgccc
     1081 ctccacccac agccctaggt gtcagggccg ccaggagcat agtccccatc ctgccgtgtt
     1141 cctccccagc agcccctgga gctgggaaat ctgatgacag tgcgtctggt tctatctcta
     1201 gtccgtctcc tttgggacca acggggaggc ctgcgggagc agtgttctac cactcctggg
     1261 tatcagaaat cactgaaatt ggggctttct gagctgactc ccacaaccat cccctaggaa
     1321 tgaggaaggt tctttatttt ctctccctga agccctaaaa gtggttgtca tgttttctgt
     1381 tttgttttct caaatggctt ctctgcagag gcacctctcc tcacccgtca gagccccact
     1441 ccctcaccct cctcaccact gaccccgata cttacctggc tccctgcagc cttttgagag
     1501 ctcagagcct cagtctcatt tcccactgac acagaggagt tgtgtggcgt cttgtgagcc
     1561 cttaggcact gtgggtccaa agccaggttg ctccaatgaa gaggtgagac acacagccca
     1621 cctcagtcgg gacgaccggt gggattcagc catcccaagc cagcaggata gaatgtactc
     1681 cctgcttccc ttcctgaaga cagaaacgga gcaggggctg cggagaagtc tctgtggctc
     1741 accccacaac agtgaaacac agaactgttc tctggtactt ctaaggcctg cagctaccat
     1801 catcccaact tcagttgtcc agatgatcgc ctactggctt gacacaccag gccaggagga
     1861 ttctccacag aatcgaagct ctgtggcagg gcatcctcac tatcaggctt ctaagttgct
     1921 tcagatagga gccagggttg ggaaggtaac agaagaaccc agctccctgt ctctcaggca
     1981 ccaccatcct ccagaactac agcccttccc acagggttcc cagtgtggag gaccagtgac
     2041 cctgatggtg gaacccccca agaggctttc tcttgggatt cagccccaga catctgagct
     2101 gcctggtttg catccggctc ccagagccca gaccgctgcc acagccaagg gctgtcaggc
     2161 tggataaaaa taactcagag gagggggaga accaccagag gtggctcttc aaggtcatgg
     2221 agtgggttga gggcctgaga gcctgctcac ccagatttcg cacagctggc tctgctcaga
     2281 agccggctca cgcctcagct ccgcctcagg ccccaggctt ctagtgggaa taaatggctg
     2341 gtggaacaac agagcctgaa ccaacattta gggttgtccc ataatcaaag tgtggaaaca
     2401 tttctgtcct ctatggtgaa cacctgctcc ccacggcgcc ctccaggacc acccagcatg
     2461 ccctccggaa gcacccggtg agaacctaga actcactacc ctgctgatca tgaaagacgt
     2521 tcaagatcac cctggaaagc cccctccccc caacaaaccc cattcccaga ctttgatgga
     2581 actgtggtcc ccagagctgt tgtaaggagc ctgtgaccgc aagattagag tttgaaaaag
     2641 ccatggagca aaacggtcac ttcagaaaag tgggacagag ggcagaggtc acctgagtga
     2701 cccagaaagt gcttgcgaat aggtcaagaa gacataaagg ctcccttttc tccctaatga
     2761 aagcaagctc tttttaatat tgctgccata gtggacctct ctgagggcgt gcatcgctgt
     2821 ggtgtgcatc accagcctgc cgatggagac agatacaggg acagcaggac agtcttgcag
     2881 gcccctgcga gtggggagag gaggcggtaa aggtcccgga tattcaggtc tctctgcaag
     2941 cctgtggttt ggcagcctcc tagccagagg ttgagtgtgg gaaacatttc taggctgcag
     3001 gtactcaaac tgcagaaccg tctcttgaca ccgagatggc agaggccgct gcaccctttc
     3061 agcatccatc ctgattggtc ttgggctcat tctcccagga gactgggcag gctaccccac
     3121 ccacacccac acccacaccc acacccacac ccacacccac acccacaccc agctgagaac
     3181 tcaagtcccc tgtttccagt cccaggcgga actctctggt gtccccaaca ctcatcccac
     3241 tgcggggtgt tgcagacaag taataaagat gtttgtttcc ttccaccaga ctctacgtgc
     3301 taagtatttc tggagtcttt gaacctacag cccctggtct ggcaatgtcc cttctcccct
     3361 agattctccc cagctccctt gcttctctct ggctgtgcca tcagttctga acagccgctg
     3421 gagagaacat agcatgggca gggcacattg catcaaccca gcctcaaacc tagacacccc
     3481 ccccccccgc accctgctat tctcgtgatg acaaccagag ccctttttac aatccaaaca
     3541 cgattcctag tcttatttct tgctggcccc aatcttgctc agtgcttatg caacactggc
     3601 ctattctctt ccaccttaga gctgctcata tgagggtccc agaatgcccc cctttatgag
     3661 gcgtacttga gcccctcaga cacctcctcc tggaggcctt ccgggactaa tgtgcttgaa
     3721 cagctcgttc atctgagaag cccattgtct cctgtcctgg agagttagct gatgtctagc
     3781 tacttatgtg tctacttgat tgggtatgtt ccccactgga acgtaagctc agtgaagcca
     3841 ggggccagag ctggcccgtg ctcccatctg cacttggcac ggagcacagt gcctatctat
     3901 caatttctgt tgcataaatc gatcgaggag gtgagacagc ttctggtttc ctgctctggc
     3961 tggccgactc tgctggagtg ggttctacct ccattcctgc tggctgactt tgagaggagg
     4021 caggagagcc aaggccaaag gactgggggt tctggaagaa tggtcagaag gccctggcca
     4081 gaggagacgc aagcgtgttg gccctggagt gaatgctgac agctgagcct gccagcgggt
     4141 ttgttctttg ctcttggcct ggctccttga tacatctagc tcctaacaag cccagcattc
     4201 acggagatct actctgcgcc agccaggcct agcagagcca acagtaacaa acacatggtc
     4261 actcagagga caatatatcc tctacctaga taagagggcc atgagacagt ccatggaaaa
     4321 ggcagagggc tgcagagccg ggtaggtatt tctggctagg taggaagtgg gagagggcct
     4381 ggaaggaagc cctcccagag gagggccagg ggactccctt ttacagatct agaggctgac
     4441 ccaggttctg aacacatgtg gaagaagggc tagcctgagc tctgaaacta atcttcttta
     4501 ttacacgctt gctaatgagg aatcattttc ttcaagttct ttgtccttct tgaacttaat
     4561 gtttccatct gtaaaatggt tatgttgtag caatggctcc ctacatgtgt gcatgtatgt
     4621 acacacaact aaataaaact gtcacatttt ttttaaag
//
