LOCUS       NM_001011946            1880 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus hexosaminidase subunit beta (Hexb), mRNA.
ACCESSION   NM_001011946 XM_215455
VERSION     NM_001011946.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1880)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   2  (bases 1 to 1880)
  AUTHORS   Brandenstein,L., Schweizer,M., Sedlacik,J., Fiehler,J. and
            Storch,S.
  TITLE     Lysosomal dysfunction and impaired autophagy in a novel mouse model
            deficient for the lysosomal membrane protein Cln7
  JOURNAL   Hum Mol Genet 25 (4), 777-791 (2016)
   PUBMED   26681805
REFERENCE   3  (bases 1 to 1880)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   4  (bases 1 to 1880)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1880)
  AUTHORS   Boonen,M., Vogel,P., Platt,K.A., Dahms,N. and Kornfeld,S.
  TITLE     Mice lacking mannose 6-phosphate uncovering enzyme activity have a
            milder phenotype than mice deficient for
            N-acetylglucosamine-1-phosphotransferase activity
  JOURNAL   Mol Biol Cell 20 (20), 4381-4389 (2009)
   PUBMED   19710420
REFERENCE   6  (bases 1 to 1880)
  AUTHORS   Hall,J.C., Kochins,J.G. and Perez,F.M.
  TITLE     Purification and characterization of N-acetyl-beta-D-hexosaminidase
            in different anatomical regions of the adult rat epididymis
  JOURNAL   Biochem Int 28 (4), 613-620 (1992)
   PUBMED   1482400
REFERENCE   7  (bases 1 to 1880)
  AUTHORS   Emiliani,C., Locci,P., Marinucci,L., Rossi,R. and Orlacchio,A.
  TITLE     Pregnancy modulates the expression of beta-N-acetylhexosaminidase
            in rat serum and tissues
  JOURNAL   Int J Biochem 24 (10), 1599-1605 (1992)
   PUBMED   1397486
REFERENCE   8  (bases 1 to 1880)
  AUTHORS   Banerjee,P., Siciliano,L., Oliveri,D., McCabe,N.R., Boyers,M.J.,
            Horwitz,A.L., Li,S.C. and Dawson,G.
  TITLE     Molecular basis of an adult form of beta-hexosaminidase B
            deficiency with motor neuron disease
  JOURNAL   Biochem Biophys Res Commun 181 (1), 108-115 (1991)
   PUBMED   1720305
REFERENCE   9  (bases 1 to 1880)
  AUTHORS   Neote,K., McInnes,B., Mahuran,D.J. and Gravel,R.A.
  TITLE     Structure and distribution of an Alu-type deletion mutation in
            Sandhoff disease
  JOURNAL   J Clin Invest 86 (5), 1524-1531 (1990)
   PUBMED   2147027
REFERENCE   10 (bases 1 to 1880)
  AUTHORS   Proia,R.L., d'Azzo,A. and Neufeld,E.F.
  TITLE     Association of alpha- and beta-subunits during the biosynthesis of
            beta-hexosaminidase in cultured human fibroblasts
  JOURNAL   J Biol Chem 259 (5), 3350-3354 (1984)
   PUBMED   6230359
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001011946.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079376.1, SRR26360186.937551.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN06680449,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               JAXUCZ010000002.1  30238465-30238771   c
            308-453             JAXUCZ010000002.1  30235199-30235344   c
            454-519             JAXUCZ010000002.1  30232779-30232844   c
            520-566             JAXUCZ010000002.1  30230758-30230804   c
            567-677             JAXUCZ010000002.1  30230420-30230530   c
            678-779             JAXUCZ010000002.1  30226501-30226602   c
            780-909             JAXUCZ010000002.1  30225076-30225205   c
            910-1090            JAXUCZ010000002.1  30223468-30223648   c
            1091-1177           JAXUCZ010000002.1  30222695-30222781   c
            1178-1250           JAXUCZ010000002.1  30221324-30221396   c
            1251-1425           JAXUCZ010000002.1  30219968-30220142   c
            1426-1516           JAXUCZ010000002.1  30219523-30219613   c
            1517-1621           JAXUCZ010000002.1  30219273-30219377   c
            1622-1880           JAXUCZ010000002.1  30218608-30218866   c
FEATURES             Location/Qualifiers
     source          1..1880
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1880
                     /gene="Hexb"
                     /note="hexosaminidase subunit beta"
                     /db_xref="GeneID:294673"
                     /db_xref="RGD:1307607"
     exon            1..307
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1688
                     /gene="Hexb"
                     /EC_number="3.2.1.52"
                     /note="beta-hexosaminidase subunit beta; hexosaminidase
                     subunit B; beta-N-acetylhexosaminidase subunit beta;
                     N-acetyl-beta-glucosaminidase subunit beta; hexosaminidase
                     B"
                     /codon_start=1
                     /product="beta-hexosaminidase subunit beta precursor"
                     /protein_id="NP_001011946.1"
                     /db_xref="GeneID:294673"
                     /db_xref="RGD:1307607"
                     /translation="MPGSPRRAPGLLLQALVAMVSLALVAPFGLQPALWPMPRSVQVF
                     PRLLYISPENFQIDNSPNSTAGPSCSLLLEAFRRYYNYIFGFYKRHHGPAKFQDKPQL
                     EKLLVFINLEPQCDAFPSMSSDESYSLLVQEPVALLKANEVWGALRGLETFSQLVYQD
                     AYGTFTINESTIADSPRFPHRGILIDTSRHYLPVKTIFKTLDAMAFNKFNVLHWHIVD
                     DQSFPYQSITFPELSNKGSYSLSHVYTPNDIHMVLEYARLRGIRVIPEFDSPGHTQSW
                     GKGQKNLLTPCFIQKIRTQKVGPVDPSLNTTYVFFDTFFKEISRVFPDQFIHLGGDEV
                     EFECWASNPNIQNFMKKKGFGNNFRRLESFYIKKILDIITSLKKSSIVWQDVFDDQVE
                     LQPGTVVEVWKSENYLNELAQVTASGFPAILSAPWYLDLISYGQDWRNYYKAEPLNFE
                     GSEKQKQLVIGGEACLWGEYVDATNLIPRLWPRASAVGERLWSPRIITNLENAYRRLA
                     VHRCRMVSRGIAAQPLFTGYCNYENKMEK"
     exon            308..453
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            454..519
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            520..566
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            567..677
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            678..779
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            780..909
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1090
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1177
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1250
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1425
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1516
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1621
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1880
                     /gene="Hexb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgctttct tcccagcgac ccaggcttga aggttgatcc gaagactctc cccggccaga
       61 ctcgcggagc agtcatgccg gggtccccgc gtcgcgcccc ggggctgctg ctgcaggcgc
      121 tggtggcgat ggtgtcgctg gccctggtgg cccccttcgg gctgcaaccc gcgctgtggc
      181 ccatgccgcg ctcggtgcag gtgttcccgc ggctgctgta catctccccg gagaacttcc
      241 agatcgacaa cagccccaat tccaccgcgg gcccctcctg ctcgctgctg ctggaggcgt
      301 ttcggcgata ttacaactat atttttggtt tctacaagag acatcatggc cctgctaaat
      361 ttcaagataa accacagtta gagaagcttc tggtcttcat taacctcgaa ccgcagtgtg
      421 atgccttccc tagtatgtca tcagatgagt cctattctct acttgtacaa gaaccagtag
      481 ctctcctcaa ggccaacgaa gtttggggag cactaagagg tttggagacc tttagccagt
      541 tggtttacca ggacgcttat gggactttta ccatcaatga atccactatt gctgattctc
      601 caagattccc tcatagagga attctaattg atacatccag acactacctg cctgtgaaga
      661 caatttttaa aactctggat gccatggctt ttaataagtt taacgtcctt cactggcaca
      721 tagtggacga ccagtctttc ccttatcaga gtatcacttt tcctgagcta agcaacaagg
      781 gaagctattc tttgtctcat gtctatacac caaacgacat ccatatggta cttgaatatg
      841 cccggctccg agggattcga gtcataccag aattcgatag ccccggccat acacagtctt
      901 gggggaaagg tcagaaaaac cttctaactc catgtttcat tcaaaaaatt agaactcaaa
      961 aggttggacc tgtagaccca agtctaaata caacatacgt attctttgac acattcttca
     1021 aagaaatcag cagggtgttt ccagaccagt ttatccactt gggaggagat gaagtggaat
     1081 ttgaatgttg ggcatcaaac ccaaacatcc aaaatttcat gaagaaaaag ggctttggca
     1141 acaattttag aagactagaa tccttttata tcaaaaagat tttggatatt atcacatcct
     1201 taaagaagag ctccattgtt tggcaagacg tttttgatga tcaagtggag cttcagccgg
     1261 gcacggtagt tgaagtgtgg aaaagtgaaa attacttaaa tgaattagca caagtcacag
     1321 catccggctt ccctgccatc ctttctgctc cttggtactt agacctgatc agctacgggc
     1381 aagactggag aaactactat aaagcggagc cccttaactt tgaaggttcg gagaagcaga
     1441 aacaacttgt tattggtgga gaggcttgcc tatggggaga atatgtggat gcaactaacc
     1501 ttattccaag actatggcct cgggcaagcg ctgttggtga gaggctctgg agccctagaa
     1561 ttatcaccaa cctggaaaac gcctacagac gactggcagt gcaccgctgt agaatggtca
     1621 gccgcggaat agctgcacaa cctctcttta ctggatattg taactacgag aataaaatgg
     1681 aaaagtgaca gaagtctaca gcactacagc tctaatcatg ttgattctga aatcatgtaa
     1741 attaatattt gttaggctat tttttaaata aactatcttt ttattgattg aatctttcta
     1801 tatctgaatc aaacactgaa tactgacatc ttttatgtga gcagcttaaa aaaaataaaa
     1861 gaaaaagctt tgcactacta
//
