LOCUS       NM_022687                957 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus hes family bHLH transcription factor 3 (Hes3),
            mRNA.
ACCESSION   NM_022687
VERSION     NM_022687.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 957)
  AUTHORS   Kinameri,E., Inoue,T., Aruga,J., Imayoshi,I., Kageyama,R.,
            Shimogori,T. and Moore,A.W.
  TITLE     Prdm proto-oncogene transcription factor family expression and
            interaction with the Notch-Hes pathway in mouse neurogenesis
  JOURNAL   PLoS One 3 (12), e3859 (2008)
   PUBMED   19050759
REFERENCE   2  (bases 1 to 957)
  AUTHORS   Sharma,S., Stolina,M., Zhu,L., Lin,Y., Batra,R., Huang,M.,
            Strieter,R. and Dubinett,S.M.
  TITLE     Secondary lymphoid organ chemokine reduces pulmonary tumor burden
            in spontaneous murine bronchoalveolar cell carcinoma
  JOURNAL   Cancer Res 61 (17), 6406-6412 (2001)
   PUBMED   11522634
REFERENCE   3  (bases 1 to 957)
  AUTHORS   Hirata,H., Tomita,K., Bessho,Y. and Kageyama,R.
  TITLE     Hes1 and Hes3 regulate maintenance of the isthmic organizer and
            development of the mid/hindbrain
  JOURNAL   EMBO J 20 (16), 4454-4466 (2001)
   PUBMED   11500373
REFERENCE   4  (bases 1 to 957)
  AUTHORS   Hirata,H., Ohtsuka,T., Bessho,Y. and Kageyama,R.
  TITLE     Generation of structurally and functionally distinct factors from
            the basic helix-loop-helix gene Hes3 by alternative first exons
  JOURNAL   J Biol Chem 275 (25), 19083-19089 (2000)
   PUBMED   10858455
REFERENCE   5  (bases 1 to 957)
  AUTHORS   Sasai,Y., Kageyama,R., Tagawa,Y., Shigemoto,R. and Nakanishi,S.
  TITLE     Two mammalian helix-loop-helix factors structurally related to
            Drosophila hairy and Enhancer of split
  JOURNAL   Genes Dev 6 (12B), 2620-2634 (1992)
   PUBMED   1340473
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_022687.3.
            
            On Nov 26, 2020 this sequence version replaced NM_022687.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13418.1, SRR22582416.489959.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               JAXUCZ010000005.1  168078734-168078987 c
            255-350             JAXUCZ010000005.1  168078148-168078243 c
            351-432             JAXUCZ010000005.1  168077989-168078070 c
            433-957             JAXUCZ010000005.1  168077093-168077617 c
FEATURES             Location/Qualifiers
     source          1..957
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..957
                     /gene="Hes3"
                     /note="hes family bHLH transcription factor 3"
                     /db_xref="GeneID:64628"
                     /db_xref="RGD:621339"
     exon            1..254
                     /gene="Hes3"
                     /inference="alignment:Splign:2.1.0"
     exon            255..350
                     /gene="Hes3"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..797
                     /gene="Hes3"
                     /note="hairy and enhancer of split 3"
                     /codon_start=1
                     /product="transcription factor HES-3"
                     /protein_id="NP_073178.1"
                     /db_xref="GeneID:64628"
                     /db_xref="RGD:621339"
                     /translation="MEKKRRARINLSLEQLRSLLERHYSHQIRKRKLEKADILELSVK
                     YVRSLQNSLQGLWLVPSGVDYPSGFRGGLPGSSQRLRPGEDDSGLRCPLLLQRRAGST
                     TDSANPQTASVLSPCLPAIWAPGPPAGGSQSPQSPFPPLGGLLESSTGILAPPPASNC
                     QAENPRPGFRVWRPW"
     exon            351..432
                     /gene="Hes3"
                     /inference="alignment:Splign:2.1.0"
     exon            433..957
                     /gene="Hes3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggccctgc ttgcaactgg ctttgagcaa ccacaggcag aaaattgcta cattgtcctg
       61 acattagggc gactaattca gcatcccagc gtggccagag cgtgaaggga gcagaaaagc
      121 atcactggcc agcatcctcg cctcagcatc tttatcaggc ctcaggacac ctagcgcccc
      181 accatcatca tttaggatgg accccagctc acacagctcc ctgccataac ggaggaccac
      241 cagaagaatg ttggatctcc aagcctctga tggagaagaa gcgtcgtgcc cgcatcaacc
      301 tgtcactgga gcagctaagg tctcttctgg agagacacta ctcccaccag atacggaagc
      361 gaaagctgga gaaggccgat atcctggagc tgagcgttaa gtacgtgaga agcctccaga
      421 actcattgca aggactttgg ctagtaccca gtggggtgga ctacccgtcc ggattccgag
      481 gcggcttgcc gggctccagc cagaggcttc ggcccggaga ggacgacagc ggcctgcgct
      541 gccccctgct tctccagcgc agggcaggca gcaccacgga cagcgccaac ccacagacgg
      601 cctctgttct cagcccctgc ctcccggcca tctgggcccc tggtccccct gcaggtggct
      661 cccaatcccc gcagtccccg ttccctcccc ttggaggtct ccttgagtcc tccactggca
      721 ttctggcacc gccacctgca tcaaactgcc aggccgagaa tccgagaccc gggtttcgcg
      781 tgtggcggcc ctggtgaggc ctaggcaaga atttagattc aagccctaac ctctgccctt
      841 atcacctcgc cgtctagttt gggggaaact atttggggac acccatggtg actgcaggga
      901 ctctatcaat cggtggcctg gtggggctgc agggaaatac acggagccat ttgctga
//
