LOCUS       NM_001105792            1607 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus hes family bHLH transcription factor 7 (Hes7),
            transcript variant 1, mRNA.
ACCESSION   NM_001105792 XM_001079254 XM_220597
VERSION     NM_001105792.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1607)
  AUTHORS   Chalamalasetty,R.B., Dunty,W.C. Jr., Biris,K.K., Ajima,R.,
            Iacovino,M., Beisaw,A., Feigenbaum,L., Chapman,D.L., Yoon,J.K.,
            Kyba,M. and Yamaguchi,T.P.
  TITLE     The Wnt3a/beta-catenin target gene Mesogenin1 controls the
            segmentation clock by activating a Notch signalling program
  JOURNAL   Nat Commun 2, 390 (2011)
   PUBMED   21750544
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1607)
  AUTHORS   Ferjentsik,Z., Hayashi,S., Dale,J.K., Bessho,Y., Herreman,A., De
            Strooper,B., del Monte,G., de la Pompa,J.L. and Maroto,M.
  TITLE     Notch is a critical component of the mouse somitogenesis oscillator
            and is essential for the formation of the somites
  JOURNAL   PLoS Genet 5 (9), e1000662 (2009)
   PUBMED   19779553
REFERENCE   3  (bases 1 to 1607)
  AUTHORS   Sparrow,D.B., Guillen-Navarro,E., Fatkin,D. and Dunwoodie,S.L.
  TITLE     Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes
            spondylocostal dysostosis
  JOURNAL   Hum Mol Genet 17 (23), 3761-3766 (2008)
   PUBMED   18775957
REFERENCE   4  (bases 1 to 1607)
  AUTHORS   Fischer,A. and Gessler,M.
  TITLE     Delta-Notch--and then? Protein interactions and proposed modes of
            repression by Hes and Hey bHLH factors
  JOURNAL   Nucleic Acids Res 35 (14), 4583-4596 (2007)
   PUBMED   17586813
  REMARK    Review article
REFERENCE   5  (bases 1 to 1607)
  AUTHORS   Chen,J., Kang,L. and Zhang,N.
  TITLE     Negative feedback loop formed by Lunatic fringe and Hes7 controls
            their oscillatory expression during somitogenesis
  JOURNAL   Genesis 43 (4), 196-204 (2005)
   PUBMED   16342160
REFERENCE   6  (bases 1 to 1607)
  AUTHORS   Morimoto,M., Takahashi,Y., Endo,M. and Saga,Y.
  TITLE     The Mesp2 transcription factor establishes segmental borders by
            suppressing Notch activity
  JOURNAL   Nature 435 (7040), 354-359 (2005)
   PUBMED   15902259
REFERENCE   7  (bases 1 to 1607)
  AUTHORS   Hirata,H., Bessho,Y., Kokubu,H., Masamizu,Y., Yamada,S., Lewis,J.
            and Kageyama,R.
  TITLE     Instability of Hes7 protein is crucial for the somite segmentation
            clock
  JOURNAL   Nat Genet 36 (7), 750-754 (2004)
   PUBMED   15170214
REFERENCE   8  (bases 1 to 1607)
  AUTHORS   Bessho,Y., Hirata,H., Masamizu,Y. and Kageyama,R.
  TITLE     Periodic repression by the bHLH factor Hes7 is an essential
            mechanism for the somite segmentation clock
  JOURNAL   Genes Dev 17 (12), 1451-1456 (2003)
   PUBMED   12783854
REFERENCE   9  (bases 1 to 1607)
  AUTHORS   Bessho,Y., Sakata,R., Komatsu,S., Shiota,K., Yamada,S. and
            Kageyama,R.
  TITLE     Dynamic expression and essential functions of Hes7 in somite
            segmentation
  JOURNAL   Genes Dev 15 (20), 2642-2647 (2001)
   PUBMED   11641270
REFERENCE   10 (bases 1 to 1607)
  AUTHORS   Bessho,Y., Miyoshi,G., Sakata,R. and Kageyama,R.
  TITLE     Hes7: a bHLH-type repressor gene regulated by Notch and expressed
            in the presomitic mesoderm
  JOURNAL   Genes Cells 6 (2), 175-185 (2001)
   PUBMED   11260262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 17, 2022 this sequence version replaced NM_001105792.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680444,
                              SAMN17050749 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000010.1  54324398-54324462
            66-161              JAXUCZ010000010.1  54325374-54325469
            162-249             JAXUCZ010000010.1  54326019-54326106
            250-1607            JAXUCZ010000010.1  54326419-54327776
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1607
                     /gene="Hes7"
                     /note="hes family bHLH transcription factor 7"
                     /db_xref="GeneID:287423"
                     /db_xref="RGD:1305914"
     exon            1..65
                     /gene="Hes7"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..701
                     /gene="Hes7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor HES-7; hairy and enhancer of split 7"
                     /codon_start=1
                     /product="transcription factor HES-7 isoform 1"
                     /protein_id="NP_001099262.1"
                     /db_xref="GeneID:287423"
                     /db_xref="RGD:1305914"
                     /translation="MVTRERAENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTR
                     DQNLRNPKLEKAEILEFAVGYLRERSRVEPPGVPRSPGQDAEALASCYLSGFRECLLR
                     LAAFAHDASPAARSQLFSALNGYRRPKPPRPEAADPGLPAPRPPLDPASPILGPALHQ
                     RPPVHQGPPSPRLAWSPSHCSPRAGDSGAPAPLTGLLPPPPPPYRQDGAPKAPPLPPP
                     AFWRPWP"
     exon            66..161
                     /gene="Hes7"
                     /inference="alignment:Splign:2.1.0"
     exon            162..249
                     /gene="Hes7"
                     /inference="alignment:Splign:2.1.0"
     exon            250..1607
                     /gene="Hes7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaccgaagg gtctggagga gcaatggtca cccgggagcg agctgagaat agggacggtc
       61 ccaagatgct gaagccgttg gtggagaaac ggcgccggga ccgcatcaac cgcagcctag
      121 aagagctgag gctgctgctg ctggagagga ccagggacca gaacctccgg aacccgaagc
      181 tggagaaagc agagatactg gagttcgccg tgggctactt gagggagcga agccgggtgg
      241 agccccccgg ggttccccgg tccccaggcc aggacgccga ggcgctcgcc agctgctact
      301 tgtccggctt ccgcgagtgc ctgcttcgct tggcggcctt tgcgcacgac gccagcccgg
      361 ccgcccgctc ccagcttttc tccgcgctaa acggttaccg gcggcccaaa ccaccgcggc
      421 cggaggccgc agatccaggg ctcccagcgc cgcgcccacc gctggacccc gcttcaccga
      481 tccttggccc cgcgctgcac cagcgccccc cagtgcacca gggccctccc agtccccgcc
      541 tcgcttggtc cccatcccac tgctcccctc gcgccgggga ttcgggcgcg ccggcccctc
      601 tcaccggact gctgccacca ccgccaccgc cttacagaca agacggggcg cccaaggccc
      661 cgccactccc accgcccgcg ttttggagac cttggccctg agctctgggg gggctggggc
      721 ggggattggg ggtggtgtag agactccagc cagagggcag gagagggatc cgggcgagga
      781 gggcagcggg gcgcgcggac tcagcgcgcg ggtgagatgt ggtctatatt agagtatcta
      841 tataaatata tattttcccg tcccctctcc ctgtcccact accctgtgtg tagaattgta
      901 ccctctctac cctagtccag tctcagtccc ttccccagtc cctagtgcat ggaataaaat
      961 cgttattgaa tcccggtgtg tcccctagcc aggggcctgc ctttatattg gcgccacgcc
     1021 tacttgccca tacccttctc ccacctttag gcctgctctc cacggcccaa gccctggggg
     1081 agacaggtaa gtaaagagcg gagcgacaga ctgaggttgg aactgaactt tacctgtggg
     1141 tctttaaata aaagccaaga aaagatttta aaacacaaaa aaataaaatc gactctggtg
     1201 ggattcgaac ccacaacctt tgaatcgctt tttcgtcact agaagtccaa tgcgctatcc
     1261 attgcgccac agagccacct ggcgggcggc gcctccttcc ggcttacgga cactagcata
     1321 gaaaaaaaag ggtagcgtgg gaacgtgtgc gcaaggaaag tgggcggagc gtcacaggag
     1381 cgagaggtga cggtctcaga ggtcacccga atgaaacgta gtactcgaaa agctctgagc
     1441 tagatgacag tcagggcgat gcgggtgcta gcaaacagag agggagagtg atgaaatttg
     1501 agctccccag cagcggcaag ctcgggctgc tccttgcgca agctacccag ctaagacttg
     1561 ctcggttccc aggtttgacc ccactaaata aactcgtttt gttgtaa
//
