LOCUS       NM_024383                592 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus hes family bHLH transcription factor 5 (Hes5),
            mRNA.
ACCESSION   NM_024383
VERSION     NM_024383.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 592)
  AUTHORS   Chen,X., Zhou,W., Hu,Q. and Huang,L.
  TITLE     Exploration of the Notch3-HES5 signal pathway in
            monocrotaline-induced pulmonary hypertension using rat model
  JOURNAL   Congenit Heart Dis 14 (3), 396-402 (2019)
   PUBMED   30811836
  REMARK    GeneRIF: Monocrotaline-induced pulmonary hypertension rats had high
            expressions of the Notch3-HES5 signal pathway in the pulmonary
            arterioles.
REFERENCE   2  (bases 1 to 592)
  AUTHORS   Zheng,X., Narayanan,S., Sunkari,V.G., Eliasson,S., Botusan,I.R.,
            Grunler,J., Catrina,A.I., Radtke,F., Xu,C., Zhao,A., Ekberg,N.R.,
            Lendahl,U. and Catrina,S.B.
  TITLE     Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes
  JOURNAL   Proc Natl Acad Sci U S A 116 (14), 6985-6994 (2019)
   PUBMED   30886104
REFERENCE   3  (bases 1 to 592)
  AUTHORS   Li,W., Wu,J., Yang,J., Sun,S., Chai,R., Chen,Z.Y. and Li,H.
  TITLE     Notch inhibition induces mitotically generated hair cells in
            mammalian cochleae via activating the Wnt pathway
  JOURNAL   Proc Natl Acad Sci U S A 112 (1), 166-171 (2015)
   PUBMED   25535395
REFERENCE   4  (bases 1 to 592)
  AUTHORS   Zhang,X., Huang,G., Liu,H., Chang,H. and Wilson,J.X.
  TITLE     Folic acid enhances Notch signaling, hippocampal neurogenesis, and
            cognitive function in a rat model of cerebral ischemia
  JOURNAL   Nutr Neurosci 15 (2), 55-61 (2012)
   PUBMED   22334042
  REMARK    GeneRIF: Folic acid stimulated the expression of Notch1, Hes1, and
            Hes5 proteins, and this effect increased with folic acid dose in
            the rat middle cerebral artery occlusion model of stroke.
REFERENCE   5  (bases 1 to 592)
  AUTHORS   Tateya,T., Imayoshi,I., Tateya,I., Ito,J. and Kageyama,R.
  TITLE     Cooperative functions of Hes/Hey genes in auditory hair cell and
            supporting cell development
  JOURNAL   Dev Biol 352 (2), 329-340 (2011)
   PUBMED   21300049
REFERENCE   6  (bases 1 to 592)
  AUTHORS   Ohtsuka,T., Sakamoto,M., Guillemot,F. and Kageyama,R.
  TITLE     Roles of the basic helix-loop-helix genes Hes1 and Hes5 in
            expansion of neural stem cells of the developing brain
  JOURNAL   J Biol Chem 276 (32), 30467-30474 (2001)
   PUBMED   11399758
REFERENCE   7  (bases 1 to 592)
  AUTHORS   Hojo,M., Ohtsuka,T., Hashimoto,N., Gradwohl,G., Guillemot,F. and
            Kageyama,R.
  TITLE     Glial cell fate specification modulated by the bHLH gene Hes5 in
            mouse retina
  JOURNAL   Development 127 (12), 2515-2522 (2000)
   PUBMED   10821751
REFERENCE   8  (bases 1 to 592)
  AUTHORS   Cau,E., Gradwohl,G., Casarosa,S., Kageyama,R. and Guillemot,F.
  TITLE     Hes genes regulate sequential stages of neurogenesis in the
            olfactory epithelium
  JOURNAL   Development 127 (11), 2323-2332 (2000)
   PUBMED   10804175
REFERENCE   9  (bases 1 to 592)
  AUTHORS   Ohtsuka,T., Ishibashi,M., Gradwohl,G., Nakanishi,S., Guillemot,F.
            and Kageyama,R.
  TITLE     Hes1 and Hes5 as notch effectors in mammalian neuronal
            differentiation
  JOURNAL   EMBO J 18 (8), 2196-2207 (1999)
   PUBMED   10205173
REFERENCE   10 (bases 1 to 592)
  AUTHORS   Akazawa,C., Sasai,Y., Nakanishi,S. and Kageyama,R.
  TITLE     Molecular characterization of a rat negative regulator with a basic
            helix-loop-helix structure predominantly expressed in the
            developing nervous system
  JOURNAL   J Biol Chem 267 (30), 21879-21885 (1992)
   PUBMED   1400497
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D12516.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D12516.1, AI548772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132276, SAMD00132289
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..592
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..592
                     /gene="Hes5"
                     /note="hes family bHLH transcription factor 5"
                     /db_xref="GeneID:79225"
                     /db_xref="RGD:621340"
     exon            1..106
                     /gene="Hes5"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..553
                     /gene="Hes5"
                     /note="hairy and enhancer of split 5"
                     /codon_start=1
                     /product="transcription factor HES-5"
                     /protein_id="NP_077359.1"
                     /db_xref="GeneID:79225"
                     /db_xref="RGD:621340"
                     /translation="MAPSTVAVEMLSPKEKNRLRKPVVEKMRRDRINSSIEQLKLLLE
                     QEFARHQPNSKLEKADILEMAVSYLKHSKAFAAAAGPKSLHQDYSEGYSWCLQEAVQF
                     LTLHAASDTQMKLLYHFQRPPAPAAPVKETPTPGAAPQPARSSTKAAASVSTSRQSAC
                     GLWRPW"
     exon            107..272
                     /gene="Hes5"
                     /inference="alignment:Splign:2.1.0"
     exon            273..592
                     /gene="Hes5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctggctctg ctcgctccgc tccgctcgcc aatcgcctcc agagctccag gcatggcccc
       61 aagtaccgtg gcggtggaga tgctcagtcc caaggagaaa aatcgactgc ggaagccggt
      121 ggtggagaag atgcgtcggg accgcatcaa cagcagcatt gagcagctga aactgctgct
      181 ggagcaggag ttcgcgcggc accagcccaa ctccaaactg gagaaggccg acatcctgga
      241 gatggccgtc agctacctga agcacagcaa agccttcgcc gcggccgccg gccccaagag
      301 cctgcaccag gactacagcg agggttactc gtggtgcctg caggaggcgg tgcagttcct
      361 gaccctgcat gcagccagcg acacgcagat gaagctgctt taccacttcc agcggccccc
      421 agctcccgcc gcgcctgtca aggagacccc gacgcccggc gctgcgcccc agccggcgcg
      481 ctcctccact aaggccgccg cctccgtctc cacctcgcgc caatctgcct gcggcctctg
      541 gcggccctgg tgacccagcg gccgacgggt gcctggagct gaccagagga cc
//
