LOCUS       NM_130417               2421 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus hes-related family bHLH transcription factor with
            YRPW motif 2 (Hey2), mRNA.
ACCESSION   NM_130417 XM_001058425 XM_344806
VERSION     NM_130417.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2421)
  AUTHORS   Miloudi,K., Oubaha,M., Menard,C., Dejda,A., Guber,V., Cagnone,G.,
            Wilson,A.M., Tetreault,N., Mawambo,G., Binet,F., Chidiac,R.,
            Delisle,C., Buscarlet,M., Cerani,A., Crespo-Garcia,S., Bentley,K.,
            Rezende,F., Joyal,J.S., Mallette,F.A., Gratton,J.P., Larrivee,B.
            and Sapieha,P.
  TITLE     NOTCH1 signaling induces pathological vascular permeability in
            diabetic retinopathy
  JOURNAL   Proc Natl Acad Sci U S A 116 (10), 4538-4547 (2019)
   PUBMED   30787185
REFERENCE   2  (bases 1 to 2421)
  AUTHORS   Pierscianek,D., Michel,A., Hindy,N.E., Keyvani,K., Dammann,P.,
            Oezkan,N., Mueller,O., Sure,U. and Zhu,Y.
  TITLE     Activation of multiple angiogenic signaling pathways in
            hemangiopericytoma
  JOURNAL   Brain Tumor Pathol 33 (3), 200-208 (2016)
   PUBMED   26951238
REFERENCE   3  (bases 1 to 2421)
  AUTHORS   Surendran,S., S Ramegowda,K., Suresh,A., Binil Raj,S.S.,
            Lakkappa,R.K., Kamalapurkar,G., Radhakrishnan,N. and C Kartha,C.
  TITLE     Arterialization and anomalous vein wall remodeling in varicose
            veins is associated with upregulated FoxC2-Dll4 pathway
  JOURNAL   Lab Invest 96 (4), 399-408 (2016)
   PUBMED   26808710
REFERENCE   4  (bases 1 to 2421)
  AUTHORS   Heisig,J., Weber,D., Englberger,E., Winkler,A., Kneitz,S.,
            Sung,W.K., Wolf,E., Eilers,M., Wei,C.L. and Gessler,M.
  TITLE     Target gene analysis by microarrays and chromatin
            immunoprecipitation identifies HEY proteins as highly redundant
            bHLH repressors
  JOURNAL   PLoS Genet 8 (5), e1002728 (2012)
   PUBMED   22615585
REFERENCE   5  (bases 1 to 2421)
  AUTHORS   Acharya,A., Hans,C.P., Koenig,S.N., Nichols,H.A., Galindo,C.L.,
            Garner,H.R., Merrill,W.H., Hinton,R.B. and Garg,V.
  TITLE     Inhibitory role of Notch1 in calcific aortic valve disease
  JOURNAL   PLoS One 6 (11), e27743 (2011)
   PUBMED   22110751
REFERENCE   6  (bases 1 to 2421)
  AUTHORS   Iso,T., Sartorelli,V., Poizat,C., Iezzi,S., Wu,H.Y., Chung,G.,
            Kedes,L. and Hamamori,Y.
  TITLE     HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling
  JOURNAL   Mol Cell Biol 21 (17), 6080-6089 (2001)
   PUBMED   11486045
REFERENCE   7  (bases 1 to 2421)
  AUTHORS   Nakagawa,O., McFadden,D.G., Nakagawa,M., Yanagisawa,H., Hu,T.,
            Srivastava,D. and Olson,E.N.
  TITLE     Members of the HRT family of basic helix-loop-helix proteins act as
            transcriptional repressors downstream of Notch signaling
  JOURNAL   Proc Natl Acad Sci U S A 97 (25), 13655-13660 (2000)
   PUBMED   11095750
REFERENCE   8  (bases 1 to 2421)
  AUTHORS   Leimeister,C., Dale,K., Fischer,A., Klamt,B., Hrabe de Angelis,M.,
            Radtke,F., McGrew,M.J., Pourquie,O. and Gessler,M.
  TITLE     Oscillating expression of c-Hey2 in the presomitic mesoderm
            suggests that the segmentation clock may use combinatorial
            signaling through multiple interacting bHLH factors
  JOURNAL   Dev Biol 227 (1), 91-103 (2000)
   PUBMED   11076679
REFERENCE   9  (bases 1 to 2421)
  AUTHORS   Maier,M.M. and Gessler,M.
  TITLE     Comparative analysis of the human and mouse Hey1 promoter: Hey
            genes are new Notch target genes
  JOURNAL   Biochem Biophys Res Commun 275 (2), 652-660 (2000)
   PUBMED   10964718
REFERENCE   10 (bases 1 to 2421)
  AUTHORS   Chin,M.T., Maemura,K., Fukumoto,S., Jain,M.K., Layne,M.D.,
            Watanabe,M., Hsieh,C.M. and Lee,M.E.
  TITLE     Cardiovascular basic helix loop helix factor 1, a novel
            transcriptional repressor expressed preferentially in the
            developing and adult cardiovascular system
  JOURNAL   J Biol Chem 275 (9), 6381-6387 (2000)
   PUBMED   10692439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 17, 2009 this sequence version replaced
            XM_344806.3, XM_001058425.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.303.1, SRR26643292.350.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000001.1  28641100-28641247
            149-227             JAXUCZ010000001.1  28643148-28643226
            228-311             JAXUCZ010000001.1  28643349-28643432
            312-393             JAXUCZ010000001.1  28646250-28646331
            394-2421            JAXUCZ010000001.1  28649160-28651187
FEATURES             Location/Qualifiers
     source          1..2421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2421
                     /gene="Hey2"
                     /gene_synonym="Herp1"
                     /note="hes-related family bHLH transcription factor with
                     YRPW motif 2"
                     /db_xref="GeneID:155430"
                     /db_xref="RGD:621405"
     exon            1..148
                     /gene="Hey2"
                     /gene_synonym="Herp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1085
                     /gene="Hey2"
                     /gene_synonym="Herp1"
                     /note="hairy/enhancer-of-split related with YRPW motif 2"
                     /codon_start=1
                     /product="hairy/enhancer-of-split related with YRPW motif
                     protein 2"
                     /protein_id="NP_569101.1"
                     /db_xref="GeneID:155430"
                     /db_xref="RGD:621405"
                     /translation="MKRPCEETTSESDLDETIDVGSENNYSGHSASSVMRSNSPTTTS
                     QIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKM
                     LQATGGKGYFDAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLSTC
                     ASQREAAVMTSSMSHHHHPLHPHHWAAAFHHLPTSLLQPNGLHTSESTPCRLSTSSEV
                     PPAHGSALLTATFAHADSALRMPSTGTVAPCVPPLSTSLLSLSATVHAAAAAATAAAH
                     SFPLSFAGAFPMLPSNAAAAAAVAAATAISPPLSVSAASSPQQTSSGTNSKPYRPWGT
                     EVGAF"
     exon            149..227
                     /gene="Hey2"
                     /gene_synonym="Herp1"
                     /inference="alignment:Splign:2.1.0"
     exon            228..311
                     /gene="Hey2"
                     /gene_synonym="Herp1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..393
                     /gene="Hey2"
                     /gene_synonym="Herp1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..2421
                     /gene="Hey2"
                     /gene_synonym="Herp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggggaggg agggaggagg cccgcgagga gctcagggtg tccgtagctc ttctttttcg
       61 ccgcgatgaa gcgcccttgc gaggagacga cctctgaaag cgacctagac gagaccatcg
      121 acgtggggag cgagaacaat tactccgggc acagtgcaag ctcagtgatg aggtccaatt
      181 cacctacaac cacctctcag attatggcaa gaaagaaaag gagagggatc atagaaaaaa
      241 ggcgtcggga tcgaataaat aacagtttat ctgaattgag aagactagtg ccaacagctt
      301 ttgaaaaaca aggatctgcc aagttggaaa aggctgaaat tctgcaaatg acagtggatc
      361 atttgaagat gctccaggca acagggggga aaggctactt tgacgcccat gcccttgcca
      421 cggactttat gagcattgga ttccgagaat gcttgacaga agtggcgagg tacctaagct
      481 ctgtggaagg ccttgaccct tcggacccac tacgcgtgcg ccttgtctct catctcagca
      541 cctgtgcctc ccagcgggag gcagcagtga tgacatcctc catgtcccac caccatcacc
      601 ccctgcaccc tcaccactgg gcagcggcct tccaccatct ccccacatcc ctgctccaac
      661 ccaatggact ccacacatca gagtcaacgc catgtcgcct atccacgtct tcagaagtgc
      721 ctcctgctca tggctctgcc ctcctcacag caacatttgc ccatgcagat tctgctcttc
      781 ggatgccatc aacgggcacc gtcgcaccct gcgtgccacc tctctccacc tctctcctgt
      841 ctctttcagc tactgtgcat gccgcagcag cagcggccac cgcagctgca cacagcttcc
      901 ctctgtcctt cgcaggggcc tttcccatgc tcccatccaa tgcagcagca gccgccgcgg
      961 ttgccgctgc aacagcaatc agcccaccgt tatcagtgtc tgcagcctcc agtcctcagc
     1021 agacaagcag tggaacaaac agtaaacctt accgaccctg ggggacagaa gttggagcct
     1081 tttaagttat tcttgaatct ctttgcaata gtaactggtg tcctccgttt cggaatcagc
     1141 ttcaaacctc tgcacccgga cggtagtcat acagatacgt ccagatctcc acagcagcaa
     1201 taaagcgatt tgagaagaaa cttcccacaa atggaaatgt agtattattt tttcctttgt
     1261 ttaaggcagc ttggcaactg acatcaacaa cttgaaagcc gcacaccggt ttccatttaa
     1321 actttcttgg aaaatacacc gatgttacca tccagtagtg catttatact cctgatttgg
     1381 aaaagaaaaa accccataac tgagttctcc tgatgcagga agggagaaga aaaaaaaaat
     1441 accatgtttc ctaagtgcct gaactaagaa acataatgta gcacaaggtc agaagggtat
     1501 aaccgttaag gtgagaaagg gagagtgcag acaaggtgtc gggctgcaga tacagtgttc
     1561 tttgggaacc agaaagatga atgaaagtta agttgaaaga cctagttttg tctttgtttt
     1621 ctttatacag acttgccagg cagtgacatt tagcagtgca ctgaaataaa aattccccca
     1681 gagcccccat taacaagcat ttctggtctg ccttcaagct tccgtacctc tggtgagccc
     1741 tagcttaaaa cgctatgctt ctttatgtaa acttacaggt atacatgcac tagaagcagt
     1801 tacctactgt gtgcccacca gaggttcact cacacgaacg ggaaaacttc agtttgccag
     1861 actttggatt aatttattgt ttcacttgga ctatgtttat atatttaact tcttcagttt
     1921 tctcctgaca acatgtaatg tctgttcttg tctgtttggg ggtggggggg gtgttgcatt
     1981 tttggaagta acgagagaag gagagatgat atggaaggga aaagctacat gatgtaaatg
     2041 tcttggtcaa atcacaacga atgtatggaa tgagttgtat ataaattatt tttgtccatg
     2101 catagactag tgctacataa tggtgttttg gttttgattt ttttttatct taacaatgaa
     2161 ataatctctt aagacattga aattgagcac atgagatttt atatttgaaa gaataaggca
     2221 cagcatgtat tcttatgcac ttcgtttctc tgctgtgtgg agaaagcagt aaacaagaga
     2281 atattaaaca ttatgcaaag ttatactcat aaatatgttt ttaaaattac tgtacctagt
     2341 ctcttctgta ttactttgta acttttttct atgcaaaagt ctacgtgtca ctaattaaat
     2401 gacgtccttt ttgactattt c
//
