LOCUS       NM_001004443            1779 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hexosaminidase subunit alpha (Hexa), mRNA.
ACCESSION   NM_001004443 XM_217144
VERSION     NM_001004443.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1779)
  AUTHORS   Seyrantepe,V., Demir,S.A., Timur,Z.K., Von Gerichten,J.,
            Marsching,C., Erdemli,E., Oztas,E., Takahashi,K., Yamaguchi,K.,
            Ates,N., Donmez Demir,B., Dalkara,T., Erich,K., Hopf,C.,
            Sandhoff,R. and Miyagi,T.
  TITLE     Murine Sialidase Neu3 facilitates GM2 degradation and bypass in
            mouse model of Tay-Sachs disease
  JOURNAL   Exp Neurol 299 (Pt A), 26-41 (2018)
   PUBMED   28974375
REFERENCE   2  (bases 1 to 1779)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   3  (bases 1 to 1779)
  AUTHORS   Redshaw,N., Camps,C., Sharma,V., Motallebipour,M., Guzman-Ayala,M.,
            Oikonomopoulos,S., Thymiakou,E., Ragoussis,J. and Episkopou,V.
  TITLE     TGF-beta/Smad2/3 signaling directly regulates several miRNAs in
            mouse ES cells and early embryos
  JOURNAL   PLoS One 8 (1), e55186 (2013)
   PUBMED   23390484
REFERENCE   4  (bases 1 to 1779)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1779)
  AUTHORS   Miklyaeva,E.I., Dong,W., Bureau,A., Fattahie,R., Xu,Y., Su,M.,
            Fick,G.H., Huang,J.Q., Igdoura,S., Hanai,N. and Gravel,R.A.
  TITLE     Late onset Tay-Sachs disease in mice with targeted disruption of
            the Hexa gene: behavioral changes and pathology of the central
            nervous system
  JOURNAL   Brain Res 1001 (1-2), 37-50 (2004)
   PUBMED   14972652
REFERENCE   6  (bases 1 to 1779)
  AUTHORS   Cohen-Tannoudji,M., Marchand,P., Akli,S., Sheardown,S.A.,
            Puech,J.P., Kress,C., Gressens,P., Nassogne,M.C., Beccari,T.,
            Muggleton-Harris,A.L. et al.
  TITLE     Disruption of murine Hexa gene leads to enzymatic deficiency and to
            neuronal lysosomal storage, similar to that observed in Tay-Sachs
            disease
  JOURNAL   Mamm Genome 6 (12), 844-849 (1995)
   PUBMED   8747922
REFERENCE   7  (bases 1 to 1779)
  AUTHORS   Wakamatsu,N., Benoit,G., Lamhonwah,A.M., Zhang,Z.X., Trasler,J.M.,
            Triggs-Raine,B.L. and Gravel,R.A.
  TITLE     Structural organization, sequence, and expression of the mouse HEXA
            gene encoding the alpha subunit of hexosaminidase A
  JOURNAL   Genomics 24 (1), 110-119 (1994)
   PUBMED   7896264
REFERENCE   8  (bases 1 to 1779)
  AUTHORS   Yamanaka,S., Johnson,M.D., Grinberg,A., Westphal,H., Crawley,J.N.,
            Taniike,M., Suzuki,K. and Proia,R.L.
  TITLE     Targeted disruption of the Hexa gene results in mice with
            biochemical and pathologic features of Tay-Sachs disease
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9975-9979 (1994)
   PUBMED   7937929
REFERENCE   9  (bases 1 to 1779)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   10 (bases 1 to 1779)
  AUTHORS   Proia,R.L., d'Azzo,A. and Neufeld,E.F.
  TITLE     Association of alpha- and beta-subunits during the biosynthesis of
            beta-hexosaminidase in cultured human fibroblasts
  JOURNAL   J Biol Chem 259 (5), 3350-3354 (1984)
   PUBMED   6230359
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082097.1.
            
            On Sep 17, 2004 this sequence version replaced XM_217144.2.
            
            Sequence Note: This sequence has been modified as follows: removed
            35 bp suspected to be vector contamination from the 3' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082097.1, SRR8487227.161955.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1779              BC082097.1         1-1779
FEATURES             Location/Qualifiers
     source          1..1779
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1779
                     /gene="Hexa"
                     /note="hexosaminidase subunit alpha"
                     /db_xref="GeneID:300757"
                     /db_xref="RGD:2792"
     exon            1..284
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1618
                     /gene="Hexa"
                     /EC_number="3.2.1.52"
                     /note="Hexose aminidase A (alpha polypeptide);
                     beta-hexosaminidase subunit alpha; hexosaminidase subunit
                     A; beta-N-acetylhexosaminidase subunit alpha;
                     N-acetyl-beta-glucosaminidase subunit alpha;
                     hexosaminidase A"
                     /codon_start=1
                     /product="beta-hexosaminidase subunit alpha precursor"
                     /protein_id="NP_001004443.1"
                     /db_xref="GeneID:300757"
                     /db_xref="RGD:2792"
                     /translation="MAGCRLWVSLLLAAALACLATALWPWPQYIQTSHRRYTLYPNNF
                     QFRYHAGSAAQAGCVVLDEAFRRYRSLLFGSGSWPRPSFSKKQQPLGKNILMVSVVTA
                     ECNEFPNLESVENYTLTINDDQCLLSSETVWGALRGLETFSQLVWKSAEGTFFINKTK
                     ITDFPRFPHRGILLDTSRHYLPLSSILNTLDVMAYNKFNVFHWHLVDDSSFPYESFTF
                     PELTRKGSFNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGAGVPGLLTP
                     CYSGSRLSGTYGPVNPSLNSTYDFMSTFFLEISSVFPDFYLHLGGDEVDFTCWKSNPN
                     IQAFMKKKGFTDYKQLESFYIQTLLDIVSDYDKGYVVWQEVFDNKVKVRPDTIIQVWR
                     EEMPVQYMKEIEAITQAGFRALLSAPWYLNRVKYGPDWKEMYKVEPLAFRGTPAQKAL
                     VIGGEACMWGEYVDSTNLVPRLWPRAGAIAERLWSSNLTTNMDFAFKRLSHFRCELLR
                     RGIQAQPISVGYCEQEFEHT"
     exon            285..377
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     exon            378..443
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     exon            444..490
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     exon            491..601
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     exon            602..703
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     exon            704..836
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1017
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1101
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1174
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1358
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1449
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1554
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1779
                     /gene="Hexa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgctgga aggggagctg gccggtgggc catggccggc tgcaggctct gggtttcgct
       61 gctgctggcg gcggcgttgg cttgcttggc cacggcgctg tggccctggc cccagtacat
      121 ccaaacctcc caccggcgct acaccctgta ccccaacaac ttccagttcc ggtaccatgc
      181 cggttcggcc gcgcaggcgg gctgcgttgt cctcgacgag gcctttcgac gctaccgtag
      241 cctgctcttc ggttccggct cttggccccg acccagcttc tcaaaaaaac agcagccgtt
      301 ggggaagaac attctgatgg tctctgtcgt cacagccgaa tgtaatgagt ttcctaattt
      361 ggagtccgta gaaaattaca ccctaaccat taatgatgac cagtgtttac tctcctctga
      421 gactgtctgg ggcgctctgc gaggtctgga gactttcagt cagcttgttt ggaagtcagc
      481 tgagggcacg ttctttatca acaagacaaa gattacagac tttcctcgat tccctcaccg
      541 gggcatactg ctggatacat ctcgccatta cctgccgtta tctagcatcc tgaacacact
      601 ggatgtcatg gcgtacaata aattcaacgt gttccactgg cacttggtgg acgactcttc
      661 cttcccatac gagagcttca ccttcccaga gctcaccaga aaggggtcct tcaaccctgt
      721 tacccacatc tacacagcac aggatgtgaa ggaggtcatt gaatatgcaa ggcttcgggg
      781 tatccgagtg ctggccgaat ttgacactcc tggccacact ttgtcctggg gggcaggtgt
      841 ccctggatta ttaacacctt gctactctgg gtcccgtctc tctggcacct atggacctgt
      901 gaaccccagc ctcaacagca cctacgactt catgagcaca ttcttcctgg agatcagctc
      961 tgtcttccct gacttttatc tccacctggg aggagatgaa gttgacttca cctgctggaa
     1021 gtccaacccc aacatccagg ccttcatgaa gaaaaagggc tttactgact acaagcagct
     1081 ggagtcattc tacatccaga cgctgctgga catcgtctct gattatgaca agggctatgt
     1141 ggtgtggcag gaagtatttg ataataaagt gaaggttcgg ccagacacaa tcatacaggt
     1201 gtggcgggaa gagatgccgg tccagtacat gaaggagata gaggccatca cccaggctgg
     1261 cttccgggcc ctgctgtctg ctccctggta cctgaaccgg gtgaagtatg gccctgactg
     1321 gaaggaaatg tacaaagtgg agcccctggc atttcgtggt acacctgcac aaaaggctct
     1381 ggtcattgga ggggaagcct gtatgtgggg agagtatgtg gacagcacaa accttgtccc
     1441 caggctctgg cccagagcag gtgccattgc cgaaagactg tggagcagta acctgacgac
     1501 taatatggac tttgccttta aacgtctgtc ccatttccgc tgtgagctgc tgaggagagg
     1561 aatccaggcc cagcccatca gcgtgggcta ctgtgagcag gagtttgagc atacttgagc
     1621 cagcagtact gagcacccag gaggccttaa gagagcagtt cccgggttag gcttccactg
     1681 cctccctgca gggggagaaa gcccctggcc catgtgctcc tgtgactaga gaggaggagg
     1741 ctggtgctgg cactggtgtt caataaagat ctatgtggc
//
