LOCUS       NM_001191845            1061 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hes-related family bHLH transcription factor with
            YRPW motif 1 (Hey1), mRNA.
ACCESSION   NM_001191845 XM_342216
VERSION     NM_001191845.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1061)
  AUTHORS   Zhu,T., Chen,H., He,C. and Liu,X.
  TITLE     Transcription Factor HEY1 Improves Brain Vascular Endothelial Cell
            Function and Alleviates Ischemic Stroke by Upregulating NOTCH3
  JOURNAL   Neurochem Res 47 (5), 1442-1458 (2022)
   PUBMED   35316462
  REMARK    GeneRIF: Transcription Factor HEY1 Improves Brain Vascular
            Endothelial Cell Function and Alleviates Ischemic Stroke by
            Upregulating NOTCH3.
REFERENCE   2  (bases 1 to 1061)
  AUTHORS   Wang,S., Zhu,G., Jiang,D., Rhen,J., Li,X., Liu,H., Lyu,Y., Tsai,P.,
            Rose,Y., Nguyen,T., White,R.J., Pryhuber,G.S., Mariani,T.J., Li,C.,
            Mohan,A., Xu,Y. and Pang,J.
  TITLE     Reduced Notch1 Cleavage Promotes the Development of Pulmonary
            Hypertension
  JOURNAL   Hypertension 79 (1), 79-92 (2022)
   PUBMED   34739767
REFERENCE   3  (bases 1 to 1061)
  AUTHORS   Qi,Z., Li,M., Zhu,K. and Zhang,J.
  TITLE     Si-Miao-Yong-An on promoting the maturation of Vasa Vasorum and
            stabilizing atherosclerotic plaque in ApoE-/- mice An experimental
            study
  JOURNAL   Biomed Pharmacother 114, 108785 (2019)
   PUBMED   30909142
REFERENCE   4  (bases 1 to 1061)
  AUTHORS   Zheng,X., Narayanan,S., Sunkari,V.G., Eliasson,S., Botusan,I.R.,
            Grunler,J., Catrina,A.I., Radtke,F., Xu,C., Zhao,A., Ekberg,N.R.,
            Lendahl,U. and Catrina,S.B.
  TITLE     Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes
  JOURNAL   Proc Natl Acad Sci U S A 116 (14), 6985-6994 (2019)
   PUBMED   30886104
REFERENCE   5  (bases 1 to 1061)
  AUTHORS   Pierscianek,D., Wolf,S., Keyvani,K., El Hindy,N., Stein,K.P.,
            Sandalcioglu,I.E., Sure,U., Mueller,O. and Zhu,Y.
  TITLE     Study of angiogenic signaling pathways in hemangioblastoma
  JOURNAL   Neuropathology 37 (1), 3-11 (2017)
   PUBMED   27388534
REFERENCE   6  (bases 1 to 1061)
  AUTHORS   Iso,T., Chung,G., Hamamori,Y. and Kedes,L.
  TITLE     HERP1 is a cell type-specific primary target of Notch
  JOURNAL   J Biol Chem 277 (8), 6598-6607 (2002)
   PUBMED   11741889
REFERENCE   7  (bases 1 to 1061)
  AUTHORS   Iso,T., Sartorelli,V., Poizat,C., Iezzi,S., Wu,H.Y., Chung,G.,
            Kedes,L. and Hamamori,Y.
  TITLE     HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling
  JOURNAL   Mol Cell Biol 21 (17), 6080-6089 (2001)
   PUBMED   11486045
REFERENCE   8  (bases 1 to 1061)
  AUTHORS   Iso,T., Sartorelli,V., Chung,G., Shichinohe,T., Kedes,L. and
            Hamamori,Y.
  TITLE     HERP, a new primary target of Notch regulated by ligand binding
  JOURNAL   Mol Cell Biol 21 (17), 6071-6079 (2001)
   PUBMED   11486044
REFERENCE   9  (bases 1 to 1061)
  AUTHORS   Leimeister,C., Dale,K., Fischer,A., Klamt,B., Hrabe de Angelis,M.,
            Radtke,F., McGrew,M.J., Pourquie,O. and Gessler,M.
  TITLE     Oscillating expression of c-Hey2 in the presomitic mesoderm
            suggests that the segmentation clock may use combinatorial
            signaling through multiple interacting bHLH factors
  JOURNAL   Dev Biol 227 (1), 91-103 (2000)
   PUBMED   11076679
REFERENCE   10 (bases 1 to 1061)
  AUTHORS   Maier,M.M. and Gessler,M.
  TITLE     Comparative analysis of the human and mouse Hey1 promoter: Hey
            genes are new Notch target genes
  JOURNAL   Biochem Biophys Res Commun 275 (2), 652-660 (2000)
   PUBMED   10964718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 9, 2021 this sequence version replaced NM_001191845.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF407145.1, BF414647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               JAXUCZ010000002.1  95003935-95004184
            251-326             JAXUCZ010000002.1  95004395-95004470
            327-410             JAXUCZ010000002.1  95004610-95004693
            411-492             JAXUCZ010000002.1  95004941-95005022
            493-1061            JAXUCZ010000002.1  95005889-95006457
FEATURES             Location/Qualifiers
     source          1..1061
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..1061
                     /gene="Hey1"
                     /gene_synonym="Herp2"
                     /note="hes-related family bHLH transcription factor with
                     YRPW motif 1"
                     /db_xref="GeneID:155437"
                     /db_xref="RGD:621403"
     exon            1..250
                     /gene="Hey1"
                     /gene_synonym="Herp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1061
                     /gene="Hey1"
                     /gene_synonym="Herp2"
                     /note="hairy/enhancer-of-split related with YRPW motif 1"
                     /codon_start=1
                     /product="hairy/enhancer-of-split related with YRPW motif
                     protein 1"
                     /protein_id="NP_001178774.2"
                     /db_xref="GeneID:155437"
                     /db_xref="RGD:621403"
                     /translation="MKRAHPDYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTS
                     SQVLARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLK
                     MLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNN
                     YASQREAASGAHGGLGHIPWGSAFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGR
                     LASAHPEAPALRAPPSGGLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFSSFHLLSP
                     STPSQAANLGKPYRPWGTEIGAF"
     exon            251..326
                     /gene="Hey1"
                     /gene_synonym="Herp2"
                     /inference="alignment:Splign:2.1.0"
     exon            327..410
                     /gene="Hey1"
                     /gene_synonym="Herp2"
                     /inference="alignment:Splign:2.1.0"
     exon            411..492
                     /gene="Hey1"
                     /gene_synonym="Herp2"
                     /inference="alignment:Splign:2.1.0"
     exon            493..1061
                     /gene="Hey1"
                     /gene_synonym="Herp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggcgcag cgtgggaaag ggatggttga gttttaacca gaggctgagc gtgagtggga
       61 tcagtgtgca cgcaccgcct gcagccgagc gccgagcggc cgcgcagtta actcctccct
      121 gcccgccgcg cgaccctcct gggagcccgc gctccgccac catgaagaga gctcacccgg
      181 actacagctc ctctgatagt gagctggacg agaccatcga ggtggagaag gagagcgcag
      241 acgagaatgg aaacttgagt tcggcgctgg gttccatgtc cccaaccaca tcgtcccagg
      301 ttttggcccg gaaaagacgg agaggcatca tcgagaagcg ccgacgagac cgaatcaata
      361 acagtttgtc tgagctgaga aggctggtac ccagtgcttt tgagaagcag ggatctgcga
      421 agctagaaaa agctgagatc ttgcagatga ctgtggatca cctgaaaatg ctgcacactg
      481 caggagggaa aggttatttt gacgcgcacg ccctggctat ggactatcgg agtttggggt
      541 ttcgggaatg cctggctgaa gttgcccgtt atctgagcat cattgaagga ctcgatgcct
      601 ccgatccgct tcgtgttcgc ctggtctccc atctcaacaa ctacgcatcc cagcgggaag
      661 ccgcgagcgg cgctcacggg ggcctcggac acattccttg gggaagcgcc ttcggacatc
      721 acccacacat cgcacacccg ctgctgctgc cccagaatgg ccacgggaac gctggcacta
      781 cggcgtcacc cacggagccg catcaccagg gcaggctggc ctctgcccat cctgaggcgc
      841 cggccttgcg agcgccccct agtggcggct tgggaccagt gcttcccgtg gtgacctcag
      901 cctccaaact gtcgccgcca ctgctctcct ccgtggcctc actctcagcc ttccccttct
      961 ccttcagctc ctttcatcta ctgagtcctt cgacaccctc acaggcagca aaccttggca
     1021 agccctatag accttggggg acagagattg gagctttcta a
//
